| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vivian C Calegari, Adriana S Torsoni, Emerielle C Vanzela, Eliana P Araújo, Joseane Morari, Claudio C Zoppi, Lourenço Sbragia, Antonio C Boschero, Lício A Vellos. Inflammation of the hypothalamus leads to defective pancreatic islet function. The Journal of biological chemistry. vol 286. issue 15. 2011-06-28. PMID:21257748. |
in addition, the injection of stearic acid intracerebroventricularly, which leads to hypothalamic inflammation through the activation of tau-like receptor-4 and endoplasmic reticulum stress, produces an impairment of insulin secretion, accompanied by increased expression of markers of apoptosis. |
2011-06-28 |
2023-08-12 |
Not clear |
| Huaqiang Zhu, Jizhou Wang, Hongchi Jiang, Yong Ma, Shangha Pan, Shiva Reddy, Xueying Su. Bilirubin protects grafts against nonspecific inflammation-induced injury in syngeneic intraportal islet transplantation. Experimental & molecular medicine. vol 42. issue 11. 2011-06-27. PMID:20881452. |
at appropriate lower concentrations, bilirubin significantly attenuated the reduced cell viability and enhanced cell apoptosis induced by cytokines, and protected the insulin secretory function of ins-1 cells. |
2011-06-27 |
2023-08-12 |
rat |
| Nicole Stieger, Kirstin Worthmann, Mario Schiffe. The role of metabolic and haemodynamic factors in podocyte injury in diabetes. Diabetes/metabolism research and reviews. vol 27. issue 3. 2011-06-16. PMID:21309047. |
in addition, mechanical stresses by stretch or shear forces, insulin deficiency or insulin resistance are independent components resulting in podocyte apoptosis and detachment. |
2011-06-16 |
2023-08-12 |
human |
| Kwang Bon Koo, Hyung Joo Suh, Kyung Soo Ra, Jang Won Cho. Protective effect of cyclo(his-pro) on streptozotocin-induced cytotoxicity and apoptosis in vitro. Journal of microbiology and biotechnology. vol 21. issue 2. 2011-06-08. PMID:21364307. |
in this study, the effects of chp on streptozotocin (stz)-induced beta-cell dysfunction and apoptosis were investigated in rat insulinoma cells (rinm5f) secreting insulin. |
2011-06-08 |
2023-08-12 |
rat |
| Yuzhen Liang, Muxun Zhang, Ning Xia, Yuelian Yang, Leping Fen. Effects of high concentration glucose on the expression of NF-kappaB, Bax and cytochrome C and apoptosis of islet cells in mice. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 4. 2011-06-06. PMID:19662359. |
the results showed that in g1, g2 and g3 groups, insulin secretion was enhanced with the increase of glucose concentration, and the nf-kappab expression was also increased (p<0.05), but bax activity, cyt c release and apoptosis rate showed no significant difference among them. |
2011-06-06 |
2023-08-12 |
mouse |
| Yuzhen Liang, Muxun Zhang, Ning Xia, Yuelian Yang, Leping Fen. Effects of high concentration glucose on the expression of NF-kappaB, Bax and cytochrome C and apoptosis of islet cells in mice. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 4. 2011-06-06. PMID:19662359. |
however, in g4, g5, and g6 groups, apoptosis rate of islet cells, nf-kappab expression, bax activity, and cyt c release were all significantly increased, and insulin secretion was impaired as compared with g1, g2, and g3 groups (p<0.05). |
2011-06-06 |
2023-08-12 |
mouse |
| Yuzhen Liang, Muxun Zhang, Ning Xia, Yuelian Yang, Leping Fen. Effects of high concentration glucose on the expression of NF-kappaB, Bax and cytochrome C and apoptosis of islet cells in mice. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 4. 2011-06-06. PMID:19662359. |
it was concluded that the exposure of islet cells to high glucose could induce islet cells apoptosis as well as impaired insulin secretion. |
2011-06-06 |
2023-08-12 |
mouse |
| Xiao-Ling Li, Tianfeng Chen, Yum-Shing Wong, Gang Xu, Rong-Rong Fan, Hai-Lu Zhao, Juliana C N Cha. Involvement of mitochondrial dysfunction in human islet amyloid polypeptide-induced apoptosis in INS-1E pancreatic beta cells: An effect attenuated by phycocyanin. The international journal of biochemistry & cell biology. vol 43. issue 4. 2011-06-03. PMID:21163363. |
insulin secretion impairment and cell apoptosis can be due to mitochondrial dysfunction in pancreatic beta cells. |
2011-06-03 |
2023-08-12 |
human |
| June Woo Lee, Won Ho Kim, Jiyoung Yeo, Myeong Ho Jun. ER stress is implicated in mitochondrial dysfunction-induced apoptosis of pancreatic beta cells. Molecules and cells. vol 30. issue 6. 2011-06-01. PMID:21340672. |
however, the inhibition of ampk by treatment with compound c, inhibitor of ampk, and overexpression of mutant dominant negative ampk (ampkk45r) blocked the induction of er stress, which was consist-ent with the decreased β-cell apoptosis and increase of insulin content. |
2011-06-01 |
2023-08-12 |
mouse |
| V N Titov, V V Krylin, Iu K Shiriaev. [Prevention of atherosclerosis. Excess of palmitic acid in food--a cause of hypercholesterolemia, inflammatory syndrome, insulin resistance in myocytes, and apoptosis]. Klinicheskaia laboratornaia diagnostika. issue 2. 2011-05-13. PMID:21506380. |
excess of palmitic acid in food--a cause of hypercholesterolemia, inflammatory syndrome, insulin resistance in myocytes, and apoptosis]. |
2011-05-13 |
2023-08-12 |
Not clear |
| Owen M Wolkowitz, Victor I Reus, Synthia H Mello. Of sound mind and body: depression, disease, and accelerated aging. Dialogues in clinical neuroscience. vol 13. issue 1. 2011-05-12. PMID:21485744. |
we then focus on several interlinked mediators occurring in mdd (or at least in subtypes of mdd) that may contribute to the medical comorbidity burden and to accelerated aging: limbic-hypothalamic-pituitary-adrenal axis alterations, diminution in glucocorticoid receptor function, altered glucose tolerance and insulin sensitivity, excitotoxicity, increases in intracellular calcium, oxidative stress, a proinflammatory milieu, lowered levels of "counter-regulatory" neurosteroids (such as allopregnanolone and dehydroepiandrosterone), diminished neurotrophic activity, and accelerated cell aging, manifest as alterations in telomerase activity and as shortening of telomeres, which can lead to apoptosis and cell death. |
2011-05-12 |
2023-08-12 |
Not clear |
| Rui Si, Ling Tao, Hai F Zhang, Qiu J Yu, Rui Zhang, An L Lv, Ning Zhou, Feng Cao, Wen Y Guo, Jun Ren, Hai C Wang, Feng Ga. Survivin: a novel player in insulin cardioprotection against myocardial ischemia/reperfusion injury. Journal of molecular and cellular cardiology. vol 50. issue 1. 2011-05-10. PMID:20801129. |
insulin inhibits ischemia/reperfusion-induced myocardial apoptosis through the activation of a survival signaling cascade including the phosphatidylinositol 3-kinase (pi3k)-akt pathway. |
2011-05-10 |
2023-08-12 |
rat |
| Rui Si, Ling Tao, Hai F Zhang, Qiu J Yu, Rui Zhang, An L Lv, Ning Zhou, Feng Cao, Wen Y Guo, Jun Ren, Hai C Wang, Feng Ga. Survivin: a novel player in insulin cardioprotection against myocardial ischemia/reperfusion injury. Journal of molecular and cellular cardiology. vol 50. issue 1. 2011-05-10. PMID:20801129. |
reperfusion with insulin inhibited myocardial apoptosis and reduced infarct size, along with significantly up-regulated myocardial svv expression (5.9±0.3 group mi/r+ins vs. 2.1±0.1 group mi/r, p<0.05) and increased phosphorylations of mtor and p70s6k compared with i/r group, which was blocked by pretreatment of pi3k inhibitor ly294002. |
2011-05-10 |
2023-08-12 |
rat |
| Rui Si, Ling Tao, Hai F Zhang, Qiu J Yu, Rui Zhang, An L Lv, Ning Zhou, Feng Cao, Wen Y Guo, Jun Ren, Hai C Wang, Feng Ga. Survivin: a novel player in insulin cardioprotection against myocardial ischemia/reperfusion injury. Journal of molecular and cellular cardiology. vol 50. issue 1. 2011-05-10. PMID:20801129. |
overexpression of svv decreased i/r-induced cardiomyocyte apoptosis in vitro, while sirna targeting svv significantly blunted the anti-apoptotic effect of insulin. |
2011-05-10 |
2023-08-12 |
rat |
| Jeremie Boucher, Yazmin Macotela, Olivier Bezy, Marcelo A Mori, Kristina Kriauciunas, C Ronald Kah. A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis. Science signaling. vol 3. issue 151. 2011-05-03. PMID:21139139. |
a kinase-independent role for unoccupied insulin and igf-1 receptors in the control of apoptosis. |
2011-05-03 |
2023-08-12 |
Not clear |
| Jeremie Boucher, Yazmin Macotela, Olivier Bezy, Marcelo A Mori, Kristina Kriauciunas, C Ronald Kah. A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis. Science signaling. vol 3. issue 151. 2011-05-03. PMID:21139139. |
we found that, unexpectedly, double-knockout (dko) cells that lacked both insulin and igf-1 receptors (ir and igf1r, respectively) were resistant to apoptosis induced through either the intrinsic or the extrinsic pathway. |
2011-05-03 |
2023-08-12 |
Not clear |
| Jeremie Boucher, Yazmin Macotela, Olivier Bezy, Marcelo A Mori, Kristina Kriauciunas, C Ronald Kah. A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis. Science signaling. vol 3. issue 151. 2011-05-03. PMID:21139139. |
insulin and igf-1 binding stimulates receptor tyrosine kinase activity and blocks apoptosis, whereas unliganded ir and igf1r, acting through a mechanism independent of their catalytic activity, exert a permissive effect on cell death. |
2011-05-03 |
2023-08-12 |
Not clear |
| M Mirasierra, A Fernández-Pérez, N Díaz-Prieto, M Vallej. Alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets. Diabetologia. vol 54. issue 2. 2011-05-02. PMID:21104068. |
alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets. |
2011-05-02 |
2023-08-12 |
mouse |
| Tamás Rosze. Inflammation as death or life signal in diabetic fracture healing. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 60. issue 1. 2011-04-29. PMID:20845059. |
prolonged hyperglycemia and insulin resistance correlate with increased apoptosis rate and, accordingly, the proapoptotic role of several inflammatory mediators, ros and ages has been also documented. |
2011-04-29 |
2023-08-12 |
Not clear |
| Joo-Won Lee, A Hyun Choi, Mira Ham, Ji-Won Kim, Sung Sik Choe, Jiyoung Park, Gha Young Lee, Kun-Ho Yoon, Jae Bum Ki. G6PD up-regulation promotes pancreatic beta-cell dysfunction. Endocrinology. vol 152. issue 3. 2011-04-27. PMID:21248143. |
to investigate the effect of g6pd on β-cell dysfunction, we assessed the levels of cellular ros, glucose-stimulated insulin secretion and β-cell apoptosis in g6pd-overexpressing pancreatic β-cells. |
2011-04-27 |
2023-08-12 |
mouse |