| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| TingXin Yan, Peng Wang, Zhilin Ca. Calcium Fructoborate Improves Knee Osteoarthritis in Rats by Activating Hedgehog Signaling Through DDIT3. Biological trace element research. 2024-11-21. PMID:39572483. |
the effects of cfb on chondrocyte apoptosis, inflammatory response, and collagen matrix degradation were assessed. |
2024-11-21 |
2024-11-24 |
rat |
| TingXin Yan, Peng Wang, Zhilin Ca. Calcium Fructoborate Improves Knee Osteoarthritis in Rats by Activating Hedgehog Signaling Through DDIT3. Biological trace element research. 2024-11-21. PMID:39572483. |
in vivo animal assays showed that cfb can inhibit the degradation of cartilage collagen matrix, inhibit chondrocyte apoptosis, improve chondrocyte damage, and alleviate pain in arthritis rats, and the effect of cfb on oa rats is related to the hh pathway mediated by ddit3. |
2024-11-21 |
2024-11-24 |
rat |
| Thanapat Sunartvanichkul, Chaiyapol Chaweewannakorn, Lueacha Tabtimmai, Wararat Chiangjong, Kengo Iwasaki, Kovit Pattanapanyasat, Hathaitip Sritanaudomcha. Apoptosis-induced exosomes from human exfoliated deciduous teeth enhance angiogenesis in human umbilical vein endothelial cells. Scientific reports. vol 14. issue 1. 2024-11-14. PMID:39537956. |
proteins associated with apoptosis, programmed cell death, and cellular senescence were downregulated in the apoptotic shed exosomes, whereas those associated with extracellular matrix organization were upregulated, indicating positive angiogenesis. |
2024-11-14 |
2024-11-17 |
human |
| Meiyue Yang, Zhibo Yang, Xiangjun Huang, Xiaoping Li, Fangqin Chou, Shuiqing Zen. Formononetin alleviates thermal injury-induced skin fibroblast apoptosis and promotes cell proliferation and migration. Burns : journal of the International Society for Burn Injuries. vol 51. issue 1. 2024-11-10. PMID:39522140. |
after thermal injury, human skin fibroblast (hsf) cells showed inhibited proliferation, migration, extracellular matrix (ecm) synthesis; and increased apoptosis, reactive oxygen species (ros) production, and inflammation. |
2024-11-10 |
2024-11-17 |
human |
| Ye Yang, Rui Gao, Zhenyu Zhu, Wenfeng Xiao, Jing Wang, Wenxia Zhao, Yingjun L. Benzophenone-3 exposure induced apoptosis via impairing mitochondrial function in human chondrocytes. Ecotoxicology and environmental safety. vol 287. 2024-11-09. PMID:39520751. |
notably, bp-3 significantly inhibited cell viability, induced apoptosis, and up-regulated matrix metalloproteinase (mmp) 1 and 13 which mediated cartilage degradation in c28/i2 human normal chondrocytes. |
2024-11-09 |
2024-11-17 |
human |
| Ye Yang, Rui Gao, Zhenyu Zhu, Wenfeng Xiao, Jing Wang, Wenxia Zhao, Yingjun L. Benzophenone-3 exposure induced apoptosis via impairing mitochondrial function in human chondrocytes. Ecotoxicology and environmental safety. vol 287. 2024-11-09. PMID:39520751. |
in brief, bp-3 exposure may increase oa risk via inducing apoptosis and increasing breakdown of extracellular matrix in chondrocytes, and mitochondrial dysfunction and mitophagy may play a crucial role in the mechanisms of bp-3-induced toxicity to articular chondrocytes. |
2024-11-09 |
2024-11-17 |
human |
| Mohit Sharma, Smitha Sammith Shetty, Sonal Soi, Raghu Radhakrishna. Myofibroblasts persist through immune privilege mechanisms to mediate oral submucous fibrosis: Uncovering the pathogenesis. Journal of oral biology and craniofacial research. vol 14. issue 6. 2024-11-06. PMID:39502133. |
however, increased matrix stiffness, in addition to activating tgf-β, reduces fas surface expression in myofibroblasts, increasing their resistance to apoptosis. |
2024-11-06 |
2024-11-08 |
Not clear |
| João Basso, Ana Miguel Matos, Saeid Ghavami, Ana Fortuna, Rui Vitorino, Carla Vitorin. Are we better together? Addressing a combined treatment of pitavastatin and temozolomide for brain cancer. European journal of pharmacology. 2024-11-04. PMID:39491742. |
the obtained qrt-pcr and proteomics data highlight the modulation of cell death via apoptosis (bax/bcl2, casp9) and autophagy (becn1, bnip3, bnip3l and lc3b), as well as an epithelial to mesenchymal transition blockage (htra1, serpine1, wnt5a, aldh3b1 and epha2) and remodeling of the extracellular matrix (vcan, serpine1 and tgfbi). |
2024-11-04 |
2024-11-06 |
Not clear |
| Pei Zhou, Si-Qing Xie, Li-Li Zhong, Xiao-Fang Din. [Effects of propranolol on the biological behavior of human umbilical vein endothelial cells and the expression of SOX18, MMP-7, and VEGFA]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 26. issue 10. 2024-10-28. PMID:39467683. |
to investigate the effects of propranolol on the proliferation, apoptosis, migration, and tube formation ability of human umbilical vein endothelial cells (huvec), as well as its impact on the expression of sex-determining region y-box 18 (sox18), matrix metalloproteinase-7 (mmp-7), and vascular endothelial growth factor a (vegfa). |
2024-10-28 |
2024-10-31 |
human |
| Prashanta Silwal, Allison M Nguyen-Thai, Peter G Alexander, Gwendolyn A Sowa, Nam V Vo, Joon Y Le. Cellular and Molecular Mechanisms of Hypertrophy of Ligamentum Flavum. Biomolecules. vol 14. issue 10. 2024-10-26. PMID:39456209. |
we also discuss in detail how several pathomechanisms such as fibrosis, proliferation and apoptosis, macrophage infiltration, and autophagy, in addition to several molecular pathways involving tgf-β1, mitogen-activated protein kinase (mapks), and nuclear factor-κb (nf-κb) signaling, pi3k/akt signaling, wnt signaling, micro-rnas, extracellular matrix proteins, reactive oxygen species (ros), etc. |
2024-10-26 |
2024-10-29 |
Not clear |
| Xin Tang, Jingsheng He, Ye Ha. Histone demethylase PHF8 protected against chondrocyte injury and alleviated posttraumatic osteoarthritis by epigenetically enhancing WWP2 expression. Human & experimental toxicology. vol 43. 2024-10-25. PMID:39454680. |
phf8 overexpression alleviated the aberrant force-induced cell apoptosis, extracellular matrix degradation, and inflammation. |
2024-10-25 |
2024-10-29 |
mouse |
| Eleftheria Theodoropoulou, Paula Pierozan, Francesco Marabita, Andrey Höglund, Oskar Karlsso. Persistent effects of di-n-butyl phthalate on liver transcriptome: impaired energy and lipid metabolic pathways. Chemosphere. 2024-10-23. PMID:39442571. |
according to the degs and the gsea findings dbp exposure disrupts several key biological processes, including protein translation, protein folding, apoptosis, hedgehog signaling, degradation of extracellular matrix and alterations in the energy/lipid metabolism. |
2024-10-23 |
2024-10-26 |
mouse |
| Li Li, Hui Cheng, Yang Peng, Dihong Tan. Targeting Mitochondrial Cholesterol Efflux via TCF21/ABCA10 Pathway to Enhance Cisplatin Efficacy in Ovarian Cancer. Biochemical genetics. 2024-10-22. PMID:39438390. |
cell proliferation was detected by cck-8 and edu staining, flow cytometry for apoptosis, mtt for metabolic activity, calcium-induced cytochrome c release, and mitochondrial matrix swelling for mitochondrial function and oil red o staining for lipid accumulation. |
2024-10-22 |
2024-10-25 |
human |
| Li Li, Hui Cheng, Yang Peng, Dihong Tan. Targeting Mitochondrial Cholesterol Efflux via TCF21/ABCA10 Pathway to Enhance Cisplatin Efficacy in Ovarian Cancer. Biochemical genetics. 2024-10-22. PMID:39438390. |
compared to the group treated solely with ddp, the overexpression of abca10 significantly inhibited the proliferation of ddp-resistant ov cells (p < 0.01), markedly reduced the staining intensity of edu in these cells (p < 0.05), and substantially accelerated apoptosis in ddp-resistant ov cells (p < 0.01).overexpression of abca10 further accelerated cytochrome c expression and mitochondrial matrix swelling in ddp-resistant ov cells compared to the ddp-alone group (p < 0.01). |
2024-10-22 |
2024-10-25 |
human |
| Dian Wang, Yi Xiang, Zhaoxuan Zhu, Jiyue Liu, Yisheng Wang, Zeyu Xu, Si Chen, Chunyuan Dai, Jiasen Feng, Jie Chen, Qianhui Ma, Ping Yan. Cytological Effects of Cadmium Poisoning and the Protective Effect of Quercetin: A Mechanism Exploration based on the Testicular Lamina Propria. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 2024-10-15. PMID:39405407. |
the findings illustrated that cd exposure results in significant morphological and cellular modifications within the lp, including the apoptosis of peritubular myoid cells, an upsurge in cd34+ stromal cells displaying anti-apoptotic behaviors, and an excessive production of collagen type i fibers and extracellular matrix. |
2024-10-15 |
2024-10-18 |
mouse |
| Xu Yan, Su Fu, Ying Xie, Chunlin Zhang, Xuejian W. Piezo1-driven mechanotransduction as a key regulator of cartilage degradation in early osteoarthritis. Biomolecules & biomedicine. 2024-10-10. PMID:39388709. |
using rat chondrocytes cultured in a 3d in vitro model, we found that fluid flow-induced physical stress activates constitutively expressed piezo1, leading to increased catabolic activity and apoptosis, which, in turn, disrupts the matrix structure. |
2024-10-10 |
2024-10-13 |
rat |
| Carolyn Twible, Rober Abdo, Chelsey Zhao, Qi Zhan. Hippocampal dentate granule cells in temporal lobe epilepsy: A morphometry and transcriptomic study. Neuropathology and applied neurobiology. vol 50. issue 5. 2024-10-08. PMID:39375854. |
dentate granule cells are more dispersed in patients with hs, and the dg shows an elevated expression of the complement system, apoptosis, and extracellular matrix remodelling-related rna. |
2024-10-08 |
2024-10-10 |
Not clear |
| Jie Qiao, Chang Cheng, Gongxu Yang, Chuanqi Zhong, Jun Jin, Bin W. Jiangu Recipe Suppresses ER Stress-Induced Apoptosis and Inhibits Extracellular Matrix Degradation in Chondrocytes through Upregulating SIRT1 Expression. Current pharmaceutical biotechnology. 2024-10-08. PMID:39377404. |
jiangu recipe suppresses er stress-induced apoptosis and inhibits extracellular matrix degradation in chondrocytes through upregulating sirt1 expression. |
2024-10-08 |
2024-10-10 |
Not clear |
| Jie Qiao, Chang Cheng, Gongxu Yang, Chuanqi Zhong, Jun Jin, Bin W. Jiangu Recipe Suppresses ER Stress-Induced Apoptosis and Inhibits Extracellular Matrix Degradation in Chondrocytes through Upregulating SIRT1 Expression. Current pharmaceutical biotechnology. 2024-10-08. PMID:39377404. |
this study aimed to explore the effects of jiangu recipe (jgr) on chondrocyte responses under tert-butyl hydroperoxide (tbhp)-induced oxidative stress, specifically focusing on apoptosis and extracellular matrix (ecm) degradation. |
2024-10-08 |
2024-10-10 |
Not clear |
| Li-Jen Soh, Siam-Yee Lee, Margaret M Roebuck, Pooi-Fong Won. Unravelling the interplay between ER stress, UPR and the cGAS-STING pathway: Implications for osteoarthritis pathogenesis and treatment strategy. Life sciences. 2024-10-08. PMID:39378929. |
aberrant protein synthesis leads to endoplasmic reticulum (er) stress and chondrocyte apoptosis with consequent cartilage matrix loss. |
2024-10-08 |
2024-10-11 |
Not clear |