| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tatsuo Okada, Jun Wada, Kazuyuki Hida, Jun Eguchi, Izumi Hashimoto, Masako Baba, Akihiro Yasuhara, Kenichi Shikata, Hirofumi Makin. Thiazolidinediones ameliorate diabetic nephropathy via cell cycle-dependent mechanisms. Diabetes. vol 55. issue 6. 2007-07-23. PMID:16731829. |
thiazolidinediones are ligands for peroxisome proliferator-activated receptor (ppar)-gamma, widely used as insulin sensitizer in type 2 diabetic patients and implicated in apoptosis, cell proliferation, and cell cycle regulation. |
2007-07-23 |
2023-08-12 |
mouse |
| Charlotta S Olofsson, Stephan Collins, Martin Bengtsson, Lena Eliasson, Albert Salehi, Kenju Shimomura, Andrei Tarasov, Cecilia Holm, Frances Ashcroft, Patrik Rorsma. Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane. Diabetes. vol 56. issue 7. 2007-07-17. PMID:17456851. |
ffa-induced inhibition of insulin secretion was not associated with increased transcript levels of the apoptosis markers bax (bclii-associated x protein) and caspase-3. |
2007-07-17 |
2023-08-12 |
mouse |
| Yasuo Terauch. [PPARgamma and metabolic syndrome]. Rinsho byori. The Japanese journal of clinical pathology. vol 55. issue 5. 2007-07-13. PMID:17593690. |
by contrast, potent activation of ppary by thiazolidinedione (tzd) stimulated adipocyte differentiation and apoptosis, thereby preventing adipocyte hypertrophy, which is associated with the alleviation of insulin resistance, presumably due to decreases in ffa, and tnfa, and the up-regulation of adiponectin. |
2007-07-13 |
2023-08-12 |
mouse |
| Laney M Weber, Kirsten N Hayda, Kathryn Haskins, Kristi S Anset. The effects of cell-matrix interactions on encapsulated beta-cell function within hydrogels functionalized with matrix-derived adhesive peptides. Biomaterials. vol 28. issue 19. 2007-07-12. PMID:17391752. |
in the absence of cell-cell and cell-matrix contacts, encapsulated min6 beta-cell survival diminishes within one week; however, in peg hydrogel derivatives including the laminin sequences iklli and ikvav, encapsulated beta-cells exhibit preserved viability, reduced apoptosis, and increased insulin secretion. |
2007-07-12 |
2023-08-12 |
Not clear |
| Joy G Ghosh, Ananth K Shenoy, John I Clar. Interactions between important regulatory proteins and human alphaB crystallin. Biochemistry. vol 46. issue 21. 2007-07-06. PMID:17487982. |
protein pin arrays assessed interactions between alphab crystallin and 12 regulatory proteins, including egf, fgf-2, igf-1, ngf-beta, tgf-beta, vegf, insulin, beta-catenin, caspase-3, caspase-8, bcl-2, and bcl-xl, which are important in cellular differentiation, proliferation, signaling, cytoskeletal assembly, and apoptosis. |
2007-07-06 |
2023-08-12 |
human |
| Laurie L Baggio, Daniel J Drucke. Biology of incretins: GLP-1 and GIP. Gastroenterology. vol 132. issue 6. 2007-07-03. PMID:17498508. |
incretin-receptor activation leads to glucose-dependent insulin secretion, induction of beta-cell proliferation, and enhanced resistance to apoptosis. |
2007-07-03 |
2023-08-12 |
human |
| Steven Patterson, Peter R Flatt, Neville H McClenagha. Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic beta-cell glucose-sensing, cellular signal transduction and integrity. Archives of biochemistry and biophysics. vol 461. issue 2. 2007-06-26. PMID:17376398. |
cellular insulin content and dna damage were not altered following culture, however, there were early signs of apoptosis consistent with impaired cellular integrity. |
2007-06-26 |
2023-08-12 |
Not clear |
| Helena M Ximenes, Stephan Lortz, Anne Jörns, Sigurd Lenze. Triiodothyronine (T3)-mediated toxicity and induction of apoptosis in insulin-producing INS-1 cells. Life sciences. vol 80. issue 22. 2007-06-20. PMID:17408701. |
only t(3) concentrations higher than 250 microm were able to decrease cell viability and proliferation rate, to increase the rate of apoptosis and to reduce glucose-induced insulin secretion. |
2007-06-20 |
2023-08-12 |
Not clear |
| Jorge D Rivas-Carrillo, Alejandro Soto-Gutierrez, Nalu Navarro-Alvarez, Hirofumi Noguchi, Teru Okitsu, Yong Chen, Takeshi Yuasa, Kimiaki Tanaka, Michiki Narushima, Atsushi Miki, Haruo Misawa, Yasuhiko Tabata, Hee-Sook Jun, Shinichi Matsumoto, Ira J Fox, Noriaki Tanaka, Naoya Kobayash. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes. vol 56. issue 5. 2007-06-19. PMID:17287463. |
cell-permeable pentapeptide v5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. |
2007-06-19 |
2023-08-12 |
mouse |
| Patricia Pérez-Matute, Nerea Pérez-Echarri, J Alfredo Martínez, Amelia Marti, María J Moreno-Aliag. Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha. The British journal of nutrition. vol 97. issue 2. 2007-06-19. PMID:17298710. |
eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha. |
2007-06-19 |
2023-08-12 |
rat |
| Patricia Pérez-Matute, Nerea Pérez-Echarri, J Alfredo Martínez, Amelia Marti, María J Moreno-Aliag. Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: role of apoptosis, adiponectin and tumour necrosis factor-alpha. The British journal of nutrition. vol 97. issue 2. 2007-06-19. PMID:17298710. |
the actions on white adipose tissue lipolysis, apoptosis and on several genes related to obesity and insulin resistance were also studied. |
2007-06-19 |
2023-08-12 |
rat |
| Juliet A Emamaullee, Laura Stanton, Colleen Schur, A M James Shapir. Caspase inhibitor therapy enhances marginal mass islet graft survival and preserves long-term function in islet transplantation. Diabetes. vol 56. issue 5. 2007-06-19. PMID:17303806. |
in addition, short-term zvad-fmk treatment significantly reduced posttransplant apoptosis in islet grafts and resulted in preservation of graft insulin reserve over time. |
2007-06-19 |
2023-08-12 |
mouse |
| Chien-Ping Liang, Seongah Han, Takafumi Senokuchi, Alan R Tal. The macrophage at the crossroads of insulin resistance and atherosclerosis. Circulation research. vol 100. issue 11. 2007-06-19. PMID:17556668. |
insulin resistant macrophages are more susceptible to endoplasmic reticulum stress and apoptosis in response to various stimuli such as nutrient deprivation, free cholesterol loading, and oxidized ldl. |
2007-06-19 |
2023-08-12 |
Not clear |
| Chien-Ping Liang, Seongah Han, Takafumi Senokuchi, Alan R Tal. The macrophage at the crossroads of insulin resistance and atherosclerosis. Circulation research. vol 100. issue 11. 2007-06-19. PMID:17556668. |
increased apoptosis of insulin resistant macrophages and impaired phagocytic clearance of apoptotic cells by insulin resistant macrophages in atherosclerotic lesions may lead to enhanced postapoptotic necrosis, larger lipid-rich cores, increased inflammation, and more complex vulnerable plaques. |
2007-06-19 |
2023-08-12 |
Not clear |
| Mourad Naïmi, Nadine Gautier, Claire Chaussade, Angela M Valverde, Domenico Accili, Emmanuel Van Obberghe. Nuclear forkhead box O1 controls and integrates key signaling pathways in hepatocytes. Endocrinology. vol 148. issue 5. 2007-06-04. PMID:17303659. |
insulin inhibits forkhead o class (foxo) transcription factors, which down-regulate the expression of genes involved in metabolism, cell cycle arrest, and apoptosis. |
2007-06-04 |
2023-08-12 |
Not clear |
| P A Sarafidis, G L Bakri. Non-esterified fatty acids and blood pressure elevation: a mechanism for hypertension in subjects with obesity/insulin resistance? Journal of human hypertension. vol 21. issue 1. 2007-05-24. PMID:17051236. |
increased levels of non-esterified fatty acids (nefas) in abdominally obese subjects were reported to contribute in the development of various disturbances related to the metabolic syndrome, such as hepatic and peripheral insulin resistance (ir), dyslipidaemia, beta-cell apoptosis, endothelial dysfunction and others. |
2007-05-24 |
2023-08-12 |
human |
| Bernardo L Wajchenber. beta-cell failure in diabetes and preservation by clinical treatment. Endocrine reviews. vol 28. issue 2. 2007-05-23. PMID:17353295. |
the tzds improve insulin secretory capacity, decrease beta-cell apoptosis, and reduce islet cell amyloid with maintenance of neogenesis. |
2007-05-23 |
2023-08-12 |
human |
| Takeshi Nishikawa, Eiichi Arak. Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications. Antioxidants & redox signaling. vol 9. issue 3. 2007-05-10. PMID:17184177. |
in liver cells, similar to that in hyperglycemia, tnf-alpha increases mitochondrial ros, which in turn activates apoptosis signal-regulating kinase 1 (ask1) and c-jun nh2-terminal kinases (jnk), increases serine phosphorylation of irs-1, and decreases insulin-stimulated tyrosine phosphorylation of irs-1, leading to insulin resistance. |
2007-05-10 |
2023-08-12 |
Not clear |
| Carmela Santangelo, Paola Matarrese, Roberta Masella, Maria Chiara Di Carlo, Angela Di Lillo, Beatrice Scazzocchio, Elio Vecci, Walter Malorni, Riccardo Perfetti, Emanuela Anastas. Hepatocyte growth factor protects rat RINm5F cell line against free fatty acid-induced apoptosis by counteracting oxidative stress. Journal of molecular endocrinology. vol 38. issue 1-2. 2007-04-24. PMID:17242177. |
type 2 diabetes is characterized by peripheral insulin resistance, pancreatic beta-cells dysfunction, and decreased beta-cell mass with increased rate of apoptosis. |
2007-04-24 |
2023-08-12 |
rat |
| Carmela Santangelo, Paola Matarrese, Roberta Masella, Maria Chiara Di Carlo, Angela Di Lillo, Beatrice Scazzocchio, Elio Vecci, Walter Malorni, Riccardo Perfetti, Emanuela Anastas. Hepatocyte growth factor protects rat RINm5F cell line against free fatty acid-induced apoptosis by counteracting oxidative stress. Journal of molecular endocrinology. vol 38. issue 1-2. 2007-04-24. PMID:17242177. |
simultaneous administration of hgf and ffas significantly suppressed the impaired insulin secretion and ffa-induced apoptosis. |
2007-04-24 |
2023-08-12 |
rat |