| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu-Feng Zhao, Chen Che. Regulation of pancreatic beta-cell function by adipocytes. Sheng li xue bao : [Acta physiologica Sinica]. vol 59. issue 3. 2008-01-08. PMID:17579776. |
adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic beta-cell function including insulin secretion, gene expression and apoptosis. |
2008-01-08 |
2023-08-12 |
Not clear |
| Sunmin Park, Sang Mee Hong, Ji Eun Lee, So Ra Sun. Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic beta-cell function and mass through IRS2 in diabetic rats. Journal of applied physiology (Bethesda, Md. : 1985). vol 103. issue 5. 2008-01-08. PMID:17761790. |
this resulted from stimulated beta-cell proliferation and reduced apoptosis, which is associated with potentiated insulin or igf-i signaling through insulin receptor substrate-2 (irs2) induction. |
2008-01-08 |
2023-08-12 |
rat |
| Sunmin Park, Sang Mee Hong, Ji Eun Lee, So Ra Sun. Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic beta-cell function and mass through IRS2 in diabetic rats. Journal of applied physiology (Bethesda, Md. : 1985). vol 103. issue 5. 2008-01-08. PMID:17761790. |
although the hf diet resulted in decreased proliferation and accelerated apoptosis by weakened insulin and igf-i signaling from reduction of irs2 protein, beta-cell mass was maintained in hf rats just as much as in control rats via increased individual beta-cell size and neogenesis from precursor cells. |
2008-01-08 |
2023-08-12 |
rat |
| Gábor Bánhegyi, Peter Baumeister, Angelo Benedetti, Dezheng Dong, Yong Fu, Amy S Lee, Jianze Li, Changhui Mao, Eva Margittai, Min Ni, Wulf Paschen, Simona Piccirella, Silvia Senesi, Roberto Sitia, Miao Wang, Wei Yan. Endoplasmic reticulum stress. Annals of the New York Academy of Sciences. vol 1113. 2007-12-20. PMID:17483206. |
this article summarizes the emerging role of er stress in diverse human pathophysiological conditions such as carcinogenesis and tumor progression, cerebral ischemia, plasma cell maturation and apoptosis, obesity, insulin resistance, and type 2 diabetes. |
2007-12-20 |
2023-08-12 |
human |
| F Fér. [The incretin effect: a new therapeutic target in type 2 diabetes]. Revue medicale de Bruxelles. vol 28. issue 4. 2007-12-18. PMID:17958029. |
both of them potentiate glucose-induced insulin response, enhance insulin biosynthesis and, at least in rodents, preserve beta-cell mass through reduction of apoptosis and stimulation of beta-cell proliferation. |
2007-12-18 |
2023-08-12 |
Not clear |
| J H Shah, D J Maguire, D Brown, A Cotteril. The role of ATP sensitive channels in insulin secretion and the implications in persistent hyperinsulinemic hypoglycaemia of infancy (PHHI). Advances in experimental medicine and biology. vol 599. 2007-12-10. PMID:17727257. |
we discuss the mutations identified, emphasise the importance of the k-atp channel in physiological processes and discuss the possibility that the disease is caused by mutations in other genes associated with insulin release, glucose metabolism in the beta cell or beta cell apoptosis and survival. |
2007-12-10 |
2023-08-12 |
human |
| Xing-Huo Wu, Shu-Hua Yang, De-Yu Duan, Heng-Hui Cheng, Yu-Ting Bao, Yukun Zhan. Anti-apoptotic effect of insulin in the control of cell death and neurologic deficit after acute spinal cord injury in rats. Journal of neurotrauma. vol 24. issue 9. 2007-11-28. PMID:17892411. |
ultimately, the data established the effectiveness of insulin treatment in improving neurologic recovery, increasing the expression of anti-apoptotic bcl-2 proteins, inhibiting caspase-3 expression decreasing neuronal apoptosis, reducing the expression of proinflammatory cytokines inos and cox-2, and ameliorating microcirculation of injured spinal cord after moderate contusive sci in rats. |
2007-11-28 |
2023-08-12 |
human |
| Linda Vona-Davis, David P Ros. Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocrine-related cancer. vol 14. issue 2. 2007-11-20. PMID:17639037. |
in contrast, adiponectin, an endogenous insulin sensitizer, exerts a direct growth-inhibitory effect on tumor cells by downregulating cell proliferation and upregulating apoptosis, and also inhibits tumor-related angiogenesis. |
2007-11-20 |
2023-08-12 |
Not clear |
| James E P Brown, Simon J Dunmor. Leptin decreases apoptosis and alters BCL-2 : Bax ratio in clonal rodent pancreatic beta-cells. Diabetes/metabolism research and reviews. vol 23. issue 6. 2007-11-13. PMID:17318810. |
the adipocyte derived peptide hormone leptin is known to regulate apoptosis and cell viability in several cells and tissues, as well as having several pancreatic islet beta-cell specific effects such as inhibition of glucose-stimulated insulin secretion. |
2007-11-13 |
2023-08-12 |
Not clear |
| Satoshi Honmo, Atsuko Ozaki, Masahiro Yamamoto, Norikazu Hashimoto, Masaaki Miyakoshi, Hiroki Tanaka, Masumi Yoshie, Susumu Tamakawa, Yoshihiko Tokusashi, Yuji Yaginuma, Shinichi Kasai, Katsuhiro Ogaw. Low p38 MAPK and JNK activation in cultured hepatocytes of DRH rats; a strain highly resistant to hepatocarcinogenesis. Molecular carcinogenesis. vol 46. issue 9. 2007-11-13. PMID:17546627. |
in primary culture, drh hepatocytes exhibited higher proliferation and less apoptosis than donryu hepatocytes in the presence of egf and insulin. |
2007-11-13 |
2023-08-12 |
rat |
| Daeyoun Hwang, Sujin Seo, Yongkyu Kim, Chuelkyu Kim, Sunbo Shim, Seungwan Jee, Suhae Lee, Mikyong Jang, Minsun Kim, Suyoun Yim, Sang-Koo Lee, Byeongcheol Kang, Insurk Jang, Jungsik Ch. Selenium acts as an insulin-like molecule for the down-regulation of diabetic symptoms via endoplasmic reticulum stress and insulin signalling proteins in diabetes-induced non-obese diabetic mice. Journal of biosciences. vol 32. issue 4. 2007-11-13. PMID:17762145. |
we conclude that (i) sel treatment induced insulin-like effects in lowering serum glucose level in sel-treated nod mice, (ii) sel-treated mice had significantly decreased serum biochemical components associated with liver damage and lipid metabolism, (iii) sel treatment led to the activation of the er stress signal through the phosphorylation of jnk and eif2 protein and insulin signal mechanisms through the phosphorylation of akt and pi3 kinase, and (iv) sel-treated mice were significantly relieved apoptosis of liver tissues indicated by dna fragmentation assay in the diabetic nod group. |
2007-11-13 |
2023-08-12 |
mouse |
| S Glisic-Milosavljevic, T Wang, M Koppen, J Kramer, S Ehlenbach, J Waukau, P Jailwala, S Jana, R Alemzadeh, S Ghos. Dynamic changes in CD4+ CD25+(high) T cell apoptosis after the diagnosis of type 1 diabetes. Clinical and experimental immunology. vol 150. issue 1. 2007-11-08. PMID:17711492. |
apoptosis of forkhead box p3 (foxp3)(+) cd4(+) cd25(+high) t cells, in addition to total daily doses of insulin (tdd), blood glucose, hba1c and age, were measured in 45 subjects with t1d at various times after diagnosis. |
2007-11-08 |
2023-08-12 |
human |
| Marc G Jeschke, Darren F Boehning, Celeste C Finnerty, David N Herndo. Effect of insulin on the inflammatory and acute phase response after burn injury. Critical care medicine. vol 35. issue 9 Suppl. 2007-11-06. PMID:17713402. |
a thermal injury, however, causes hepatic damage by inducing hepatic edema, fatty infiltration, hepatocyte apoptosis, and metabolic derangements associated with insulin resistance and impaired insulin signaling. |
2007-11-06 |
2023-08-12 |
Not clear |
| Marvin Boris, Claudia C Kaiser, Allan Goldblatt, Michael W Elice, Stephen M Edelson, James B Adams, Douglas L Feinstei. Effect of pioglitazone treatment on behavioral symptoms in autistic children. Journal of neuroinflammation. vol 4. 2007-11-05. PMID:17207275. |
thiazolidinediones (tzds) are agonists of the peroxisome proliferator activated receptor gamma (ppargamma), a nuclear hormone receptor which modulates insulin sensitivity, and have been shown to induce apoptosis in activated t-lymphocytes and exert anti-inflammatory effects in glial cells. |
2007-11-05 |
2023-08-12 |
Not clear |
| Mark F McCart. Exenatide and biotin in conjunction with a protein-sparing fast for normalization of beta cell function in type 2 diabetics. Medical hypotheses. vol 69. issue 4. 2007-10-24. PMID:17292559. |
the dysdifferentiation of beta cells in type 2 diabetes appears to be caused and maintained by a vicious cycle of glucolipotoxicity: chronic elevations of glucose and free fatty acids induce beta cell dysdifferentiation as well as apoptosis; the resulting failure of glucose-stimulated insulin secretion tends to maintain the elevations of glucose and free fatty acids. |
2007-10-24 |
2023-08-12 |
Not clear |
| E M Klebanova, M I Balabolkin, V M Kreminskai. [The role of the fat tissue and its hormones in the mechanisms of insulin resistance and the development of type 2 diabetes mellitus]. Klinicheskaia meditsina. vol 85. issue 7. 2007-10-19. PMID:17882804. |
the article also cover the participation of other mechanisms - insulin secretion defect, oxidation stress, low secretion of glucagon-like peptide 1, apoptosis, an increased quantity of amyloid and the fl-cell pull in the pancreatic island--in dm2 pathogenesis. |
2007-10-19 |
2023-08-12 |
Not clear |
| Craig Ricci, Viktor Pastukh, Mahmood Mozaffari, Stephen W Schaffe. Insulin withdrawal induces apoptosis via a free radical-mediated mechanism. Canadian journal of physiology and pharmacology. vol 85. issue 3-4. 2007-10-16. PMID:17612655. |
insulin withdrawal induces apoptosis via a free radical-mediated mechanism. |
2007-10-16 |
2023-08-12 |
Not clear |
| Craig Ricci, Viktor Pastukh, Mahmood Mozaffari, Stephen W Schaffe. Insulin withdrawal induces apoptosis via a free radical-mediated mechanism. Canadian journal of physiology and pharmacology. vol 85. issue 3-4. 2007-10-16. PMID:17612655. |
to examine this possibility, cultured neonatal cardiomyocytes were subjected to insulin withdrawal and examined for apoptosis. |
2007-10-16 |
2023-08-12 |
Not clear |
| Craig Ricci, Viktor Pastukh, Mahmood Mozaffari, Stephen W Schaffe. Insulin withdrawal induces apoptosis via a free radical-mediated mechanism. Canadian journal of physiology and pharmacology. vol 85. issue 3-4. 2007-10-16. PMID:17612655. |
insulin deficient cells succumbed to apoptosis, an effect associated with impaired pi3-kinase/akt signaling and reduction in the bcl-2 to bax ratio. |
2007-10-16 |
2023-08-12 |
Not clear |
| Craig Ricci, Viktor Pastukh, Mahmood Mozaffari, Stephen W Schaffe. Insulin withdrawal induces apoptosis via a free radical-mediated mechanism. Canadian journal of physiology and pharmacology. vol 85. issue 3-4. 2007-10-16. PMID:17612655. |
collectively, these data demonstrate that insulin deficiency leads to apoptosis and suggest a role for oxidative mitochondrial dna damage in this cascade. |
2007-10-16 |
2023-08-12 |
Not clear |