| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Reza Meshkani, Sanaz Vakil. Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications. Clinica chimica acta; international journal of clinical chemistry. vol 462. 2017-02-08. PMID:27570063. |
data from human and animal studies also suggest that macrophages contribute to t2d complications such as nephropathy, neuropathy, retinopathy and cardiovascular diseases through cell-cell interactions and the release of pro-inflammatory cytokines, chemokines, and proteases to induce inflammatory cell recruitment, cell apoptosis, angiogenesis, and matrix protein remodeling. |
2017-02-08 |
2023-08-13 |
human |
| Hongwei Chen, Yun Tia. MiR-15a-5p regulates viability and matrix degradation of human osteoarthritis chondrocytes via targeting VEGFA. Bioscience trends. vol 10. issue 6. 2017-02-08. PMID:27916780. |
functional analysis including cck-8 assay and flow cytometry revealed that overexpression of vegfa or inhibition of mir-15a-5p promoted cell proliferation, suppressed cell apoptosis and reduced matrix degradation in oa chondrocytes. |
2017-02-08 |
2023-08-13 |
human |
| Hongwei Chen, Yun Tia. MiR-15a-5p regulates viability and matrix degradation of human osteoarthritis chondrocytes via targeting VEGFA. Bioscience trends. vol 10. issue 6. 2017-02-08. PMID:27916780. |
moreover, rescue assays carried out with both expression of vegfa and mir-15a-5p demonstrated that mir-15a-5p contributes to cell apoptosis and matrix degradation via inhibiting vegfa. |
2017-02-08 |
2023-08-13 |
human |
| L B Kim, V A Shkurupy, A N Putyatin. Altered Liver Proteoglycan/Glycosaminoglycan Structure as a Manifestation of Extracellular Matrix Remodeling upon BCG-induced Granulomatosis in Mice. Bulletin of experimental biology and medicine. vol 162. issue 3. 2017-02-08. PMID:28091914. |
later, reduced reserve capacity of the extracellular matrix, development of interstitial fibrosis and granuloma fibrosis can lead to trophic shortage for cells within the granulomas, migration of macrophages out of them, and development of spontaneous necrosis and apoptosis typical of tuberculosis. |
2017-02-08 |
2023-08-13 |
mouse |
| Tao Xu, Ying-Hua He, Ming-Quan Wang, Hong-Wei Yao, Ming-Ming Ni, Lei Zhang, Xiao-Ming Meng, Cheng Huang, Yun-Xuan Ge, Jun L. Therapeutic potential of cysteine-rich protein 61 in rheumatoid arthritis. Gene. vol 592. issue 1. 2017-02-06. PMID:27457285. |
moreover, cyr61-sirna decreased the levels of matrix metalloproteinase (mmp)-3 and mmp-13, and induced apoptosis in ra-fls cells. |
2017-02-06 |
2023-08-13 |
Not clear |
| Wen-Kang Chen, Xiao-Hua Yu, Wei Yang, Cheng Wang, Wen-Si He, Yi-Guo Yan, Jian Zhang, Wen-Jun Wan. lncRNAs: novel players in intervertebral disc degeneration and osteoarthritis. Cell proliferation. vol 50. issue 1. 2017-02-06. PMID:27859817. |
moreover, some lncrnas have been shown to be involved in multiple pathological processes during oa, including extracellular matrix (ecm) degradation, inflammatory responses, apoptosis and angiogenesis. |
2017-02-06 |
2023-08-13 |
human |
| Sylvie Ricard-Blum, Frank Gondelau. [Shuttling from the extracellular matrix to the nucleus]. Biologie aujourd'hui. vol 210. issue 1. 2017-01-30. PMID:27286579. |
several enzymes secreted in the extracellular space, such as matrix metalloproteinases and lysyl oxidase, are internalized and translocated to the nucleus, where they may act as proteases and transcription factors to regulate gene expression and enhance apoptosis. |
2017-01-30 |
2023-08-13 |
Not clear |
| Cheng Wang, Xiaohua Yu, Yiguo Yan, Wei Yang, Shujun Zhang, Yongxiao Xiang, Jian Zhang, Wenjun Wan. Tumor necrosis factor-α: a key contributor to intervertebral disc degeneration. Acta biochimica et biophysica Sinica. vol 49. issue 1. 2017-01-30. PMID:27864283. |
tnf-α is highly expressed in degenerative ivd tissues, and it is deeply involved in multiple pathological processes of disc degeneration, including matrix destruction, inflammatory responses, apoptosis, autophagy, and cell proliferation. |
2017-01-30 |
2023-08-13 |
Not clear |
| Pamela Valva, Daniela A Ríos, Elena De Matteo, Maria V Preciad. Chronic hepatitis C virus infection: Serum biomarkers in predicting liver damage. World journal of gastroenterology. vol 22. issue 4. 2017-01-17. PMID:26819506. |
we will discuss: (1) class i serum biomarkers individually and as combined panels, particularly those that mirror the metabolism of liver extracellular matrix turnover and/or fibrogenic cell changes; (2) class ii biomarkers that are indirect serum markers and are based on the evaluation of common functional alterations in the liver; and (3) biomarkers of liver cell death, since hepatocyte apoptosis plays a significant role in the pathogenesis of hcv infection. |
2017-01-17 |
2023-08-13 |
Not clear |
| Naoya Kondo, Takashi Temma, Jun Deguchi, Kohei Sano, Masahiro Ono, Hideo Saj. Development of PEGylated peptide probes conjugated with (18)F-labeled BODIPY for PET/optical imaging of MT1-MMP activity. Journal of controlled release : official journal of the Controlled Release Society. vol 220. issue Pt A. 2017-01-10. PMID:26578437. |
since the processing activity of the matrix metalloproteinase mt1-mmp regulates various cellular functions such as motility, invasion, growth, differentiation and apoptosis, precise in vivo evaluation of mt1-mmp activity in cancers can provide beneficial information for both basic and clinical studies. |
2017-01-10 |
2023-08-13 |
mouse |
| Zhengru Liu, Beibei Chen, Man He, Xing Zhang, Han Wang, Bin H. Application of inductively coupled plasma mass spectrometry in the study of apoptosis: determination of caspase-3 using a gold nanoparticle tag. The Analyst. vol 141. issue 3. 2017-01-09. PMID:26623460. |
this method is easy, sensitive and selective, and has excellent capability of tolerating a complex biological matrix, indicating the potential of the icp-ms-based assay in the study of apoptosis. |
2017-01-09 |
2023-08-13 |
Not clear |
| Jorge U Carmona, Diana L Ríos, Catalina López, María E Álvarez, Jorge E Pérez, Mabel E Bohórque. In vitro effects of platelet-rich gel supernatants on histology and chondrocyte apoptosis scores, hyaluronan release and gene expression of equine cartilage explants challenged with lipopolysaccharide. BMC veterinary research. vol 12. issue 1. 2017-01-09. PMID:27369779. |
the aims were to study the influence of leukocyte- and platelet-rich gel (l-prg) and pure platelet-rich gel (p-prg) supernatants on the histological changes of cartilage, the degree of chondrocyte apoptosis, the production of hyaluronan (ha) and the gene expression of nuclear factor kappa beta (nfkβ), matrix metalloproteinase 13 (mmp-13), a disintegrin and metalloproteinase with thrombospondin motifs 4 (adamts-4), collagen type i alpha 1 (col1a1), collagen type ii alpha 1 (col2a1) and cartilage oligomeric matrix protein (comp) in normal cartilage explants (ces) challenged with lipopolysaccharide (lps). |
2017-01-09 |
2023-08-13 |
Not clear |
| Feng Xu, Feng Gao, Yadong Liu, Zhenyu Wang, Xinming Zhuang, Zhigang Qu, Hui Ma, Yi Liu, Changfeng Fu, Qi Zhang, Xiaoying Dua. Bioinformatics analysis of molecular mechanisms involved in intervertebral disc degeneration induced by TNF-α and IL-1β. Molecular medicine reports. vol 13. issue 3. 2017-01-03. PMID:26847698. |
pathways of apoptosis and extracellular matrix ‑ receptor interaction may have important roles in idd progression. |
2017-01-03 |
2023-08-13 |
Not clear |
| N M Attupuram, A Kumaresan, K Narayanan, H Kuma. Cellular and molecular mechanisms involved in placental separation in the bovine: A review. Molecular reproduction and development. vol 83. issue 4. 2017-01-03. PMID:26970238. |
maturation of the placentome, a gradual and concerted event of late gestation, is likely initiated by the up-regulation of fetal major histocompatibility complex class i in the interplacentomal region-which increases the apoptosis of binucleate and other trophoblastic cells, the degradation of collagen in the extracellular matrix by matrix metalloproteinases, and an influx of phagocytic leukocytes. |
2017-01-03 |
2023-08-13 |
cattle |
| Kai-Xuan Sun, Ying Chen, Shuo Chen, Bo-Liang Liu, Miao-Xiao Feng, Zhi-Hong Zong, Yang Zha. The correlation between microRNA490-3p and TGFα in endometrial carcinoma tumorigenesis and progression. Oncotarget. vol 7. issue 8. 2016-12-30. PMID:26843615. |
mir-490-3p overexpression reduced proliferation; promoted g1 arrest and apoptosis; suppressed migration and invasion; and reduced tgfα, nf-kb, cyclin d1, survivin, matrix metalloproteinase 2 (mmp2) mrna and protein expression, and improved bax mrna and protein expression. |
2016-12-30 |
2023-08-13 |
mouse |
| Peipei Xing, Zhichao Liao, Zhiwu Ren, Jun Zhao, Fengju Song, Guowen Wang, Kexin Chen, Jilong Yan. Roles of low-density lipoprotein receptor-related protein 1 in tumors. Chinese journal of cancer. vol 35. 2016-12-28. PMID:26738504. |
for example, lrp1 not only promotes tumor cell migration and invasion by regulating matrix metalloproteinase (mmp)-2 and mmp-9 expression and functions but also inhibits cell apoptosis by regulating the insulin receptor, the serine/threonine protein kinase signaling pathway, and the expression of caspase-3. |
2016-12-28 |
2023-08-13 |
Not clear |
| Shihong Ma, Wenhua Tan, Botao Du, Wei Liu, Weijia Li, Dehong Che, Guangmei Zhan. Oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression. Molecular medicine reports. vol 13. issue 4. 2016-12-28. PMID:26935490. |
oridonin effectively reverses cisplatin drug resistance in human ovarian cancer cells via induction of cell apoptosis and inhibition of matrix metalloproteinase expression. |
2016-12-28 |
2023-08-13 |
human |
| Yuhui Li, Guoyou Huang, Moxiao Li, Lin Wang, Elliot L Elson, Tian Jian Lu, Guy M Genin, Feng X. An approach to quantifying 3D responses of cells to extreme strain. Scientific reports. vol 6. 2016-12-23. PMID:26887698. |
cellular strain-threshold and saturation behaviors were observed in hydrogel matrix, including strain-dependent proliferation, spreading, polarization, and differentiation, and matrix adhesion retained at strains sufficient for apoptosis. |
2016-12-23 |
2023-08-13 |
Not clear |
| Chalamart Pramchu-em, Kulwara Meksawan, Pithi Chanvorachot. Zinc Sensitizes Lung Cancer Cells to Anoikis through Down-Regulation of Akt and Caveolin-1. Nutrition and cancer. vol 68. issue 2. 2016-12-21. PMID:26928126. |
anoikis is a particular type of apoptosis induced by the loss of cell attachment from extracellular matrix. |
2016-12-21 |
2023-08-13 |
human |
| Bin Xu, Yao-yao Li, Jun Ma, Fu-xing Pe. Roles of microRNA and signaling pathway in osteoarthritis pathogenesis. Journal of Zhejiang University. Science. B. vol 17. issue 3. 2016-12-20. PMID:26984840. |
various signaling pathways play important roles in oa pathogenesis, including genetic expression, matrix synthesis and degradation, cell proliferation, differentiation, apoptosis, and so on. |
2016-12-20 |
2023-08-13 |
Not clear |