| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Zhang, Xin Zhao, Yanzhong Chang, Yuanyuan Zhang, Xi Chu, Xuan Zhang, Zhenyi Liu, Hui Guo, Na Wang, Yonggang Gao, Jianping Zhang, Li Ch. Calcium channel blockers ameliorate iron overload-associated hepatic fibrosis by altering iron transport and stellate cell apoptosis. Toxicology and applied pharmacology. vol 301. 2017-05-26. PMID:27095094. |
in iron-overloaded hsc-t6 cells, ccbs reduced iron deposition, inhibited proliferation, induced apoptosis, and elevated expression of matrix metalloproteinase-13 (mmp-13) and tissue inhibitor of metalloproteinase-1 (timp-1). |
2017-05-26 |
2023-08-13 |
mouse |
| Yinhe Tang, Qiyu Zhang, Yefan Zhu, Gang Chen, Fuxiang Y. Low concentrations of bilirubin inhibit activation of hepatic stellate cells in vitro. Molecular medicine reports. vol 15. issue 4. 2017-05-22. PMID:28260031. |
as the bilirubin concentration increased, hscs demonstrated reduced production of reactive oxygen species, reduced protein expression levels of α‑smooth muscle actin, a decreased mrna expression ratio of tissue inhibitor of matrix metalloproteinase‑1/matrix metalloproteinase‑2, decreased proliferation and increased apoptosis. |
2017-05-22 |
2023-08-13 |
rat |
| W H Yang, Y T Deng, Y P Hsieh, K J Wu, M Y P Ku. Thrombin Activates Latent TGFβ1 via Integrin αvβ1 in Gingival Fibroblasts. Journal of dental research. vol 95. issue 8. 2017-05-15. PMID:26912222. |
transforming growth factor β (tgfβ) regulates cell proliferation, differentiation, migration, apoptosis, and extracellular matrix production. |
2017-05-15 |
2023-08-13 |
human |
| Amanda K Wheaton, Miranda Velikoff, Manisha Agarwal, Tiffany T Loo, Jeffrey C Horowitz, Thomas H Sisson, Kevin K Ki. The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis. American journal of physiology. Lung cellular and molecular physiology. vol 310. issue 11. 2017-05-15. PMID:27106291. |
to determine the role of specific matrix proteins on tgf-β-induced apoptosis, we studied primary aecs cultured on different matrix conditions and utilized mice with deletion of vitronectin (vtn(-/-)) or mice in which the vitronectin rgd motif is mutated to nonintegrin-binding arginine-glycine-glutamate (rge) (vtn(rge/rge)). |
2017-05-15 |
2023-08-13 |
mouse |
| Jie Zan, Juan Liu, Jian-Wei Zhou, Hai-Long Wang, Kai-Kun Mo, Yan Yan, Yun-Bin Xu, Min Liao, Shuo Su, Rong-Liang Hu, Ji-Yong Zho. Rabies virus matrix protein induces apoptosis by targeting mitochondria. Experimental cell research. vol 347. issue 1. 2017-05-15. PMID:27426727. |
rabies virus matrix protein induces apoptosis by targeting mitochondria. |
2017-05-15 |
2023-08-13 |
Not clear |
| Nathaniel Teng, Ghassan J Maghzal, Jihan Talib, Imran Rashid, Antony K Lau, Roland Stocke. The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture. Redox report : communications in free radical research. vol 22. issue 2. 2017-05-15. PMID:27884085. |
mpo and mpo-derived oxidants have been shown to contribute to the formation of foam cells, endothelial dysfunction and apoptosis, the activation of latent matrix metalloproteinases, and the expression of tissue factor that can promote the development of vulnerable plaque. |
2017-05-15 |
2023-08-13 |
Not clear |
| Ting Xu, Gaoli Xu, Zhiyuan Gu, Huiling W. Role of endoplasmic reticulum stress pathway in hydrostatic pressure-induced apoptosis in rat mandibular condylar chondrocytes. Molecular and cellular biochemistry. vol 429. issue 1-2. 2017-05-12. PMID:28190169. |
suppression of er stress by salubrinal prevents chondrocytes from undergoing apoptosis and matrix degradation induced by hp. |
2017-05-12 |
2023-08-13 |
rat |
| Dorota Dziewulska, Ewelina Nyc. Disturbed integrin expression in the vascular media in CADASIL. Folia neuropathologica. vol 54. issue 4. 2017-05-09. PMID:28139819. |
many functions of vsmcs, such as adhesion, apoptosis, contraction, differentiation, migration, and proliferation are determined by integrins - surface adhesion receptors involved in binding and interactions between cells and extracellular matrix (ecm). |
2017-05-09 |
2023-08-13 |
Not clear |
| b' Agnieszka Irena Mazur-Bialy, Ewa Poche\\xc4\\x8. Riboflavin Reduces Pro-Inflammatory Activation of Adipocyte-Macrophage Co-culture. Potential Application of Vitamin B2 Enrichment for Attenuation of Insulin Resistance and Metabolic Syndrome Development. Molecules (Basel, Switzerland). vol 21. issue 12. 2017-04-28. PMID:27983705.' |
the apoptosis of adipocytes and macrophages as well as tumor necrosis factor-alpha (tnf-α), interleukin 6 (il-6), interleukin 1beta (il-1β), monocyte chemotactic protein 1 (mcp-1), high-mobility group box 1 (hmgb1), transforming growth factor-beta 1 (tgfβ), interleukin 10 (il-10), inducible nitric oxide synthase (inos), nitric oxide (no), matrix metalloproteinase 9 (mmp-9), tissue inhibitor of metalloproteinases-1 (timp-1) expression and release, macrophage migration and adipokines (adiponectin and leptin) were determined. |
2017-04-28 |
2023-08-13 |
Not clear |
| Charles J Malemu. Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis. International journal of molecular sciences. vol 18. issue 3. 2017-04-28. PMID:28245561. |
however, cytokine gene expression, matrix metalloproteinase gene expression and aberrant immune cell and synoviocyte survival via reduced apoptosis are most critical in the context of inflammation characteristic of ra and oa. |
2017-04-28 |
2023-08-13 |
human |
| Sheng Chen, Jinqi Luo, Cesar Reis, Anatol Manaenko, Jianmin Zhan. Hydrocephalus after Subarachnoid Hemorrhage: Pathophysiology, Diagnosis, and Treatment. BioMed research international. vol 2017. 2017-04-28. PMID:28373987. |
it has been reported that inflammation, apoptosis, autophagy, and oxidative stress are the important causes of hcp, and well-known molecules including transforming growth factor, matrix metalloproteinases, and iron terminally lead to fibrosis and blockage of hcp. |
2017-04-28 |
2023-08-13 |
Not clear |
| Ryoji Eguchi, Yumiko Fujita, Chiharu Tabata, Hiroyasu Ogawa, Ichiro Wakabayashi, Takashi Nakano, Yoshihiro Fujimor. Inhibition of Src family kinases overcomes anoikis resistance induced by spheroid formation and facilitates cisplatin-induced apoptosis in human mesothelioma cells. Oncology reports. vol 34. issue 5. 2017-04-27. PMID:26323315. |
we examined the levels of anoikis, apoptosis induced by the detachment of cells from the extracellur matrix, in suspension culture in the human mesothelioma cell line nci-h2052. |
2017-04-27 |
2023-08-13 |
human |
| Ping Zhan. Ginsenoside‑Rg5 treatment inhibits apoptosis of chondrocytes and degradation of cartilage matrix in a rat model of osteoarthritis. Oncology reports. vol 37. issue 3. 2017-04-25. PMID:28112382. |
ginsenoside‑rg5 treatment inhibits apoptosis of chondrocytes and degradation of cartilage matrix in a rat model of osteoarthritis. |
2017-04-25 |
2023-08-13 |
rat |
| Stefanie Endesfelder, Ulrike Weichelt, Evelyn Strauß, Anja Schlör, Marco Sifringer, Till Scheuer, Christoph Bührer, Thomas Schmit. Neuroprotection by Caffeine in Hyperoxia-Induced Neonatal Brain Injury. International journal of molecular sciences. vol 18. issue 1. 2017-04-24. PMID:28106777. |
in the present study, we investigated the effects of caffeine on oxidative stress markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, and extracellular matrix following the induction of hyperoxia in neonatal rats. |
2017-04-24 |
2023-08-13 |
human |
| Stefanie Endesfelder, Ulrike Weichelt, Evelyn Strauß, Anja Schlör, Marco Sifringer, Till Scheuer, Christoph Bührer, Thomas Schmit. Neuroprotection by Caffeine in Hyperoxia-Induced Neonatal Brain Injury. International journal of molecular sciences. vol 18. issue 1. 2017-04-24. PMID:28106777. |
six-day-old wistar rats were pre-treated with caffeine and exposed to 80% oxygen for 24 and 48 h. caffeine reduced oxidative stress marker (heme oxygenase-1, lipid peroxidation, hydrogen peroxide, and glutamate-cysteine ligase catalytic subunit (gclc)), promoted anti-oxidative response (superoxide dismutase, peroxiredoxin 1, and sulfiredoxin 1), down-regulated pro-inflammatory cytokines, modulated redox-sensitive transcription factor expression (nrf2/keap1, and nfκb), reduced pro-apoptotic effectors (poly (adp-ribose) polymerase-1 (parp-1), apoptosis inducing factor (aif), and caspase-3), and diminished extracellular matrix degeneration (matrix metalloproteinases (mmp) 2, and inhibitor of metalloproteinase (timp) 1/2). |
2017-04-24 |
2023-08-13 |
human |
| Manfred Richter, Sawa Kosti. The failing human heart is characterized by decreased numbers of telocytes as result of apoptosis and altered extracellular matrix composition. Journal of cellular and molecular medicine. vol 19. issue 11. 2017-04-18. PMID:26311501. |
the failing human heart is characterized by decreased numbers of telocytes as result of apoptosis and altered extracellular matrix composition. |
2017-04-18 |
2023-08-13 |
human |
| M L McNiff, E P Haynes, N Dixit, F P Gao, J S Laurenc. Thioredoxin fusion construct enables high-yield production of soluble, active matrix metalloproteinase-8 (MMP-8) in Escherichia coli. Protein expression and purification. vol 122. 2017-04-17. PMID:26923061. |
in disease states these remodeling and repair functions support, for example, metastasis of cancer by both loosening the matrix around tumors to enable cellular invasion and by affecting proliferation and apoptosis, and they promote degradation of biological restorations by weakening the substrate to which the restoration is attached. |
2017-04-17 |
2023-08-13 |
Not clear |
| Yu-Ping Liu, Chong-Ming Yuan, Shuai-Gong Zhang, Qing-Hai Hao, Ming-Ming Wang, Zhong Zhang, Qian Meng, Ming Li, Yue-Dong Ha. TWEAK/Fn14 signaling: a promising target in intervertebral disc degeneration. Histology and histopathology. vol 31. issue 9. 2017-04-14. PMID:26907852. |
the interaction of tweak with fn14 is involved in physiological and pathological activities of ivd degeneration patients, which includes apoptosis of endplate chondrocytes, extracellular matrix degradation, reduction in proteoglycan synthesis and so on. |
2017-04-14 |
2023-08-13 |
Not clear |
| Patricia L Bustos, Alina E Perrone, Natalia Milduberger, Miriam Postan, Jacqueline Bu. Oxidative stress damage in the protozoan parasite Trypanosoma cruzi is inhibited by Cyclosporin A. Parasitology. vol 142. issue 8. 2017-04-13. PMID:25823521. |
opening of the mptp, which is triggered by high levels of matrix [ca2+] and/or oxidative stress, leads to mitochondrial dysfunction and thus to cell death by either apoptosis or necrosis. |
2017-04-13 |
2023-08-13 |
Not clear |
| Claudia Metz, Remziye Döger, Elizabeth Riquelme, Priscilla Cortés, Christopher Holmes, Ronan Shaughnessy, Claudia Oyanadel, Catalina Grabowski, Alfonso González, Andrea Soz. Galectin-8 promotes migration and proliferation and prevents apoptosis in U87 glioblastoma cells. Biological research. vol 49. issue 1. 2017-04-13. PMID:27459991. |
galectins are unconventionally secreted glycan-binding proteins that modulate processes of cell adhesion, migration, proliferation and apoptosis by interacting with beta-galactosides of cell surface glycoproteins and the extracellular matrix. |
2017-04-13 |
2023-08-13 |
Not clear |