| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Huiping Yuan, Yonggang Lu, Xiuqing Huang, Qinghua He, Yong Man, Yingsheng Zhou, Shu Wang, Jian L. Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells. The FEBS journal. vol 277. issue 24. 2011-01-13. PMID:21073655. |
furthermore, high glucose concentrations led to apoptosis of β-cells by activation of p38mapk and p53, and dysfunction of β-cells through phosphatase and tensih homolog (pten)-dependent jun n-terminal kinase (jnk) activation and protein kinase b (akt/pkb) inhibition, which induced the translocation of forkhead box o1 and pancreatic duodenal homeobox-1, followed by reduced insulin expression and secretion. |
2011-01-13 |
2023-08-12 |
rat |
| S R Sampson, E Bucris, M Horovitz-Fried, A Parnas, S Kahana, G Abitbol, M Chetboun, T Rosenzweig, C Brodie, S Franke. Insulin increases H2O2-induced pancreatic beta cell death. Apoptosis : an international journal on programmed cell death. vol 15. issue 10. 2010-12-30. PMID:20544287. |
we conclude that elevated levels of insulin may act to exacerbate cell death induced by h(2)o(2) and, perhaps, other inducers of apoptosis. |
2010-12-30 |
2023-08-12 |
Not clear |
| Ji Yeon Kim, Eun Hyun Song, Hyun Jung Lee, Yeo Kyoung Oh, Yoon Shin Park, Joo-Won Park, Bong Jo Kim, Dae Jin Kim, Inkyu Lee, Jihyun Song, Won-Ho Ki. Chronic ethanol consumption-induced pancreatic {beta}-cell dysfunction and apoptosis through glucokinase nitration and its down-regulation. The Journal of biological chemistry. vol 285. issue 48. 2010-12-30. PMID:20855893. |
specific blockade of atf3 using sirna or c-terminally deleted atf3(Δc) attenuated ethanol-induced pancreatic β-cell apoptosis or dysfunction and restored the down-regulation of glucokinase (gck), insulin, and pancreatic duodenal homeobox-1 induced by ethanol. |
2010-12-30 |
2023-08-12 |
Not clear |
| Larysa Yuzefovych, Glenn Wilson, Lyudmila Rache. Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. American journal of physiology. Endocrinology and metabolism. vol 299. issue 6. 2010-12-28. PMID:20876761. |
different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in l6 skeletal muscle cells: role of oxidative stress. |
2010-12-28 |
2023-08-12 |
Not clear |
| Larysa Yuzefovych, Glenn Wilson, Lyudmila Rache. Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. American journal of physiology. Endocrinology and metabolism. vol 299. issue 6. 2010-12-28. PMID:20876761. |
only palmitate caused a significant increase of mtros production, which correlated with concomitant mtdna damage, mitochondrial dysfunction, induction of jnk, apoptosis, and inhibition of insulin signaling. |
2010-12-28 |
2023-08-12 |
Not clear |
| Larysa Yuzefovych, Glenn Wilson, Lyudmila Rache. Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. American journal of physiology. Endocrinology and metabolism. vol 299. issue 6. 2010-12-28. PMID:20876761. |
we propose that 1) mtros generation is the initial event in the induction of mitochondrial dysfunction and consequent apoptosis and the inhibition of insulin signaling and that 2) oleate ameliorates palmitate-induced mitochondrial dysfunction and thus may contribute to the prevention of palmitate-induced ir. |
2010-12-28 |
2023-08-12 |
Not clear |
| Ji Yeon Kim, Eun Hyeon Song, Sena Lee, Joo Hyun Lim, Joo Sun Choi, In-uk Koh, Jihyun Song, Won-Ho Ki. The induction of STAT1 gene by activating transcription factor 3 contributes to pancreatic beta-cell apoptosis and its dysfunction in streptozotocin-treated mice. Cellular signalling. vol 22. issue 11. 2010-12-21. PMID:20600850. |
genetic depletion using ifn-gamma(-/-) or stat1(-/-) mice strongly inhibited the reduction of islet cell mass or insulin synthesis/secretion and the increase of beta-cell apoptosis observed in stz-treated wild-type mice. |
2010-12-21 |
2023-08-12 |
mouse |
| Riccarda Granata, Alessandra Baragli, Fabio Settanni, Francesca Scarlatti, Ezio Ghig. Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. Journal of molecular endocrinology. vol 45. issue 3. 2010-12-02. PMID:20595321. |
indeed, ag, uag, and ob regulate insulin secretion in beta-cells and isolated islets, promote beta-cell proliferation and survival, inhibit beta-cell and human islet cell apoptosis, and modulate the expression of genes that are essential in pancreatic islet cell biology. |
2010-12-02 |
2023-08-12 |
human |
| Jae Soon Jang, Jong Seok Lee, Jung Hyun Lee, Duck Soo Kwon, Keun Eok Lee, Shin Young Lee, Eock Kee Hon. Hispidin produced from Phellinus linteus protects pancreatic beta-cells from damage by hydrogen peroxide. Archives of pharmacal research. vol 33. issue 6. 2010-11-16. PMID:20607489. |
in addition, hispidin was shown to inhibit hydrogen peroxide-induced apoptosis and increased insulin secretion in hydrogen peroxide-treated cells. |
2010-11-16 |
2023-08-12 |
Not clear |
| Nadeeja Wijesekara, Mansa Krishnamurthy, Alpana Bhattacharjee, Aamir Suhail, Gary Sweeney, Michael B Wheele. Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. The Journal of biological chemistry. vol 285. issue 44. 2010-11-16. PMID:20709750. |
adiponectin-induced erk and akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. |
2010-11-16 |
2023-08-12 |
mouse |
| Nadeeja Wijesekara, Mansa Krishnamurthy, Alpana Bhattacharjee, Aamir Suhail, Gary Sweeney, Michael B Wheele. Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. The Journal of biological chemistry. vol 285. issue 44. 2010-11-16. PMID:20709750. |
min6 beta cells and mouse islets were stimulated with globular (2.5 μg/ml) or full-length (5 μg/ml) adiponectin under serum starvation, and cell viability, proliferation, apoptosis, insulin gene expression, and secretion were measured. |
2010-11-16 |
2023-08-12 |
mouse |
| Nadeeja Wijesekara, Mansa Krishnamurthy, Alpana Bhattacharjee, Aamir Suhail, Gary Sweeney, Michael B Wheele. Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. The Journal of biological chemistry. vol 285. issue 44. 2010-11-16. PMID:20709750. |
this study demonstrates a lack of ampk involvement and implicates akt and erk in adiponectin signaling, leading to protection against apoptosis and stimulation of insulin gene expression and secretion in pancreatic beta cells. |
2010-11-16 |
2023-08-12 |
mouse |
| Haowei Song, Henry Rohrs, Min Tan, Mary Wohltmann, Jack H Ladenson, John Tur. Effects of endoplasmic reticulum stress on group VIA phospholipase A2 in beta cells include tyrosine phosphorylation and increased association with calnexin. The Journal of biological chemistry. vol 285. issue 44. 2010-11-16. PMID:20732873. |
the group via phospholipase a(2) (ipla(2)β) hydrolyzes glycerophospholipids at the sn-2-position to yield a free fatty acid and a 2-lysophospholipid, and ipla(2)β has been reported to participate in apoptosis, phospholipid remodeling, insulin secretion, transcriptional regulation, and other processes. |
2010-11-16 |
2023-08-12 |
mouse |
| Christa Buechler, Josef Wanninger, Markus Neumeie. Adiponectin receptor binding proteins--recent advances in elucidating adiponectin signalling pathways. FEBS letters. vol 584. issue 20. 2010-11-16. PMID:20875820. |
adiponectin whose systemic levels are reduced in obesity-related diseases ameliorates insulin sensitivity and regulates biological processes like apoptosis, proliferation, migration and inflammation. |
2010-11-16 |
2023-08-12 |
Not clear |
| Mariana N Nikolova-Karakashian, Krassimira A Rozenov. Ceramide in stress response. Advances in experimental medicine and biology. vol 688. 2010-11-05. PMID:20919648. |
these findings are described in the context of several physiological and pathophysiological conditions, namely septic shock, obesity-induced insulin resistance, aging and apoptosis of tumor cells in response to radiation and chemotherapy. |
2010-11-05 |
2023-08-12 |
Not clear |
| Minoru Ito, Michiaki Nagasawa, Tomoko Hara, Tomohiro Ide, Koji Murakam. Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes. Journal of lipid research. vol 51. issue 7. 2010-10-18. PMID:20154362. |
both insulin and the cell death-inducing dna fragmentation factor-alpha-like effector (cide) family play important roles in apoptosis and lipid droplet formation. |
2010-10-18 |
2023-08-12 |
human |
| Minoru Ito, Michiaki Nagasawa, Tomoko Hara, Tomohiro Ide, Koji Murakam. Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes. Journal of lipid research. vol 51. issue 7. 2010-10-18. PMID:20154362. |
starvation-induced apoptosis in adipocytes was significantly inhibited when insulin decreased the cidea mrna level. |
2010-10-18 |
2023-08-12 |
human |
| Minoru Ito, Michiaki Nagasawa, Tomoko Hara, Tomohiro Ide, Koji Murakam. Differential roles of CIDEA and CIDEC in insulin-induced anti-apoptosis and lipid droplet formation in human adipocytes. Journal of lipid research. vol 51. issue 7. 2010-10-18. PMID:20154362. |
small interfering rna-mediated depletion of cidea inhibited starvation-induced apoptosis similarly to insulin and restored insulin deprivation-reduced adipocyte number, whereas cidec depletion did not. |
2010-10-18 |
2023-08-12 |
human |
| Yuexiu Wu, Jinming Li, Saira Saleem, Siu-Pok Yee, Anandwardhan A Hardikar, Rennian Wan. c-Kit and stem cell factor regulate PANC-1 cell differentiation into insulin- and glucagon-producing cells. Laboratory investigation; a journal of technical methods and pathology. vol 90. issue 9. 2010-09-29. PMID:20531294. |
cells cultured with exogenous scf showed an increase in insulin(+) (26%) and glucagon(+) (35%) cell differentiation (p<0.01), an increase in cell proliferation (p<0.05) and a decrease in cell apoptosis (p<0.01). |
2010-09-29 |
2023-08-12 |
human |
| Pengcheng Luo, Hsin-Hsin Chang, Yiqiang Zhou, Shali Zhang, Sung Hee Hwang, Christophe Morisseau, Cong-Yi Wang, Edward W Inscho, Bruce D Hammock, Mong-Heng Wan. Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. The Journal of pharmacology and experimental therapeutics. vol 334. issue 2. 2010-08-17. PMID:20439437. |
inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis. |
2010-08-17 |
2023-08-12 |
mouse |