| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ba Qiu, Xiaoxing Xie, Yanhai X. Mitochondrial quality control: the real dawn of intervertebral disc degeneration? Journal of translational medicine. vol 22. issue 1. 2024-12-21. PMID:39707402. |
disc degeneration is characterized by np cell apoptosis, extracellular matrix degradation and disc structure changes. |
2024-12-21 |
2024-12-24 |
Not clear |
| Chen-Mo-Ji Wang, Ya-Dong Wu, Song-Lin Liang, Shang Gao, Ze-Lin Yue, Lu-Ming Kong, Kuan-Hui Gao, Nian-Hu L. [Mechanism of kaempferol on intervertebral disc degeneration based on p38 MAPK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 21. 2024-12-19. PMID:39701783. |
cell apoptosis was detected by tunel staining, and immunofluorescence staining was used to detect type Ⅱ collagen and matrix metalloproteinase 3(mmp3). |
2024-12-19 |
2024-12-22 |
rat |
| Zhenzhong Yan, Lin J. Hck promotes IL-1β-induced extracellular matrix degradation, inflammation, and apoptosis in osteoarthritis via activation of the JAK-STAT3 signaling pathway. Advances in rheumatology (London, England). vol 64. issue 1. 2024-12-19. PMID:39696562. |
hck promotes il-1β-induced extracellular matrix degradation, inflammation, and apoptosis in osteoarthritis via activation of the jak-stat3 signaling pathway. |
2024-12-19 |
2024-12-21 |
human |
| Zhiqin Li, Xiaofeng Li, Hongli Xia, Yiqi Wang, Ning We. NEK2 promotes the progression of osteoarthritis by stabilizing ATF2 through phosphorylation at Ser-112 and inhibiting autophagy. International immunopharmacology. vol 146. 2024-12-18. PMID:39693952. |
the results indicated that silencing nek2 or atf2 impeded the il-1β-induced decrease in cell proliferation and increase in inflammation, extracellular matrix (ecm) degradation, and apoptosis in chondrocytes. |
2024-12-18 |
2024-12-21 |
mouse |
| Zhe Li, Ting He, Zhichao Xing, Jingqiang Zhu, Wenshuang Wu, Anping S. Inhibition of THBS1 axis contributes to the antitumor effect of PA-MSHA in anaplastic thyroid cancer. Experimental cell research. vol 444. issue 2. 2024-12-14. PMID:39672500. |
thrombospondin-1 (thbs1) is a multifunctional extracellular matrix (ecm) glycoprotein that regulates cell proliferation, apoptosis, and metastasis, and is considered a potential clinical biomarker for the monitoring and prognostication of various tumors. |
2024-12-14 |
2024-12-21 |
Not clear |
| Guangze Li, Xiangyu Hu, Xiguang Y. Robinin protects chondrocytes injury via TLR2/TLR4/NF-κB signaling in osteoarthritis. Cell biochemistry and biophysics. 2024-12-14. PMID:39673685. |
western blotting assessed the levels of proteins related to apoptosis, extracellular matrix (ecm), and signaling pathways. |
2024-12-14 |
2024-12-21 |
mouse |
| Beatrice Bighi, Gregorio Ragazzini, Alessia Gallerani, Andrea Mescola, Chiara Scagliarini, Chiara Zannini, Martina Marcuzzi, Elena Olivi, Claudia Cavallini, Riccardo Tassinari, Michele Bianchi, Lorenzo Corsi, Carlo Ventura, Andrea Alessandrin. Cell stretching devices integrated with live cell imaging: a powerful approach to study how cells react to mechanical cues. Progress in biomedical engineering (Bristol, England). vol 7. issue 1. 2024-12-10. PMID:39655854. |
mechanical stimuli have multiple effects on cell behavior, affecting a number of cellular processes including orientation, proliferation or apoptosis, migration and invasion, the production of extracellular matrix proteins, the activation and translocation of transcription factors, the expression of different genes such as those involved in inflammation and the reprogramming of cell fate. |
2024-12-10 |
2024-12-12 |
Not clear |
| J Praveen, M Anusuyadevi, K S Jayachandr. Unraveling the potential of Epicatechin gallate from crataegus oxyacantha in targeting aberrant cardiac Ca2+ signalling proteins: an in-depth Journal of biomolecular structure & dynamics. 2024-12-09. PMID:39648361. |
moreover, ca2+ overload in sr leads to mitochondrial matrix ca2+ overload, which can trigger the generation of reactive oxygen species (ros), culminating in the triggering of the permeability transition pore (ptp) and cytochrome c release, resulting in apoptosis that leads to arrhythmias and numerous disorders. |
2024-12-09 |
2024-12-11 |
Not clear |
| Heng Chen, Tian Tang, Congyang Xue, Xin Liu, Zhipeng Xi, Lin Xie, Ran Kan. Exploration and breakthrough in the mode of intervertebral disc cell death may lead to significant advances in treatments for intervertebral disc degeneration. Journal of orthopaedic surgery and research. vol 19. issue 1. 2024-12-06. PMID:39639370. |
although previous research have revealed that the mechanisms of intervertebral disc cell apoptosis, pyroptosis and necroptosis can aggravate idd damage by mediating inflammation and promoting extracellular matrix degradation, but they cannot explain the connection between different cell death mechanisms and ion metabolism disorders. |
2024-12-06 |
2024-12-08 |
Not clear |
| Shenghao Cai, Rui Ding, Hongjun Zhang, Qirui Chen, Fen Yu, Yong Xia, Qi Chen, Xinxin Miao, Bin Zhou, Jiahui Chen, Le Liao, Xigao Cheng, Xiaoling F. Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus. Materials today. Bio. vol 29. 2024-12-03. PMID:39624051. |
at the cellular level, the qcs-ost/sc hydrogel enhances cell viability, initiates autophagy and release of the extracellular matrix (ecm), and inhibits cellular senescence and apoptosis. |
2024-12-03 |
2024-12-06 |
human |
| Giada Colombo, Tor Biering-Sorensen, Joao P Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M Inciard. Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy. ESC heart failure. 2024-11-27. PMID:39600110. |
simultaneous initiation of guideline directed medical therapy (gdmt) through a synergistic effect promotes a 'reverse remodelling', leading to a full or partial recovered structure and function by enhancing systemic neurohumoral regulation and energy metabolism, reducing cardiomyocyte apoptosis, lowering oxidative stress and inflammation and adverse extracellular matrix deposition. |
2024-11-27 |
2024-11-29 |
Not clear |
| Huasong Bai, Tong Liu, Hengyan Wang, Yunliang Li, Zhanzhong Wan. Chondroitin sulfate alleviated lipopolysaccharide-induced arthritis in feline and canine articular chondrocytes through regulation of neurotrophic signaling pathways and apoptosis. Tissue & cell. vol 91. 2024-11-27. PMID:39603024. |
furthermore, cs treatment effectively suppressed lps-induced secretion of pro-inflammatory cytokines, including interleukin-1, tumor necrosis factor-α, interleukin-8, interleukin-10, and matrix metalloproteinases-3, and reduced apoptosis, as confirmed by fluorescence staining and flow cytometry. |
2024-11-27 |
2024-11-30 |
Not clear |
| Yingjie Mai, Siying Wu, Penghui Zhang, Ningning Chen, Jun Wu, Fuxin We. The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair. Bioactive materials. vol 45. 2024-11-26. PMID:39588482. |
consequently, oxidative stress contributes to the degradation of the extracellular matrix (ecm), promotes cell apoptosis, and exacerbates disc tissue damage. |
2024-11-26 |
2024-11-28 |
Not clear |
| Inae Jeong, Jinbum Park, Shinjung Park, Tatuya Wada, Dae Soo Lim, Ok-Kyung Ki. Salmon Nasal Cartilage-Derived Proteoglycans Alleviate Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Marine drugs. vol 22. issue 11. 2024-11-26. PMID:39590787. |
key aspects of osteoarthritis pathology, including impaired exercise ability, inflammation, extracellular matrix degradation, and chondrocyte apoptosis, were assessed using histological analysis, micro-ct, treadmill testing, serum assays, and mrna/protein expression studies. |
2024-11-26 |
2024-11-29 |
rat |
| Guang Yang, Bingzhou Ji, Hengzhen Li, Xiu Liu, Gaoming Liu, Jianfeng Sun, Yuming Yao, Yusheng Li, Shuguang Liu, Wenfeng Xia. Inhibition of CRLF1 expression by miR-8485 alleviates IL-1β-induced chondrocyte inflammation, apoptosis, and extracellular matrix degradation. International immunopharmacology. vol 144. 2024-11-24. PMID:39580860. |
inhibition of crlf1 expression by mir-8485 alleviates il-1β-induced chondrocyte inflammation, apoptosis, and extracellular matrix degradation. |
2024-11-24 |
2024-11-27 |
Not clear |
| Meng'en Zhou, Yan Chen, Wenqi Jin, Peng Li, Jie Hu, Xiutian Gu. Traditional Chinese Medicine: A Promising Treatment Option for Intestinal Fibrosis. The American journal of Chinese medicine. 2024-11-24. PMID:39581857. |
these mechanisms include immune cell balance regulation, suppression of inflammatory responses, reduction of inflammatory mediators, alleviation of colon tissue damage, restoration of intestinal function, modulation of growth factors to inhibit fibroblast activation, dynamic regulation of timps and mmps to reduce extracellular matrix deposition, inhibition of epithelial-mesenchymal transition and endothelial-mesenchymal transition, autophagy modulation, maintenance of the intestinal mucosal barrier, prevention of tissue damage by harmful factors, and regulation of cell proliferation and apoptosis. |
2024-11-24 |
2024-11-27 |
Not clear |
| Song Wang, Yutao Wang, Sichen Wang, Yuhan Sun, Yitong Du, Song Zhang, Jingyi Yao, Jiangxu Wu, Dan Xi. Single-cell RNA sequencing reveals S100A8/A9 Biochemical and biophysical research communications. vol 741. 2024-11-23. PMID:39579533. |
additionally, we reveal the contrasting roles of cxcr2 and cxcr4 in neutrophil movement and identify neutrophil-derived damage-associated molecular patterns (damps) and matrix metalloproteinases (mmps) as key drivers of endothelial cell apoptosis. |
2024-11-23 |
2024-11-26 |
Not clear |
| Jiangliang Chu, Yifan Yang, Keyu Zhang, Yiping Fu, Beilei Yua. Integration of transcriptomics and metabolomics reveal cytotoxic mechanisms of Polyethylene terephthalate microplastics in BEAS-2B cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-11-23. PMID:39580014. |
transcriptomic analysis identified 1,412 differentially expressed genes (degs) mainly enriched in apoptosis and extracellular matrix organization processes. |
2024-11-23 |
2024-11-26 |
human |
| Ziliang Shi, Zi Sang, Junmeng Xiao, Jianbin Hou, Mingfei Gen. Prediction of the Survival Status, Immunotherapy Response, and Medication of Lung Adenocarcinoma Patients Based on Hypoxia- and Apoptosis-Related Genes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2024-11-22. PMID:39577840. |
a 13-gene-prognostic model incorporating hypoxia and apoptosis genes was developed using univariate/multivariate cox regression, nonnegative matrix factorization (nmf) clustering, and lasso regression. |
2024-11-22 |
2024-11-25 |
Not clear |
| Haifeng Wang, Yi Huang, Chenhui Zhou, Fanyong Gong, Jiangyong Wang, Gao Che. Engineering VEGF-like peptide QKCMP promotes rapid endothelialization of blood vessels. Journal of applied biomaterials & functional materials. vol 22. 2024-11-21. PMID:39568108. |
human umbilical vein endothelial cells (huvecs) was then treated with different concentrations of qkcmp, which proved that qkcmp could promote cell proliferation and inhibit cell apoptosis, and thus obtain a complete gene expression matrix. |
2024-11-21 |
2024-11-23 |
human |