| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin Woo Kim, Ji Eun Lee, Myung Jin Kim, Eun-Gyung Cho, Ssang-Goo Cho, Eui-Ju Cho. Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1). The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12584189. |
glycogen synthase kinase 3beta (gsk3 beta) is implicated in many biological events, including embryonic development, cell differentiation, apoptosis, and insulin response. |
2003-05-22 |
2023-08-12 |
mouse |
| M Pinget, S Boullu-Sanchi. [Physiological basis of insulin secretion abnormalities]. Diabetes & metabolism. vol 28. issue 6 Suppl. 2003-05-14. PMID:12703062. |
hyperglycaemia, even moderate, induces a reduced insulin biosynthesis potential (glucotoxicity), and the increased free fatty acid flux accelerates pancreatic beta-cell apoptosis (lipotoxicity). |
2003-05-14 |
2023-08-12 |
Not clear |
| James D Johnson, Noreen T Ahmed, Dan S Luciani, Zhiqiang Han, Hung Tran, Jun Fujita, Stanley Misler, Helena Edlund, Kenneth S Polonsk. Increased islet apoptosis in Pdx1+/- mice. The Journal of clinical investigation. vol 111. issue 8. 2003-05-08. PMID:12697734. |
these results suggest that an increase in apoptosis, with abnormal regulation of islet number and beta cell mass, represents a key mechanism whereby partial pdx1 deficiency leads to an organ-level defect in insulin secretion and diabetes. |
2003-05-08 |
2023-08-12 |
mouse |
| Kristina S Kovacina, Grace Y Park, Sun Sik Bae, Andrew W Guzzetta, Erik Schaefer, Morris J Birnbaum, Richard A Rot. Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. The Journal of biological chemistry. vol 278. issue 12. 2003-05-05. PMID:12524439. |
this protein kinase has been implicated in insulin signaling, stimulation of cellular growth, and inhibition of apoptosis as well as transformation of cells. |
2003-05-05 |
2023-08-12 |
Not clear |
| Laura L Listenberger, Xianlin Han, Sarah E Lewis, Sylvaine Cases, Robert V Farese, Daniel S Ory, Jean E Schaffe. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 6. 2003-04-21. PMID:12629214. |
excess lipid accumulation in non-adipose tissues is associated with insulin resistance, pancreatic beta-cell apoptosis and heart failure. |
2003-04-21 |
2023-08-12 |
Not clear |
| Giorgio Sest. Apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes? Annals of medicine. vol 34. issue 6. 2003-04-15. PMID:12523500. |
apoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes? |
2003-04-15 |
2023-08-12 |
mouse |
| Gianpaolo Papaccio, Ferdinando Nicoletti, Francesco A Pisanti, Michela Galdieri, Klaus Bendtze. An imidazoline compound completely counteracts interleukin-1[beta] toxic effects to rat pancreatic islet [beta] cells. Molecular medicine (Cambridge, Mass.). vol 8. issue 9. 2003-03-27. PMID:12456992. |
in vitro studies have demonstrated that interleukin (il)-1beta decreases insulin and dna contents in pancreatic islet beta cells, causing structural damage, that it is toxic to cultured human islet beta cells and that it is able to induce apoptosis in these cells. |
2003-03-27 |
2023-08-12 |
human |
| Shivapriya Ramaswamy, Noriaki Nakamura, Isabelle Sansal, Louise Bergeron, William R Seller. A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. Cancer cell. vol 2. issue 1. 2003-03-25. PMID:12150827. |
the mammalian daf-16-like transcription factors, fkhr, fkhrl1, and afx, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. |
2003-03-25 |
2023-08-12 |
Not clear |
| Kuntebommanahalli N Thimmaiah, John Easton, Shile Huang, Karen A Veverka, Glen S Germain, Franklin C Harwood, Peter J Houghto. Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways. Cancer research. vol 63. issue 2. 2003-03-13. PMID:12543789. |
insulin-like growth factor i (igf-i) and insulin, but not epidermal growth factor or platelet-derived growth factor, completely prevented apoptosis of this cell line. |
2003-03-13 |
2023-08-12 |
human |
| A T Byrne, J Southgate, D R Brison, H J Lees. Regulation of apoptosis in the bovine blastocyst by insulin and the insulin-like growth factor (IGF) superfamily. Molecular reproduction and development. vol 62. issue 4. 2003-03-12. PMID:12112582. |
regulation of apoptosis in the bovine blastocyst by insulin and the insulin-like growth factor (igf) superfamily. |
2003-03-12 |
2023-08-12 |
cattle |
| A T Byrne, J Southgate, D R Brison, H J Lees. Regulation of apoptosis in the bovine blastocyst by insulin and the insulin-like growth factor (IGF) superfamily. Molecular reproduction and development. vol 62. issue 4. 2003-03-12. PMID:12112582. |
we have therefore sought to establish the effects of insulin, igf-i and igf-ii on apoptosis and cell proliferation in bovine blastocysts in vitro. |
2003-03-12 |
2023-08-12 |
cattle |
| A T Byrne, J Southgate, D R Brison, H J Lees. Regulation of apoptosis in the bovine blastocyst by insulin and the insulin-like growth factor (IGF) superfamily. Molecular reproduction and development. vol 62. issue 4. 2003-03-12. PMID:12112582. |
insulin decreased the incidence of apoptosis without affecting blastocyst cell number. |
2003-03-12 |
2023-08-12 |
cattle |
| Shinhae Kang, Jihoon Song, Heekyoung Kang, Sejae Kim, Youngki Lee, Deokbae Par. Insulin can block apoptosis by decreasing oxidative stress via phosphatidylinositol 3-kinase- and extracellular signal-regulated protein kinase-dependent signaling pathways in HepG2 cells. European journal of endocrinology. vol 148. issue 1. 2003-02-24. PMID:12534368. |
insulin can block apoptosis by decreasing oxidative stress via phosphatidylinositol 3-kinase- and extracellular signal-regulated protein kinase-dependent signaling pathways in hepg2 cells. |
2003-02-24 |
2023-08-12 |
Not clear |
| Shinhae Kang, Jihoon Song, Heekyoung Kang, Sejae Kim, Youngki Lee, Deokbae Par. Insulin can block apoptosis by decreasing oxidative stress via phosphatidylinositol 3-kinase- and extracellular signal-regulated protein kinase-dependent signaling pathways in HepG2 cells. European journal of endocrinology. vol 148. issue 1. 2003-02-24. PMID:12534368. |
recently, several studies have suggested that insulin may protect cells from apoptosis in different cell lines; however, little is known about the nature of its anti-apoptotic activity. |
2003-02-24 |
2023-08-12 |
Not clear |
| Shinhae Kang, Jihoon Song, Heekyoung Kang, Sejae Kim, Youngki Lee, Deokbae Par. Insulin can block apoptosis by decreasing oxidative stress via phosphatidylinositol 3-kinase- and extracellular signal-regulated protein kinase-dependent signaling pathways in HepG2 cells. European journal of endocrinology. vol 148. issue 1. 2003-02-24. PMID:12534368. |
with these facts as a background, we examined here whether insulin protects hepg2 cells from apoptosis by decreasing oxidative stress and, if so, which signaling steps are involved in this process. |
2003-02-24 |
2023-08-12 |
Not clear |
| Yazhou Li, Tanya Hansotia, Bernardo Yusta, Frederic Ris, Philippe A Halban, Daniel J Drucke. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. The Journal of biological chemistry. vol 278. issue 1. 2003-02-10. PMID:12409292. |
mice administered streptozotocin (stz), an agent known to induce beta cell apoptosis, exhibit sustained improvement in glycemic control and increased levels of plasma insulin with concomitant administration of the glp-1 agonist exendin-4 (ex-4). |
2003-02-10 |
2023-08-12 |
mouse |
| F Garrouste, M Remacle-Bonnet, C Fauriat, J Marvaldi, J Luis, G Pommie. Prevention of cytokine-induced apoptosis by insulin-like growth factor-I is independent of cell adhesion molecules in HT29-D4 colon carcinoma cells-evidence for a NF-kappaB-dependent survival mechanism. Cell death and differentiation. vol 9. issue 7. 2003-01-14. PMID:12058282. |
we have previously established that insulin-like growth factor (igf)-i, -ii and insulin exert a strong protective effect against tumor necrosis factor-alpha (tnf)-induced apoptosis in interferon-gamma (ifn)-sensitized ht29-d4 human colon carcinoma cells. |
2003-01-14 |
2023-08-12 |
human |
| Rolf K Berge, Jon Skorve, Karl Johan Tronstad, Kjetil Berge, Oddrun Anita Gudbrandsen, Hans Gra. Metabolic effects of thia fatty acids. Current opinion in lipidology. vol 13. issue 3. 2002-12-26. PMID:12045400. |
the biological responses to tetradecylthioacetic acid include mitochondrial proliferation, increased catabolism of fatty acids, antiadiposity, improvement in insulin sensitivity, antioxidant properties, reduced proliferation and induction of apoptosis in rapidly proliferating cells, cell differentiation and antiinflammatory action. |
2002-12-26 |
2023-08-12 |
Not clear |
| Laura Sciacca, Rossana Mineo, Giuseppe Pandini, Antonella Murabito, Riccardo Vigneri, Antonino Belfior. In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A. Oncogene. vol 21. issue 54. 2002-12-13. PMID:12447687. |
insulin was more potent than igf-ii in activating the pi3-k/akt pathway and in protecting cells from apoptosis. |
2002-12-13 |
2023-08-12 |
human |
| Richard Barry, Mohammad Tadayyon, Irene C Gree. Reproducibility of targeted gene expression measurements in human islets of Langerhans. Biochemical and biophysical research communications. vol 298. issue 3. 2002-12-12. PMID:12413947. |
the expression of 47 genes involved in the biosynthesis and secretion of insulin, apoptosis, and cellular stress was evaluated in isolated human islets using cdna probes arrayed on nitrocellulose membranes. |
2002-12-12 |
2023-08-12 |
human |