| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter Kovacs, Andras Hajna. In vivo electrophysiological effects of insulin in the rat brain. Neuropeptides. vol 43. issue 4. 2009-10-14. PMID:19541365. |
brain insulin has widespread metabolic, neurotrophic, and neuromodulatory functions and is involved in the central regulation of food intake and body weight, learning and memory, neuronal development, neuronal apoptosis, and aging. |
2009-10-14 |
2023-08-12 |
rat |
| Mee-Hyun Lee, Bu Young Choi, Joydeb Kumar Kundu, Young Kee Shin, Hye-Kyung Na, Young-Joon Sur. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer research. vol 69. issue 18. 2009-10-07. PMID:19738051. |
resveratrol also activated caspase-9, -7, and -3 and induced apoptosis in pa-1 cells in the presence of insulin or serum. |
2009-10-07 |
2023-08-12 |
mouse |
| József Mandl, Tamás Mészáros, Gábor Bánhegyi, László Hunyady, Miklós Csal. Endoplasmic reticulum: nutrient sensor in physiology and pathology. Trends in endocrinology and metabolism: TEM. vol 20. issue 4. 2009-09-24. PMID:19349192. |
in response to hypoglycemia, hyperglycemia or fatty acid overload, the er triggers the unfolded protein response, which represses protein synthesis, alters insulin responsiveness and favors apoptosis. |
2009-09-24 |
2023-08-12 |
Not clear |
| Naoko Sakurai, Kazuki Mochizuki, Hiroyuki Kameji, Masaya Shimada, Toshinao God. (-)-Epigallocatechin gallate enhances the expression of genes related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation. Nutrition (Burbank, Los Angeles County, Calif.). vol 25. issue 10. 2009-09-24. PMID:19535224. |
(-)-epigallocatechin gallate (egcg) is thought to enhance insulin sensitivity in adipocytes, although doses used in in vitro experiments have been shown to promote apoptosis. |
2009-09-24 |
2023-08-12 |
Not clear |
| Hanumanthappa Nandeesh. Insulin: a novel agent in the pathogenesis of prostate cancer. International urology and nephrology. vol 41. issue 2. 2009-08-20. PMID:18665451. |
insulin is known to increase cancer risk through its effect on cell proliferation, differentiation and apoptosis. |
2009-08-20 |
2023-08-12 |
Not clear |
| Valérie Plaisance, Véronique Perret, Dimitri Favre, Amar Abderrahmani, Jiang-Yan Yang, Christian Widmann, Romano Regazz. Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure. Molecular and cellular endocrinology. vol 305. issue 1-2. 2009-08-12. PMID:19133313. |
fatty acids can favour the development of type 2 diabetes by reducing insulin secretion and inducing apoptosis of pancreatic beta-cells. |
2009-08-12 |
2023-08-12 |
Not clear |
| Valérie Plaisance, Véronique Perret, Dimitri Favre, Amar Abderrahmani, Jiang-Yan Yang, Christian Widmann, Romano Regazz. Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure. Molecular and cellular endocrinology. vol 305. issue 1-2. 2009-08-12. PMID:19133313. |
overexpression of c/ebpbeta mimicked the detrimental effects of palmitate and resulted in a drastic reduction in insulin promoter activity, impairment in the capacity to respond to secretory stimuli and an increase in apoptosis. |
2009-08-12 |
2023-08-12 |
Not clear |
| Mira M Sachdeva, Doris A Stoffer. Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. Molecular endocrinology (Baltimore, Md.). vol 23. issue 6. 2009-08-11. PMID:19196831. |
normal ss-cell compensation for an increased insulin demand includes both enhanced insulin-secretory capacity and an expansion of morphological ss-cell mass, due largely to changes in the balance between ss-cell proliferation and apoptosis. |
2009-08-11 |
2023-08-12 |
Not clear |
| Teresa Salvatore, Ornella Carbonara, Domenico Cozzolino, Roberto Torella, Ferdinando C Sass. Progress in the oral treatment of type 2 diabetes: update on DPP-IV inhibitors. Current diabetes reviews. vol 5. issue 2. 2009-08-11. PMID:19442094. |
enhanced insulin secretion as well as delayed gastric emptying, reduced glucagon secretion, and inhibited apoptosis of beta cells resulting from blockade of incretin degradation, have been proposed as the major actions of dpp-iv inhibitors as antidiabetic agents. |
2009-08-11 |
2023-08-12 |
Not clear |
| Malou Friederich, Peter Hansell, Fredrik Pal. Diabetes, oxidative stress, nitric oxide and mitochondria function. Current diabetes reviews. vol 5. issue 2. 2009-08-11. PMID:19442097. |
altered mitochondria function has also been implicated in the ageing process, defective insulin secretion, hypertension, arteriosclerosis, ischemia-reperfusion injury and apoptosis. |
2009-08-11 |
2023-08-12 |
Not clear |
| M Karaca, C Magnan, C Karga. Functional pancreatic beta-cell mass: involvement in type 2 diabetes and therapeutic intervention. Diabetes & metabolism. vol 35. issue 2. 2009-08-05. PMID:19251449. |
glucagon-like peptide-1 (glp-1), an incretin, enhances beta-cell survival (by activating beta-cell proliferation and differentiation, and inhibiting beta-cell apoptosis), thus contributing to the long-term regulation of insulin secretion by maintaining a functional beta-cell mass. |
2009-08-05 |
2023-08-12 |
Not clear |
| Jörgen Borg, Cecilia Klint, Nils Wierup, Kristoffer Ström, Sara Larsson, Frank Sundler, Roberto Lupi, Piero Marchetti, Guoheng Xu, Alan Kimmel, Constantine Londos, Cecilia Hol. Perilipin is present in islets of Langerhans and protects against lipotoxicity when overexpressed in the beta-cell line INS-1. Endocrinology. vol 150. issue 7. 2009-07-24. PMID:19299455. |
lipids have been shown to play a dual role in pancreatic beta-cells: a lipid-derived signal appears to be necessary for glucose-stimulated insulin secretion, whereas lipid accumulation causes impaired insulin secretion and apoptosis. |
2009-07-24 |
2023-08-12 |
mouse |
| Annamaria Sandomenico, Simona M Monti, Marco Sabatella, Antonia De Capua, Laura Tornatore, Nunzianna Doti, Francesca Viparelli, Nina A Dathan, Carlo Pedone, Menotti Ruvo, Daniela Marasc. Protein-protein interactions: a simple strategy to identify binding sites and peptide antagonists. Chemical biology & drug design. vol 73. issue 5. 2009-07-17. PMID:19366357. |
here, we present several studies including the complex between phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes and phospholipase 1, believed to play a relevant role in the insulin resistance mechanism in phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes-overexpressing tissues, the self-association of bcl10 caspase recruitment domain that mediates a protein oligomerization process responsible for nf-kappab activation and the self-association of growth arrest and dna damage-inducible factor 45 beta, a major player of the endogenous nf-kappab-mediated resistance to apoptosis. |
2009-07-17 |
2023-08-12 |
Not clear |
| Rodica Pop-Busui, Elif Oral, David Raffel, Jaeman Byun, Valida Bajirovic, Anuradha Vivekanandan-Giri, Aaron Kellogg, Subramaniam Pennathur, Martin J Steven. Impact of rosiglitazone and glyburide on nitrosative stress and myocardial blood flow regulation in type 2 diabetes mellitus. Metabolism: clinical and experimental. vol 58. issue 7. 2009-07-13. PMID:19394661. |
hyperglycemia, oxidative-nitrosative stress, systemic inflammation, and insulin resistance are implicated in the pathogenesis of abnormal mbf regulation, myocardial ischemia, and apoptosis. |
2009-07-13 |
2023-08-12 |
human |
| Hua-Pei Song, Hong Yan, Dong-Xia Zhang, Zhi-Gang Chu, Qiong Zhang, Yue-Sheng Huan. [The influence of insulin growth factor-I on the apoptosis of cardiomyocytes subjected to ischemia and hypoxia]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 23. issue 6. 2009-07-07. PMID:18457256. |
[the influence of insulin growth factor-i on the apoptosis of cardiomyocytes subjected to ischemia and hypoxia]. |
2009-07-07 |
2023-08-12 |
Not clear |
| Hua-Pei Song, Hong Yan, Dong-Xia Zhang, Zhi-Gang Chu, Qiong Zhang, Yue-Sheng Huan. [The influence of insulin growth factor-I on the apoptosis of cardiomyocytes subjected to ischemia and hypoxia]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 23. issue 6. 2009-07-07. PMID:18457256. |
to investigate the influence of insulin growth factor-i (igf-i) on apoptosis of cardiomyocytes subjected to ischemia and hypoxia and its possible mechanism. |
2009-07-07 |
2023-08-12 |
Not clear |
| Décio L Eizirik, Maikel L Colli, Fernanda Orti. The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nature reviews. Endocrinology. vol 5. issue 4. 2009-06-29. PMID:19352320. |
inflammatory mediators probably contribute to the suppression of beta-cell function and subsequent apoptosis; they may also inhibit or stimulate beta-cell regeneration and might cause peripheral insulin resistance. |
2009-06-29 |
2023-08-12 |
Not clear |
| John P Plastaras, Jay F Dorsey, Kristina Carroll, Seok-Hyun Kim, Morris J Birnbaum, Wafik S El-Deir. Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis. Cancer biology & therapy. vol 7. issue 12. 2009-06-19. PMID:19106634. |
we evaluated the time course of akt stimulation by insulin and found it overlapped with protection from apoptosis induced by trail (tnfalpha related apoptosis inducing ligand) in cell lines. |
2009-06-19 |
2023-08-12 |
mouse |
| John P Plastaras, Jay F Dorsey, Kristina Carroll, Seok-Hyun Kim, Morris J Birnbaum, Wafik S El-Deir. Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis. Cancer biology & therapy. vol 7. issue 12. 2009-06-19. PMID:19106634. |
pre-treatment with insulin and glucose did not significantly alter levels of ir-induced apoptosis in the gut. |
2009-06-19 |
2023-08-12 |
mouse |
| M Akiyama, M Hatanaka, Y Ohta, K Ueda, A Yanai, Y Uehara, K Tanabe, M Tsuru, M Miyazaki, S Saeki, T Saito, K Shinoda, Y Oka, Y Tanizaw. Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice. Diabetologia. vol 52. issue 4. 2009-06-19. PMID:19190890. |
increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in wfs1 knockout mice. |
2009-06-19 |
2023-08-12 |
mouse |