| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shanta J Persaud, Dany Muller, Peter M Jone. Insulin signalling in islets. Biochemical Society transactions. vol 36. issue Pt 3. 2008-11-03. PMID:18481944. |
it protects beta-cells against apoptosis and increases preproinsulin mrna synthesis, but does not affect insulin secretion. |
2008-11-03 |
2023-08-12 |
mouse |
| Spiros Fourlanos, Leonard C Harrison, Peter G Colma. The accelerator hypothesis and increasing incidence of type 1 diabetes. Current opinion in endocrinology, diabetes, and obesity. vol 15. issue 4. 2008-10-31. PMID:18594271. |
the 'accelerator hypothesis' proposes 'three processes in type 1 diabetes which variably accelerate the loss of beta cells through apoptosis: constitution, insulin resistance and autoimmunity'. |
2008-10-31 |
2023-08-12 |
Not clear |
| E Maria Sol, Ernest Sargsyan, Göran Akusjärvi, Peter Bergste. Glucolipotoxicity in INS-1E cells is counteracted by carnitine palmitoyltransferase 1 over-expression. Biochemical and biophysical research communications. vol 375. issue 4. 2008-10-27. PMID:18706397. |
we examined how over-expression of the mitochondrial fa transporter carnitine palmitoyltransferase 1 (cpt1) affects glucose-stimulated insulin secretion (gsis), apoptosis and er stress in ins-1e cells cultured in the presence of elevated levels of glucose and palmitate. |
2008-10-27 |
2023-08-12 |
Not clear |
| Yuan Li, Changhong Shi, Qiujun Lv, Huming Zhang, Biehu Li, Guangxing Bian, Qingsheng Huang, Weihua Zhang, Xiaoping Xue, Xin Ren, Hua Gao, Chunyi Sun, Juan Wang, Mingjie Zhan. GLP-1 C-terminal structures affect its blood glucose lowering-function. Journal of peptide science : an official publication of the European Peptide Society. vol 14. issue 7. 2008-10-24. PMID:18200618. |
sglp-1 reduced apoptosis of the old islets, enhanced insulin production, and promoted new islets replication. |
2008-10-24 |
2023-08-12 |
rat |
| Satish Patel, Bradley W Doble, Katrina MacAulay, Elaine M Sinclair, Daniel J Drucker, James R Woodget. Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action. Molecular and cellular biology. vol 28. issue 20. 2008-10-24. PMID:18694957. |
mice engineered to lack gsk-3beta die in late embryogenesis from liver apoptosis, whereas mice engineered to lack gsk-3alpha are viable and exhibit improved insulin sensitivity and hepatic glucose homeostasis. |
2008-10-24 |
2023-08-12 |
mouse |
| Jing Zhao, Feng-Xia Xue, Shao-Fang Hua, Li-Zhi Zhan. [Effects of insulin on proliferation and apoptosis of endometrial carcinoma cell]. Zhonghua fu chan ke za zhi. vol 42. issue 10. 2008-10-21. PMID:18241547. |
[effects of insulin on proliferation and apoptosis of endometrial carcinoma cell]. |
2008-10-21 |
2023-08-12 |
Not clear |
| Jing Zhao, Feng-Xia Xue, Shao-Fang Hua, Li-Zhi Zhan. [Effects of insulin on proliferation and apoptosis of endometrial carcinoma cell]. Zhonghua fu chan ke za zhi. vol 42. issue 10. 2008-10-21. PMID:18241547. |
to study the expression of insulin receptor (insr) in endometrial cell line ishikawa3-h-12, and the effects of insulin on proliferation, cell cycle distribution and apoptosis of ishikawa3-h-12 cells. |
2008-10-21 |
2023-08-12 |
Not clear |
| N Bresgen, I Ohlenschläger, N Wacht, S Afazel, G Ladurner, P M Eck. Ferritin and FasL (CD95L) mediate density dependent apoptosis in primary rat hepatocytes. Journal of cellular physiology. vol 217. issue 3. 2008-10-16. PMID:18726999. |
supplementation with dexamethasone (dex) or proliferative stimulation by epidermal growth factor (egf) and insulin strongly suppresses density dependent apoptosis. |
2008-10-16 |
2023-08-12 |
human |
| Erika Bosio, Michela Seveso, Arben Dedja, Giovanni Luca, Mario Calvitti, Riccardo Calafiore, Paolo Rigotti, Roberto Busetto, Ermanno Ancona, Emanuele Cozz. Cobalt protoporpyhrin reduces caspase-3,-7 enzyme activity in neonatal porcine islets, but does not inhibit cell death induced by TNF-alpha. Cell transplantation. vol 17. issue 6. 2008-10-15. PMID:18819247. |
strategies to reduce apoptosis of islet tissue prior to and posttransplantation may improve graft survival and function and reduce the amount of tissue necessary to achieve insulin independence. |
2008-10-15 |
2023-08-12 |
Not clear |
| Jyuhn-Huarng Juang, Chien-Hung Kuo, Chun-Hsing Wu, Charity Juan. Exendin-4 treatment expands graft beta-cell mass in diabetic mice transplanted with a marginal number of fresh islets. Cell transplantation. vol 17. issue 6. 2008-10-15. PMID:18819252. |
exendin-4 stimulates insulin secretion, suppresses glucagons secretion, increases beta-cell replication and neogenesis, and reduces beta-cell apoptosis. |
2008-10-15 |
2023-08-12 |
mouse |
| Donatella Gniuli, Alessandra Calcagno, Maria Emiliana Caristo, Alessandra Mancuso, Veronica Macchi, Geltrude Mingrone, Roberto Vetto. Effects of high-fat diet exposure during fetal life on type 2 diabetes development in the progeny. Journal of lipid research. vol 49. issue 9. 2008-10-06. PMID:18493032. |
the aim of our study was to verify: 1) whether a high-fat (hf) diet in young adult mice induces alterations in beta-cell mass, proliferation, neogenesis, and apoptosis, as well as insulin sensitivity and secretion; 2) whether these alterations may be reversible after hf diet suspension; 3) the effects in a first (f1) and second generation (f2) of mice without direct exposure to a hf diet after birth. |
2008-10-06 |
2023-08-12 |
mouse |
| Nalú Navarro-Alvarez, Jorge David Rivas-Carrillo, Alejandro Soto-Gutierrez, Takeshi Yuasa, Teru Okitsu, Hirofumi Noguchi, Shinichi Matsumoto, Jiro Takei, Noriaki Tanaka, Naoya Kobayash. Reestablishment of microenvironment is necessary to maintain in vitro and in vivo human islet function. Cell transplantation. vol 17. issue 1-2. 2008-10-03. PMID:18468241. |
islet grafts were removed after 14 days to evaluate insulin content, insulin expression, and apoptosis. |
2008-10-03 |
2023-08-12 |
mouse |
| Lise Madsen, Rasmus K Petersen, Knut R Steffensen, Lone M Pedersen, Philip Hallenborg, Tao Ma, Livar Frøyland, Stein Ove Døskeland, Jan-Ake Gustafsson, Karsten Kristianse. Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes. The Journal of biological chemistry. vol 283. issue 33. 2008-10-03. PMID:18487205. |
furthermore, forced expression of bcl-2 did not prevent statin-induced apoptosis; nor did lxr action depend on protein kinase b, whose activation by insulin was impaired in statin-treated cells. |
2008-10-03 |
2023-08-12 |
mouse |
| Filip K Knop, Jens J Holst, Tina Vilsbøl. Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: challenges and feasibility. IDrugs : the investigational drugs journal. vol 11. issue 7. 2008-09-30. PMID:18600596. |
in recent studies, su has proven to be associated with increased beta-cell apoptosis, suggesting that su may actually accelerate the progressive decrease in beta-cell mass, thereby promoting the need for insulin replacement. |
2008-09-30 |
2023-08-12 |
Not clear |
| Markus Meier, Martin Nitschke, Caroline Hocke, Jan Kramer, Wolfram Jabs, Jurgen Steinhoff, Morten Schut. Insulin inhibits caspase-3 activity in human renal tubular epithelial cells via the PI3-kinase/Akt pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 21. issue 4. 2008-09-29. PMID:18441516. |
our data indicate that apoptosis in ptec is regulated by the insulin dependent pi3-kinase/akt pathway. |
2008-09-29 |
2023-08-12 |
human |
| Yi-Ping Chuang, Chi-Hong Chu, Huey-Kang Sytw. Genetic manipulation of islet cells in autoimmune diabetes: from bench to bedside. Frontiers in bioscience : a journal and virtual library. vol 13. 2008-09-19. PMID:18508650. |
transgenic mice overexpressing a variety of transgenes driven by insulin promoter demonstrate that both apoptosis and necrosis lead to islet cells death; furthermore, various immune cells and cytokine effectors are involved in the immunoprogression of t1d. |
2008-09-19 |
2023-08-12 |
mouse |
| Claudia Gragnol. CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians. Journal of cellular physiology. vol 217. issue 2. 2008-09-12. PMID:18680108. |
chop is a candidate gene for the linkage, as it is located in the chromosome 12q13.1 region, and may contribute to t2d by increasing beta-cell apoptosis susceptibility and by impairing insulin sensitivity. |
2008-09-12 |
2023-08-12 |
human |
| Hongqiang Fei, Bin Zhao, Shangang Zhao, Qin Wan. Requirements of calcium fluxes and ERK kinase activation for glucose- and interleukin-1beta-induced beta-cell apoptosis. Molecular and cellular biochemistry. vol 315. issue 1-2. 2008-09-08. PMID:18498041. |
exposure of rat islets for 4 days to 33.3 mm glucose and 140 ng/ml il-1beta- induced beta-cell apoptosis and impaired glucose-stimulated insulin secretion. |
2008-09-08 |
2023-08-12 |
rat |
| Fumi Sawada, Toyoshi Inoguchi, Hirotaka Tsubouchi, Shuji Sasaki, Masakazu Fujii, Yasutaka Maeda, Hidetaka Morinaga, Masatoshi Nomura, Kunihisa Kobayashi, Ryoichi Takayanag. Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic beta-cell line, MIN6. Metabolism: clinical and experimental. vol 57. issue 8. 2008-09-04. PMID:18640379. |
here, we examined the effects of various sulfonylureas and a short-acting insulin secretagogue, nateglinide, on oxidative stress and apoptosis using the beta-cell line min6. |
2008-09-04 |
2023-08-12 |
Not clear |
| Cheng J. Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. Journal of gastroenterology and hepatology. vol 23 Suppl 1. 2008-08-29. PMID:18336657. |
however, delayed or insufficient responses or interplay with mitochondrial dysfunction may turn physiological mechanisms into pathological consequences including apoptosis, fat accumulation and inflammation all of which have an important role in the pathogenesis of liver disorders such as genetic mutations, viral hepatitis, insulin resistance, ischemia/reperfusion injury, and alcoholic and non-alcoholic steatosis. |
2008-08-29 |
2023-08-12 |
mouse |