| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiujuan Liu, Quan Hong, Zhen Wang, Yanyan Yu, Xin Zou, Lihong X. Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells. Experimental biology and medicine (Maywood, N.J.). vol 241. issue 3. 2016-06-06. PMID:26376826. |
renal fibrosis is a progressive pathological change characterized by tubular cell apoptosis, tubulointerstitial fibroblast proliferation, and excessive deposition of extracellular matrix (ecm). |
2016-06-06 |
2023-08-13 |
Not clear |
| Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Reem Almomani, Shoujian Wang, Nader Sheibani, Christine M Sorenso. Endothelium Expression of Bcl-2 Is Essential for Normal and Pathological Ocular Vascularization. PloS one. vol 10. issue 10. 2016-06-03. PMID:26444547. |
in vitro studies indicated that in addition to modulating apoptosis, bcl-2 expression also impacts endothelial and epithelial cell adhesion, migration and extracellular matrix production. |
2016-06-03 |
2023-08-13 |
mouse |
| Theophilus I Emeto, Joseph V Moxon, Minnie Au, Jonathan Golledg. Oxidative stress and abdominal aortic aneurysm: potential treatment targets. Clinical science (London, England : 1979). vol 130. issue 5. 2016-06-01. PMID:26814202. |
these have been suggested to promote degradation of the extracellular matrix (ecm) and vascular smooth muscle apoptosis. |
2016-06-01 |
2023-08-13 |
human |
| Peihua Zhang, Jin Li, Yawei Qi, Xudong Tang, Jianfeng Duan, Li Liu, Zeyong Wu, Jie Liang, Jiangfeng Li, Xian Wang, Guofang Zeng, Hongwei Li. Tissue Inhibitor of Matrix Metalloproteinases-1 Knockdown Suppresses the Proliferation of Human Adipose-Derived Stem Cells. Stem cells international. vol 2016. 2016-05-30. PMID:27239203. |
tissue inhibitor of metalloproteinases-1 (timp-1) is a multifunctional matrix metalloproteinase, and it is involved in the regulation of cell proliferation and apoptosis in various cell types. |
2016-05-30 |
2023-08-13 |
human |
| Saeideh Jafarinejad-Farsangi, Ali Farazmand, Mahdi Mahmoudi, Farhad Gharibdoost, Elham Karimizadeh, Farshid Noorbakhsh, Habibeh Faridani, Ahmad Reza Jamshid. MicroRNA-29a induces apoptosis via increasing the Bax:Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis. Autoimmunity. vol 48. issue 6. 2016-05-24. PMID:25857445. |
the most prominent feature of systemic sclerosis (ssc) and other diseases associated with fibrosis is the prolonged activation of fibroblasts not eliminated by apoptosis, hence characterized by accumulation of more extra cellular matrix (ecm). |
2016-05-24 |
2023-08-13 |
Not clear |
| Longfeng Sun, Gang Li, Bing Dai, Wei Tan, Hongwen Zhao, Xiaofei Li, Aiping Wan. Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells. Molecular medicine reports. vol 12. issue 3. 2016-05-24. PMID:26043756. |
western blotting and fluorescence‑activated cell sorting (facs) revealed a g0/g1 phase cell cycle arrest regulated by cyclins d1 and e; cell apoptosis regulated by caspase‑3; and cell invasion and migration regulated by matrix metalloproteinases 2 and 9, respectively. |
2016-05-24 |
2023-08-13 |
human |
| Weixin Li, Lintao Wang, Weijian Huang, Melissa Skibba, Qilu Fang, Longteng Xie, Tiemin Wei, Zhiguo Feng, Guang Lian. Inhibition of ROS and inflammation by an imidazopyridine derivative X22 attenuate high fat diet-induced arterial injuries. Vascular pharmacology. vol 72. 2016-05-19. PMID:25989105. |
in hfd-fed rats, administration of x22 at 10mg/kg significantly decreased the arterial inflammation and oxidative stress, and eventually improved the arterial matrix remodeling and apoptosis. |
2016-05-19 |
2023-08-13 |
rat |
| Yuzhou Fan, Ioscani Jimenez Del Val, Christian Müller, Anne Mathilde Lund, Jette Wagtberg Sen, Søren Kofoed Rasmussen, Cleo Kontoravdi, Deniz Baycin-Hizal, Michael J Betenbaugh, Dietmar Weilguny, Mikael Rørdam Anderse. A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture. Biotechnology and bioengineering. vol 112. issue 10. 2016-05-16. PMID:25899530. |
generally higher expression of proteins involved in regulating cellular metabolism, extracellular matrix, apoptosis, protein secretion and glycosylation was found in early stationary phase. |
2016-05-16 |
2023-08-13 |
Not clear |
| Li-Yan Li, Hong Jiang, Yang-Min Xie, Lian-Di Liao, Hui-Hui Cao, Xiu-E Xu, Bo Chen, Fa-Min Zeng, Ying-Li Zhang, Ze-Peng Du, Hong Chen, Wei Huang, Wei Jia, Wei Zheng, Jian-Jun Xie, En-Min Li, Li-Yan X. Macrolide analog F806 suppresses esophageal squamous cell carcinoma (ESCC) by blocking β1 integrin activation. Oncotarget. vol 6. issue 18. 2016-05-12. PMID:25909284. |
mechanistic studies revealed that f806 inhibited the activation of β1 integrin in part by binding to a novel site arg610 of β1 integrin, suppressed focal adhesion formation, decreased cell adhesion to extracellular matrix and eventually triggered apoptosis. |
2016-05-12 |
2023-08-13 |
human |
| Xihai Li, Wenna Liang, Hongzhi Ye, Xiaping Weng, Fayuan Liu, Pingdong Lin, Xianxiang Li. Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression-associated congenital dysplasia of the temporomandibular joint in mice. Molecular medicine reports. vol 12. issue 3. 2016-05-12. PMID:26096903. |
however, overexpression of ihh did not inhibit the shox2 overexpression-associated increase of matrix metalloproteinases (mmps) mmp9, mmp13 and apoptosis in the tmj. |
2016-05-12 |
2023-08-13 |
mouse |
| Ning Wu, Jiao Luo, Bo Jiang, Lijun Wang, Shuaiyu Wang, Changhui Wang, Changqing Fu, Jian Li, Dayong Sh. Marine bromophenol bis (2,3-dibromo-4,5-dihydroxy-phenyl)-methane inhibits the proliferation, migration, and invasion of hepatocellular carcinoma cells via modulating β1-integrin/FAK signaling. Marine drugs. vol 13. issue 2. 2016-05-10. PMID:25689564. |
further studies have shown that prior to the onset of apoptosis, the bddpm induces bel-7402 cell detachment by decreasing the adherence of cells to the extracellular matrix (ecm). |
2016-05-10 |
2023-08-13 |
Not clear |
| Anna Gorta. Analysis of CDK Inhibitor Action on Mitochondria-Mediated Apoptosis. Methods in molecular biology (Clifton, N.J.). vol 1336. 2016-05-10. PMID:26231711. |
this chapter describes procedures to study apoptosis induction upon treatment with any cdki through the evaluation of morphological and functional mitochondrial alterations, in particular, how to measure the mitochondrial membrane potential (ΔΨm) using tmre dye, determine the content of intracellular atp, observe mitochondrial network morphology using hela cells stably expressing fluorescent reporter dsred targeting mitochondrial matrix, observe ultrastructure of the organelle using transmission electron microscopy, and, finally, assure that mitochondrial outer membrane permeabilization takes place by assessing the subcellular localization of cyt c in hela cells stably expressing fluorescent cyt c-gfp. |
2016-05-10 |
2023-08-13 |
Not clear |
| Lisanna Paladin, Silvio C E Tosatto, Giovanni Minervin. Structural in silico dissection of the collagen V interactome to identify genotype-phenotype correlations in classic Ehlers-Danlos Syndrome (EDS). FEBS letters. vol 589. issue 24 Pt B. 2016-05-10. PMID:26608033. |
we found that ceds heterogeneous manifestations may be explained by the involvement in two different extracellular matrix pathways, related to cell adhesion and tissue repair or cell differentiation, growth and apoptosis. |
2016-05-10 |
2023-08-13 |
Not clear |
| Paolo Fagone, Katia Mangano, Santa Mammana, Antonio Pesce, Aurora Pesce, Rosario Caltabiano, Alexandra Giorlandino, Teresa Rosanna Portale, Eugenio Cavalli, Giuseppe A G Lombardo, Marinella Coco, Stefano Puleo, Ferdinando Nicolett. Identification of novel targets for the diagnosis and treatment of liver fibrosis. International journal of molecular medicine. vol 36. issue 3. 2016-05-09. PMID:26135677. |
liver fibrosis is characterized by the excessive deposition of extracellular matrix (ecm) in the hepatic parenchyma and represents an intrinsic response to chronic injury, maintaining organ integrity when extensive necrosis or apoptosis occurs. |
2016-05-09 |
2023-08-13 |
Not clear |
| Hui Gao, Yongji Liu, Kan Li, Tianhui Wu, Jianjun Peng, Fanbo Jin. Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer. American journal of translational research. vol 8. issue 2. 2016-05-09. PMID:27158398. |
hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer. |
2016-05-09 |
2023-08-13 |
human |
| Hui Gao, Yongji Liu, Kan Li, Tianhui Wu, Jianjun Peng, Fanbo Jin. Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer. American journal of translational research. vol 8. issue 2. 2016-05-09. PMID:27158398. |
our results also revealed that hispidulin treatment significantly inhibits extracellular matrix metalloproteinase inducer (emmprin) expression in both tested aml cell lines in a dose-dependent manner, and that the overexpression of emmprin protein markedly attenuates hispidulin-induced cell apoptosis. |
2016-05-09 |
2023-08-13 |
human |
| Shijin Lu, Xungang Xiao, Minghua Chen. Matrine inhibits IL-1β-induced expression of matrix metalloproteinases by suppressing the activation of MAPK and NF-κB in human chondrocytes in vitro. International journal of clinical and experimental pathology. vol 8. issue 5. 2016-05-05. PMID:26191166. |
interleukin (il)-1β plays an important role in promoting osteoarthritis (oa) lesions by inducing chondrocytes to secrete matrix metalloproteinases (mmps), which degrade the extracellular matrix and facilitate chondrocyte apoptosis. |
2016-05-05 |
2023-08-13 |
human |
| Chee Ren Ivan Lam, Hui Kian Wong, Spencer Nai, Chee Kai Chua, Nguan Soon Tan, Lay Poh Ta. A 3D biomimetic model of tissue stiffness interface for cancer drug testing. Molecular pharmaceutics. vol 11. issue 7. 2016-05-04. PMID:24754837. |
we importantly found that cancer cells which more extensively infiltrated the 300 pa matrix also succumbed to paclitaxel induced apoptosis earlier than cells in stiffer matrices of 1200 and 6000 pa respectively. |
2016-05-04 |
2023-08-13 |
Not clear |
| M M Al-Qatta. Formation of normal interdigital web spaces in the hand revisited: implications for the pathogenesis of syndactyly in humans and experimental animals. The Journal of hand surgery, European volume. vol 39. issue 5. 2016-05-03. PMID:23719174. |
this paper presents evidence that lysosomal-mediated cell death and extracellular matrix degradation are important events in addition to cell death by apoptosis. |
2016-05-03 |
2023-08-12 |
Not clear |
| M M Al-Qatta. Formation of normal interdigital web spaces in the hand revisited: implications for the pathogenesis of syndactyly in humans and experimental animals. The Journal of hand surgery, European volume. vol 39. issue 5. 2016-05-03. PMID:23719174. |
the author proposes the use of the term interdigital cell death- extracellular matrix degradation instead of interdigital apoptosis. |
2016-05-03 |
2023-08-12 |
Not clear |