| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kohtaro Yamasaki, Yoshihiro Hayashi, Sumika Okamoto, Makoto Osanai, Gang-Hong Le. Insulin-independent promotion of chemically induced hepatocellular tumor development in genetically diabetic mice. Cancer science. vol 101. issue 1. 2010-03-30. PMID:19775285. |
they were mated with normal c3h/hej mice with high sensitivity to liver carcinogenesis and the resultant f(1) littermates, which were either normal or insulin deficient, were exposed to diethylnitrosamine and induced hepatocellular tumors were evaluated for number, size, proliferative activity, and apoptosis. |
2010-03-30 |
2023-08-12 |
mouse |
| Mark D McKenzie, Emma Jamieson, Elisa S Jansen, Clare L Scott, David C S Huang, Philippe Bouillet, Janette Allison, Thomas W H Kay, Andreas Strasser, Helen E Thoma. Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes. vol 59. issue 3. 2010-03-30. PMID:19959756. |
high concentrations of circulating glucose are believed to contribute to defective insulin secretion and beta-cell function in diabetes and at least some of this effect appears to be caused by glucose-induced beta-cell apoptosis. |
2010-03-30 |
2023-08-12 |
mouse |
| S M A Pascal, M Veiga-da-Cunha, P Gilon, E Van Schaftingen, J C Jona. Effects of fructosamine-3-kinase deficiency on function and survival of mouse pancreatic islets after prolonged culture in high glucose or ribose concentrations. American journal of physiology. Endocrinology and metabolism. vol 298. issue 3. 2010-03-30. PMID:20009024. |
to test that hypothesis, we cultured pancreatic islets from fn3k-knockout (fn3k(-/-)) mice and their wild-type (wt) littermates for 1-3 wk in the presence of 10 or 30 mmol/l glucose (g10 or g30, respectively) and measured protein glycation, apoptosis, preproinsulin gene expression, and ca(2+) and insulin secretory responses to acute glucose stimulation. |
2010-03-30 |
2023-08-12 |
mouse |
| Angelo Avogaro, Saula Vigili de Kreutzenberg, Gian Paolo Fadin. Insulin signaling and life span. Pflugers Archiv : European journal of physiology. vol 459. issue 2. 2010-03-23. PMID:19756720. |
insulin indeed activates a complex web of intracellular downstream pathways, which are involved in mechanisms regulating longevity, primarily affecting cellular proliferation and apoptosis. |
2010-03-23 |
2023-08-12 |
human |
| Lei Qian, Lihong Xu, Yi Lin, Yongde Pen. Statins and beta-cell function. Medical science monitor : international medical journal of experimental and clinical research. vol 16. issue 1. 2010-03-22. PMID:20037497. |
though the mechanism underlying this phenomenon is still elusive, it was recently found that elevated serum cholesterol can impair insulin secretion and increase the rate of apoptosis in beta cells, which may offer a promising clue to how statins work. |
2010-03-22 |
2023-08-12 |
Not clear |
| Cui-Qin Huang, Robin B Gasser, Cinzia Cantacessi, Alasdair J Nisbet, Weiwei Zhong, Paul W Sternberg, Alex Loukas, Jason Mulvenna, Rui-Qing Lin, Ning Chen, Xing-Quan Zh. Genomic-bioinformatic analysis of transcripts enriched in the third-stage larva of the parasitic nematode Ascaris suum. PLoS neglected tropical diseases. vol 2. issue 6. 2010-03-10. PMID:18560474. |
in silico analyses inferred the c. elegans orthologues/homologues (n = 50) to be involved in apoptosis and insulin signaling (2%), atp synthesis (2%), carbon metabolism (6%), fatty acid biosynthesis (2%), gap junction (2%), glucose metabolism (6%), or porphyrin metabolism (2%), although 34 (68%) of them could not be mapped to a specific metabolic pathway. |
2010-03-10 |
2023-08-12 |
caenorhabditis_elegans |
| Christopher M Mayer, Denise D Belsha. Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation. Endocrinology. vol 151. issue 2. 2010-02-26. PMID:19952270. |
palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation. |
2010-02-26 |
2023-08-12 |
Not clear |
| Christopher M Mayer, Denise D Belsha. Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation. Endocrinology. vol 151. issue 2. 2010-02-26. PMID:19952270. |
we investigated the role of endoplasmic reticulum (er) stress, which is known to promote cellular insulin resistance and apoptosis in peripheral tissues. |
2010-02-26 |
2023-08-12 |
Not clear |
| Christopher M Mayer, Denise D Belsha. Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation. Endocrinology. vol 151. issue 2. 2010-02-26. PMID:19952270. |
thus, activation of amp kinase prevents the deleterious effects of palmitate on hypothalamic neurons by inhibiting the onset of insulin resistance and apoptosis. |
2010-02-26 |
2023-08-12 |
Not clear |
| Naim Alkhouri, Agnieszka Gornicka, Michael P Berk, Samjhana Thapaliya, Laura J Dixon, Sangeeta Kashyap, Philip R Schauer, Ariel E Feldstei. Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. The Journal of biological chemistry. vol 285. issue 5. 2010-02-25. PMID:19940134. |
adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. |
2010-02-25 |
2023-08-12 |
mouse |
| Naim Alkhouri, Agnieszka Gornicka, Michael P Berk, Samjhana Thapaliya, Laura J Dixon, Sangeeta Kashyap, Philip R Schauer, Ariel E Feldstei. Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. The Journal of biological chemistry. vol 285. issue 5. 2010-02-25. PMID:19940134. |
genetic inactivation of bid, a key pro-apoptotic molecule that serves as a link between these two cell death pathways, significantly reduced caspase activation, adipocyte apoptosis, prevented adipose tissue macrophage infiltration, and protected against the development of systemic insulin resistance and hepatic steatosis independent of body weight. |
2010-02-25 |
2023-08-12 |
mouse |
| Naim Alkhouri, Agnieszka Gornicka, Michael P Berk, Samjhana Thapaliya, Laura J Dixon, Sangeeta Kashyap, Philip R Schauer, Ariel E Feldstei. Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. The Journal of biological chemistry. vol 285. issue 5. 2010-02-25. PMID:19940134. |
these data strongly suggest that adipocyte apoptosis is a key initial event that contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis associated with obesity in both mice and humans. |
2010-02-25 |
2023-08-12 |
mouse |
| Marie Courbebaisse, Jean-Claude Souberbielle, Eric Therve. Potential nonclassical effects of vitamin D in transplant recipients. Transplantation. vol 89. issue 2. 2010-02-24. PMID:20098273. |
these effects may be secondary to local production of calcitriol and to its autocrine and paracrine actions on cellular proliferation and differentiation, apoptosis, insulin and renin secretion, interleukin and bactericidal proteins production. |
2010-02-24 |
2023-08-12 |
Not clear |
| S Orciari, S Di Nuzzo, R Lazzarini, P Caprari, A Procopio, A Catalan. The effects of insulin and insulin-like growth factors on tumor vascularization: new insights of insulin-like growth factor family in cancer. Current medicinal chemistry. vol 16. issue 30. 2010-02-22. PMID:19747131. |
the insulin and insulin-like growth factors (igfs) systems play a key role in cellular metabolism, differentiation, proliferation, transformation and apoptosis, during normal and malignant growth. |
2010-02-22 |
2023-08-12 |
Not clear |
| Jun Wan, Li Jiang, Qingguo Lü, Linqiu Ke, Xiaoyu Li, Nanwei Ton. Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells. Biochemical and biophysical research communications. vol 391. issue 3. 2010-02-22. PMID:20040361. |
gw-induced activation of ppardelta up-regulated carnitine palmitoyltransferase 1 (cpt1), long-chain acyl-coa dehydrogenase (lcad), pyruvate dehydrogenase kinase 4 (pdk4), and uncoupling protein 2 (ucp2); alleviated mitochondrial swelling; attenuated apoptosis; and reduced basal insulin secretion induced by increased palmitate in hit cells. |
2010-02-22 |
2023-08-12 |
Not clear |
| b' Esther Liz\\xc3\\xa1rraga-Mollinedo, Elisa Fern\\xc3\\xa1ndez-Mill\\xc3\\xa1n, Laura de Miguel-Santos, Carlos Jos\\xc3\\xa9 Mart\\xc3\\xadnez-Honduvilla, Carmen Alvarez, Fernando Escriv\\xc3\\xa. Early undernutrition increases glycogen content and reduces the activated forms of GSK3, AMPK, p38 MAPK, and JNK in the cerebral cortex of suckling rats. Journal of neurochemistry. vol 112. issue 1. 2010-02-08. PMID:19840222.' |
in this study, we examined the effects of early undernutriton on molecular targets of insulin actions such as glucose transporters, glycogen, glycogen synthase kinase-3 (gsk3) and mitogen-activated protein kinases, as well as proteins involved in apoptosis in the cortex from 10-day-old rats. |
2010-02-08 |
2023-08-12 |
rat |
| Kristina I Rother, Lisa M Spain, Robert A Wesley, Benigno J Digon, Alain Baron, Kim Chen, Patric Nelson, H-Michael Dosch, Jerry P Palmer, Barbara Brooks-Worrell, Michael Ring, David M Harla. Effects of exenatide alone and in combination with daclizumab on beta-cell function in long-standing type 1 diabetes. Diabetes care. vol 32. issue 12. 2010-02-03. PMID:19808924. |
in patients with long-standing type 1 diabetes, we investigated whether improved beta-cell function can be achieved by combining intensive insulin therapy with agents that may 1) promote beta-cell growth and/or limit beta-cell apoptosis and 2) weaken the anti-beta-cell autoimmunity. |
2010-02-03 |
2023-08-12 |
Not clear |
| Viviana Madrid, Héctor Del Zotto, Bárbara Maiztegui, María A Raschia, María E Alzugaray, Antonio C Boschero, Helena C Barbosa, Luis E Flores, María I Borelli, Juan J Gagliardin. Islet neogenesis-associated protein pentadecapeptide (INGAP-PP): mechanisms involved in its effect upon beta-cell mass and function. Regulatory peptides. vol 157. issue 1-3. 2010-02-02. PMID:19501121. |
ingap-pp treated animals had significantly higher homa-ir and homa-beta and their islets released more insulin in response to glucose; they had lower islet dna content, significantly increased number of islets/unit area, beta-cell replication rate and mass, cells co-expressing pdx-1/ingap and islets in contact with ducts, and decreased beta-cell apoptosis rate. |
2010-02-02 |
2023-08-12 |
Not clear |
| James D Johnson, Ziliang Ao, Peter Ao, Hong Li, Long-Jun Dai, Zehua He, May Tee, Kathryn J Potter, Agnieszka M Klimek, R Mark Meloche, David M Thompson, C Bruce Verchere, Garth L Warnoc. Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. Cell transplantation. vol 18. issue 8. 2010-02-01. PMID:19500470. |
different effects of fk506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. |
2010-02-01 |
2023-08-12 |
mouse |
| Masahiro Okouchi, Naotsuka Okayama, Tak Yee A. Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apoptosis. Current neurovascular research. vol 6. issue 4. 2010-01-26. PMID:19807652. |
preservation of cellular glutathione status and mitochondrial membrane potential by n-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apoptosis. |
2010-01-26 |
2023-08-12 |
human |