| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei Li, Ye Zhu, Hongbin Zhang, Lihua Li, Peng He, Hong Xia, Yu Zhang, Chuanbin Ma. Delivery of inhibitor of growth 4 (ING4) gene significantly inhibits proliferation and invasion and promotes apoptosis of human osteosarcoma cells. Scientific reports. vol 4. 2015-10-05. PMID:25490312. |
the up-regulation of ing4 in the osteosarcoma cells, arising from the stable pegfp-ing4 gene transfection, was found to significantly inhibit the cell proliferation by the cell cycle alteration with s phase reduction and g0/g1 phase arrest, induce cell apoptosis via the activation of the mitochondria pathway, and suppress cell invasion through the down-regulation of the matrix metalloproteinase 2 (mmp-2) and mmp-9 expression. |
2015-10-05 |
2023-08-13 |
human |
| Fen Wang, Yuanyuan Li, Yingqiang Shen, Anming Wang, Shuling Wang, Tian Xi. The functions and applications of RGD in tumor therapy and tissue engineering. International journal of molecular sciences. vol 14. issue 7. 2015-10-01. PMID:23807504. |
further, rgd as a biomimetic peptide can also promote cell adherence to the matrix, prevent cell apoptosis and accelerate new tissue regeneration. |
2015-10-01 |
2023-08-12 |
Not clear |
| Atsushi Shio. [Vascular Calcification - Pathological Mechanism and Clinical Application - . Mechanisms of vascular calcification]. Clinical calcium. vol 25. issue 5. 2015-09-30. PMID:25926566. |
matrix vesicles released from macrophages and vascular smooth muscle cells (vsmc) during apoptosis play a pivotal role in formation of fine granular calcification, while osteogenic differentiation of vsmc contributes to progression of advanced calcification. |
2015-09-30 |
2023-08-13 |
Not clear |
| Arantzazu Alfranca, Lucia Martinez-Cruzado, Juan Tornin, Ander Abarrategi, Teresa Amaral, Enrique de Alava, Pablo Menendez, Javier Garcia-Castro, Rene Rodrigue. Bone microenvironment signals in osteosarcoma development. Cellular and molecular life sciences : CMLS. vol 72. issue 16. 2015-09-30. PMID:25935149. |
the interaction between them is finely balanced through the processes of bone formation and bone remodeling, which regulates the production and biological activity of many soluble factors and extracellular matrix components needed to maintain the bone homeostasis in terms of cell proliferation, differentiation and apoptosis. |
2015-09-30 |
2023-08-13 |
Not clear |
| Carlos Tarín, Valvanera Fernández-Laso, Cristina Sastre, Julio Madrigal-Matute, Mónica Gómez, Carlos Zaragoza, Jesús Egido, Linda C Burkly, Jose L Martín-Ventura, Luis M Blanco-Coli. Tumor necrosis factor-like weak inducer of apoptosis or Fn14 deficiency reduce elastase perfusion-induced aortic abdominal aneurysm in mice. Journal of the American Heart Association. vol 3. issue 4. 2015-09-28. PMID:25092786. |
tumor necrosis factor-like weak inducer of apoptosis (tweak) is a cytokine implicated in proinflammatory responses, angiogenesis, and matrix degradation but its role in aaa formation is currently unknown. |
2015-09-28 |
2023-08-13 |
mouse |
| Shuo Cui, Xinying Zhang, Sen Hai, Hong Lu, Yongcai Chen, Chao Li, Pengfei Tong, Fei Lu, Zhengjiang Yua. Molecular mechanisms of osteoarthritis using gene microarrays. Acta histochemica. vol 117. issue 1. 2015-09-18. PMID:25468726. |
from this study we conclude that genes involved in cell death and apoptosis, as well as cell-extracellular matrix interaction, may be essential for oa pathogenesis by altering multiple signaling pathways. |
2015-09-18 |
2023-08-13 |
human |
| Souvik Dey, Carly M Sayers, Ioannis I Verginadis, Stacey L Lehman, Yi Cheng, George J Cerniglia, Stephen W Tuttle, Michael D Feldman, Paul J L Zhang, Serge Y Fuchs, J Alan Diehl, Constantinos Koumeni. ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis. The Journal of clinical investigation. vol 125. issue 7. 2015-09-16. PMID:26011642. |
here, we have shown that activating transcription factor 4 (atf4), a master transcriptional effector of the isr, protects transformed cells against anoikis - a specialized form of apoptosis - following matrix detachment and also contributes to tumor metastatic properties. |
2015-09-16 |
2023-08-13 |
human |
| Justin G Lees, Nick N Gorgani, Alaina J Ammit, Adam McCluskey, Phillip J Robinson, Geraldine M O'Neil. Role of dynamin in elongated cell migration in a 3D matrix. Biochimica et biophysica acta. vol 1853. issue 3. 2015-09-15. PMID:25498249. |
treated u87mg cells adopt a rounded morphology that is not due to apoptosis, loss of matrix metalloprotease activity or inhibition of clathrin-mediated endocytosis. |
2015-09-15 |
2023-08-13 |
Not clear |
| Li-Gang Jie, Run-Yue Huang, Wei-Feng Sun, Song Wei, Yong-Liang Chu, Qing-Chun Huang, Hong-Yan D. Role of cysteine‑rich angiogenic inducer 61 in fibroblast‑like synovial cell proliferation and invasion in rheumatoid arthritis. Molecular medicine reports. vol 11. issue 2. 2015-09-14. PMID:25351421. |
furthermore, it decreased the levels of matrix metalloproteinase (mmp)‑3 and mmp‑13, and induced apoptosis in ra‑fls cells. |
2015-09-14 |
2023-08-13 |
human |
| Buket Reel, Ceren Gonen Korkmaz, Mehmet Zuhuri Arun, Gokce Yildirim, Deniz Ogut, Aysegul Kaymak, Serap Cilaker Micili, Bekir Ugur Ergu. The Regulation of Matrix Metalloproteinase Expression and the Role of Discoidin Domain Receptor 1/2 Signalling in Zoledronate-treated PC3 Cells. Journal of Cancer. vol 6. issue 10. 2015-09-14. PMID:26366216. |
ddr signalling regulates cell migration, proliferation, apoptosis and matrix metalloproteinase (mmp) production. |
2015-09-14 |
2023-08-13 |
Not clear |
| Hsi-Lung Hsieh, Pei-Ling Chi, Chih-Chung Lin, Chien-Chung Yang, Chuen-Mao Yan. Up-regulation of ROS-dependent matrix metalloproteinase-9 from high-glucose-challenged astrocytes contributes to the neuronal apoptosis. Molecular neurobiology. vol 50. issue 2. 2015-09-11. PMID:24395134. |
up-regulation of ros-dependent matrix metalloproteinase-9 from high-glucose-challenged astrocytes contributes to the neuronal apoptosis. |
2015-09-11 |
2023-08-12 |
Not clear |
| F Ishikawa, K Ushida, K Mori, M Shibanum. Loss of anchorage primarily induces non-apoptotic cell death in a human mammary epithelial cell line under atypical focal adhesion kinase signaling. Cell death & disease. vol 6. 2015-09-11. PMID:25611393. |
anoikis, a type of apoptosis specifically induced by lack of appropriate cell-extracellular matrix adhesion, has been established as the dominant response of normal epithelial cells to anchorage loss. |
2015-09-11 |
2023-08-13 |
human |
| Maria Akhmanova, Egor Osidak, Sergey Domogatsky, Sergey Rodin, Anna Domogatskay. Physical, Spatial, and Molecular Aspects of Extracellular Matrix of In Vivo Niches and Artificial Scaffolds Relevant to Stem Cells Research. Stem cells international. vol 2015. 2015-09-09. PMID:26351461. |
extracellular matrix can influence stem cell choices, such as self-renewal, quiescence, migration, proliferation, phenotype maintenance, differentiation, or apoptosis. |
2015-09-09 |
2023-08-13 |
Not clear |
| Tamara Advedissian, Frédérique Deshayes, Françoise Poirier, Cyrille Grandjean, Mireille Viguie. [Galectins, a class of unconventional lectins]. Medecine sciences : M/S. vol 31. issue 5. 2015-08-17. PMID:26059300. |
indeed, galectins are multifunctional proteins involved in cell-cell and cell-extracellular matrix interactions, organization of membrane domains, cell signalling and also in intracellular trafficking, apoptosis, regulation of cell cycle. |
2015-08-17 |
2023-08-13 |
mouse |
| Ferda Kaleağasıoğlu, Martin R Berge. SIBLINGs and SPARC families: their emerging roles in pancreatic cancer. World journal of gastroenterology. vol 20. issue 40. 2015-08-13. PMID:25356037. |
in this complex scenario of pancreatic cancer, especially members of the "small integrin binding ligand n-linked glycoproteins" (siblings) and "secreted protein acidic and rich in cysteine" (sparc) families have emerged due to their prominent roles in properties including proliferation, differentiation, apoptosis, adhesion, migration, angiogenesis, wound repair and regulation of extracellular matrix remodeling. |
2015-08-13 |
2023-08-13 |
Not clear |
| Dania A Shah, Raouf A Khali. Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia. Biochemical pharmacology. vol 95. issue 4. 2015-08-12. PMID:25916268. |
predisposing demographic, genetic and environmental risk factors could cause localized abnormalities in uteroplacental cytoactive factors such as integrins, matrix metalloproteinases, cytokines and major histocompatibility complex molecules leading to decreased vascular remodeling, uteroplacental vasoconstriction, trophoblast cells apoptosis, and abnormal development of the placenta. |
2015-08-12 |
2023-08-13 |
Not clear |
| A Kopuz, S Kurt, O Demirtas, E Toz, A Tasyur. Relation of peritoneal fluid and serum vascular endothelial growth factor levels to endometriosis stage. Clinical and experimental obstetrics & gynecology. vol 41. issue 5. 2015-08-06. PMID:25864257. |
it is a well known fact that endometriosis is linked with apoptosis, extracellular matrix formation, and angiogenesis. |
2015-08-06 |
2023-08-13 |
Not clear |
| Eva Yg De Vilder, Olivier M Vanakke. From variome to phenome: Pathogenesis, diagnosis and management of ectopic mineralization disorders. World journal of clinical cases. vol 3. issue 7. 2015-08-05. PMID:26244149. |
these hypotheses include intracellular and extracellular mechanisms, such as the formation of matrix vesicles, aberrant osteogenic and chondrogenic signaling, apoptosis and oxidative stress. |
2015-08-05 |
2023-08-13 |
Not clear |
| Tzvetanka Bondeva, Gunter Wol. Role of Neuropilin-1 in Diabetic Nephropathy. Journal of clinical medicine. vol 4. issue 6. 2015-08-04. PMID:26239560. |
in vitro studies of podocytes implicated nrp-1 in the regulation of podocytes' adhesion to extracellular matrix proteins, cytoskeleton reorganization, and apoptosis via not completely understood mechanisms. |
2015-08-04 |
2023-08-13 |
mouse |
| Seung Hyo Jung, Kyung-Jong Won, Kang Pa Lee, Hyun-Joong Kim, Eun-Hye Seo, Hwan Myung Lee, Eun Seok Park, Seung Hyun Lee, Bokyung Ki. The serum protein fetuin-B is involved in the development of acute myocardial infarction. Clinical science (London, England : 1979). vol 129. issue 1. 2015-07-24. PMID:25671698. |
fetuin-b also affected vascular plaque-stabilizing factors, including lipid deposition and cytokine production in macrophages, the activation of matrix metalloproteinase (mmp)-2 in monocytes, and the activation of apoptosis and mmp-2 in vascular smooth muscle cells. |
2015-07-24 |
2023-08-13 |
human |