| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alecia Malin Fair, Kara Montgomer. Energy balance, physical activity, and cancer risk. Methods in molecular biology (Clifton, N.J.). vol 472. 2009-01-14. PMID:19107429. |
in vitro studies have clearly established that both insulin and igf-i act as growth factors that promote cell proliferation and inhibit apoptosis. |
2009-01-14 |
2023-08-12 |
Not clear |
| Kimberly A Brown, Amy-Joan L Ham, Cara N Clark, Nahum Meller, Brian K Law, Anna Chytil, Nikki Cheng, Jennifer A Pietenpol, Harold L Mose. Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. Journal of cellular biochemistry. vol 105. issue 2. 2009-01-05. PMID:18729074. |
in addition, a number of putative novel smad2 and smad3 associated proteins were identified that have functions in cell proliferation, apoptosis, actin cytoskeleton regulation, cell motility, transcription, and ras or insulin signaling. |
2009-01-05 |
2023-08-12 |
human |
| K J Chang-Chen, R Mullur, E Bernal-Mizrach. Beta-cell failure as a complication of diabetes. Reviews in endocrine & metabolic disorders. vol 9. issue 4. 2009-01-05. PMID:18777097. |
these processes adversely affect beta-cells by impairing insulin secretion, decreasing insulin gene expression and ultimately causing apoptosis. |
2009-01-05 |
2023-08-12 |
Not clear |
| Pascal Lovis, Elodie Roggli, D Ross Laybutt, Sonia Gattesco, Jiang-Yan Yang, Christian Widmann, Amar Abderrahmani, Romano Regazz. Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes. vol 57. issue 10. 2008-12-31. PMID:18633110. |
chronic exposure to these lipids is detrimental for pancreatic beta-cells, resulting in reduced insulin content, defective insulin secretion, and apoptosis. |
2008-12-31 |
2023-08-12 |
Not clear |
| S Halimi, I Debaty, L Villaret, M Mulle. [New therapies for type 2 diabetes: what place for incretin-based agents and rimonabant compared to the previous ones?]. La Revue de medecine interne. vol 29. issue 11. 2008-12-30. PMID:18722695. |
glp1 enhances insulin secretion and inhibits glucagon secretion in a glucose-dependent manner, delays gastric emptying and, in animal studies, preserves beta-cell mass by reducing apoptosis and stimulates of beta-cell proliferation. |
2008-12-30 |
2023-08-12 |
Not clear |
| Yao Zhang, Ju-Ming Lu, Wei-Jun Gu, Guo-Qing Yang, Yi-Ming Mu, Jing-Tao Dou, Bao-An Wang, Chang-Yu Pa. [Detrimental effects of homocysteine on insulin release and apoptosis of pancreatic beta cells]. Zhonghua yi xue za zhi. vol 88. issue 14. 2008-12-22. PMID:18756974. |
[detrimental effects of homocysteine on insulin release and apoptosis of pancreatic beta cells]. |
2008-12-22 |
2023-08-12 |
Not clear |
| Yao Zhang, Ju-Ming Lu, Wei-Jun Gu, Guo-Qing Yang, Yi-Ming Mu, Jing-Tao Dou, Bao-An Wang, Chang-Yu Pa. [Detrimental effects of homocysteine on insulin release and apoptosis of pancreatic beta cells]. Zhonghua yi xue za zhi. vol 88. issue 14. 2008-12-22. PMID:18756974. |
to study the effects of homocysteine (hcy) on the insulin secretion and apoptosis of pancreatic beta cells. |
2008-12-22 |
2023-08-12 |
Not clear |
| Chin Hee Kim, Zobair M Younoss. Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome. Cleveland Clinic journal of medicine. vol 75. issue 10. 2008-12-16. PMID:18939388. |
the pathogenesis is thought to be a multiple-hit process involving insulin resistance, oxidative stress, apoptosis, and adipokines. |
2008-12-16 |
2023-08-12 |
Not clear |
| Brian C Smith, William C Hallows, John M Den. Mechanisms and molecular probes of sirtuins. Chemistry & biology. vol 15. issue 10. 2008-12-12. PMID:18940661. |
sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle, and apoptosis. |
2008-12-12 |
2023-08-12 |
human |
| Hye Seung Jung, Kun Wook Chung, Jeong Won Kim, Jin Kim, Masaaki Komatsu, Keiji Tanaka, Yen Hoang Nguyen, Tong Mook Kang, Kun-Ho Yoon, Ji-Won Kim, Yeon Taek Jeong, Myoung Sook Han, Moon-Kyu Lee, Kwang-Won Kim, Jaekyoon Shin, Myung-Shik Le. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell metabolism. vol 8. issue 4. 2008-12-02. PMID:18840362. |
beta cell mass and pancreatic insulin content were reduced because of increased apoptosis and decreased proliferation of beta cells. |
2008-12-02 |
2023-08-12 |
mouse |
| Seong-Woon Yu, Seung-Hoon Baek, Ryan T Brennan, Christopher J Bradley, Se Kyong Park, Yoon Sun Lee, Eun Jung Jun, Keith J Lookingland, Eun-Kyoung Kim, Heuiran Lee, John L Goudreau, Seong Who Ki. Autophagic death of adult hippocampal neural stem cells following insulin withdrawal. Stem cells (Dayton, Ohio). vol 26. issue 10. 2008-11-28. PMID:18653772. |
to understand the type of cell death in hcn cells following insulin withdrawal, apoptosis markers were assessed. |
2008-11-28 |
2023-08-12 |
rat |
| Seong-Woon Yu, Seung-Hoon Baek, Ryan T Brennan, Christopher J Bradley, Se Kyong Park, Yoon Sun Lee, Eun Jung Jun, Keith J Lookingland, Eun-Kyoung Kim, Heuiran Lee, John L Goudreau, Seong Who Ki. Autophagic death of adult hippocampal neural stem cells following insulin withdrawal. Stem cells (Dayton, Ohio). vol 26. issue 10. 2008-11-28. PMID:18653772. |
staurosporine induced robust activation of caspase-3 and nucleosomal dna fragmentation, suggesting that the machinery of apoptosis is intact in hcn cells despite the apparent absence of apoptosis following insulin withdrawal. |
2008-11-28 |
2023-08-12 |
rat |
| Benbo Song, Donalyn Scheuner, David Ron, Subramaniam Pennathur, Randal J Kaufma. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. The Journal of clinical investigation. vol 118. issue 10. 2008-11-18. PMID:18776938. |
these findings suggest that chop is a fundamental factor that links protein misfolding in the er to oxidative stress and apoptosis in beta cells under conditions of increased insulin demand. |
2008-11-18 |
2023-08-12 |
mouse |
| Hongxia Shuai, Ji Zhang, Yikai Yu, Muxun Zhan. Expression of EPO receptor in pancreatic cells and its effect on cell apoptosis. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 28. issue 1. 2008-11-17. PMID:18278456. |
nit-1 apoptosis was induced by cytokines and their effects on cell apoptosis and cell insulin secretion were assayed after binding of epo to epor. |
2008-11-17 |
2023-08-12 |
human |
| Igor Sukhotnik, Naim Shehadeh, Arnold G Coran, Jorge G Mogilner, Rahel Karry, Benhoor Shamian, Benno M Ure, Raanan Shami. Oral insulin enhances cell proliferation and decreases enterocyte apoptosis during methotrexate-induced mucositis in the rat. Journal of pediatric gastroenterology and nutrition. vol 47. issue 2. 2008-11-17. PMID:18664860. |
oral insulin enhances cell proliferation and decreases enterocyte apoptosis during methotrexate-induced mucositis in the rat. |
2008-11-17 |
2023-08-12 |
rat |
| Barbara Bellei, Enrica Flori, Enzo Izzo, Vittoria Maresca, Mauro Picard. GSK3beta inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytes. Cellular signalling. vol 20. issue 10. 2008-11-14. PMID:18602000. |
glycogen synthase kinase 3beta (gsk3beta) is implicated in many biological events, including embryonic development, cell differentiation, apoptosis, and the insulin response. |
2008-11-14 |
2023-08-12 |
mouse |
| Vincent Poitou. Glucolipotoxicity of the pancreatic beta-cell: myth or reality? Biochemical Society transactions. vol 36. issue Pt 5. 2008-11-12. PMID:18793158. |
in vitro, prolonged exposure of insulin-secreting cells or isolated islets to concomitantly elevated levels of fatty acids and glucose impairs insulin secretion, inhibits insulin gene expression and, under certain circumstances, induces beta-cell death by apoptosis. |
2008-11-12 |
2023-08-12 |
human |
| Deirdre Keane, Philip Newsholm. Saturated and unsaturated (including arachidonic acid) non-esterified fatty acid modulation of insulin secretion from pancreatic beta-cells. Biochemical Society transactions. vol 36. issue Pt 5. 2008-11-12. PMID:18793168. |
acute exposure of the pancreatic beta-cell to high glucose concentrations and/or saturated nefas results in a substantial increase in insulin release, whereas chronic exposure results in desensitization and suppression of secretion followed by induction of apoptosis. |
2008-11-12 |
2023-08-12 |
Not clear |
| Shanta J Persaud, Dany Muller, Peter M Jone. Insulin signalling in islets. Biochemical Society transactions. vol 36. issue Pt 3. 2008-11-03. PMID:18481944. |
very little is known about the in vitro roles played by insulin in human islets, and the regulatory role of insulin in protecting against beta-cell apoptosis. |
2008-11-03 |
2023-08-12 |
mouse |
| Shanta J Persaud, Dany Muller, Peter M Jone. Insulin signalling in islets. Biochemical Society transactions. vol 36. issue Pt 3. 2008-11-03. PMID:18481944. |
studies using the mouse min6 beta-cell line indicated that glucose protected beta-cells from undergoing apoptosis and that this was a consequence, at least in part, of insulin release in response to elevated glucose. |
2008-11-03 |
2023-08-12 |
mouse |