| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kevin A Janes, John G Albeck, Lili X Peng, Peter K Sorger, Douglas A Lauffenburger, Michael B Yaff. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Molecular & cellular proteomics : MCP. vol 2. issue 7. 2006-07-27. PMID:12832460. |
when applied to a model of sepsis-induced colon epithelial apoptosis, this approach identified a late phase of akt activity as a critical mediator of cell survival that quantitatively contributed to the efficacy of insulin as an anti-apoptotic cue. |
2006-07-27 |
2023-08-12 |
human |
| Philippe Devos, René Chioléro, Greet Van den Berghe, Jean-Charles Preise. Glucose, insulin and myocardial ischaemia. Current opinion in clinical nutrition and metabolic care. vol 9. issue 2. 2006-07-24. PMID:16477178. |
we have reviewed (1) the physiological and physiopathological consequences of hyperglycaemia focusing on potential machanisms of myocardial ischaemia, (2) the effects of insulin on vascular tone, on the release of free fatty acids, on inflammatory pathways, on the switch of energy source and on apoptosis, and (3) clinical data reporting the effects of intensive insulin therapy and glucose-insulin-potassium solutions during myocardial ischaemia and ischaemic heart failure. |
2006-07-24 |
2023-08-12 |
Not clear |
| J R Porter, T G Barret. Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure. Journal of medical genetics. vol 42. issue 12. 2006-07-17. PMID:15772126. |
three main areas of defect contribute to diabetes: defects in insulin signalling leading to insulin resistance; defects of insulin secretion leading to hypoinsulinaemia; and apoptosis leading to decreased beta cell mass. |
2006-07-17 |
2023-08-12 |
Not clear |
| Fawzia Bardag-Gorce, Barbara A French, Jennifer Dedes, Jun Li, Samuel W Frenc. Gene expression patterns of the liver in response to alcohol: in vivo and in vitro models compared. Experimental and molecular pathology. vol 80. issue 3. 2006-07-05. PMID:16770850. |
these included the insulin signaling pathway, tgfbeta signaling pathway, apoptosis, mapk signaling pathway, wnt signaling pathway and apoptosis. |
2006-07-05 |
2023-08-12 |
Not clear |
| Roberto Baldelli, Simonetta Bellone, Fabio Broglio, Ezio Ghigo, Gianni Bon. Ghrelin: a new hormone with endocrine and non-endocrine activities. Pediatric endocrinology reviews : PER. vol 2. issue 1. 2006-06-26. PMID:16429099. |
ghrelin and ghss, acting on central and peripheral receptors, exert other actions such as: stimulation of acth and prolactin secretion; influence insulin secretion and glucose metabolism; have an orexigenic effect and modulatory activity on the neuroendocrine and metabolic response to starvation; influencing exocrine gastro-entero-pancreatic functions; influencing cardiovascular activities and modulation of cell proliferation and apoptosis. |
2006-06-26 |
2023-08-12 |
Not clear |
| Koujiro Imoto, Daisuke Kukidome, Takeshi Nishikawa, Takako Matsuhisa, Kazuhiro Sonoda, Kazuo Fujisawa, Miyuki Yano, Hiroyuki Motoshima, Tetsuya Taguchi, Kaku Tsuruzoe, Takeshi Matsumura, Hidenori Ichijo, Eiichi Arak. Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling. Diabetes. vol 55. issue 5. 2006-06-26. PMID:16644673. |
impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling. |
2006-06-26 |
2023-08-12 |
human |
| Xiuli Lu, Fukushi Kambe, Xia Cao, Taemi Yoshida, Sachiko Ohmori, Kohji Murakami, Takahide Kaji, Takehisa Ishii, David Zadworny, Hisao Se. DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling. Endocrinology. vol 147. issue 6. 2006-06-22. PMID:16513830. |
however, this impairment was partial because treatment of the mefs with insulin restored akt activation and prevented apoptosis. |
2006-06-22 |
2023-08-12 |
mouse |
| Zandong Yang, Meng Chen, Jeffrey D Carter, Craig S Nunemaker, James C Garmey, Sarah D Kimble, Jerry L Nadle. Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes. Biochemical and biophysical research communications. vol 344. issue 3. 2006-06-22. PMID:16643856. |
the therapeutic effect of this regimen was associated with improved beta-cell metabolism and insulin secretion, while reducing beta-cell apoptosis. |
2006-06-22 |
2023-08-12 |
mouse |
| Mark F McCart. cGMP may have trophic effects on beta cell function comparable to those of cAMP, implying a role for high-dose biotin in prevention/treatment of diabetes. Medical hypotheses. vol 66. issue 2. 2006-06-08. PMID:16309850. |
camp is the primary mediator of these effects, and has been shown to potentiate glucose-stimulated insulin secretion, promote proper beta cells differentiation by increasing expression of the crucial transcription factor pdx-1, and prevent beta cell apoptosis. |
2006-06-08 |
2023-08-12 |
Not clear |
| C Murgia, C J Lang, A Q Truong-Tran, D Grosser, L Jayaram, R E Ruffin, G Perozzi, P D Zalewsk. Zinc and its specific transporters as potential targets in airway disease. Current drug targets. vol 7. issue 5. 2006-06-08. PMID:16719771. |
it regulates a number of cellular processes including mitosis, apoptosis, secretion and signal transduction as well as critical events in physiological processes as diverse as insulin release, t cell cytokine production, wound healing, vision and neurotransmission. |
2006-06-08 |
2023-08-12 |
Not clear |
| Julie C Kiefe. microRNAs under the microscope. Developmental dynamics : an official publication of the American Association of Anatomists. vol 235. issue 3. 2006-06-06. PMID:16408285. |
once regarded as a biological anomaly, micrornas (mirnas) have since been recognized as a prevalent rna species that regulates a wide array of biological processes, from fat storage and insulin secretion, to apoptosis and cell growth. |
2006-06-06 |
2023-08-12 |
Not clear |
| Xiao-Rui Yu, Guo-Rong Jia, Guang-Dao Gao, Shu-Hong Wang, Yan Han, Wei Ca. Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway. Acta biochimica et biophysica Sinica. vol 38. issue 4. 2006-06-06. PMID:16604263. |
neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/akt signal pathway. |
2006-06-06 |
2023-08-12 |
rat |
| Xiao-Rui Yu, Guo-Rong Jia, Guang-Dao Gao, Shu-Hong Wang, Yan Han, Wei Ca. Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway. Acta biochimica et biophysica Sinica. vol 38. issue 4. 2006-06-06. PMID:16604263. |
we observed that treatment with 100 microm h2o2 for 24 h significantly decreased cell viability and induced apoptotic death of retinal neurons, and that pretreatment with 10 nm insulin significantly inhibited or attenuated h2o2-induced cytotoxicity and apoptosis. |
2006-06-06 |
2023-08-12 |
rat |
| Xiao-Rui Yu, Guo-Rong Jia, Guang-Dao Gao, Shu-Hong Wang, Yan Han, Wei Ca. Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway. Acta biochimica et biophysica Sinica. vol 38. issue 4. 2006-06-06. PMID:16604263. |
these results suggest that insulin protects retinal neurons from oxidative stress-induced apoptosis and that the pi3k/akt signal pathway is involved in insulin-mediated retinal neuroprotection. |
2006-06-06 |
2023-08-12 |
rat |
| b' Francisco C Mu\\xc3\\xb1oz-Casares, Francisco J Padillo, Javier Brice\\xc3\\xb1o, Juan A Collado, Juan R Mu\\xc3\\xb1oz-Casta\\xc3\\xb1eda, Rosa Ortega, Adolfo Cruz, Isaac T\\xc3\\xbanez, Pedro Montilla, Carlos Pera, Jordi Muntan\\xc3\\xa. Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas. Journal of pineal research. vol 40. issue 3. 2006-05-30. PMID:16499554.' |
the animals were killed at 24 and 48 hr after reperfusion and there were evaluated parameters of oxidative stress (lipoperoxides, superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione), glandular endocrine and exocrine function (lipase, amylase, insulin) and cell injury (apoptosis and necrosis). |
2006-05-30 |
2023-08-12 |
rat |
| Xuebin Li, Yongqing Jiang, Zhengchao Wang, Gentao Liu, Reinhold J Hutz, Wenbin Liu, Zhuang Xie, Fangxiong Sh. Regulation of FoxO1 transcription factor by nitric oxide and cyclic GMP in cultured rat granulosa cells. Zoological science. vol 22. issue 12. 2006-05-25. PMID:16462106. |
foxo1 is a transcription factor implicated in a multitude of physiological processes including cell cycle progression, apoptosis and insulin signaling. |
2006-05-25 |
2023-08-12 |
rat |
| Milena Sokołowska, Marek L Kowalski, Rafał Pawlicza. [Peroxisome proliferator-activated receptors-gamma (PPAR-gamma) and their role in immunoregulation and inflammation control]. Postepy higieny i medycyny doswiadczalnej (Online). vol 59. 2006-05-16. PMID:16258412. |
ppar-gamma have attracted attention so far as key factors in adipogenesis, lipid metabolism, insulin sensitivity, and apoptosis. |
2006-05-16 |
2023-08-12 |
Not clear |
| Yu-Feng Zhao, Dan Dan Feng, Chen Che. Contribution of adipocyte-derived factors to beta-cell dysfunction in diabetes. The international journal of biochemistry & cell biology. vol 38. issue 5-6. 2006-05-08. PMID:16378747. |
leptin, free fatty acids, adiponectin, tumor necrosis factor-alpha and interleukin-6 are all produced and secreted by adipocytes, and may directly influence aspects of beta-cell function, including insulin synthesis and secretion, insulin cell survival and apoptosis. |
2006-05-08 |
2023-08-12 |
Not clear |
| Eija Bencomo, Rosa Pérez, Mari-Francis Arteaga, Elisa Acosta, Oscar Peña, Lourdes Lopez, Julio Avila, Angela Palumb. Apoptosis of cultured granulosa-lutein cells is reduced by insulin-like growth factor I and may correlate with embryo fragmentation and pregnancy rate. Fertility and sterility. vol 85. issue 2. 2006-05-08. PMID:16595230. |
to correlate apoptosis of cultured human granulosa-lutein cells (gl cells) with the outcome of ivf (embryo fragmentation and pregnancy rate) and to study the effect of insulin and insulin-like growth factor i (igf-i) on apoptosis. |
2006-05-08 |
2023-08-12 |
human |
| Laurie L Baggio, Daniel J Drucke. Therapeutic approaches to preserve islet mass in type 2 diabetes. Annual review of medicine. vol 57. 2006-05-04. PMID:16409149. |
similarly, glucose-dependent insulinotropic polypeptide (gip) receptor activation stimulates insulin secretion, enhances beta-cell proliferation, and reduces apoptosis. |
2006-05-04 |
2023-08-12 |
Not clear |