| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yael Aschner, Gregory P Downe. Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease. American journal of respiratory cell and molecular biology. vol 54. issue 5. 2017-06-30. PMID:26796672. |
the tgf-β family is responsible for initiation of the intracellular signaling pathways that direct numerous cellular activities including proliferation, differentiation, extracellular matrix synthesis, and apoptosis. |
2017-06-30 |
2023-08-13 |
Not clear |
| Belinda J Thomas, Keiko Kan-O, Kate L Loveland, Jack A Elias, Philip G Bardi. In the Shadow of Fibrosis: Innate Immune Suppression Mediated by Transforming Growth Factor-β. American journal of respiratory cell and molecular biology. vol 55. issue 6. 2017-06-30. PMID:27603223. |
transforming growth factor-β (tgfb) regulates cell proliferation, differentiation, apoptosis, and matrix homeostasis and is intimately involved in fibrosis. |
2017-06-30 |
2023-08-13 |
Not clear |
| Bu-Nam Jeon, Jae-Hyeon Yoon, Min-Kyeong Kim, Won-Il Choi, Dong-In Koh, Benjamin Hur, Kunhong Kim, Kyung-Sup Kim, Man-Wook Hu. Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription. Biochimica et biophysica acta. vol 1859. issue 11. 2017-06-29. PMID:27646874. |
matrix metalloproteinases (mmps) are zinc-containing endopeptidases that play roles in cell proliferation, migration, differentiation, angiogenesis, and apoptosis. |
2017-06-29 |
2023-08-13 |
Not clear |
| Patrick Antonietti, Benedikt Linder, Stephanie Hehlgans, Iris C Mildenberger, Michael C Burger, Simone Fulda, Joachim P Steinbach, Florian Gessler, Franz Rödel, Michel Mittelbronn, Donat Köge. Interference with the HSF1/HSP70/BAG3 Pathway Primes Glioma Cells to Matrix Detachment and BH3 Mimetic-Induced Apoptosis. Molecular cancer therapeutics. vol 16. issue 1. 2017-06-29. PMID:27777286. |
interference with the hsf1/hsp70/bag3 pathway primes glioma cells to matrix detachment and bh3 mimetic-induced apoptosis. |
2017-06-29 |
2023-08-13 |
mouse |
| b' Terezie Pelik\\xc3\\xa1nov\\xc3\\xa. [Diabetic retinopathy: pathogenesis and therapeutic implications]. Vnitrni lekarstvi. vol 62. issue 7-8. 2017-06-26. PMID:27627088.' |
these activated cells change the production pattern of a number of mediators such as growth factors, proinflammatory cytokines, vasoactive molecules, coagulation factors and adhesion molecules resulting in increased blood flow, increased capillary permeability, proliferation of extracellular matrix and thickening of basal membranes, altered cell turnover (apoptosis, proliferation, hypertrophy), procoagulant and proaggregant pattern, and finally in angiogenesis and tissue remodelling. |
2017-06-26 |
2023-08-13 |
Not clear |
| Hong Rye Kim, Jae Eun Lee, Reza Kheirkhahi Oqani, So Yeon Kim, Teruhiko Wakayama, Chong Li, Su Jin Sa, Je Seok Woo, Dong Il Ji. Aberrant Expression of TIMP-2 and PBEF Genes in the Placentae of Cloned Mice Due to Epigenetic Reprogramming Error. PloS one. vol 11. issue 11. 2017-06-26. PMID:27855185. |
cloned placentae showed upregulation of tissue inhibitor of metalloproteinase-2 (timp-2), which is involved in extracellular matrix degradation and tissue remodeling, and downregulation of pre-b cell colony enhancing factor 1 (pbef), which inhibits apoptosis and induces spontaneous labor. |
2017-06-26 |
2023-08-13 |
mouse |
| X Zhang, W-J Huang, W-W Che. TGF-β1 factor in the cerebrovascular diseases of Alzheimer's disease. European review for medical and pharmacological sciences. vol 20. issue 24. 2017-06-26. PMID:28051272. |
however, related to the pathological features of ad, the brain overexpression of tgf-β1 was associated with neuroinflammation, accumulation of extracellular matrix compounds and cerebrovascular stiffness, neuronal apoptosis along with the development of vascular hypertrophy. |
2017-06-26 |
2023-08-13 |
mouse |
| P Siengdee, T Euppayo, K Buddhachat, S Chomdej, K Nganvongpani. Two fluoroquinolones and their combinations with hyaluronan: comparison of effects on canine chondrocyte culture. Journal of veterinary pharmacology and therapeutics. vol 39. issue 5. 2017-06-23. PMID:26969871. |
cell viability, cell apoptosis, s-gag production, and expression patterns of inflammatory, extracellular matrix (ecm) component and protease genes were measured. |
2017-06-23 |
2023-08-13 |
Not clear |
| Fanglong Song, Yi Wang, Dawei Jiang, Tianchen Wang, Yinquan Zhang, Hui Ma, Yifan Kan. Cyclic Compressive Stress Regulates Apoptosis in Rat Osteoblasts: Involvement of PI3K/Akt and JNK MAPK Signaling Pathways. PloS one. vol 11. issue 11. 2017-06-22. PMID:27806136. |
it is widely accepted that physiological mechanical stimulation suppresses apoptosis and induces synthesis of extracellular matrix by osteoblasts; however, the effect of stress overloading on osteoblasts has not been fully illustrated. |
2017-06-22 |
2023-08-13 |
rat |
| Chencheng Feng, Minghui Yang, Minghong Lan, Chang Liu, Yang Zhang, Bo Huang, Huan Liu, Yue Zho. ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration. Oxidative medicine and cellular longevity. vol 2017. 2017-06-21. PMID:28392887. |
they regulate the matrix metabolism, proinflammatory phenotype, apoptosis, autophagy, and senescence of disc cells. |
2017-06-21 |
2023-08-13 |
Not clear |
| E A Braga, M V Fridman, N E Kushlinski. Molecular Mechanisms of Ovarian Carcinoma Metastasis: Key Genes and Regulatory MicroRNAs. Biochemistry. Biokhimiia. vol 82. issue 5. 2017-06-21. PMID:28601063. |
information and data on the genes and regulatory micrornas involved in the formation of cancer stem cells, epithelial-mesenchymal transition, reducing focal adhesion, degradation of extracellular matrix, increasing migration activity of cancer cells, formation of spheroids, apoptosis, autophagy, angiogenesis, formation of metastases, and development of ascites are presented. |
2017-06-21 |
2023-08-13 |
Not clear |
| A Speziali, M Delcogliano, M Tei, G Placella, M Chillemi, R Tiribuzi, G Cerull. Chondropenia: current concept review. Musculoskeletal surgery. vol 99. issue 3. 2017-06-15. PMID:26068954. |
in addition nitric oxide and reactive oxygen species modulate the physiopathology of the condral matrix inducing apoptosis of chondrocytes through a mitochondria-dependent pathway. |
2017-06-15 |
2023-08-13 |
Not clear |
| A Speziali, M Delcogliano, M Tei, G Placella, M Chillemi, R Tiribuzi, G Cerull. Chondropenia: current concept review. Musculoskeletal surgery. vol 99. issue 3. 2017-06-15. PMID:26068954. |
in addition, "lonely death": chondrocytes, are confined within a dense, avascular extracellular matrix capsule, and can trigger a genetically induced apoptosis and necrosis. |
2017-06-15 |
2023-08-13 |
Not clear |
| Renu A Kowluru, Yang Shan, Manish Mishr. Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy. Laboratory investigation; a journal of technical methods and pathology. vol 96. issue 10. 2017-06-12. PMID:27454437. |
diabetes elevates matrix metalloproteinase-9 (mmp-9) in the retina and its capillary cells, and activated mmp-9 damages mitochondria, accelerating retinal capillary cell apoptosis, a phenomenon which precedes the development of retinopathy. |
2017-06-12 |
2023-08-13 |
mouse |
| Shingo Matsushima, Junichi Ishiyam. MicroRNA-29c regulates apoptosis sensitivity via modulation of the cell-surface death receptor, Fas, in lung fibroblasts. American journal of physiology. Lung cellular and molecular physiology. vol 311. issue 6. 2017-06-12. PMID:27765762. |
here, we investigated the role of mir-29, which is the most downregulated microrna in ipf lungs and is also known as a regulator of extracellular matrix (ecm), in the mechanism of apoptosis resistance. |
2017-06-12 |
2023-08-13 |
Not clear |
| Yong Yi, Deshi Chen, Juan Ao, Shengnan Sun, Min Wu, Xiaorong Li, Johann Bergholz, Yujun Zhang, Zhi-Xiong Xia. Metformin Promotes AMP-activated Protein Kinase-independent Suppression of ΔNp63α Protein Expression and Inhibits Cancer Cell Viability. The Journal of biological chemistry. vol 292. issue 13. 2017-06-12. PMID:28193839. |
in this study, we report that, under glucose deprivation, metformin inhibited expression of Δnp63α, a p53 family member involved in cell adhesion pathways, resulting in disruption of cell matrix adhesion and subsequent apoptosis in human squamous carcinoma cells. |
2017-06-12 |
2023-08-13 |
human |
| Xiaofei Cheng, Bin Ni, Feng Zhang, Ying Hu, Jie Zha. High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells. Journal of diabetes research. vol 2016. 2017-06-09. PMID:27635402. |
high glucose-induced oxidative stress mediates apoptosis and extracellular matrix metabolic imbalances possibly via p38 mapk activation in rat nucleus pulposus cells. |
2017-06-09 |
2023-08-13 |
rat |
| Xiaofei Cheng, Bin Ni, Feng Zhang, Ying Hu, Jie Zha. High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells. Journal of diabetes research. vol 2016. 2017-06-09. PMID:27635402. |
to investigate whether high glucose-induced oxidative stress is implicated in apoptosis of rat nucleus pulposus cells (npcs) and abnormal expression of critical genes involved in the metabolic balance of extracellular matrix (ecm). |
2017-06-09 |
2023-08-13 |
rat |
| Jianfei Tang, Qirong Don. Knockdown of TREM-1 suppresses IL-1β-induced chondrocyte injury via inhibiting the NF-κB pathway. Biochemical and biophysical research communications. vol 482. issue 4. 2017-06-06. PMID:27932245. |
knockdown of trem-1 suppressed interleukin 1 beta (il-1β)-induced extracellular matrix (ecm) metabolic imbalance, pro-inflammatory cytokine production, decrease in cell viability and apoptosis. |
2017-06-06 |
2023-08-13 |
mouse |
| Robert F Foronjy, Matthias A Salathe, Abdoulaye J Dabo, Nathalie Baumlin, Neville Cummins, Edward Eden, Patrick Geraght. TLR9 expression is required for the development of cigarette smoke-induced emphysema in mice. American journal of physiology. Lung cellular and molecular physiology. vol 311. issue 1. 2017-05-30. PMID:27288485. |
tlr9 expression also regulated smoke-mediated immune cell recruitment to the lung; apoptosis; expression of granulocyte-colony stimulating factor (g-csf), the cxcl5 protein, and matrix metalloproteinase-2 (mmp-2); and protein tyrosine phosphatase 1b (ptp1b) activity in the lung. |
2017-05-30 |
2023-08-13 |
mouse |