| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fragiska Sigala, Paraskevi Savvari, Michalis Liontos, Panagiotis Sigalas, Ioannis S Pateras, Alexandros Papalampros, Efthimia K Basdra, Evangelos Kolettas, Athanasios G Papavassiliou, Vassilis G Gorgouli. Increased expression of bFGF is associated with carotid atherosclerotic plaques instability engaging the NF-κB pathway. Journal of cellular and molecular medicine. vol 14. issue 9. 2016-02-29. PMID:20455997. |
the degradation of the extracellular matrix by matrix metalloproteinases (mmps) and no-induced apoptosis of vascular smooth muscle cells (vsmcs) contribute to the vulnerability of the atherosclerotic plaques. |
2016-02-29 |
2023-08-12 |
human |
| Helena Kuivaniemi, Evan J Ryer, James R Elmore, Gerard Trom. Understanding the pathogenesis of abdominal aortic aneurysms. Expert review of cardiovascular therapy. vol 13. issue 9. 2016-02-25. PMID:26308600. |
on the histological level, visible hallmarks of aaa pathogenesis include inflammation, smooth muscle cell apoptosis, extracellular matrix degradation and oxidative stress. |
2016-02-25 |
2023-08-13 |
Not clear |
| Ping Wang, Yukinori Koyama, Xiao Liu, Jun Xu, Hsiao-Yen Ma, Shuang Liang, In H Kim, David A Brenner, Tatiana Kisselev. Promising Therapy Candidates for Liver Fibrosis. Frontiers in physiology. vol 7. 2016-02-24. PMID:26909046. |
based on the extensive pathogenesis knowledge of liver fibrosis, therapeutic strategies have been designed to target each step of this process, including hepatocyte apoptosis, cholangiocyte proliferation, inflammation, and activation of myofibroblasts to deposit extracellular matrix, yet the current therapies are still in early-phase clinical development. |
2016-02-24 |
2023-08-13 |
human |
| Haiyang Li, Wenjian Jiang, Weihong Ren, Dong Guo, Jialong Guo, Xiaolong Wang, Yuyong Liu, Feng Lan, Jie Du, Hongjia Zhan. Downregulation of the Yes-Associated Protein Is Associated with Extracellular Matrix Disorders in Ascending Aortic Aneurysms. Stem cells international. vol 2016. 2016-02-23. PMID:26904131. |
previous studies indicate that extracellular matrix (ecm) disorders lead to the apoptosis of vascular smooth muscle cells (vsmcs), which impairs the aortic wall by reducing the generation of elastic fibers, and ultimately result in ascending aortic aneurysm. |
2016-02-23 |
2023-08-13 |
Not clear |
| Anna Malashicheva, Daria Kostina, Aleksandra Kostina, Olga Irtyuga, Irina Voronkina, Larisa Smagina, Elena Ignatieva, Natalia Gavriliuk, Vladimir Uspensky, Olga Moiseeva, Jarle Vaage, Anna Kostarev. Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms. International journal of vascular medicine. vol 2016. 2016-02-23. PMID:26904289. |
the expression of key markers of endothelial (cd31, vwf, and ve-cadherin) and smooth muscle (sma, sm22α, calponin, and vimentin) cells as well extracellular matrix and mmp activity was studied as well as and apoptosis and cell proliferation. |
2016-02-23 |
2023-08-13 |
Not clear |
| Anna Malashicheva, Daria Kostina, Aleksandra Kostina, Olga Irtyuga, Irina Voronkina, Larisa Smagina, Elena Ignatieva, Natalia Gavriliuk, Vladimir Uspensky, Olga Moiseeva, Jarle Vaage, Anna Kostarev. Phenotypic and Functional Changes of Endothelial and Smooth Muscle Cells in Thoracic Aortic Aneurysms. International journal of vascular medicine. vol 2016. 2016-02-23. PMID:26904289. |
in conclusion both endothelial and smooth muscle cells from aneurysms of the ascending aorta have downregulated specific cellular markers and altered functional properties, such as growth rate, apoptosis induction, and extracellular matrix synthesis. |
2016-02-23 |
2023-08-13 |
Not clear |
| Jianquan Chen, Nilsson Holguin, Yu Shi, Matthew J Silva, Fanxin Lon. mTORC2 signaling promotes skeletal growth and bone formation in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 30. issue 2. 2016-02-22. PMID:25196701. |
subsequently, the embryonic skeletal elements are shortened due to a delay in chondrocyte hypertrophy, with no change in proliferation, apoptosis, cell size, or matrix production. |
2016-02-22 |
2023-08-13 |
mouse |
| Anna Santoro, Javier Conde, Morena Scotece, Vanessa Abella, Verónica López, Jesús Pino, Rodolfo Gómez, Juan Jesús Gómez-Reino, Oreste Gualill. Choosing the right chondrocyte cell line: Focus on nitric oxide. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 33. issue 12. 2016-02-22. PMID:26016689. |
nitric oxide (no) has been considered a catabolic factor that contributes to oa pathology by inducing chondrocytes apoptosis, matrix metalloproteinases synthesis, and pro-inflammatory cytokines expression. |
2016-02-22 |
2023-08-13 |
human |
| Joel Davis, Michelle Tucci, George Russell, Hamed Benghuzz. The intracellular signaling pathways of deminerlized bone matrix - biomed 2010. Biomedical sciences instrumentation. vol 46. 2016-02-18. PMID:20467073. |
the current understanding is that the bmps utilize the smad signaling pathway within the cell to regulate target gene expression and thus control cellular events such as proliferation, differentiation, migration, apoptosis, and matrix remodeling. |
2016-02-18 |
2023-08-12 |
Not clear |
| Tracye Lawyer, Scott Wingerter, Michelle Tucci, Hamed Benghuzz. Cellular effects of catabolic inflammatory cytokines on chondrocytes - biomed 2011. Biomedical sciences instrumentation. vol 47. 2016-02-18. PMID:21525629. |
the objective of this study was to evaluate matrix degradation markers, apoptosis, cellular damage markers, and cellular morphology of chondrocytes following a challenge with these inflammatory cytokines. |
2016-02-18 |
2023-08-12 |
human |
| Catherine Baugé, Sylvain Leclercq, Thierry Conrozier, Karim Boumedien. TOL19-001 reduces inflammation and MMP expression in monolayer cultures of tendon cells. BMC complementary and alternative medicine. vol 15. 2016-02-18. PMID:26156631. |
tendinopathies are tendon conditions associated with degeneration and disorganization of the matrix collagen fibers, tendon cells apoptosis and inflammation through up-regulation of proinflammatory cytokines, matrix metalloproteinase (mmp) expression, and prostaglandin e2 (pge2) production. |
2016-02-18 |
2023-08-13 |
Not clear |
| D Malin, E Strekalova, V Petrovic, H Rajanala, B Sharma, A Ugolkov, W J Gradishar, V L Cryn. ERK-regulated αB-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo. Oncogene. vol 34. issue 45. 2016-02-17. PMID:25684139. |
evasion of extracellular matrix detachment-induced apoptosis ('anoikis') is a defining characteristic of metastatic tumor cells. |
2016-02-17 |
2023-08-13 |
Not clear |
| D Malin, E Strekalova, V Petrovic, H Rajanala, B Sharma, A Ugolkov, W J Gradishar, V L Cryn. ERK-regulated αB-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo. Oncogene. vol 34. issue 45. 2016-02-17. PMID:25684139. |
strikingly, silencing αb-crystallin increased matrix detachment-induced caspase activation and apoptosis but did not affect cell viability of adherent cancer cells. |
2016-02-17 |
2023-08-13 |
Not clear |
| Hai-Kun Wei, Si-Dong Yang, Zhi-Long Bai, Xu Zhang, Da-Long Yang, Wen-Yuan Din. Levofloxacin increases apoptosis of rat annulus fibrosus cells via the mechanism of upregulating MMP-2 and MMP-13. International journal of clinical and experimental medicine. vol 8. issue 11. 2016-02-17. PMID:26884932. |
levofloxacin was previously reported to induce apoptosis of rat annulus fibrosus (af) cells by upregulating active caspase-3 and matrix metalloproteinase (mmp)-3 expression in vitro. |
2016-02-17 |
2023-08-13 |
rat |
| Hai-Kun Wei, Si-Dong Yang, Zhi-Long Bai, Xu Zhang, Da-Long Yang, Wen-Yuan Din. Levofloxacin increases apoptosis of rat annulus fibrosus cells via the mechanism of upregulating MMP-2 and MMP-13. International journal of clinical and experimental medicine. vol 8. issue 11. 2016-02-17. PMID:26884932. |
the purpose of this study was to further explore the changes in extracellular matrix and mmps of rat af cells based on levofloxacin-induced apoptosis. |
2016-02-17 |
2023-08-13 |
rat |
| Kevin Dzobo, Matjaz Vogelsang, Nicholas E Thomford, Collet Dandara, Karlien Kallmeyer, Michael S Pepper, M Iqbal Parke. Wharton's Jelly-Derived Mesenchymal Stromal Cells and Fibroblast-Derived Extracellular Matrix Synergistically Activate Apoptosis in a p21-Dependent Mechanism in WHCO1 and MDA MB 231 Cancer Cells In Vitro. Stem cells international. vol 2016. 2016-02-16. PMID:26880967. |
wharton's jelly-derived mesenchymal stromal cells and fibroblast-derived extracellular matrix synergistically activate apoptosis in a p21-dependent mechanism in whco1 and mda mb 231 cancer cells in vitro. |
2016-02-16 |
2023-08-13 |
Not clear |
| Chong-Chong Gao, Ben-Gang Gong, Jun-Ben Wu, Pi-Guang Cheng, Huai-Yong Xu, De-Kun Song, Fei L. MMI-166, a selective matrix metalloproteinase inhibitor, promotes apoptosis in human pancreatic cancer. Medical oncology (Northwood, London, England). vol 32. issue 1. 2016-02-09. PMID:25471789. |
mmi-166, a selective matrix metalloproteinase inhibitor, promotes apoptosis in human pancreatic cancer. |
2016-02-09 |
2023-08-13 |
mouse |
| Evan J Ryer, Robert P Garvin, Charles M Schworer, Kamell R Bernard-Eckroth, Gerard Tromp, David P Franklin, James R Elmore, Helena Kuivaniem. Proinflammatory role of stem cells in abdominal aortic aneurysms. Journal of vascular surgery. vol 62. issue 5. 2016-02-08. PMID:24997808. |
the pathogenesis of abdominal aortic aneurysm (aaa) formation includes inflammation, vascular smooth muscle cell apoptosis, extracellular matrix degradation, and oxidative stress. |
2016-02-08 |
2023-08-13 |
human |
| Shuo Chen, Xi Chen, Yin-Ling Xiu, Kai-Xuan Sun, Yang Zha. Inhibition of Ovarian Epithelial Carcinoma Tumorigenesis and Progression by microRNA 106b Mediated through the RhoC Pathway. PloS one. vol 10. issue 5. 2016-02-04. PMID:25933027. |
mir-106b transfection reduced cell proliferation; promoted g1 or s arrest and apoptosis (p < 0.05); suppressed cell migration and invasion (p < 0.05); reduced ras homolog gene family member c (rhoc), p70 ribosomal s6 kinase (p70s6k), bcl-xl, matrix metallopeptidase 2 (mmp2), mmp9 mrna and protein expression; and induced p53 expression (p < 0.05). |
2016-02-04 |
2023-08-13 |
mouse |
| Yu-Feng Hu, Yi-Jen Chen, Yenn-Jiang Lin, Shih-Ann Che. Inflammation and the pathogenesis of atrial fibrillation. Nature reviews. Cardiology. vol 12. issue 4. 2016-02-02. PMID:25622848. |
myolysis, cardiomyocyte apoptosis, and the activation of fibrotic pathways via fibroblasts, transforming growth factor-β and matrix metalloproteases are also mediated by inflammatory pathways, which can all contribute to structural remodelling of the atria. |
2016-02-02 |
2023-08-13 |
Not clear |