| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhijian Wu, Binhua Huang, Dawei Zhang, Qian Yu, Chunyan Ya. Structural characterization of a pectin-like polysaccharide from Clematis chinensis Osbeck and its anti-rheumatoid arthritis activity. International journal of biological macromolecules. 2025-03-11. PMID:40068746. |
ccpb-2-2 could inhibit lipopolysaccharide -induced mh7a cell proliferation, down-regulate the expression of pro-inflammatory factors (interleukin-6, interleukin-8, and interleukin-1 beta) and matrix metalloproteinase genes (matrix metallopeptidase 1 and matrix metallopeptidase 3), regulate apoptosis proteins (bcl2-associated x and b-cell lymphoma-2) and inhibit cell migration. |
2025-03-11 |
2025-03-14 |
Not clear |
| Xiaoting Qiu, Feiyu Zhao, Dongqin He, Guanghui He, Xiaoke Li, Ruxing Liu, Jie Yuan, Yongfeng Wan. BQU57 suppresses IL-1β-induced apoptosis and extracellular matrix degradation in nucleus pulposus cells by blocking the NF-κB signaling pathway. Cellular signalling. 2025-03-10. PMID:40064280. |
bqu57 suppresses il-1β-induced apoptosis and extracellular matrix degradation in nucleus pulposus cells by blocking the nf-κb signaling pathway. |
2025-03-10 |
2025-03-13 |
Not clear |
| Ting-Ting Wang, Gui-Hua Son. Progress on clinical and mechanism researches of acupuncture therapy for asthma. Zhen ci yan jiu = Acupuncture research. vol 50. issue 2. 2025-03-09. PMID:40059057. |
the results showed that the mechanism of acupuncture in treatment of asthma may be related to modulating immune cytokines, ameliorating iron metabolism disorder, regulating the expression of neurotransmitter and receptor, promoting eosinophile apoptosis, inhibiting the expression of matrix metalloproteinase-9 and matrix metalloproteinase inhibitor-1, suppressing the expression of the related proteins and genes in type 2 innate lymphoid cells, inhibiting the signal pathways such as transforming growth factor-β1/smad, mitogen-activated protein kinase, phosphatidylinositol 3-kinase/protein kinase b, signal transducer and activator of transcription, and nuclear factor-κb. |
2025-03-09 |
2025-03-12 |
Not clear |
| Xin Zhang, Jing Zou, Jinghua Ning, Yanhong Zhao, Run Qu, Yuzhe Zhan. Identification of potential diagnostic targets and therapeutic strategies for anoikis-related biomarkers in lung squamous cell carcinoma using machine learning and computational virtual screening. Frontiers in pharmacology. vol 16. 2025-03-04. PMID:40028162. |
anoikis, a specific form of apoptosis triggered by cell detachment from the extracellular matrix (ecm), plays a crucial role in tumor metastasis. |
2025-03-04 |
2025-03-06 |
Not clear |
| Xing Zhou, Yu Pan, Jinlei Li, Rujie Zhuang, Peijian Tong, Hanting Xi. Notopterol mitigates osteoarthritis progression and relieves pain in mice by inhibiting PI3K/Akt/GPX4-mediated ferroptosis. International immunopharmacology. vol 151. 2025-02-28. PMID:40020461. |
in vitro, chondrocytes treated with il-1β to simulate oa conditions exhibited increased viability following np pretreatment, with concurrent reductions in apoptosis, reactive oxygen species (ros) accumulation, and chondrocyte catabolic dysfunction, along with enhanced extracellular matrix (ecm) synthesis. |
2025-02-28 |
2025-03-04 |
mouse |
| Jun Lai, Likang Li, Jun Liu, Qingwei Yan, Zhicheng Xu, Meifang Leng, Wen Jin, Zebing Y. CELF1 Promotes Post-myocardial Infarction Cardiac Remodeling Via Suppression of FMO2. Cardiovascular toxicology. 2025-02-28. PMID:40021568. |
lad ligation induced cardiac remodeling [cardiac enlargement, myocardial tissue damage, increased myocardial collagen fiber tissues, poor cardiac function, cardiomyocyte hypertrophy, myocardial apoptosis, and extracellular matrix (ecm) deposition]. |
2025-02-28 |
2025-03-04 |
mouse |
| Pengchao Guo, Ahmad Alhaskawi, Safwat Adel Abdo Moqbel, Zhijun Pa. Recent development of mitochondrial metabolism and dysfunction in osteoarthritis. Frontiers in pharmacology. vol 16. 2025-02-28. PMID:40017603. |
recent insights have identified mitochondrial dysfunction as a pivotal factor in oa pathogenesis, contributing to chondrocyte apoptosis, oxidative stress, and extracellular matrix degradation. |
2025-02-28 |
2025-03-02 |
Not clear |
| Fei Ran, Kailang Mu, Lingli Zhou, Leqiang Peng, Gang Liu, Yuchen Liu, Yuxin Pang, Guo Feng, Changmao Guo, Tianjian Wang, Qiumei Lu. Plant-Derived B-CGT Hydrogel Accelerates Diabetic Wound Healing Through Multitarget Modulation of Inflammation, Angiogenesis, and Tissue Remodeling. Gels (Basel, Switzerland). vol 11. issue 2. 2025-02-25. PMID:39996646. |
network pharmacology and molecular docking analyses suggest that b-cgt may regulate key mechanisms, such as apoptosis, inflammation, and matrix remodeling, through core targets including sirt1, casp8, and mmp8. |
2025-02-25 |
2025-02-27 |
mouse |
| Faihaa Ahmed, Shaymaa Abousaad, Ayman Abouzeid, Christine Adhiambo, Elimelda Moige Onger. Meprin β regulates osteopontin-signaling in ischemia/reperfusion-induced kidney injury. BMC nephrology. vol 26. issue 1. 2025-02-22. PMID:39987047. |
meprin β proteolytically processes several mediators of cell signaling pathways involved in apoptosis and extracellular matrix metabolism. |
2025-02-22 |
2025-02-25 |
Not clear |
| Xiangwen Zhou, Wei Zu, Lian Zhao, Xiaojiao Gong, Qingsong Jian. Sodium fluoride accelerates apoptosis, oxidative stress and matrix degradation of condylar chondrocytes by upregulating MMP-13 and RANKL. American journal of translational research. vol 17. issue 1. 2025-02-17. PMID:39959228. |
sodium fluoride accelerates apoptosis, oxidative stress and matrix degradation of condylar chondrocytes by upregulating mmp-13 and rankl. |
2025-02-17 |
2025-02-23 |
Not clear |
| Xiangwen Zhou, Wei Zu, Lian Zhao, Xiaojiao Gong, Qingsong Jian. Sodium fluoride accelerates apoptosis, oxidative stress and matrix degradation of condylar chondrocytes by upregulating MMP-13 and RANKL. American journal of translational research. vol 17. issue 1. 2025-02-17. PMID:39959228. |
to explore the regulatory effects of sodium fluoride (naf) exposure on apoptosis, oxidative stress, and matrix degradation in condylar chondrocytes and subchondral osteoblasts using |
2025-02-17 |
2025-02-23 |
Not clear |
| Samah S Arafa, Heba A Elnoury, Sahar Badr El-Din, Mohamed A Sakr, Fatma Fawzi Hendawi, Rehab Ali Elsayed Masoud, Samia Soliman Barghash, Doaa Sabry Elbehairy, Ayat Abdelaty Hemeda, Islam Mostafa Farrag, Doaa Sayed Abdelrahman, Amira Mohammad Elsadek, Sahar K Ghanem, Hind S AboShabaan, Ahmed M Atwa, Mahmoud Nour El Din, Abdullah F Radwan, Majid Al-Zahrani, Ahmad F Alhomodi, Ahmed M Abdulfattah, Afaf Abdelkade. Acetamiprid-induced pulmonary toxicity via oxidative stress, epithelial-mesenchymal transition, apoptosis, and extracellular matrix accumulation in human lung epithelial cells and fibroblasts: Protective role of heat-killed Lactobacilli. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2025-02-17. PMID:39961414. |
acetamiprid-induced pulmonary toxicity via oxidative stress, epithelial-mesenchymal transition, apoptosis, and extracellular matrix accumulation in human lung epithelial cells and fibroblasts: protective role of heat-killed lactobacilli. |
2025-02-17 |
2025-02-23 |
human |
| Samah S Arafa, Heba A Elnoury, Sahar Badr El-Din, Mohamed A Sakr, Fatma Fawzi Hendawi, Rehab Ali Elsayed Masoud, Samia Soliman Barghash, Doaa Sabry Elbehairy, Ayat Abdelaty Hemeda, Islam Mostafa Farrag, Doaa Sayed Abdelrahman, Amira Mohammad Elsadek, Sahar K Ghanem, Hind S AboShabaan, Ahmed M Atwa, Mahmoud Nour El Din, Abdullah F Radwan, Majid Al-Zahrani, Ahmad F Alhomodi, Ahmed M Abdulfattah, Afaf Abdelkade. Acetamiprid-induced pulmonary toxicity via oxidative stress, epithelial-mesenchymal transition, apoptosis, and extracellular matrix accumulation in human lung epithelial cells and fibroblasts: Protective role of heat-killed Lactobacilli. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2025-02-17. PMID:39961414. |
the following implications were explored: oxidative stress, epithelial-mesenchymal transition, apoptosis, cellular proliferation, and extracellular matrix accumulation. |
2025-02-17 |
2025-02-23 |
human |
| Heng Yu, Kaiye Chen, Xiang Li, Jinghao Liang, Yangcan Jin, Yingying Bao, Hao Chen, Yong Gou, Keyu Lu, Long Wu, Zhongke Li. Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 139. 2025-02-11. PMID:39933468. |
intervertebral disc degeneration (idd) is integral in lower back pain and involves complex pathophysiological processes, including nucleus pulposus (np) cell apoptosis and extracellular matrix (ecm) breakdown. |
2025-02-11 |
2025-02-14 |
Not clear |
| Zaiwei Fan, Jianyuan Gao, Yikun Chen, Qirui Chen, Qingshan Peng, Jiadi Le, Yiming Li, Chunhui Chen, Haihong Jiang, Jun Tao, Yang Zho. Psoralen remodels the articular cartilage microenvironment by pharmacologically regulating the Nrf2 pathway in osteoarthritis treatment. International immunopharmacology. vol 149. 2025-02-06. PMID:39914283. |
osteoarthritis (oa) is a common degenerative joint disease featuring extracellular matrix degradation and apoptosis in the inflammatory microenvironment. |
2025-02-06 |
2025-02-09 |
Not clear |
| Ashwani Kumar Gupta, Ekta Minocha, Kyle M Koss, Bilal A Naved, Luisa Safar-Boueri, Jason A Wertheim, Lorenzo Gallo. A kidney organoid-based readout to assess disease activity in primary and recurrent focal segmental glomerulosclerosis. Kidney international. 2025-02-06. PMID:39914654. |
the pfsgs plasma treatment induced podocytopathy, extracellular matrix protein deposition, fibrosis and apoptosis within organoids, whereas non-recurrent plasma did not affect organoid structure. |
2025-02-06 |
2025-02-09 |
human |
| Siew Wee Chan, Camellia Ong, Wanjin Hon. The recent advances and implications in cancer therapy for the hippo pathway. Current opinion in cell biology. vol 93. 2025-02-05. PMID:39908768. |
these cues include cytoskeletal organization, mechanical force, cell-cell interaction, cell polarity, cell-extracellular matrix interaction to govern cell proliferation, differentiation, apoptosis, stem cell property and tissue microenvironment. |
2025-02-05 |
2025-02-08 |
Not clear |
| Ekaterina Legchenko, Philippe Chouvarine, Klea Hysko, Fatimunnisa Qadri, Radoslaw Wesolowski, Edgar Specker, Silke Glage, Martin Meier, Katharina Schwarz, Joerg Heineke, Gerhard Pohlmann, Mehmet Ramazanoglu, Michael Bader, Georg Hansman. Inhalation of the Novel Tryptophan Hydroxylase 1 Inhibitor TPT-004 Alleviates Pulmonary Arterial Hypertension. American journal of respiratory cell and molecular biology. 2025-02-04. PMID:39899532. |
rna-sequencing unraveled tphi-induced changes in pulmonary gene expression: 1) increased cell adhesion and reduced cell motility/migration; 2) suppressed extracellular matrix remodeling; 3) modulated immune response; 4) suppressed pulmonary vascular remodeling via modulating proliferation, apoptosis, and homeostasis. |
2025-02-04 |
2025-02-06 |
rat |
| Dengbo Yao, Ming Li, Weike Zeng, Kun Wang, Zhuangyao Liao, Enming Chen, Tong Xing, Yuwei Liang, Jun Tang, Guoming Wen, Qing Ning, Yuxi Li, Lin Huan. LRP1 mitigates intervertebral disc degeneration by inhibiting endoplasmic reticulum stress through stabilizing the PPARγ. Journal of orthopaedic translation. vol 50. 2025-02-03. PMID:39895867. |
intervertebral disc degeneration (idd) is a significant cause of lower back pain, characterized by inflammation-mediated extracellular matrix (ecm) degradation, apoptosis, and aging of nucleus pulposus (np) cells. |
2025-02-03 |
2025-02-05 |
Not clear |
| Zhixin Jiang, Boyang Zhang, Shichong Jia, Xiaoyong Yua. Molecular Subtype Identification and Potential Drug Prediction Based on Anoikis-Related Genes Expression in Keratoconus. Investigative ophthalmology & visual science. vol 66. issue 2. 2025-02-03. PMID:39898909. |
anoikis is a special apoptosis accompanied by the loss of extracellular matrix (ecm) environment and the decomposition of ecm is an important process in the occurrence of keratoconus (kc). |
2025-02-03 |
2025-02-05 |
Not clear |