| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xihai Li, Wenna Liang, Hongzhi Ye, Xiaping Weng, Fayuan Liu, Xianxiang Li. Overexpression of Shox2 leads to congenital dysplasia of the temporomandibular joint in mice. International journal of molecular sciences. vol 15. issue 8. 2015-03-30. PMID:25062348. |
in situ zymography and immunohistochemistry further demonstrate an up-regulation of matrix metalloproteinases (mmps), mmp9 and mmp13, accompanied by a significantly increased cell apoptosis. |
2015-03-30 |
2023-08-13 |
mouse |
| Xihai Li, Wenna Liang, Hongzhi Ye, Xiaping Weng, Fayuan Liu, Xianxiang Li. Overexpression of Shox2 leads to congenital dysplasia of the temporomandibular joint in mice. International journal of molecular sciences. vol 15. issue 8. 2015-03-30. PMID:25062348. |
our results show that overexpression of shox2 leads to the loss of extracellular matrix and the increase of cell apoptosis in tmj dysplasia by up-regulating mmps and down-regulating the ihh signaling pathway. |
2015-03-30 |
2023-08-13 |
mouse |
| Nobuaki Ozeki, Rie Kawai, Naoko Hase, Taiki Hiyama, Hideyuki Yamaguchi, Ayami Kondo, Kazuhiko Nakata, Makio Mog. Α2 integrin, extracellular matrix metalloproteinase inducer, and matrix metalloproteinase-3 act sequentially to induce differentiation of mouse embryonic stem cells into odontoblast-like cells. Experimental cell research. vol 331. issue 1. 2015-03-26. PMID:25194508. |
we previously reported that interleukin 1β acts via matrix metalloproteinase (mmp)-3 to regulate cell proliferation and suppress apoptosis in α2 integrin-positive odontoblast-like cells differentiated from mouse embryonic stem (es) cells. |
2015-03-26 |
2023-08-13 |
mouse |
| Ilze Bot, Guo-Ping Shi, Petri T Kovane. Mast cells as effectors in atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. vol 35. issue 2. 2015-03-25. PMID:25104798. |
this results in matrix degradation, apoptosis, and enhanced recruitment of inflammatory cells, thereby actively contributing to cardiovascular diseases. |
2015-03-25 |
2023-08-13 |
Not clear |
| Batoul Sadat Haerian, Hidayati Mohd Sha'ari, Choong Yi Fong, Hui Jan Tan, Sau Wei Wong, Lai Choo Ong, Azman Ali Raymond, Chong Tin Tan, Zahurin Mohame. Contribution of TIMP4 rs3755724 polymorphism to susceptibility to focal epilepsy in Malaysian Chinese. Journal of neuroimmunology. vol 278. 2015-03-23. PMID:25595263. |
tissue inhibitor of metalloproteinase 4 (timp4) is an inflammation-induced apoptosis and matrix turnover factor involved in several neuronal disorders and inflammatory diseases. |
2015-03-23 |
2023-08-13 |
human |
| X-C Xu, Y-H Zhang, W-B Zhang, T Li, H Gao, Y-H Wan. MicroRNA-133a functions as a tumor suppressor in gastric cancer. Journal of biological regulators and homeostatic agents. vol 28. issue 4. 2015-03-23. PMID:25620172. |
functional analysis studies revealed that ectopic expression of mir-133a reduced cell proliferation and invasion, and induced cell apoptosis and cycle arrest via suppressing the level of tagln2 from transcriptional and translational levels and downregulated the expression of proliferating cell nuclear antigen (pcna) and matrix metalloproteinase-2 (mmp-2) in gastric cancer cells. |
2015-03-23 |
2023-08-13 |
Not clear |
| Chunfang Xu, Jiaqing Shen, Jing Zhang, Zhenyu Jia, Zhilong He, Xiaohui Zhuang, Ting Xu, Yuqi Shi, Shunying Zhu, Mingyuan Wu, Wei Ha. Recombinant interleukin-1 receptor antagonist attenuates the severity of chronic pancreatitis induced by TNBS in rats. Biochemical pharmacology. vol 93. issue 4. 2015-03-20. PMID:25559498. |
we found that rhil-1ra could attenuate the severity of chronic pancreatic injury, modulate the extracellular matrix secretion, focal proliferation and apoptosis, and cellular immunity in tnbs-induced cp. |
2015-03-20 |
2023-08-13 |
rat |
| Christopher D Owens, Warren J Gasper, Amreen S Rahman, Michael S Cont. Vein graft failure. Journal of vascular surgery. vol 61. issue 1. 2015-03-19. PMID:24095042. |
these changes, which are commonly referred to as remodeling, include an inflammatory response, the development of a neointima, matrix turnover, and cellular proliferation and apoptosis. |
2015-03-19 |
2023-08-12 |
Not clear |
| T E Nichik, N S Lin'kova, N A Kraskovskaia, A V Dudkov, V Kh Khavinso. [Molecular aspects of renal desease]. Uspekhi fiziologicheskikh nauk. vol 45. issue 2. 2015-03-17. PMID:25707263. |
this signal molecules regulate the activity of immune cells and remodeling extracellular matrix (ecm) components taken place in inflammatory reactions, proliferation, apoptosis and also in the differentiation of kidney cells. |
2015-03-17 |
2023-08-13 |
Not clear |
| Guo-Fu Huang, Jing Zou, Jing Shi, Dong-You Zhang, Hong-Fen Peng, Qi Zhang, Yu Gao, Bo-Yi Wang, Tang-Fa Zhan. Electroacupuncture stimulates remodeling of extracellular matrix by inhibiting apoptosis in a rabbit model of disc degeneration. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-03-12. PMID:25763091. |
electroacupuncture stimulates remodeling of extracellular matrix by inhibiting apoptosis in a rabbit model of disc degeneration. |
2015-03-12 |
2023-08-13 |
rabbit |
| Guo-Fu Huang, Jing Zou, Jing Shi, Dong-You Zhang, Hong-Fen Peng, Qi Zhang, Yu Gao, Bo-Yi Wang, Tang-Fa Zhan. Electroacupuncture stimulates remodeling of extracellular matrix by inhibiting apoptosis in a rabbit model of disc degeneration. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-03-12. PMID:25763091. |
the present study was designed to determine whether ea stimulates remodeling of extracellular matrix by inhibiting apoptosis in degenerated disc. |
2015-03-12 |
2023-08-13 |
rabbit |
| G G Sun, Y F Lu, Y J Cheng, C R Yang, Q Liu, S W Jing, X C Ha. Expression of BTG1 in hepatocellular carcinoma and its correlation with cell cycles, cell apoptosis, and cell metastasis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25173640. |
the result of biological function has shown that hepg2 cell-transfected btg1 had a lower survival fraction; higher percentage of the g0/g1 phases; higher cell apoptosis; significant decrease in migration and invasion; and lower cyclin d1 (cnd1), b cell lymphoma 2 (bcl-2), and matrix metalloproteinases (mmp)-9 protein expression compared with hepg2 cell-untransfected btg1 (p < 0.05). |
2015-03-10 |
2023-08-13 |
Not clear |
| Lei Wu, Liang Yang, Yu Xiong, Hua Guo, Xiaoli Shen, Zujue Cheng, Yan Zhang, Ziyun Gao, Xingen Zh. Annexin A5 promotes invasion and chemoresistance to temozolomide in glioblastoma multiforme cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 12. 2015-03-10. PMID:25245332. |
overexpression of annexin a5 in both cell lines significantly increased cell invasion, matrix metalloproteinase-2 (mmp-2) expression/activity, akt phosphorylation at serine 473, and the half maximal inhibitory concentration (ic50) values of temozolomide and markedly decreased temozolomide-induced apoptosis, all of which were abolished by selective pi3k inhibitor bkm120. |
2015-03-10 |
2023-08-13 |
human |
| Anne Hilgendorff, Michael A O'Reill. Bronchopulmonary dysplasia early changes leading to long-term consequences. Frontiers in medicine. vol 2. 2015-03-02. PMID:25729750. |
remodeling of the extracellular matrix, apoptosis as well as altered growth factor signaling characterize the disease. |
2015-03-02 |
2023-08-13 |
Not clear |
| Tian-Biao Zhou, Hui-Ling Xu, Yuan-Han Qin, Feng-Ying Lei, Wei-Fang Huang, Gregor P C Drumme. LIM homeobox transcription factor 1B is associated with pro-fibrotic components and apoptosis in hypoxia/reoxygenation renal tubular epithelial cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 4. 2015-02-26. PMID:24310985. |
since no reports were available that studied the link between lmx1b expression and pro-fibrotic components and apoptosis in hypoxic renal tubular epithelial cells (rtec), we explored if lmx1b was associated with extracellular matrix components, profibrotic factors, and apoptosis induced by hypoxia/reoxygenation (h-r). |
2015-02-26 |
2023-08-12 |
Not clear |
| Orr Hadass, Brittany N Tomlinson, Major Gooyit, Shanyan Chen, Justin J Purdy, Jennifer M Walker, Chunyang Zhang, Andrew B Giritharan, Whitley Purnell, Christopher R Robinson, Dmitriy Shin, Valerie A Schroeder, Mark A Suckow, Agnes Simonyi, Grace Y Sun, Shahriar Mobashery, Jiankun Cui, Mayland Chang, Zezong G. Selective inhibition of matrix metalloproteinase-9 attenuates secondary damage resulting from severe traumatic brain injury. PloS one. vol 8. issue 10. 2015-02-24. PMID:24194849. |
matrix metalloproteinase-9 (mmp-9 or gelatinase b) expression is elevated in neurological diseases and its activation is an important factor in detrimental outcomes including excitotoxicity, mitochondrial dysfunction and apoptosis, and increases in inflammatory responses and astrogliosis. |
2015-02-24 |
2023-08-12 |
mouse |
| C Ali-von Laue, C Zoschke, N Do, D Lehnen, S Küchler, W Mehnert, T Blaschke, K D Kramer, J Plendl, G Weindl, H C Korting, D Hoeller Obrigkeit, H-F Merk, M Schäfer-Kortin. Improving topical non-melanoma skin cancer treatment: In vitro efficacy of a novel guanosine-analog phosphonate. Skin pharmacology and physiology. vol 27. issue 4. 2015-02-21. PMID:24503861. |
tumour response and apoptosis induction were evaluated by an increase in caspase-cleaved fragment of keratin-18, caspase-7 activation as well as by reduced expression of matrix metallopeptidase-2 and ki-67. |
2015-02-21 |
2023-08-12 |
Not clear |
| Tatyana Y Sharova, Krzysztof Poterlowicz, Natalia V Botchkareva, Nikita A Kondratiev, Ahmar Aziz, Jeffrey H Spiegel, Vladimir A Botchkarev, Andrey A Sharo. Complex changes in the apoptotic and cell differentiation programs during initiation of the hair follicle response to chemotherapy. The Journal of investigative dermatology. vol 134. issue 12. 2015-02-18. PMID:24999588. |
chemotherapy has severe side effects in normal rapidly proliferating organs, such as hair follicles, and causes massive apoptosis in hair matrix keratinocytes followed by hair loss. |
2015-02-18 |
2023-08-13 |
human |
| X Chen, X-S Duan, L-J Xu, J-J Zhao, Z-F She, W-W Chen, Z-J Zheng, G-D Jian. Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against traumatic brain injury in mice. Neuroscience. vol 266. 2015-02-13. PMID:24291771. |
hbo therapy after tbi reduced lesion volume, attenuated cerebral edema, improved neurological status including motor and cognitive function, inhibited apoptosis evidenced by decreased ratio of cleaved caspase-3 (c3) to pro-c3 and bax expression and increased bcl-2 expression, and attenuated inflammation marked by reduced expression of il-1β, il-6, macrophage inflammatory protein-2 (mip-2), and monocyte chemoattractant protein-1 (mcp-1) and activity of matrix metalloproteinase-9 (mmp9). |
2015-02-13 |
2023-08-12 |
mouse |
| Radosław Januchowski, Piotr Zawierucha, Marcin Ruciński, Michał Nowicki, Maciej Zabe. Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line. BioMed research international. vol 2014. 2015-02-12. PMID:24804215. |
extracellular matrix (ecm) can affect drug resistance by preventing the penetration of the drug into cancer cells and increased resistance to apoptosis. |
2015-02-12 |
2023-08-13 |
human |