| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ingeborg Klaassen, Rob J van Geest, Esther J Kuiper, Cornelis J F van Noorden, Reinier O Schlingeman. The role of CTGF in diabetic retinopathy. Experimental eye research. vol 133. 2015-05-26. PMID:25819453. |
ctgf is a secreted protein that modulates the actions of many growth factors and extracellular matrix (ecm) proteins, leading to tissue reorganization, such as ecm formation and remodeling, basal lamina (bl) thickening, pericyte apoptosis, angiogenesis, wound healing and fibrosis. |
2015-05-26 |
2023-08-13 |
Not clear |
| Masanori Sato, Kazuaki Nakanishi, Sanae Haga, Masato Fujiyoshi, Motoi Baba, Kazuhiro Mino, Haruki Niwa, Hideki Yokoo, Kazuo Umezawa, Yoshihiro Ohmiya, Toshiya Kamiyama, Satoru Todo, Akinobu Taketomi, Michitaka Ozak. Anoikis induction and inhibition of peritoneal metastasis of pancreatic cancer cells by a nuclear factor-κB inhibitor, (-)-DHMEQ. Oncology research. vol 21. issue 6. 2015-05-22. PMID:25198663. |
nf-κb is also involved in resistance to anoikis, a special type of apoptosis induced when cells are detached from the extracellular matrix or other cells. |
2015-05-22 |
2023-08-13 |
Not clear |
| Shao-Liang Chen, Zuo-Ying Hu, Guang-Feng Zuo, Ming-Hui Li, Bin L. I(f) current channel inhibitor (ivabradine) deserves cardioprotective effect via down-regulating the expression of matrix metalloproteinase (MMP)-2 and attenuating apoptosis in diabetic mice. BMC cardiovascular disorders. vol 14. 2015-05-21. PMID:25361902. |
i(f) current channel inhibitor (ivabradine) deserves cardioprotective effect via down-regulating the expression of matrix metalloproteinase (mmp)-2 and attenuating apoptosis in diabetic mice. |
2015-05-21 |
2023-08-13 |
mouse |
| Ali Roohbakhsh, Hamideh Parhiz, Fatemeh Soltani, Ramin Rezaee, Mehrdad Iranshah. Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. Life sciences. vol 124. 2015-05-19. PMID:25625242. |
unlike conventional anti-cancer drugs, hsd and hst inhibit tumor growth by targeting multiple cellular protein targets at the same time, including caspases, bcl-2 (b-cell lymphoma 2) and bax (bcl-2 associated x protein) for the induction of apoptosis, and cox-2 (cyclooxygenase-2), mmp-2 (matrix metalloproteinase-2) and mmp-9 for the inhibition of angiogenesis and metastasis. |
2015-05-19 |
2023-08-13 |
Not clear |
| Nikolina Giotopoulou, Vaia Valiakou, Vassilios Papanikolaou, Stephanie Dubos, Evangelos Athanassiou, Aspasia Tsezou, Lefteris C Zacharia, Vasiliki Gkrets. Ras suppressor-1 promotes apoptosis in breast cancer cells by inhibiting PINCH-1 and activating p53-upregulated-modulator of apoptosis (PUMA); verification from metastatic breast cancer human samples. Clinical & experimental metastasis. vol 32. issue 3. 2015-05-19. PMID:25647720. |
extracellular matrix (ecm)-related adhesion and apoptosis resistance play pivotal role in metastasis. |
2015-05-19 |
2023-08-13 |
human |
| Wen-Jie Nie, Xiu-Qin Cao, Gui-Qiang Sha. [Protective effects of hyperbaric oxygen treatment on kidney cells of type 2 diabetic rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 2. 2015-05-16. PMID:24777409. |
these results indicate that the hbo treatment can inhibit the apoptosis and caspase-3 expression of renal cells of gk rats, adjust the activity of mmp-2 and its inhibitors, and reduce the accumulation of extracellular matrix. |
2015-05-16 |
2023-08-13 |
rat |
| Liqin Li, Heng L. Role of microRNA-mediated MMP regulation in the treatment and diagnosis of malignant tumors. Cancer biology & therapy. vol 14. issue 9. 2015-05-12. PMID:23917402. |
matrix metalloproteinases (mmps) play important roles in tumor cell proliferation and apoptosis and contribute to tumor growth, angiogenesis, migration, and invasion primarily via extracellular matrix (ecm) degradation and/or the activation of pre-pro-growth factors. |
2015-05-12 |
2023-08-12 |
Not clear |
| C Tzao, J-S Jin, B-H Chen, H-Y Chung, C-C Chang, T-Y Hsu, G-H Su. Anticancer effects of suberoylanilide hydroxamic acid in esophageal squamous cancer cells in vitro and in vivo. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 27. issue 7. 2015-05-12. PMID:24033428. |
cell viability assay; flow cytometry for cell cycle and annexin v apoptosis assays; assays for cell migration, invasion, and adhesion to extracellular matrix (ecm); and immunoblotting and immunofluorescence staining were performed in three escc cell lines. |
2015-05-12 |
2023-08-12 |
Not clear |
| Keisuke Mishiro, Takahiko Imai, Sou Sugitani, Akira Kitashoji, Yukiya Suzuki, Toshinori Takagi, Huayue Chen, Yasunori Oumi, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Har. Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis. PloS one. vol 9. issue 8. 2015-05-12. PMID:25133692. |
high-glucose exposure increased apoptosis, capase-3 activity, and release of apoptosis inducing factor (aif) and cytochrome c in hbmvecs as well as affected mitochondrial functions (decreased cell proliferation, atp contents, mitochondrial membrane potential, and increased matrix metalloproteinase (mmp)-9 activity, but not reactive oxygen species production). |
2015-05-12 |
2023-08-13 |
mouse |
| Yueqiang Liu, Xuefeng Tian, Mingzhu Cui, Suzhen Zha. Safflower yellow inhibits angiotensin II-induced adventitial fibroblast proliferation and migration. Journal of pharmacological sciences. vol 126. issue 2. 2015-05-12. PMID:25231558. |
this study aims to investigate the effects of sy on angiotensin ii (ang ii)-induced cell proliferation, migration, apoptosis, and extracellular matrix in rat aortic adventitial fibroblasts (afs). |
2015-05-12 |
2023-08-13 |
rat |
| Shuhei Sakata, Shinya Hayashi, Takaaki Fujishiro, Kohei Kawakita, Noriyuki Kanzaki, Shingo Hashimoto, Kenjiro Iwasa, Nobuaki Chinzei, Shinsuke Kihara, Masahiko Haneda, Takeshi Ueha, Takayuki Nishiyama, Ryosuke Kuroda, Masahiro Kurosak. Oxidative stress-induced apoptosis and matrix loss of chondrocytes is inhibited by eicosapentaenoic acid. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 33. issue 3. 2015-04-30. PMID:25469820. |
oxidative stress-induced apoptosis and matrix loss of chondrocytes is inhibited by eicosapentaenoic acid. |
2015-04-30 |
2023-08-13 |
mouse |
| Paul E Bourgine, Celeste Scotti, Sebastien Pigeot, Laurent A Tchang, Atanas Todorov, Ivan Marti. Osteoinductivity of engineered cartilaginous templates devitalized by inducible apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 49. 2015-04-28. PMID:25422415. |
ecm was engineered by inducing chondrogenesis of human mesenchymal stromal cells and devitalized by the implementation of a death-inducible genetic device, leading to cell apoptosis on activation and matrix protein preservation. |
2015-04-28 |
2023-08-13 |
human |
| Sébastien A Felt, Megan J Moerdyk-Schauwecker, Valery Z Grdzelishvil. Induction of apoptosis in pancreatic cancer cells by vesicular stomatitis virus. Virology. vol 474. 2015-04-24. PMID:25463614. |
here, using 10 human pdac cell lines and three different vsv recombinants (expressing Δm51 or wild type matrix protein), we examined cellular and viral factors affecting vsv-mediated apoptosis activation in pdacs. |
2015-04-24 |
2023-08-13 |
human |
| C Agostinelli, P P Piccaluga, P Went, M Rossi, A Gazzola, S Righi, T Sista, C Campidelli, P L Zinzani, B Falini, S A Piler. Peripheral T cell lymphoma, not otherwise specified: the stuff of genes, dreams and therapies. Journal of clinical pathology. vol 61. issue 11. 2015-04-23. PMID:18755717. |
gene expression profiling studies have revealed that ptcl/nos derive from activated t lymphocytes, more often of the cd4+ type, and bear a signature composed of 155 genes and related products that play a pivotal role in cell signalling transduction, proliferation, apoptosis and matrix remodelling. |
2015-04-23 |
2023-08-12 |
human |
| Belinda Baquero-Perez, Suresh V Kuchipudi, Jemima Ho, Sujith Sebastian, Anita Puranik, Wendy Howard, Sharon M Brookes, Ian H Brown, Kin-Chow Chan. Chicken and duck myotubes are highly susceptible and permissive to influenza virus infection. Journal of virology. vol 89. issue 5. 2015-04-20. PMID:25540384. |
notably, the rapid accumulation of viral nucleoprotein and matrix (m) gene rna in chicken and duck myotubes was accompanied by extensive cytopathic damage with marked myotube apoptosis (widespread microscopic blebs, caspase 3/7 activation, and annexin v binding at the plasma membrane). |
2015-04-20 |
2023-08-13 |
human |
| Umar Wazir, Mona Maw Orakzai, Zubair S Khanzada, Wen G Jiang, Anup K Sharma, Abdul Kasem, Kefah Mokbe. The role of death-associated protein 3 in apoptosis, anoikis and human cancer. Cancer cell international. vol 15. 2015-04-17. PMID:25883535. |
anoikis is subset of apoptosis which occurs in epithelial cells in response to detachment from the surrounding matrix. |
2015-04-17 |
2023-08-13 |
human |
| Elena Talero, Sofia Garcia-Maurino, Virginia Motilv. Melatonin, autophagy and intestinal bowel disease. Current pharmaceutical design. vol 20. issue 30. 2015-04-13. PMID:24251670. |
these actions have been associated to a variety of mechanisms, such as reduction of t cells number, modulation of macrophage activity, suppression of nfκb activity, inhibition of cell adhesion molecules and proinflammatory cytokines , suppression of cox-2 and inos levels and the consequent synthesis of pge2 and no, reduction of matrix metalloproteinase (mmp) -2 and -9 activity, and modulation of apoptosis. |
2015-04-13 |
2023-08-12 |
human |
| Sophia M R Lannon, Jeroen P Vanderhoeven, David A Eschenbach, Michael G Gravett, Kristina M Adams Waldor. Synergy and interactions among biological pathways leading to preterm premature rupture of membranes. Reproductive sciences (Thousand Oaks, Calif.). vol 21. issue 10. 2015-04-13. PMID:24840939. |
recent investigations identify cytokine and matrix metalloproteinase activation, oxidative stress, and apoptosis as primary pathways to pprom. |
2015-04-13 |
2023-08-13 |
Not clear |
| N Bezdenezhnykh, N Semesiuk, O Lykhova, V Zhylchuk, Y Kudryavet. Impact of stromal cell components of tumor microenvironment on epithelial-mesenchymal transition in breast cancer cells. Experimental oncology. vol 36. issue 2. 2015-04-13. PMID:24980759. |
cell and tissue homeostasis results from the dynamic balance of cell - cell and cell - extracellular component crosstalk that regulates proliferation, differentiation, and apoptosis of cells as well as secretion and activation of soluble factors and/or deposition of extracellular matrix (ecm) components. |
2015-04-13 |
2023-08-13 |
Not clear |
| Ali Najafi, Ali Masoudi-Nejad, Abbas Ali Imani Fooladi, Mostafa Ghanei, Mohamad Reza Nouran. Microarray gene expression analysis of the human airway in patients exposed to sulfur mustard. Journal of receptor and signal transduction research. vol 34. issue 4. 2015-03-30. PMID:24823320. |
these genes are associated with the extracellular matrix components, apoptosis, stress response, inflammation and mucus secretion. |
2015-03-30 |
2023-08-13 |
human |