| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuxia Wu, Jelai Wang, Xiangqin Cui, Lidia Maianu, Brian Rhees, James Rosinski, W Venus So, Steven M Willi, Michael V Osier, Helliner S Hill, Grier P Page, David B Allison, Mitchell Martin, W Timothy Garve. The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle. Endocrine. vol 31. issue 1. 2007-10-16. PMID:17709892. |
interestingly, insulin caused an accumulation of ngfi-b (nr4a1) protein in the nucleus where it functions as a transcription factor, without translocation to the cytoplasm to promote apoptosis. |
2007-10-16 |
2023-08-12 |
human |
| M J Pagliassotti, Y Wei, D Wan. Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity. Endocrinology. vol 148. issue 7. 2007-10-02. PMID:17431009. |
insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-jun nh2 terminal kinase activity. |
2007-10-02 |
2023-08-12 |
rat |
| M J Pagliassotti, Y Wei, D Wan. Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity. Endocrinology. vol 148. issue 7. 2007-10-02. PMID:17431009. |
insulin or sp600125, a chemical inhibitor of c-jun nh2 terminal kinase, blocked palmitate-mediated activation of c-jun nh2 terminal kinase and reduced apoptosis. |
2007-10-02 |
2023-08-12 |
rat |
| M J Pagliassotti, Y Wei, D Wan. Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity. Endocrinology. vol 148. issue 7. 2007-10-02. PMID:17431009. |
these data suggest that insulin is an important determinant of saturated fatty acid-induced apoptosis in liver cells and may have implications for fatty acid-mediated liver cell injury in insulin-deficient and/or -resistant states. |
2007-10-02 |
2023-08-12 |
rat |
| Cheng-Chieh Yen, Fung-Jou Lu, Chun-Fa Huang, Wen-Kang Chen, Shing-Hwa Liu, Shoei-Yn Lin-Shia. The diabetogenic effects of the combination of humic acid and arsenic: in vitro and in vivo studies. Toxicology letters. vol 172. issue 3. 2007-10-02. PMID:17624697. |
treatment of hit-t15 cells with ha, as, or both of them resulted loss of cell viability, apoptosis, depletion of atp, increment of oxidative stress, activation of caspase 3, and dysfunction of insulin secretion. |
2007-10-02 |
2023-08-12 |
mouse |
| W Truong, J A Emamaullee, S Merani, C C Anderson, A M James Shapir. Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. vol 7. issue 8. 2007-09-25. PMID:17617868. |
we set out to evaluate the effects of fty720 on human islets in vitro by investigating glucose-stimulated insulin and apoptosis; and in vivo, after transplantation into immunodeficient mice with chemically induced diabetes, by examining blood glucose levels, oral glucose tolerance tests and stimulated human c-peptide over a 50-day follow-up period. |
2007-09-25 |
2023-08-12 |
mouse |
| Nicole Liadis, Leonardo Salmena, Edwin Kwan, Panteha Tajmir, Stephanie A Schroer, Anna Radziszewska, Xie Li, Laura Sheu, Mohamed Eweida, Shilong Xu, Herbert Y Gaisano, Razqallah Hakem, Minna Wo. Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models. Diabetes. vol 56. issue 9. 2007-09-21. PMID:17563067. |
our results show distinct context-specific roles of casp8 in physiological and disease states; casp8 is essential for beta-cell apoptosis in type 1 and type 2 diabetes models and in regulating beta-cell mass and insulin secretion under physiological conditions. |
2007-09-21 |
2023-08-12 |
mouse |
| Dongming Su, Nan Zhang, Jing He, Shen Qu, Sandra Slusher, Rita Bottino, Suzanne Bertera, Jonathan Bromberg, H Henry Don. Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis. Diabetes. vol 56. issue 9. 2007-09-21. PMID:17596403. |
in contrast, control islets exhibited increased apoptosis and diminished glucose-stimulated insulin release in response to cytokine treatment. |
2007-09-21 |
2023-08-12 |
mouse |
| Lars Adamson, Erik Walu. Insulin and IGF-1 mediated inhibition of apoptosis in CHO cells grown in suspension in a protein-free medium. Alternatives to laboratory animals : ATLA. vol 35. issue 3. 2007-09-19. PMID:17650954. |
insulin and igf-1 mediated inhibition of apoptosis in cho cells grown in suspension in a protein-free medium. |
2007-09-19 |
2023-08-12 |
Not clear |
| Lars Adamson, Erik Walu. Insulin and IGF-1 mediated inhibition of apoptosis in CHO cells grown in suspension in a protein-free medium. Alternatives to laboratory animals : ATLA. vol 35. issue 3. 2007-09-19. PMID:17650954. |
also, insulin was shown to inhibit cell death - at 1.0 microg/ml, cell viability was 95%, whereas 10% of the cells stained for apoptosis. |
2007-09-19 |
2023-08-12 |
Not clear |
| Xiang Gu, Yibai Feng, Chunzhi Shi, Ming Li, Zuolin Fu, Xinping Zhan. Antiapoptotic mechanism of insulin in reoxygenation-induced injury in cultured cardiomyocytes of neonatal rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 25. issue 6. 2007-08-28. PMID:16696310. |
these data strongly suggest that early administration of insulin at reoxygenation protects cardiomyocytes from reoxygenation-induced apoptosis through pi3k/akt signaling pathway. |
2007-08-28 |
2023-08-12 |
rat |
| Dieter Häussinger, Freimut Schlies. Glutamine metabolism and signaling in the liver. Frontiers in bioscience : a journal and virtual library. vol 12. 2007-08-23. PMID:17127305. |
recent progress concerns the understanding of glutamine-induced hepatocyte swelling and the downstream activation of integrins, src, and map-kinases in the regulation of autophagic proteolysis, canalicular bile acid excretion, glycogen and fatty acid synthesis, insulin signaling, and protection from apoptosis. |
2007-08-23 |
2023-08-12 |
human |
| Wanda Mäuser, Nina Perwitz, Britta Meier, Mathias Fasshauer, Johannes Klei. Direct adipotropic actions of atorvastatin: differentiation state-dependent induction of apoptosis, modulation of endocrine function, and inhibition of glucose uptake. European journal of pharmacology. vol 564. issue 1-3. 2007-08-17. PMID:17376428. |
taken together, our data for the first time demonstrate direct differentiation state-dependent effects of atorvastatin including apoptosis, modulation of pro-inflammatory and glucostatic adipokine expression, and insulin resistance in adipose cells. |
2007-08-17 |
2023-08-12 |
Not clear |
| Marcella Pedullà, Riccardo d'Aquino, Vincenzo Desiderio, Francesco de Francesco, Andrew Puca, Gianpaolo Papacci. MnSOD mimic compounds can counteract mechanical stress and islet beta cell apoptosis, although at appropriate concentration ranges. Journal of cellular physiology. vol 212. issue 2. 2007-08-16. PMID:17311287. |
we demonstrate that this mnsod mimic diminishes the negative effects of mechanical stress by blocking insulin impairment, production of non-specific islet beta-cell proteins, transcription of inos and fas, activation of caspase-3 and -9 and, ultimately, apoptosis. |
2007-08-16 |
2023-08-12 |
Not clear |
| T Brun, D L Duhamel, K H Hu He, C B Wollheim, B R Gauthie. The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells. Oncogene. vol 26. issue 29. 2007-08-15. PMID:17260022. |
rna interference-mediated repression of insulin had no adverse effects on either pax4 or pdx1 expression as well as on cell replication or apoptosis. |
2007-08-15 |
2023-08-12 |
human |
| Yongzhong Wei, Adam T Whaley-Connell, Kemin Chen, Javad Habibi, Grace M-E Uptergrove, Suzanne E Clark, Craig S Stump, Carlos M Ferrario, James R Sower. NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat. Hypertension (Dallas, Tex. : 1979). vol 50. issue 2. 2007-08-08. PMID:17533199. |
to explore the impact of angiotensin ii on insulin signaling, nadph oxidase-derived reactive oxygen species formation, vascular inflammation, apoptosis, and remodeling, we used transgenic tg(mren2)27 (ren2) rats, which harbor the mouse renin transgene and exhibits elevated tissue angiotensin ii levels. |
2007-08-08 |
2023-08-12 |
mouse |
| Yongzhong Wei, Adam T Whaley-Connell, Kemin Chen, Javad Habibi, Grace M-E Uptergrove, Suzanne E Clark, Craig S Stump, Carlos M Ferrario, James R Sower. NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat. Hypertension (Dallas, Tex. : 1979). vol 50. issue 2. 2007-08-08. PMID:17533199. |
collectively, these data suggest that increased angiotensin type 1 receptor/nadph oxidase activation/reactive oxygen species contribute to vascular insulin resistance, endothelial dysfunction, apoptosis, and inflammation. |
2007-08-08 |
2023-08-12 |
mouse |
| Mazda Jenab, Elio Riboli, Rebecca J Cleveland, Teresa Norat, Sabina Rinaldi, Alexandra Nieters, Carine Biessy, Ann Tjønneland, Anja Olsen, Kim Overvad, Henning Grønbaek, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Jakob Linseisen, Heiner Boeing, Tobias Pischon, Dimitrios Trichopoulos, Eleni Oikonomou, Antonia Trichopoulou, Salvatore Panico, Paolo Vineis, Franco Berrino, Rosario Tumino, Giovanna Masala, Petra H Peters, Carla H van Gils, H Bas Bueno-de-Mesquita, Marga C Ocké, Eiliv Lund, Michelle A Mendez, María José Tormo, Aurelio Barricarte, Carmen Martínez-García, Miren Dorronsoro, José Ramón Quirós, Göran Hallmans, Richard Palmqvist, Göran Berglund, Jonas Manjer, Timothy Key, Naomi E Allen, Sheila Bingham, Kay-Tee Khaw, Anne Cust, Rudolf Kaak. Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition. International journal of cancer. vol 121. issue 2. 2007-08-06. PMID:17372899. |
higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of igf-i and decreasing the bioactivity of some of its binding proteins. |
2007-08-06 |
2023-08-12 |
human |
| Federica Corallini, Claudio Celeghini, Clara Rizzardi, Assunta Pandolfi, Sara Di Silvestre, Mauro Vaccarezza, Giorgio Zaul. Insulin down-regulates TRAIL expression in vascular smooth muscle cells both in vivo and in vitro. Journal of cellular physiology. vol 212. issue 1. 2007-07-27. PMID:17352408. |
to dissect the effect of hyperinsulinemia versus hyperglycemia on tnf-related apoptosis inducing ligand (trail) expression in the macrovascular district, we measured trail mrna and protein in four groups of animals: streptozotocin (szt)-induced diabetic rats, vehicle-treated control animals, diabetic rats treated with insulin and non-diabetic rats treated with insulin. |
2007-07-27 |
2023-08-12 |
human |
| Fanny Lalloyer, Brigitte Vandewalle, Frédéric Percevault, Gérard Torpier, Julie Kerr-Conte, Maaike Oosterveer, Réjane Paumelle, Jean-Charles Fruchart, Folkert Kuipers, François Pattou, Catherine Fiévet, Bart Stael. Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets. Diabetes. vol 55. issue 6. 2007-07-23. PMID:16731822. |
in primary human pancreatic islets, pparalpha agonist treatment prevented fatty acid-induced impairment of glucose-stimulated insulin secretion, apoptosis, and triglyceride accumulation. |
2007-07-23 |
2023-08-12 |
mouse |