| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Hairong Song, Mona Fares, Kim R Maguire, Ake Sid\\xc3\\xa9n, Zuzana Pot\\xc3\\xa1cov\\xc3\\xa. Cytotoxic effects of tetracycline analogues (doxycycline, minocycline and COL-3) in acute myeloid leukemia HL-60 cells. PloS one. vol 9. issue 12. 2015-11-30. PMID:25502932.' |
tetracycline analogues (tcnas) have been shown to inhibit matrix metalloproteinases and to induce apoptosis in several cancer cell types. |
2015-11-30 |
2023-08-13 |
human |
| Francesca Polverino, Melanie Doyle-Eisele, Jacob McDonald, Julie A Wilder, Christopher Royer, Maria Laucho-Contreras, Emer M Kelly, Miguel Divo, Victor Pinto-Plata, Joe Mauderly, Bartolome R Celli, Yohannes Tesfaigzi, Caroline A Owe. A novel nonhuman primate model of cigarette smoke-induced airway disease. The American journal of pathology. vol 185. issue 3. 2015-11-25. PMID:25542772. |
although cs-exposed nhps did not develop emphysema over the study time, they exhibited pathologies that precede emphysema development, including increases in the following: i) matrix metalloproteinase-9 and proinflammatory mediator levels in bronchoalveolar lavage fluid, ii) lung parenchymal leukocyte counts and lymphoid aggregates, iii) lung oxidative stress levels, and iv) alveolar septal cell apoptosis. |
2015-11-25 |
2023-08-13 |
mouse |
| Mengran Zhang, Jinqian Zhang, Shunai Liu, Qi Wang, Guoxian Lin, Rongxian Qiu, Min Quan, Jun Chen. NS5ATP9 suppresses activation of human hepatic stellate cells, possibly via inhibition of Smad3/phosphorylated-Smad3 expression. Inflammation. vol 38. issue 1. 2015-11-20. PMID:25300817. |
ns5atp9 suppresses hsc activation, extracellular matrix production, and promotes apoptosis, in part through reducing smad3/phosphorylated-smad3 expression. |
2015-11-20 |
2023-08-13 |
human |
| Clara Ibel Chamorro, Said Zeiai, Gisela Reinfeldt Engberg, David Brodin, Agneta Nordenskjöld, Magdalena Fossu. A study on proliferation and gene expression in normal human urothelial cells in culture. Tissue engineering. Part A. vol 21. issue 3-4. 2015-11-16. PMID:25159583. |
downregulated genes at passage eight clustered in biological pathways of cell cycle and dna repair processes; upregulated genes had no obvious association to any specific biological function or pathway according to webgestalt analysis, but individual genes with extracellular matrix, apoptosis, and cell morphology. |
2015-11-16 |
2023-08-13 |
human |
| Edna Suarez, Farhatullah Syed, Teresa Alonso-Rasgado, Ardeshir Baya. Identification of biomarkers involved in differential profiling of hypertrophic and keloid scars versus normal skin. Archives of dermatological research. vol 307. issue 2. 2015-11-12. PMID:25322916. |
development and progression of raised dermal scars comprises the activation of several molecular pathways and cell defence mechanisms leading to elevated extracellular matrix component synthesis, delayed apoptosis, altered migration and differentiation. |
2015-11-12 |
2023-08-13 |
Not clear |
| Eui Seok Shin, Qiong Huang, Zafer Gurel, Christine M Sorenson, Nader Sheiban. High glucose alters retinal astrocytes phenotype through increased production of inflammatory cytokines and oxidative stress. PloS one. vol 9. issue 7. 2015-11-09. PMID:25068294. |
here we show that high glucose conditions did not induce the apoptosis of retinal ac, but instead increased their rate of dna synthesis and adhesion to extracellular matrix proteins. |
2015-11-09 |
2023-08-13 |
Not clear |
| Sophie Niedermaier, Anne Hilgendorf. Bronchopulmonary dysplasia - an overview about pathophysiologic concepts. Molecular and cellular pediatrics. vol 2. issue 1. 2015-11-06. PMID:26542292. |
triggered in the immature lung by infectious complications, oxygen toxicity and the impact of mechanical ventilation, a sustained inflammatory response, extensive remodeling of the extracellular matrix, increased apoptosis as well as altered growth factor signaling characterize the disease. |
2015-11-06 |
2023-08-13 |
Not clear |
| Nicholas C Lister, Matthew Clemson, Kevin V Morri. RNA-directed epigenetic silencing of Periostin inhibits cell motility. Royal Society open science. vol 2. issue 6. 2015-11-06. PMID:26543579. |
it is thought that periostin plays a major role in the development of metastases owing to its apparent involvement in restructuring of the extracellular matrix to create a microenvironment favouring invasion and metastases, angiogenesis, independent proliferation, avoidance of apoptosis and the ability for cells to re-enter the cell cycle. |
2015-11-06 |
2023-08-13 |
Not clear |
| Sang Yoon Jung, Chulwon Kim, Wan-Seok Kim, Seok-Geun Lee, Jun-Hee Lee, Bum Sang Shim, Sung-Hoon Kim, Kyoo Seok Ahn, Kwang Seok Ah. Korean Red Ginseng Extract Enhances the Anticancer Effects of Imatinib Mesylate Through Abrogation p38 and STAT5 Activation in KBM-5 Cells. Phytotherapy research : PTR. vol 29. issue 7. 2015-11-05. PMID:25857479. |
it also abrogated the expression of bcl-2 (b-cell lymphoma 2), bcl-xl (b-cell lymphoma-extra large), survivin, inhibitors of apoptosis protein 1/2, cox-2 (cyclooxygenase-2), cyclin d1, matrix metalloproteinase-9, and vegf (vascular endothelial growth factor), as well as upregulated the expression of pro-apoptotic gene products. |
2015-11-05 |
2023-08-13 |
human |
| Cheng-Lin Zhang, Ce Wang, Wang-Jun Yan, Rui Gao, Yong-Hua Li, Xu-Hui Zho. Knockdown of TNFAIP1 inhibits growth and induces apoptosis in osteosarcoma cells through inhibition of the nuclear factor-κB pathway. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:24969828. |
knockdown of tnfaip1 suppressed cell proliferation and invasion, and induced cell apoptosis in the os cells together with the downregulation of p65 nuclear factor-κb (nf-κb), proliferating cell nuclear antigen (pcna) and matrix metalloproteinase-2 (mmp-2) and upregulation of caspase-3. |
2015-11-03 |
2023-08-13 |
human |
| Tejinder Singh, Veerpal Kaur, Manish Kumar, Prabhjot Kaur, R S R Murthy, Ravindra K Rawa. The critical role of bisphosphonates to target bone cancer metastasis: an overview. Journal of drug targeting. vol 23. issue 1. 2015-11-03. PMID:25203856. |
bps binds avidly to the bone matrix, and released from matrix during bone resorption process, bps are internalized by the osteoclasts where they interfere with biochemical pathways and induce osteoclast apoptosis. |
2015-11-03 |
2023-08-13 |
Not clear |
| Tejinder Singh, Veerpal Kaur, Manish Kumar, Prabhjot Kaur, R S R Murthy, Ravindra K Rawa. The critical role of bisphosphonates to target bone cancer metastasis: an overview. Journal of drug targeting. vol 23. issue 1. 2015-11-03. PMID:25203856. |
in addition to inhibition of cell multiplication and initiation of apoptosis in cultured cancer cells, they also interfere with adhesion of cancer cells to the bone matrix and inhibit cell migration and invasion. |
2015-11-03 |
2023-08-13 |
Not clear |
| Justin M M Cates, Vincent A Memoli, Raul S Gonzale. Cell cycle and apoptosis regulatory proteins, proliferative markers, cell signaling molecules, CD209, and decorin immunoreactivity in low-grade myxofibrosarcoma and myxoma. Virchows Archiv : an international journal of pathology. vol 467. issue 2. 2015-11-03. PMID:25940995. |
ten cases each of intramuscular myxoma and low-grade myxofibrosarcoma were stained with antibodies directed against apoptosis regulatory proteins (bcl2, activated caspase-3, phospho-h2a.x, and cleaved parp), cell cycle regulatory proteins (rb1, cyclin-a, cdkn1b, and cdt1), proliferative markers (ki67, mcm2, phospho-histone h3, and geminin), cell signalling molecules (c-myc, egf, egfr, pla2g4a, and hsp90), a dendritic cell marker (cd209), and the extracellular matrix proteoglycan decorin. |
2015-11-03 |
2023-08-13 |
Not clear |
| Radosław Januchowski, Piotr Zawierucha, Marcin Ruciński, Maciej Zabe. Microarray-based detection and expression analysis of extracellular matrix proteins in drug‑resistant ovarian cancer cell lines. Oncology reports. vol 32. issue 5. 2015-10-26. PMID:25199881. |
extracellular matrix (ecm) can influence drug resistance by inhibiting the penetration of the drug into cancer tissue as well as increased apoptosis resistance. |
2015-10-26 |
2023-08-13 |
human |
| Feng Long, Xinyan Cai, Wei Luo, Liang Chen, Kanghua L. Role of aldolase A in osteosarcoma progression and metastasis: in vitro and in vivo evidence. Oncology reports. vol 32. issue 5. 2015-10-26. PMID:25215901. |
overexpression of aldoa in mg-63 cells significantly increased in vitro cell invasion, matrix metalloproteinase (mmp)-2 expression, and cell survival against cisplatin-induced apoptosis. |
2015-10-26 |
2023-08-13 |
mouse |
| Cindy Neuzillet, Annemilaï Tijeras-Raballand, Romain Cohen, Jérôme Cros, Sandrine Faivre, Eric Raymond, Armand de Gramon. Targeting the TGFβ pathway for cancer therapy. Pharmacology & therapeutics. vol 147. 2015-10-26. PMID:25444759. |
the tgfβ signaling pathway has pleiotropic functions regulating cell growth, differentiation, apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune response. |
2015-10-26 |
2023-08-13 |
Not clear |
| Tianhui Niu, Yan Tian, Qu Ren, Lizhao Wei, Xiaoxin Li, Qing Ca. Red light interferes in UVA-induced photoaging of human skin fibroblast cells. Photochemistry and photobiology. vol 90. issue 6. 2015-10-20. PMID:25039464. |
red light irradiation retarded the cumulative low-dose uva irradiation-induced skin photoaging, decreased the expression of senescence-associated β-galactosidase, upregulated sirt1 expression, decreased matrix metalloproteinase mmp-1 and the acetylation of p53 expression, reduced the horizon of cell apoptosis and enhanced cell viability. |
2015-10-20 |
2023-08-13 |
human |
| Thomas Neill, Liliana Schaefer, Renato V Iozz. Decoding the Matrix: Instructive Roles of Proteoglycan Receptors. Biochemistry. vol 54. issue 30. 2015-10-16. PMID:26177309. |
the extracellular matrix is a dynamic repository harboring instructive cues that embody substantial regulatory dominance over many evolutionarily conserved intracellular activities, including proliferation, apoptosis, migration, motility, and autophagy. |
2015-10-16 |
2023-08-13 |
Not clear |
| Su-hyun Park, Eun-Ho Jung, Geun-Young Kim, Byung-Chul Kim, Jae Hyang Lim, Chang-Hoon Wo. Itch E3 ubiquitin ligase positively regulates TGF-β signaling to EMT via Smad7 ubiquitination. Molecules and cells. vol 38. issue 1. 2015-10-15. PMID:25518932. |
tgf-β regulates pleiotropic cellular responses including cell growth, differentiation, migration, apoptosis, extracellular matrix production, and many other biological processes. |
2015-10-15 |
2023-08-13 |
Not clear |
| Irene Amigo-Jiménez, Elvira Bailón, Estefanía Ugarte-Berzal, Noemí Aguilera-Montilla, José A García-Marco, Angeles García-Pard. Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. PloS one. vol 9. issue 6. 2015-10-12. PMID:24956101. |
matrix metalloproteinase-9 (mmp-9) contributes to chronic lymphocytic leukemia (cll) pathology by regulating cell migration and preventing spontaneous apoptosis. |
2015-10-12 |
2023-08-13 |
Not clear |