| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Girar. [Fatty acids and beta cells]. Diabetes & metabolism. vol 26 Suppl 3. 2000-08-24. PMID:10945143. |
this is correlated with a reduction in insulin secretion and an increase in cellular apoptosis phenomena. |
2000-08-24 |
2023-08-12 |
human |
| A K Jonassen, B K Brar, O D Mjøs, M N Sack, D S Latchman, D M Yello. Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism. Journal of molecular and cellular cardiology. vol 32. issue 5. 2000-08-11. PMID:10775481. |
we have therefore begun to investigate an insulin activated signalling pathway and the putative role of apoptosis in this insulin-induced cardioprotection. |
2000-08-11 |
2023-08-12 |
rat |
| A K Jonassen, B K Brar, O D Mjøs, M N Sack, D S Latchman, D M Yello. Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism. Journal of molecular and cellular cardiology. vol 32. issue 5. 2000-08-11. PMID:10775481. |
thus, we conclude that the early administration of insulin appears to be an effective modality to reduce reoxgygenation injury in cardiocytes, in part, via the attenuation of ischemia/reoxygenation-induced apoptosis. |
2000-08-11 |
2023-08-12 |
rat |
| A R Tee, C G Prou. DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling. Oncogene. vol 19. issue 26. 2000-07-12. PMID:10871854. |
insulin elicited full activation of p70 s6 kinase and phosphorylation of 4e-pb1 in etoposide-treated cells prior to the onset of apoptosis, but not during cell death. |
2000-07-12 |
2023-08-12 |
Not clear |
| B Díaz, J Serna, F De Pablo, E J de la Ros. In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor during early retinal neurogenesis. Development (Cambridge, England). vol 127. issue 8. 2000-06-30. PMID:10725240. |
we have previously described specific in vivo patterns of apoptosis during early retinal neurogenesis, and that exogenous insulin acts as survival factor (díaz, b., pimentel, b., de pablo, f. and de la rosa, e. j. |
2000-06-30 |
2023-08-12 |
chicken |
| B Díaz, J Serna, F De Pablo, E J de la Ros. In vivo regulation of cell death by embryonic (pro)insulin and the insulin receptor during early retinal neurogenesis. Development (Cambridge, England). vol 127. issue 8. 2000-06-30. PMID:10725240. |
in ovo treatment at day 2 of embryonic development with specific antibodies against (pro)insulin or the insulin receptor induced apoptosis in the neuroretina. |
2000-06-30 |
2023-08-12 |
chicken |
| E Shafrir, E Ziv, L Mostha. Nutritionally induced insulin resistance and receptor defect leading to beta-cell failure in animal models. Annals of the New York Academy of Sciences. vol 892. 2000-06-28. PMID:10842665. |
animals with genetically or nutritionally induced insulin resistance and type 2 diabetes comprise two groups: those with resilient beta-cells, e.g., ob/ob mice or fa/fa rats, capable of longstanding compensatory insulin hypersecretion and those with labile beta-cells in which the secretion pressure leads to beta-cell degranulation and apoptosis, e.g., db/db mice and psammomys gerbils (sand rats). |
2000-06-28 |
2023-08-12 |
mouse |
| J M Frad. Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones. Journal of cell science. vol 113 ( Pt 7). 2000-06-23. PMID:10704365. |
in this system, ngf-induced apoptosis was only observed in the presence of insulin and neurotrophin-3, conditions that favour the birth of rgcs and other neurones expressing the glycoprotein g4. |
2000-06-23 |
2023-08-12 |
Not clear |
| J W Davis, K Melendez, V M Salas, F T Lauer, S W Burchie. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits growth factor withdrawal-induced apoptosis in the human mammary epithelial cell line, MCF-10A. Carcinogenesis. vol 21. issue 5. 2000-06-15. PMID:10783307. |
the mechanism for this effect appears to be complex as tcdd inhibited apoptosis stimulated by egf, or egf and insulin, withdrawal by almost 80% as determined by annexin v binding. |
2000-06-15 |
2023-08-12 |
human |
| J W Davis, K Melendez, V M Salas, F T Lauer, S W Burchie. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits growth factor withdrawal-induced apoptosis in the human mammary epithelial cell line, MCF-10A. Carcinogenesis. vol 21. issue 5. 2000-06-15. PMID:10783307. |
however, withdrawal of insulin alone did not induce apoptosis even though tcdd did increase cell number in its absence. |
2000-06-15 |
2023-08-12 |
human |
| M L De Santis, I Martinez-Lacaci, C Bianco, M Seno, B Wallace-Jones, N Kim, A Ebert, C Wechselberger, D S Salomo. Cripto-1 induces apoptosis in HC-11 mouse mammary epithelial cells. Cell death and differentiation. vol 7. issue 2. 2000-05-16. PMID:10713733. |
apoptosis could be observed after 2 days of exposure of confluent hc-11 cells to cr-1 in the absence of the survival factors egf and insulin, with maximum apoptosis occurring at 3 days. |
2000-05-16 |
2023-08-12 |
mouse |
| M M Remacle-Bonnet, F L Garrouste, S Heller, F André, J L Marvaldi, G J Pommie. Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. Cancer research. vol 60. issue 7. 2000-05-04. PMID:10766192. |
we report here that insulin and insulin-like growth factor-i (igf-i) fully protect ht29-d4 colon carcinoma cells from ifn-gamma/tumor necrosis factor-alpha (tnf) induced apoptosis. |
2000-05-04 |
2023-08-12 |
Not clear |
| K Liu, A J Paterson, E Chin, J E Kudlo. Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 6. 2000-04-25. PMID:10717000. |
the pancreatic beta cell can respond in the long term to hyperglycemia both with an increased capacity for insulin production and, in susceptible individuals, with apoptosis. |
2000-04-25 |
2023-08-12 |
mouse |
| B C Yang, Y S Wang, C H Wang, H H Lin, M J Tang, T L Yan. Transient apoptosis elicited by insulin in serum-starved glioma cells involves Fas/Fas-L and Bcl-2. Cell biology international. vol 23. issue 8. 2000-04-11. PMID:10704237. |
transient apoptosis elicited by insulin in serum-starved glioma cells involves fas/fas-l and bcl-2. |
2000-04-11 |
2023-08-12 |
Not clear |
| A J Weinhaus, N V Bhagroo, T C Brelje, R L Sorenso. Dexamethasone counteracts the effect of prolactin on islet function: implications for islet regulation in late pregnancy. Endocrinology. vol 141. issue 4. 2000-04-11. PMID:10746642. |
as placental lactogen levels remain elevated through late gestation, it was of interest to determine whether glucocorticoids (which increase during late gestation) could counteract the effects of lactogens on insulin secretion, beta-cell proliferation, and apoptosis. |
2000-04-11 |
2023-08-12 |
Not clear |
| A J Weinhaus, N V Bhagroo, T C Brelje, R L Sorenso. Dexamethasone counteracts the effect of prolactin on islet function: implications for islet regulation in late pregnancy. Endocrinology. vol 141. issue 4. 2000-04-11. PMID:10746642. |
these data show that the increased plasma glucocorticoid levels found during the late stages of pregnancy could effectively reverse prl-induced up-regulation of islet function by inhibiting insulin secretion and cell proliferation while increasing apoptosis. |
2000-04-11 |
2023-08-12 |
Not clear |
| K M Noh, J C Lee, Y H Ahn, S H Hong, J Y Ko. Insulin-induced oxidative neuronal injury in cortical culture: mediation by induced N-methyl-D-aspartate receptors. IUBMB life. vol 48. issue 3. 2000-03-29. PMID:10690636. |
while effectively attenuating neuronal apoptosis in mouse cortical culture, insulin paradoxically induced neuronal necrosis with 48 h of exposure. |
2000-03-29 |
2023-08-12 |
mouse |
| T J Moran, S Gray, C A Mikosz, S D Conze. The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer research. vol 60. issue 4. 2000-03-20. PMID:10706096. |
withdrawal of glucocorticoid from defined media triggers apoptosis, despite the presence of epidermal growth factor and insulin. |
2000-03-20 |
2023-08-12 |
human |
| C Desbois-Mouthon, A Cadoret, M J Blivet-Van Eggelpoël, F Bertrand, M Caron, A Atfi, G Cherqui, J Capea. Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a phosphatidylinositol 3-kinase- and mitogen-activated protein kinase phosphatase-1-dependent pathway. Endocrinology. vol 141. issue 3. 2000-03-16. PMID:10698166. |
the overexpression of a dominant negative jnk1 mutant increased insulin stimulation of dna synthesis and mimicked the protective effect of insulin against serum withdrawal-induced apoptosis. |
2000-03-16 |
2023-08-12 |
Not clear |
| C Hermann, B Assmus, C Urbich, A M Zeiher, S Dimmele. Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells. Arteriosclerosis, thrombosis, and vascular biology. vol 20. issue 2. 2000-03-03. PMID:10669636. |
therefore, we investigated whether insulin inhibits tumor necrosis factor-alpha (tnf-alpha)-induced apoptosis in human umbilical vein endothelial cells (huvecs). |
2000-03-03 |
2023-08-12 |
human |