| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinjiang Yang, Ying Lu, Ai Gu. Platelet-rich plasma protects rat chondrocytes from interleukin-1β-induced apoptosis. Molecular medicine reports. vol 14. issue 5. 2017-04-10. PMID:27665780. |
the present study demonstrated the protective effects of prp on chondrocyte apoptosis and extracellular matrix anabolism, and provided scientific evidence to support the potential use of prp as a promising therapeutic strategy for the treatment of arthritis. |
2017-04-10 |
2023-08-13 |
rat |
| Monica Montesi, Katharina Jähn, Lynda Bonewald, Susanna Stea, Barbara Bordini, Alina Beraud. Hypoxia mediates osteocyte ORP150 expression and cell death in vitro. Molecular medicine reports. vol 14. issue 5. 2017-04-10. PMID:27748851. |
hypoxic osteocytes either undergo apoptosis or actively stimulate osteoclasts to remove bone matrix during hypoxia. |
2017-04-10 |
2023-08-13 |
Not clear |
| Shaofeng Wang, Wenhua Li. Paeoniflorin inhibits proliferation and promotes apoptosis of multiple myeloma cells via its effects on microRNA‑29b and matrix metalloproteinase‑2. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27430753. |
paeoniflorin inhibits proliferation and promotes apoptosis of multiple myeloma cells via its effects on microrna‑29b and matrix metalloproteinase‑2. |
2017-04-06 |
2023-08-13 |
Not clear |
| Shaofeng Wang, Wenhua Li. Paeoniflorin inhibits proliferation and promotes apoptosis of multiple myeloma cells via its effects on microRNA‑29b and matrix metalloproteinase‑2. Molecular medicine reports. vol 14. issue 3. 2017-04-06. PMID:27430753. |
the present study aimed to investigate the effects of paeoniflorin on the proliferation and apoptosis of sko‑007 mm cells, via its effects on the regulation of matrix metalloproteinase‑2 (mmp‑2) and microrna (mir)‑29b. |
2017-04-06 |
2023-08-13 |
Not clear |
| Sara Häggblad Sahlberg, Anja C Mortensen, Jakob Haglöf, Mikael K R Engskog, Torbjörn Arvidsson, Curt Pettersson, Bengt Glimelius, Bo Stenerlöw, Marika Nesto. Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells. International journal of oncology. vol 50. issue 1. 2017-04-04. PMID:27878243. |
in conclusion, downregulation of genes in the cell adhesion, extracellular matrix and notch-pathways and upregulation of apoptosis and metastasis inhibitory genes in the p53-pathway, confirm that the knockout of both akt1 and akt2 will attenuate metastasis and tumor cell growth. |
2017-04-04 |
2023-08-13 |
Not clear |
| Hui Liu, Yonghui Dong, Yutong Gao, Zhipeng Du, Yuting Wang, Peng Cheng, Anmin Chen, Hui Huan. The Fascinating Effects of Baicalein on Cancer: A Review. International journal of molecular sciences. vol 17. issue 10. 2017-03-31. PMID:27735841. |
the anti-tumor functions of baicalein are mainly due to its capacities to inhibit complexes of cyclins to regulate the cell cycle, to scavenge oxidative radicals, to attenuate mitogen activated protein kinase (mapk), protein kinase b (akt) or mammalian target of rapamycin (mtor) activities, to induce apoptosis by activating caspase-9/-3 and to inhibit tumorinvasion and metastasis by reducing the expression of matrix metalloproteinase-2/-9 (mmp-2/-9). |
2017-03-31 |
2023-08-13 |
Not clear |
| Xiaorong Qi, Licheng Du, Xiancheng Chen, Lijuan Chen, Tao Yi, Xiang Chen, Yanjun Wen, Yuquan Wei, Xia Zha. VEGF-D-enhanced lymph node metastasis of ovarian cancer is reversed by vesicular stomatitis virus matrix protein. International journal of oncology. vol 49. issue 1. 2017-03-30. PMID:27211072. |
matrix protein (mp) of vesicular stomatitis virus (vsv) exhibits potent antitumor and antiangiogenic activities through inducing apoptosis and inhibiting angiogenesis. |
2017-03-30 |
2023-08-13 |
mouse |
| b' M\\xc3\\xa1ja Polakovi\\xc4\\x8dov\\xc3\\xa1, Peter Musil, Eugen Laczo, Du\\xc5\\xa1an Hamar, J\\xc3\\xa1n Kyselovi\\xc4\\x8. Circulating MicroRNAs as Potential Biomarkers of Exercise Response. International journal of molecular sciences. vol 17. issue 10. 2017-03-29. PMID:27782053.' |
a growing body of evidence suggests that mirnas affect many processes and play a crucial role not only in cell differentiation, proliferation and apoptosis, but also affect extracellular matrix composition and maintaining processes of homeostasis. |
2017-03-29 |
2023-08-13 |
Not clear |
| Cuilan Hou, Wenguang Li, Zengyou Li, Jing Gao, Zhenjie Chen, Xiqiong Zhao, Yaya Yang, Xiaoyu Zhang, Yong Son. Synthetic Isoliquiritigenin Inhibits Human Tongue Squamous Carcinoma Cells through Its Antioxidant Mechanism. Oxidative medicine and cellular longevity. vol 2017. 2017-03-27. PMID:28203317. |
the associated regulatory mechanisms were examined using fcm and fluorescence microscopy for intracellular reactive oxygen species (ros) generation, gelatin zymography assay for matrix metalloproteinase (mmp) activities, and western blot for apoptosis regulatory proteins (bcl-2 and bax). |
2017-03-27 |
2023-08-13 |
human |
| Jeong-Hyeon Ko, Seung Ho Baek, Dongwoo Nam, Won-Seok Chung, Seok-Geun Lee, Junhee Lee, Woong Mo Yang, Jae-Young Um, Kwang Seok Ah. 3-Formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating STAT3 signaling through the induction of PIAS3. Immunopharmacology and immunotoxicology. vol 38. issue 5. 2017-03-21. PMID:27324722. |
3fc also downregulated the expression of stat3-regulated gene products such as bcl-2, bcl-xl, mcl-1, survivin, inhibitor of apoptosis protein-1 (iap-1), cyclin d1, cyclooxygenase-2 (cox-2), and matrix metalloproteinases-9 (mmp-9) in mm cells. |
2017-03-21 |
2023-08-13 |
Not clear |
| Xinran Ji, Yiling Zhang, Lihai Zhang, Hua Chen, Ye Peng, Peifu Tan. Inhibition of p21-Activated Kinase 1 by IPA-3 Promotes Locomotor Recovery After Spinal Cord Injury in Mice. Spine. vol 41. issue 11. 2017-03-20. PMID:26863260. |
expression of matrix metalloproteinase (mmp)-2 and mmp-9, production of tumor necrosis factors (tnf)-α and interleukin (il)-1β, tissue edema, blood-spinal cord barrier penetrability, neural cell apoptosis, and neurological function recovery were measured. |
2017-03-20 |
2023-08-13 |
mouse |
| Concepcion Parrado, Marta Mascaraque, Yolanda Gilaberte, Angeles Juarranz, Salvador Gonzale. Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review. International journal of molecular sciences. vol 17. issue 7. 2017-03-20. PMID:27367679. |
at the cellular level, pl decreases cellular apoptosis and necrosis mediated uv and inhibits abnormal extracellular matrix remodeling. |
2017-03-20 |
2023-08-13 |
Not clear |
| Wenzhou Huang, Peng Ao, Jian Li, Tianlong Wu, Libiao Xu, Zhongbo Deng, Wenjie Chen, Changchang Yin, Xigao Chen. Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes. BioMed research international. vol 2017. 2017-03-09. PMID:28265573. |
the aim of this study is to determine whether autophagy participates in the pathology of age-treated chondrocytes and to investigate the exact role of autophagy in age-induced cell apoptosis and expression of matrix metalloproteinase- (mmp-) 3 and mmp-13. |
2017-03-09 |
2023-08-13 |
rat |
| Fan Zeng, Rui-Jun Ju, Lei Liu, Hong-Jun Xie, Li-Min Mu, Yao Zhao, Yan Yan, Ying-Jie Hu, Jia-Shuan Wu, Wan-Liang L. Application of functional vincristine plus dasatinib liposomes to deletion of vasculogenic mimicry channels in triple-negative breast cancer. Oncotarget. vol 6. issue 34. 2017-03-02. PMID:26429872. |
the liposomes exhibited the superior performances in the following aspects: the enhancement of cellular uptake via targeted action; the induction of apoptosis via activation of caspase 8, 9, and 3, increased expression of bax, decreased expression of mcl-1, and generation of reactive oxygen species (ros); and the deletion of vm channels via inhibitions on the vm channel indicators, which consisted of vascular endothelial-cadherin (ve-cad), focal adhesion kinase (fak), phosphatidylinositide 3-kinase (pi3k), and matrix metallopeptidases (mmp-2, and mmp-9). |
2017-03-02 |
2023-08-13 |
mouse |
| Supawadee Patathananone, Sompong Thammasirirak, Jureerut Daduang, Jing Gung Chung, Yosapong Temsiripong, Sakda Daduan. Inhibition of HeLa cells metastasis by bioactive compounds in crocodile (Crocodylus siamensis) white blood cells extract. Environmental toxicology. vol 31. issue 11. 2017-03-01. PMID:25855086. |
matrix metalloproteinases (mmps) play a key role in cancer progression, including cell invasion, metastasis, cell growth, apoptosis, angiogenesis, and cell adhesion. |
2017-03-01 |
2023-08-13 |
Not clear |
| Lei Dai, Gang Wang, Wensheng Pa. Andrographolide Inhibits Proliferation and Metastasis of SGC7901 Gastric Cancer Cells. BioMed research international. vol 2017. 2017-02-16. PMID:28194420. |
the cell survival ratio, cell migration and invasion, cell cycle, apoptosis, and matrix metalloproteinase activity were assessed. |
2017-02-16 |
2023-08-13 |
Not clear |
| Haoyuan Yin, Ying Shao, Xuan Che. The effects of CD147 on the cell proliferation, apoptosis, invasion, and angiogenesis in glioma. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 38. issue 1. 2017-02-14. PMID:27761842. |
to analyze the effects of extracellular matrix metalloproteinase inducer (cd147) on glioma proliferation, apoptosis, invasion, and angiogenesis. |
2017-02-14 |
2023-08-13 |
human |
| N S Lin'kova, A O Drobintseva, O A Orlova, E P Kuznetsova, V O Polyakova, I M Kvetnoy, V Kh Khavinso. Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro. Bulletin of experimental biology and medicine. vol 161. issue 1. 2017-02-13. PMID:27259496. |
the effect peptides ke, ked, aed and aedg on proliferation (ki-67), regeneration and aging (cd98hc), apoptosis (caspase-3), and extracellular matrix remodeling (mmp-9) in skin fibroblasts during their aging in culture were studied by immunofluorescent confocal microscopy. |
2017-02-13 |
2023-08-13 |
Not clear |
| Wangping Duan, Lei Wei, Xiaoming Cao, Heng Guo, Lei Wang, Yongzhuang Hao, Xiaochun We. Effect of the disruption of three cytoskeleton components on chondrocyte metabolism in rabbit knee cartilage. Chinese medical journal. vol 127. issue 21. 2017-02-10. PMID:25382333. |
the aims of this study were to determine and compare the effects of the disruption of these three cytoskeletal elements on the apoptosis and matrix synthesis by rabbit knee chondrocytes in vitro. |
2017-02-10 |
2023-08-13 |
rabbit |
| Stephen J White, Andrew C Newby, Thomas W Johnso. Endothelial erosion of plaques as a substrate for coronary thrombosis. Thrombosis and haemostasis. vol 115. issue 3. 2017-02-10. PMID:26791872. |
multiple mechanisms may contribute to endothelial erosion, including endothelial dysfunction, tlr signalling, leukocyte activation and modification of sub-endothelial matrix by endothelial or smooth muscle cells, which may trigger loss of adhesion to the extracellular matrix or endothelial apoptosis. |
2017-02-10 |
2023-08-13 |
Not clear |