| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B Ursø, C U Niesler, S O'Rahilly, K Siddl. Comparison of anti-apoptotic signalling by the insulin receptor and IGF-I receptor in preadipocytes and adipocytes. Cellular signalling. vol 13. issue 4. 2001-07-19. PMID:11306245. |
we conclude that ir and igfr have equal potential to inhibit apoptosis in cell backgrounds, which are normally responsive to either igf-i or insulin. |
2001-07-19 |
2023-08-12 |
Not clear |
| H Qian, D B Hausman, M M Compton, R J Martin, M A Della-Fera, D L Hartzell, C A Bail. TNFalpha induces and insulin inhibits caspase 3-dependent adipocyte apoptosis. Biochemical and biophysical research communications. vol 284. issue 5. 2001-07-19. PMID:11414707. |
tnfalpha induces and insulin inhibits caspase 3-dependent adipocyte apoptosis. |
2001-07-19 |
2023-08-12 |
rat |
| H Qian, D B Hausman, M M Compton, R J Martin, M A Della-Fera, D L Hartzell, C A Bail. TNFalpha induces and insulin inhibits caspase 3-dependent adipocyte apoptosis. Biochemical and biophysical research communications. vol 284. issue 5. 2001-07-19. PMID:11414707. |
to investigate this process, cultured rat adipocytes were treated with various concentrations of tumor necrosis factor alpha (tnfalpha) and/or insulin to determine the roles of these factors in adipocyte apoptosis. |
2001-07-19 |
2023-08-12 |
rat |
| H Qian, D B Hausman, M M Compton, R J Martin, M A Della-Fera, D L Hartzell, C A Bail. TNFalpha induces and insulin inhibits caspase 3-dependent adipocyte apoptosis. Biochemical and biophysical research communications. vol 284. issue 5. 2001-07-19. PMID:11414707. |
decreasing media insulin concentration from 8.5 to 0.85 nm resulted in increased adipocyte apoptosis, whereas high doses of insulin protected adipocytes from tnfalpha-induced apoptosis. |
2001-07-19 |
2023-08-12 |
rat |
| F Francini, H Del Zotto, J J Gagliardin. Effect of an acute glucose overload on Islet cell morphology and secretory function in the toad. General and comparative endocrinology. vol 122. issue 2. 2001-07-12. PMID:11316418. |
immunolabeled beta cell area, replication (bromodeoxyuridine) and apoptosis (propidium iodide) rate, islet neogenesis (cytokeratin), and insulin secretion in vitro were measured in adult male specimens of bufo arenarum during and after interruption of the injection of either a 50% glucose solution (2 g/100 g) or its vehicle for 4 days. |
2001-07-12 |
2023-08-12 |
Not clear |
| H H Zhang, S Kumar, A H Barnett, M C Egg. Dexamethasone inhibits tumor necrosis factor-alpha-induced apoptosis and interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes. The Journal of clinical endocrinology and metabolism. vol 86. issue 6. 2001-07-05. PMID:11397893. |
we examined the effects of insulin and the synthetic glucocorticoid, dexamethasone (dex), on tnf alpha-induced apoptosis and gene expression in human adipocytes and preadipocytes. |
2001-07-05 |
2023-08-12 |
human |
| H H Zhang, S Kumar, A H Barnett, M C Egg. Dexamethasone inhibits tumor necrosis factor-alpha-induced apoptosis and interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes. The Journal of clinical endocrinology and metabolism. vol 86. issue 6. 2001-07-05. PMID:11397893. |
insulin had no significant effect on tnf alpha-induced apoptosis and gene expression. |
2001-07-05 |
2023-08-12 |
human |
| H Tchórzewski, E Głowacka, M Banasik, P Lewkowicz, M Szałapska-Zawodnia. Activated T lymphocytes from patients with high risk of type I diabetes mellitus have different ability to produce interferon-gamma, interleukin-6 and interleukin-10 and undergo anti-CD95 induced apoptosis after insulin stimulation. Immunology letters. vol 75. issue 3. 2001-06-21. PMID:11166380. |
activated t lymphocytes from patients with high risk of type i diabetes mellitus have different ability to produce interferon-gamma, interleukin-6 and interleukin-10 and undergo anti-cd95 induced apoptosis after insulin stimulation. |
2001-06-21 |
2023-08-12 |
Not clear |
| H Tchórzewski, E Głowacka, M Banasik, P Lewkowicz, M Szałapska-Zawodnia. Activated T lymphocytes from patients with high risk of type I diabetes mellitus have different ability to produce interferon-gamma, interleukin-6 and interleukin-10 and undergo anti-CD95 induced apoptosis after insulin stimulation. Immunology letters. vol 75. issue 3. 2001-06-21. PMID:11166380. |
insulin activated t lymphocytes, which undergo apoptosis were not observed in peripheral blood of healthy people and in patients with dm1. |
2001-06-21 |
2023-08-12 |
Not clear |
| Y L Woods, G Rena, N Morrice, A Barthel, W Becker, S Guo, T G Unterman, P Cohe. The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site. The Biochemical journal. vol 355. issue Pt 3. 2001-05-31. PMID:11311120. |
forkhead in rhabdomyosarcoma (fkhr) is a transcription factor that has been implicated in the control of gene expression by insulin, as well as the regulation of apoptosis by survival factors. |
2001-05-31 |
2023-08-12 |
rabbit |
| C V Zerbinatti, L P Mayer, R G Audet, C A Dye. Apolipoprotein E is a putative autocrine regulator of the rat ovarian theca cell compartment. Biology of reproduction. vol 64. issue 4. 2001-05-21. PMID:11259253. |
however, apoptosis alone was not responsible for apo e suppression of androstenedione production because both insulin and igf-i prevented apo e-induced apoptosis, but neither restored androstenedione production. |
2001-05-21 |
2023-08-12 |
rat |
| Y Suresh, U N Da. Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus. Prostaglandins, leukotrienes, and essential fatty acids. vol 64. issue 1. 2001-05-17. PMID:11161584. |
here we show that alloxan-induced in vitro cytotoxicity and apoptosis in an insulin secreting rat insulinoma, rin, cells can be prevented by arachidonic acid (aa) and that both cyclo-oxygenase and lipoxygenase inhibitors do not block this protective action. |
2001-05-17 |
2023-08-12 |
rat |
| C L Buenemann, C Willy, A Buchmann, A Schmiechen, M Schwar. Transforming growth factor-beta1-induced Smad signaling, cell-cycle arrest and apoptosis in hepatoma cells. Carcinogenesis. vol 22. issue 3. 2001-04-12. PMID:11238185. |
tgfbeta-induced apoptosis of fto-2b cells was inhibited by dexamethasone, insulin, phenobarbital and dieldrin. |
2001-04-12 |
2023-08-12 |
mouse |
| C L Buenemann, C Willy, A Buchmann, A Schmiechen, M Schwar. Transforming growth factor-beta1-induced Smad signaling, cell-cycle arrest and apoptosis in hepatoma cells. Carcinogenesis. vol 22. issue 3. 2001-04-12. PMID:11238185. |
of these agents, only insulin led to a significant reduction of tgfbeta-stimulated smad-reporter activity, suggesting that the other compounds interfere with tgfbeta-induced apoptosis downstream of smad-mediated primary transcriptional responses at a level that may be constitutively altered in apoptosis-resistant hepatoma cell lines. |
2001-04-12 |
2023-08-12 |
mouse |
| R H Unger, Y T Zho. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes. vol 50 Suppl 1. 2001-04-05. PMID:11272168. |
fa overload in skeletal muscle causes insulin resistance; in myocardium, it impairs cardiac function; and in pancreatic islets, it causes beta-cell dysfunction, apoptosis, and diabetes. |
2001-04-05 |
2023-08-12 |
Not clear |
| F Hong, V A Nguyen, X Shen, G Kunos, B Ga. Rapid activation of protein kinase B/Akt has a key role in antiapoptotic signaling during liver regeneration. Biochemical and biophysical research communications. vol 279. issue 3. 2001-03-29. PMID:11162460. |
moreover, hgf and insulin were able to attenuate transforming growth factor beta-induced apoptosis in hepatic cells, and these effects were antagonized by ly294002. |
2001-03-29 |
2023-08-12 |
mouse |
| M N Pertsev. [Hypothesis of the key coordinating role of adenylate cyclase signal mechanism and cAMP in regulatory effect of insulin superfamily peptides on fundamental cellular processes: cell growth, apoptosis, metabolism (Development of the L. G. Leĭbson's works)]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 36. issue 6. 2001-03-29. PMID:11212527. |
[hypothesis of the key coordinating role of adenylate cyclase signal mechanism and camp in regulatory effect of insulin superfamily peptides on fundamental cellular processes: cell growth, apoptosis, metabolism (development of the l. g. leĭbson's works)]. |
2001-03-29 |
2023-08-12 |
Not clear |
| R Conejo, M Lorenz. Insulin signaling leading to proliferation, survival, and membrane ruffling in C2C12 myoblasts. Journal of cellular physiology. vol 187. issue 1. 2001-03-29. PMID:11241354. |
insulin rescued serum-deprived cells from apoptosis in an akt-dependent manner, as demonstrated by the inhibition of akt-activity by the use of ly294002 and ml-9, meanwhile neither inhibition of p70s6-kinase, nor mapk affected insulin-induced survival. |
2001-03-29 |
2023-08-12 |
mouse |
| D Drummond-Barbosa, A C Spradlin. Stem cells and their progeny respond to nutritional changes during Drosophila oogenesis. Developmental biology. vol 231. issue 1. 2001-03-22. PMID:11180967. |
to initiate a genetic analysis of these changes in cell proliferation and apoptosis, we show that ovarian cells require an intact insulin pathway to fully upregulate their rate of cycling in response to a protein-rich diet and to enter vitellogenesis. |
2001-03-22 |
2023-08-12 |
drosophila_melanogaster |
| M Maruyama, T Sudo, Y Kasuya, T Shiga, B Hu, H Osad. Immunolocalization of p38 MAP kinase in mouse brain. Brain research. vol 887. issue 2. 2001-02-15. PMID:11134625. |
p38 has been implicated to play a critical role in regulating apoptosis in pc12 and cerebellar granule cells, and is inactivated in cultured fetal neurons in response to insulin. |
2001-02-15 |
2023-08-12 |
mouse |