| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Won-Ho Kim, June Woo Lee, Young Ho Suh, Hyun Jung Lee, Seung Hee Lee, Yeo Kyoung Oh, Bin Gao, Myeong Ho Jun. AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. Cellular signalling. vol 19. issue 4. 2007-04-18. PMID:17127032. |
here, we show that prolonged exposure of 5-aminoimidazole-4-carboxamide (aica)-riboside potentiated apoptosis induced by high glucose in min6n8 pancreatic beta-cells, correlating with enhanced gck downregulation and decreased production of atp and insulin. |
2007-04-18 |
2023-08-12 |
Not clear |
| Won-Ho Kim, June Woo Lee, Young Ho Suh, Hyun Jung Lee, Seung Hee Lee, Yeo Kyoung Oh, Bin Gao, Myeong Ho Jun. AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. Cellular signalling. vol 19. issue 4. 2007-04-18. PMID:17127032. |
overexpression of gck prevents apoptosis; decreased cellular atp and insulin secretion, and ros production enhanced by aicar, but does not affect ampk activation. |
2007-04-18 |
2023-08-12 |
Not clear |
| Claus M Larsen, Mirjam Faulenbach, Allan Vaag, Aage Vølund, Jan A Ehses, Burkhardt Seifert, Thomas Mandrup-Poulsen, Marc Y Donat. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. The New England journal of medicine. vol 356. issue 15. 2007-04-17. PMID:17429083. |
the expression of interleukin-1-receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the production of interleukin-1beta in human pancreatic beta cells, leading to impaired insulin secretion, decreased cell proliferation, and apoptosis. |
2007-04-17 |
2023-08-12 |
human |
| Robert A Ritzel, Juris J Meier, Chia-Yu Lin, Johannes D Veldhuis, Peter C Butle. Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets. Diabetes. vol 56. issue 1. 2007-03-26. PMID:17192466. |
human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets. |
2007-03-26 |
2023-08-12 |
human |
| Tie-jian Jiang, Zhi-guang Zhou, Heng S. [Inhibition of islet beta cell apoptosis and prevention diabetes by subcutaneous administration of insulin in NOD mice]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 31. issue 4. 2007-03-20. PMID:16951506. |
[inhibition of islet beta cell apoptosis and prevention diabetes by subcutaneous administration of insulin in nod mice]. |
2007-03-20 |
2023-08-12 |
mouse |
| Tie-jian Jiang, Zhi-guang Zhou, Heng S. [Inhibition of islet beta cell apoptosis and prevention diabetes by subcutaneous administration of insulin in NOD mice]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 31. issue 4. 2007-03-20. PMID:16951506. |
to investigate the effects of subcutaneous administration of insulin on insulitis,beta cell apoptosis and diabetes in non-obese diabetic (nod) mice, and to explore the mechanism of immune tolerance induced by insulin. |
2007-03-20 |
2023-08-12 |
mouse |
| Jessica K Boehrs, Jinghua He, Marie-Jo Halaby, Da-Qing Yan. Constitutive expression and cytoplasmic compartmentalization of ATM protein in differentiated human neuron-like SH-SY5Y cells. Journal of neurochemistry. vol 100. issue 2. 2007-03-06. PMID:17241156. |
our results further demonstrated that, in response to insulin, atm protects differentiated neuron-like sh-sy5y cells from serum starvation-induced apoptosis. |
2007-03-06 |
2023-08-12 |
mouse |
| James D Johnson, Ernesto Bernal-Mizrachi, Emilyn U Alejandro, Zhiqiang Han, Tatyana B Kalynyak, Hong Li, Jennifer L Beith, Julia Gross, Garth L Warnock, R Reid Townsend, M Alan Permutt, Kenneth S Polonsk. Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 51. 2007-03-02. PMID:17158802. |
insulin protects islets from apoptosis via pdx1 and specific changes in the human islet proteome. |
2007-03-02 |
2023-08-12 |
mouse |
| James D Johnson, Ernesto Bernal-Mizrachi, Emilyn U Alejandro, Zhiqiang Han, Tatyana B Kalynyak, Hong Li, Jennifer L Beith, Julia Gross, Garth L Warnock, R Reid Townsend, M Alan Permutt, Kenneth S Polonsk. Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 51. 2007-03-02. PMID:17158802. |
in the present study, the role of insulin in beta-cell apoptosis was examined. |
2007-03-02 |
2023-08-12 |
mouse |
| James D Johnson, Ernesto Bernal-Mizrachi, Emilyn U Alejandro, Zhiqiang Han, Tatyana B Kalynyak, Hong Li, Jennifer L Beith, Julia Gross, Garth L Warnock, R Reid Townsend, M Alan Permutt, Kenneth S Polonsk. Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 51. 2007-03-02. PMID:17158802. |
exogenous insulin completely prevented apoptosis induced by serum withdrawal when given at picomolar or low nanomolar concentrations but not at higher concentrations, indicating that physiological concentrations of insulin are antiapoptotic and that insulin signaling is self-limiting in islets. |
2007-03-02 |
2023-08-12 |
mouse |
| Philip Newsholme, Deirdre Keane, Hannah J Welters, Noel G Morga. Life and death decisions of the pancreatic beta-cell: the role of fatty acids. Clinical science (London, England : 1979). vol 112. issue 1. 2007-02-23. PMID:17132138. |
acute exposure of the pancreatic beta-cell to high glucose concentrations and/or saturated nefas results in a substantial increase in insulin release, whereas chronic exposure results in desensitization and suppression of secretion, followed by induction of apoptosis. |
2007-02-23 |
2023-08-12 |
Not clear |
| Francesco Negr. Mechanisms and significance of liver steatosis in hepatitis C virus infection. World journal of gastroenterology. vol 12. issue 42. 2007-02-20. PMID:17106922. |
most studies have shown a correlation between presence and/or severity of steatosis and fibrosis stage, but it is unclear whether this effect is direct or mediated by the associated insulin resistance, increased susceptibility to apoptosis, or by inflammatory cytokines. |
2007-02-20 |
2023-08-12 |
Not clear |
| Qin Huang, Shizhong Bu, Yongwei Yu, Zhiyong Guo, Gautam Ghatnekar, Min Bu, Linhui Yang, Bin Lu, Zhengkang Feng, Shanrong Liu, Fengqi Wan. Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase. Endocrinology. vol 148. issue 1. 2007-02-13. PMID:17053028. |
we found a significant increase with age in the frequency of apoptosis, the sequential enlargement of islets, and the proliferation of the connective tissue surrounding islets, accompanied with defective insulin secretory capacity and increased blood glucose in untreated oletf rats. |
2007-02-13 |
2023-08-12 |
human |
| Qin Huang, Shizhong Bu, Yongwei Yu, Zhiyong Guo, Gautam Ghatnekar, Min Bu, Linhui Yang, Bin Lu, Zhengkang Feng, Shanrong Liu, Fengqi Wan. Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase. Endocrinology. vol 148. issue 1. 2007-02-13. PMID:17053028. |
in contrast, diazoxide treatment (25 mg.kg(-1).d(-1), administered ip) inhibited beta-cell apoptosis, ameliorated changes of islet morphology and insulin secretory function, and increased insulin stores significantly in islet beta-cells whether diazoxide was used at the prediabetic or diabetic stage. |
2007-02-13 |
2023-08-12 |
human |
| Qin Huang, Shizhong Bu, Yongwei Yu, Zhiyong Guo, Gautam Ghatnekar, Min Bu, Linhui Yang, Bin Lu, Zhengkang Feng, Shanrong Liu, Fengqi Wan. Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase. Endocrinology. vol 148. issue 1. 2007-02-13. PMID:17053028. |
in this study, we demonstrate that diazoxide prevents the onset and development of diabetes in oletf rats by inhibiting beta-cell apoptosis via increasing p38beta mapk, elevating bcl-2/bax ratio, and ameliorating insulin secretory capacity and action. |
2007-02-13 |
2023-08-12 |
human |
| Robert Hägerkvist, Natalia Makeeva, Stephen Elliman, Nils Wels. Imatinib mesylate (Gleevec) protects against streptozotocin-induced diabetes and islet cell death in vitro. Cell biology international. vol 30. issue 12. 2007-02-09. PMID:17020808. |
the aim of the present study was to establish whether imatinib protects the insulin producing beta-cell from the different apoptosis promoting agents in vitro and whether imatinib counteracts streptozotocin-induced diabetes in nmri mice. |
2007-02-09 |
2023-08-12 |
mouse |
| Dany Muller, Peter M Jones, Shanta J Persau. Autocrine anti-apoptotic and proliferative effects of insulin in pancreatic beta-cells. FEBS letters. vol 580. issue 30. 2007-01-30. PMID:17161395. |
insulin and glucose inhibited apoptosis in the min6 insulin-secreting cell line. |
2007-01-30 |
2023-08-12 |
Not clear |
| Dany Muller, Peter M Jones, Shanta J Persau. Autocrine anti-apoptotic and proliferative effects of insulin in pancreatic beta-cells. FEBS letters. vol 580. issue 30. 2007-01-30. PMID:17161395. |
the protective effect of 25 mm glucose was prevented by an anti-insulin antibody and this antibody-induced increase in apoptosis was reversed by the presence of excess insulin. |
2007-01-30 |
2023-08-12 |
Not clear |
| Dany Muller, Peter M Jones, Shanta J Persau. Autocrine anti-apoptotic and proliferative effects of insulin in pancreatic beta-cells. FEBS letters. vol 580. issue 30. 2007-01-30. PMID:17161395. |
these data indicate that insulin secreted by beta-cells in response to elevated glucose exerts autocrine effects to protect against apoptosis and stimulate proliferation, and suggest that the insulin signalling cascade, through the pi-3k pathway, may be an effective means of maintaining beta-cell mass in diabetes. |
2007-01-30 |
2023-08-12 |
Not clear |
| A J Whitmars. The JIP family of MAPK scaffold proteins. Biochemical Society transactions. vol 34. issue Pt 5. 2007-01-29. PMID:17052208. |
jip proteins have been demonstrated to form complexes with specific jnk and p38 mapk signalling modules and to play important roles in brain development, neuronal trafficking, apoptosis, beta-cell function and insulin responses. |
2007-01-29 |
2023-08-12 |
Not clear |