| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carmine Morisco, Chiara Marrone, Valentina Trimarco, Salvatore Crispo, Maria Gaia Monti, Junichi Sadoshima, Bruno Trimarc. Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression. Cardiovascular research. vol 76. issue 3. 2009-03-10. PMID:17698050. |
insulin protects cardiomyocytes from apoptosis. |
2009-03-10 |
2023-08-12 |
Not clear |
| C Schramm, A Schneider, A Marx, A W Lohs. Adalimumab could suppress the activity of non alcoholic steatohepatitis (NASH). Zeitschrift fur Gastroenterologie. vol 46. issue 12. 2009-03-05. PMID:19053005. |
several lines of evidence suggest that tnf-alpha may be involved in the pathogenesis of nash by promoting liver inflammation, insulin resistance and hepatocyte apoptosis. |
2009-03-05 |
2023-08-12 |
Not clear |
| Hai-Lu Zhao, Yi Sui, Jing Guan, Lan He, Xue-Mei Gu, Harriet Kt Wong, Larry Baum, Fernand M M Lai, Peter C Y Tong, Juliana C N Cha. Amyloid oligomers in diabetic and nondiabetic human pancreas. Translational research : the journal of laboratory and clinical medicine. vol 153. issue 1. 2009-03-05. PMID:19100955. |
several markers for insulin, iapp, amyloid fibrils (thioflavin t), and apoptosis (cleaved caspase-3) were used in combination with an oligomer-specific antibody. |
2009-03-05 |
2023-08-12 |
human |
| Rayyan A Kayal, Jazia Alblowi, Erin McKenzie, Nanarao Krothapalli, Lee Silkman, Louis Gerstenfeld, Thomas A Einhorn, Dana T Grave. Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment. Bone. vol 44. issue 2. 2009-03-03. PMID:19010456. |
chondrocyte apoptosis was significantly higher in diabetic mice and this increase was blocked by insulin. |
2009-03-03 |
2023-08-12 |
mouse |
| Yoshifumi Saisho, Erica Manesso, Tatyana Gurlo, Chang-Jiang Huang, Gianna M Toffolo, Claudio Cobelli, Peter C Butle. Development of factors to convert frequency to rate for beta-cell replication and apoptosis quantified by time-lapse video microscopy and immunohistochemistry. American journal of physiology. Endocrinology and metabolism. vol 296. issue 1. 2009-02-19. PMID:18940937. |
similarly, we quantified the rate of beta-cell apoptosis by tlvm and then the frequency of apoptosis in the same islets using tdt-mediated dutp nick-end labeling and insulin. |
2009-02-19 |
2023-08-12 |
rat |
| S Piro, L Spadaro, M Russello, D Spampinato, C E Oliveri, E Vasquez, R Benigno, F Brancato, F Purrello, A M Rabuazz. Molecular determinants of insulin resistance, cell apoptosis and lipid accumulation in non-alcoholic steatohepatitis. Nutrition, metabolism, and cardiovascular diseases : NMCD. vol 18. issue 8. 2009-02-13. PMID:18063353. |
molecular determinants of insulin resistance, cell apoptosis and lipid accumulation in non-alcoholic steatohepatitis. |
2009-02-13 |
2023-08-12 |
Not clear |
| S Piro, L Spadaro, M Russello, D Spampinato, C E Oliveri, E Vasquez, R Benigno, F Brancato, F Purrello, A M Rabuazz. Molecular determinants of insulin resistance, cell apoptosis and lipid accumulation in non-alcoholic steatohepatitis. Nutrition, metabolism, and cardiovascular diseases : NMCD. vol 18. issue 8. 2009-02-13. PMID:18063353. |
this study investigates insulin signalling in liver tissue from nash, and the molecular mechanisms by which insulin-resistance could lead to liver damage (apoptosis). |
2009-02-13 |
2023-08-12 |
Not clear |
| Jonathan M Peterson, Yan Wang, Randall W Bryner, David L Williamson, Stephen E Alwa. Bax signaling regulates palmitate-mediated apoptosis in C(2)C(12) myotubes. American journal of physiology. Endocrinology and metabolism. vol 295. issue 6. 2009-02-11. PMID:18840766. |
several lines of evidence suggest that accumulation of free fatty acids in skeletal muscle may at least in part contribute to insulin resistance and may be linked to mitochondrial dysfunction, leading to apoptosis. |
2009-02-11 |
2023-08-12 |
Not clear |
| Jonathan M Peterson, Yan Wang, Randall W Bryner, David L Williamson, Stephen E Alwa. Bax signaling regulates palmitate-mediated apoptosis in C(2)C(12) myotubes. American journal of physiology. Endocrinology and metabolism. vol 295. issue 6. 2009-02-11. PMID:18840766. |
palmitate treatment of several cell lines in vitro results in apoptosis and inhibits protein kinase b (akt) activity in response to insulin. |
2009-02-11 |
2023-08-12 |
Not clear |
| Yongmei Gao, Ronald Ordas, Janet D Klein, S Russ Pric. Regulation of caspase-3 activity by insulin in skeletal muscle cells involves both PI3-kinase and MEK-1/2. Journal of applied physiology (Bethesda, Md. : 1985). vol 105. issue 6. 2009-02-06. PMID:18832759. |
insulin suppressed caspase-3 activity by a complex mechanism that included direct inhibition due to an increased interaction between caspase-3 and cellular inhibitor of apoptosis-1 and indirect inhibition via phosphorylation (i.e., inactivation) of the proapoptotic protein bad, which participates in the intrinsic (i.e., mitochondrial) apoptosis activation cascade. |
2009-02-06 |
2023-08-12 |
Not clear |
| June Woo Lee, Won Ho Kim, Joo Hyun Lim, Eun Hyeon Song, Jihyun Song, Kang Yuel Choi, Myeong Ho Jun. Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells. Cellular signalling. vol 21. issue 1. 2009-02-06. PMID:18940247. |
in pancreatic beta-cells especially, mitochondrial dysfunction impairs insulin secretion and the eventual apoptosis of beta-cells. |
2009-02-06 |
2023-08-12 |
mouse |
| June Woo Lee, Won Ho Kim, Joo Hyun Lim, Eun Hyeon Song, Jihyun Song, Kang Yuel Choi, Myeong Ho Jun. Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells. Cellular signalling. vol 21. issue 1. 2009-02-06. PMID:18940247. |
concurrent with reduction in mitochondrial membrane potential (deltapsim) and cellular atp content, impaired mitochondrial function reduced gck expression and resulted in decreased insulin secretion and beta-cell apoptosis. |
2009-02-06 |
2023-08-12 |
mouse |
| June Woo Lee, Won Ho Kim, Joo Hyun Lim, Eun Hyeon Song, Jihyun Song, Kang Yuel Choi, Myeong Ho Jun. Mitochondrial dysfunction: glucokinase downregulation lowers interaction of glucokinase with mitochondria, resulting in apoptosis of pancreatic beta-cells. Cellular signalling. vol 21. issue 1. 2009-02-06. PMID:18940247. |
collectively, these data demonstrate that mitochondrial dysfunction by metabolic stress reduces gck expression through pdx-1 downregulation via production of ros, which then decreases the association of gck with mitochondria, resulting in pancreatic beta-cell apoptosis and reduction of insulin secretion. |
2009-02-06 |
2023-08-12 |
mouse |
| Jai Parkas. Tumor necrosis factor alpha inducing spatial interactions between calcium-sensing receptor and L-type voltage-dependent calcium channel. Annals of the New York Academy of Sciences. vol 1150. 2009-02-06. PMID:19120320. |
the temporal and spatial regulation of intracellular calcium concentration ([ca(2+)](i)) is very crucial for maintaining calcium ion homeostasis within cells, and consequently in the regulation of cellular functions such as beta cell replication and differentiation, insulin secretion, and apoptosis. |
2009-02-06 |
2023-08-12 |
Not clear |
| Pedro Geraldes, Kunimasa Yagi, Yuzuru Ohshiro, Zhiheng He, Yasuhiro Maeno, Junko Yamamoto-Hiraoka, Christian Rask-Madsen, Su Wol Chung, Mark A Perrella, George L Kin. Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway. The Journal of biological chemistry. vol 283. issue 49. 2009-02-04. PMID:18854316. |
further, insulin treatment prevented h(2)o(2)-induced nf-kappab and caspase-8 activation and apoptosis via the irs1/pi3k/akt2/ho-1 pathway in the pericytes. |
2009-02-04 |
2023-08-12 |
rat |
| C Guillen, A Bartolomé, C Nevado, M Benit. Biphasic effect of insulin on beta cell apoptosis depending on glucose deprivation. FEBS letters. vol 582. issue 28. 2009-02-02. PMID:18950630. |
biphasic effect of insulin on beta cell apoptosis depending on glucose deprivation. |
2009-02-02 |
2023-08-12 |
Not clear |
| C Guillen, A Bartolomé, C Nevado, M Benit. Biphasic effect of insulin on beta cell apoptosis depending on glucose deprivation. FEBS letters. vol 582. issue 28. 2009-02-02. PMID:18950630. |
we observed that a prolonged effect of high levels of insulin on the presence of serum (15-24h) in glucose-deprived beta cells induced apoptosis. |
2009-02-02 |
2023-08-12 |
Not clear |
| Hanna K Nyblom, Ernest Sargsyan, Peter Bergste. AMP-activated protein kinase agonist dose dependently improves function and reduces apoptosis in glucotoxic beta-cells without changing triglyceride levels. Journal of molecular endocrinology. vol 41. issue 3. 2009-01-30. PMID:18579684. |
prolonged hyperglycaemia leads to impaired glucose-stimulated insulin secretion (gsis) and apoptosis in insulin-producing beta-cells. |
2009-01-30 |
2023-08-12 |
Not clear |
| O Osborn, S E Brownell, M Sanchez-Alavez, D Salomon, H Gram, T Bartfa. Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity. Cytokine. vol 44. issue 1. 2009-01-23. PMID:18723371. |
the proinflammatory cytokine interleukin 1 beta (il-1beta) is elevated in obese individuals and rodents and it is implicated in impaired insulin secretion, decreased cell proliferation and apoptosis of pancreatic beta cells. |
2009-01-23 |
2023-08-12 |
mouse |
| Ying Zhang, Mingtong Xu, Shaoling Zhang, Li Yan, Chuan Yang, Wensheng Lu, Yan Li, Hua Chen. The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1. Journal of molecular endocrinology. vol 38. issue 6. 2009-01-20. PMID:17556534. |
acute exposure to ffas stimulates insulin secretion, whereas chronic exposure impairs beta-cell function and induces apoptosis. |
2009-01-20 |
2023-08-12 |
mouse |