| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexandre T Fabro, Pedro H R Q da Silva, William S Zocolaro, Mozar S de Almeida, Maristela P Rangel, Cristiano C de Oliveira, Igor O Minatel, Erika D C Prando, Claudia A Rainho, Walcy R Teodoro, Ana P P Velosa, Alexandre M A Saber, Edwin R Parra-Cuentas, Helmut H Popper, Vera L Capelozz. The Th17 pathway in the peripheral lung microenvironment interacts with expression of collagen V in the late state of experimental pulmonary fibrosis. Immunobiology. vol 220. issue 1. 2015-07-23. PMID:25172545. |
myofibroblasts derived from fibroblasts in the pathogenesis of pulmonary fibrosis causes excessive and disordered deposition of matrix proteins, including collagen v, which can cause a th17-mediated immune response and lead to apoptosis. |
2015-07-23 |
2023-08-13 |
Not clear |
| Y Li, Y Wang, S Chubinskaya, B Schoeberl, E Florine, P Kopesky, A J Grodzinsk. Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis. Osteoarthritis and cartilage. vol 23. issue 2. 2015-07-23. PMID:25450855. |
interleukin-1 is one of the inflammatory cytokines elevated after traumatic joint injury that plays a critical role in mediating cartilage tissue degradation, suppressing matrix biosynthesis, and inducing chondrocyte apoptosis, events associated with progression to post-traumatic osteoarthritis (ptoa). |
2015-07-23 |
2023-08-13 |
Not clear |
| Mai Akada, Kohei Harada, Manabu Negishi, Hironori Kato. EphB6 promotes anoikis by modulating EphA2 signaling. Cellular signalling. vol 26. issue 12. 2015-07-21. PMID:25239188. |
anoikis is a specific type of apoptosis induced by detachment of epithelial cells from extracellular matrix, and acquiring resistance to anoikis is an important step that enables cancer cells to metastasize. |
2015-07-21 |
2023-08-13 |
human |
| Ou Huang, Weili Zhang, Qiaoming Zhi, Xiaofeng Xue, Hongchun Liu, Daoming Shen, Meiyu Geng, Zuoquan Xie, Min Jian. Teriflunomide, an immunomodulatory drug, exerts anticancer activity in triple negative breast cancer cells. Experimental biology and medicine (Maywood, N.J.). vol 240. issue 4. 2015-07-20. PMID:25304315. |
among them, we identified down-regulation of growth factor receptors to abolish growth maintenance, suppression of c-myc, and cyclin d1 to contribute to its anti-proliferative effect, modulation of components of cell cycle to induce s-phase arrest, degradation of bcl-xl, and up-regulation of bax via activation of mapk pathway to induce apoptosis, and inhibition of epithelial-mesenchymal transition (emt) process, matrix metalloproteinase-9 (mmp9) expression, and inactivation of src/fak to reduce tnbc migration and invasion. |
2015-07-20 |
2023-08-13 |
human |
| Tzu-Chun Cheng, Ching-Shu Lai, Min-Ching Chung, Nagabhushanam Kalyanam, Muhammed Majeed, Chi-Tang Ho, Yuan-Soon Ho, Min-Hsiung Pa. Potent anti-cancer effect of 3'-hydroxypterostilbene in human colon xenograft tumors. PloS one. vol 9. issue 11. 2015-07-20. PMID:25389774. |
these inhibitory effects were accompanied by mechanistic down-regulation of the protein levels of cyclooxygenase-2 (cox-2), matrix metallopeptidase-9 (mmp-9), vascular endothelial growth factor (vegf), and cyclin d1, as well as by the induction of apoptosis in colon tumors. |
2015-07-20 |
2023-08-13 |
mouse |
| Walter Manuch. [Mitochondria and oxidative stress participation in renal inflammatory process]. Medicina. vol 74. issue 3. 2015-07-17. PMID:24918679. |
the injured tubular cells linked to the interstitial macrophages and myofibroblasts produce cytokines and growth factors that encourage an inflammatory condition, inducing the apoptosis of the tubular cells and enabling the accumulation of the extracellular matrix. |
2015-07-17 |
2023-08-13 |
Not clear |
| Angelo D'Alessandro, Monika Dzieciatkowska, Erik D Peltz, Ernest E Moore, Janeen R Jordan, Christopher C Silliman, Anirban Banerjee, Kirk C Hanse. Dynamic changes in rat mesenteric lymph proteins following trauma using label-free mass spectrometry. Shock (Augusta, Ga.). vol 42. issue 6. 2015-07-17. PMID:25243424. |
these results underlie the triggering of coagulation and proinflammatory responses secondary to trauma/hemorrhagic shock, metabolic deregulation and apoptosis, and alterations to proteases/antiproteases homeostasis, which are suggestive of the potential implication of extracellular matrix proteases in priming neutrophil activation. |
2015-07-17 |
2023-08-13 |
rat |
| Si-Dong Yang, Zhi-Long Bai, Feng Zhang, Lei Ma, Da-Long Yang, Wen-Yuan Din. Levofloxacin increases the effect of serum deprivation on anoikis of rat nucleus pulposus cells via Bax/Bcl-2/caspase-3 pathway. Toxicology mechanisms and methods. vol 24. issue 9. 2015-07-15. PMID:25224805. |
thus, levofloxacin-induced apoptosis exhibits characteristics of anoikis, the process by which cell death is triggered by separation from the extracellular matrix, which contains col2. |
2015-07-15 |
2023-08-13 |
rat |
| Hagai Yanai, Dimitri Toren, Klemens Vierlinger, Manuela Hofner, Christa Nöhammer, Marco Chilosi, Arie Budovsky, Vadim E Fraifel. Wound healing and longevity: lessons from long-lived αMUPA mice. Aging. vol 7. issue 3. 2015-07-14. PMID:25960543. |
in contrast, old fvb/n mice still exhibited significant upregulation of genes associated with growth-promoting pathways, apoptosis and cell-cell/cell-extra cellular matrix interaction, indicating an ongoing tissue remodeling or an inability to properly shut down the repair process. |
2015-07-14 |
2023-08-13 |
mouse |
| Guohua Zhu, Qi Zhang, Haiping Dai, Qun She. [Effect of curcumin on expressions of mitogen-activated protein kinases and matrix metalloproteinases in Jurkat cells]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 33. issue 12. 2015-07-09. PMID:24369247. |
to investigate the expressions of mitogen-activated protein kinases (mapks) and matrix metalloproteinases (mmps) in apoptotic human t cell lymphoma jurkat cells induced by curcumin in vitro and explore the possible molecular mechanisms of curcumin-induced apoptosis. |
2015-07-09 |
2023-08-12 |
human |
| B Wang, B W Li, H W Li, A L Li, X C Yuan, Q Wang, R J Xi. Enhanced matrix metalloproteinases-2 activates aortic endothelial hypermeability, apoptosis and vascular rarefaction in spontaneously hypertensive rat. Clinical hemorheology and microcirculation. vol 57. issue 4. 2015-07-08. PMID:23481598. |
enhanced matrix metalloproteinases-2 activates aortic endothelial hypermeability, apoptosis and vascular rarefaction in spontaneously hypertensive rat. |
2015-07-08 |
2023-08-12 |
rat |
| B Wang, B W Li, H W Li, A L Li, X C Yuan, Q Wang, R J Xi. Enhanced matrix metalloproteinases-2 activates aortic endothelial hypermeability, apoptosis and vascular rarefaction in spontaneously hypertensive rat. Clinical hemorheology and microcirculation. vol 57. issue 4. 2015-07-08. PMID:23481598. |
matrix metalloproteinase, mmps) activity and apoptosis in aortic endothelial cells of shr were found when compared to its normotensive control. |
2015-07-08 |
2023-08-12 |
rat |
| Eun-Mee Kim, Eun-Jung Shin, Ji Ae Lee, Hyo Jin Son, Dong Hee Choi, Ji Man Han, Onyou Hwan. Caspase-9 activation and Apaf-1 cleavage by MMP-3. Biochemical and biophysical research communications. vol 453. issue 3. 2015-07-08. PMID:25285627. |
we have previously demonstrated that matrix metalloprotease-3 (mmp-3) can act inside the cell to trigger apoptosis in response to various cell stresses in dopaminergic neuronal cells. |
2015-07-08 |
2023-08-13 |
Not clear |
| Teresa Barber, Guillermo Esteban-Pretel, María Pilar Marín, Joaquín Timoned. Vitamin a deficiency and alterations in the extracellular matrix. Nutrients. vol 6. issue 11. 2015-07-08. PMID:25389900. |
as cell behavior, differentiation and apoptosis, and tissue mechanics are influenced by the extracellular matrix, its modifications potentially compromise organ function and may lead to disease. |
2015-07-08 |
2023-08-13 |
Not clear |
| Mateja Mancek-Kebe. Inflammation-mediating proteases: structure, function in (patho) physiology and inhibition. Protein and peptide letters. vol 21. issue 12. 2015-07-07. PMID:25141937. |
proteases regulating inflammation are versatile enzymes, usually extracellular matrix degrading enzymes that are involved in wound healing, angiogenesis, coagulation, development, apoptosis and other physiological processes. |
2015-07-07 |
2023-08-13 |
Not clear |
| Terrence J Piva, Catherine M Davern, Paula M Hall, Clay M Winterford, Kay A O Elle. Increased activity of cell surface peptidases in HeLa cells undergoing UV-induced apoptosis is not mediated by caspase 3. International journal of molecular sciences. vol 13. issue 3. 2015-07-06. PMID:22489116. |
the increase in csp activity observed in uvb-irradiated cells undergoing apoptosis was unaffected when the cultures were treated with the aminopeptidase inhibitor bestatin, and matrix metalloprotease inhibitor bb3103, but greatly enhanced when treated with the caspase 3 inhibitor-devd, and reduced in the presence of the poly(adp-ribose) polymerase (parp) inhibitor-3-aminobenzamide (3ab). |
2015-07-06 |
2023-08-12 |
Not clear |
| Masahiro Kondo, Kunihiro Yamaoka, Yoshiya Tanak. Acquiring chondrocyte phenotype from human mesenchymal stem cells under inflammatory conditions. International journal of molecular sciences. vol 15. issue 11. 2015-07-02. PMID:25407530. |
an inflammatory milieu breaks down the cartilage matrix and induces chondrocyte apoptosis, resulting in cartilage destruction in patients with cartilage degenerative diseases, such as rheumatoid arthritis or osteoarthritis. |
2015-07-02 |
2023-08-13 |
human |
| Eduard Yakubov, Michael Buchfelder, Ilker Y Eyüpoglu, Nic E Savaska. Selenium action in neuro-oncology. Biological trace element research. vol 161. issue 3. 2015-06-29. PMID:25164034. |
reliable supply of selenium is important since selenium compounds can affect tumor microenvironment and neoangiogenesis in malignant gliomas (who grade iii and iv [glioblastoma, gbm]) via induction of apoptosis and alteration of matrix metalloproteinases expression. |
2015-06-29 |
2023-08-13 |
Not clear |
| Wenbo Meng, Xun Li, Zhongtian Bai, Yan Li, Jinqiu Yuan, Tao Liu, Jun Yan, Wence Zhou, Kexiang Zhu, Hui Zhang, Yumin L. Silencing alpha-fetoprotein inhibits VEGF and MMP-2/9 production in human hepatocellular carcinoma cell. PloS one. vol 9. issue 2. 2015-06-26. PMID:24587407. |
silencing of alpha-fetoprotein led to an increased apoptosis, which was associated with a decreased expression of vascular endothelial growth factor, vascular endothelial growth factor receptor 2, matrix metalloproteinases-2/9. |
2015-06-26 |
2023-08-12 |
human |
| Jingjing Wang, Yang Zhang, Xianling Liu, Jinan Ma, Ping Liu, Chunhong Hu, Guangsen Zhan. Annexin A5 inhibits diffuse large B-cell lymphoma cell invasion and chemoresistance through phosphatidylinositol 3-kinase signaling. Oncology reports. vol 32. issue 6. 2015-06-26. PMID:25323007. |
overexpression of annexin a5 in both cell lines significantly decreased cell invasion, matrix metalloproteinase-9 (mmp-9) expression/activity, phosphatidylinositol 3-kinase (pi3k) activity/akt phosphorylation, and cell survival against chop-induced apoptosis. |
2015-06-26 |
2023-08-13 |
human |