| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Hu, J H N Yik, D D Cissell, P V Michelier, K A Athanasiou, D R Haudenschil. Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. European cells & materials. vol 30. 2017-09-11. PMID:26859911. |
inhibition of cdk9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. |
2017-09-11 |
2023-08-13 |
cattle |
| Z Hu, J H N Yik, D D Cissell, P V Michelier, K A Athanasiou, D R Haudenschil. Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. European cells & materials. vol 30. 2017-09-11. PMID:26859911. |
cdk9 inhibitor also attenuated chondrocyte apoptosis and reduced cartilage matrix degradation. |
2017-09-11 |
2023-08-13 |
cattle |
| Z Hu, J H N Yik, D D Cissell, P V Michelier, K A Athanasiou, D R Haudenschil. Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants. European cells & materials. vol 30. 2017-09-11. PMID:26859911. |
our results provide a temporal profile connecting the chain of events from mechanical impact, acute injury responses, to the subsequent induction of chondrocyte apoptosis and cartilage matrix deterioration. |
2017-09-11 |
2023-08-13 |
cattle |
| Alessandra Granata, Felipe Serrano, William George Bernard, Madeline McNamara, Lucinda Low, Priya Sastry, Sanjay Sinh. An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death. Nature genetics. vol 49. issue 1. 2017-09-07. PMID:27893734. |
our mfs-hipsc-derived smooth muscle cells (smcs) recapitulated the pathology seen in marfan aortas, including defects in fibrillin-1 accumulation, extracellular matrix degradation, transforming growth factor-β (tgf-β) signaling, contraction and apoptosis; abnormalities were corrected by crispr-based editing of the fbn1 mutation. |
2017-09-07 |
2023-08-13 |
human |
| Shilpa Rani, Pradeep Kumar Sreenivasaiah, Jin Ock Kim, Mi Young Lee, Wan Seok Kang, Yong Sook Kim, Youngkeun Ahn, Woo Jin Park, Chunghee Cho, Do Han Ki. Tauroursodeoxycholic acid (TUDCA) attenuates pressure overload-induced cardiac remodeling by reducing endoplasmic reticulum stress. PloS one. vol 12. issue 4. 2017-09-07. PMID:28426781. |
microarray analysis followed by gene ontology (go) and pathway analysis demonstrated that extracellular matrix genes responsible for hypertrophy and fibrosis, and mitochondrial genes responsible for apoptosis and fatty acid metabolism were significantly altered in the veh-tac group, but the alterations were normalized in the tudca-tac group, suggesting potential of tudca in treatment of heart diseases related to pressure-overload. |
2017-09-07 |
2023-08-13 |
mouse |
| I A Khan, B H Yoo, O Masson, S Baron, D Corkery, G Dellaire, L D Attardi, K V Rose. ErbB2-dependent downregulation of a pro-apoptotic protein Perp is required for oncogenic transformation of breast epithelial cells. Oncogene. vol 35. issue 44. 2017-09-06. PMID:27109096. |
the ability of breast cancer cells to resist anoikis, apoptosis caused by detachment of the non-malignant epithelial cells from the extracellular matrix (ecm), is thought to be critical for breast tumor growth, invasion and metastasis. |
2017-09-06 |
2023-08-13 |
human |
| Amaris A Genemaras, Hayley Ennis, Lee Kaplan, Chun-Yuh Huan. Inflammatory cytokines induce specific time- and concentration-dependent MicroRNA release by chondrocytes, synoviocytes, and meniscus cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 34. issue 5. 2017-09-05. PMID:26505891. |
several micrornas (mirna) have been associated with apoptosis (mir-16), inflammation (mir-22, mir-146a), and matrix degradation (mir-140, mir-27b) in developed oa or its symptoms. |
2017-09-05 |
2023-08-13 |
Not clear |
| Matthew L Fisher, Gautam Adhikary, Dan Grun, David M Kaetzel, Richard L Ecker. The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane. Molecular carcinogenesis. vol 55. issue 12. 2017-09-05. PMID:26693692. |
a375 melanoma cell-derived mcs cells form rapidly growing tumors in immune-compromised mice and sfn treatment of these tumors reduces tumor growth and this is associated with reduced ezh2 level and h3k27me3 formation, reduced matrix metalloproteinase expression, increased timp3 expression and increased apoptosis. |
2017-09-05 |
2023-08-13 |
mouse |
| Gordon A Begg, Arun V Holden, Gregory Y H Lip, Sven Plein, Muzahir H Tayebje. Assessment of atrial fibrosis for the rhythm control of atrial fibrillation. International journal of cardiology. vol 220. 2017-08-28. PMID:27389440. |
fibrosis causes an increase in volume of dysfunctional extracellular matrix, and is associated with cellular alterations such as hypertrophy, apoptosis and membrane dysfunction within the atrial myocardium. |
2017-08-28 |
2023-08-13 |
Not clear |
| Megan N Michalski, Amy J Koh, Savannah Weidner, Hernan Roca, Laurie K McCaule. Modulation of Osteoblastic Cell Efferocytosis by Bone Marrow Macrophages. Journal of cellular biochemistry. vol 117. issue 12. 2017-08-22. PMID:27061191. |
bone formation requires that bone marrow stromal cells (bmscs) differentiate into osteoblasts which direct matrix formation and either become osteocytes, bone lining cells, or undergo apoptosis. |
2017-08-22 |
2023-08-13 |
human |
| Adrian Santos-Ledo, Marina Garcia-Macia, Philip D Campbell, Marta Gronska, Florence L Marlo. Kinesin-1 promotes chondrocyte maintenance during skeletal morphogenesis. PLoS genetics. vol 13. issue 7. 2017-08-22. PMID:28715414. |
further, kif5blof does not activate er stress response genes, but instead disrupts lysosomal function, matrix secretion, and causes deregulated autophagic markers and eventual chondrocyte apoptosis. |
2017-08-22 |
2023-08-13 |
zebrafish |
| Anna Gustafsson, Helena K M Fritz, Björn Dahlbäc. Gas6-Axl signaling in presence of Sunitinib is enhanced, diversified and sustained in renal tumor cells, resulting in tumor-progressive advantages. Experimental cell research. vol 355. issue 1. 2017-08-21. PMID:28327411. |
gas6+sunitinib-adapted ccrcc cells present increased viability and decreased apoptosis and enhanced production of the multi-tumorigenic osteopontin (opn) and of one of its activator matrix metalloproteinase-7. |
2017-08-21 |
2023-08-13 |
Not clear |
| Herbert Tilg, Alexander R Moschen, Gyongyi Szab. Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology (Baltimore, Md.). vol 64. issue 3. 2017-08-02. PMID:26773297. |
this sensitization enhances the production of various proinflammatory cytokines such as interleukin-1 (il-1) and tumor necrosis factor-alpha, thereby contributing to hepatocyte dysfunction, necrosis, and apoptosis and the generation of extracellular matrix proteins leading to fibrosis/cirrhosis. |
2017-08-02 |
2023-08-13 |
Not clear |
| Amanda K Wheaton, Manisha Agarwal, Shijing Jia, Kevin K Ki. Lung epithelial cell focal adhesion kinase signaling inhibits lung injury and fibrosis. American journal of physiology. Lung cellular and molecular physiology. vol 312. issue 5. 2017-07-31. PMID:28283477. |
our studies support a model in which dynamic changes to the extracellular matrix after injury promote fibroblast activation and inhibition of epithelial cell apoptosis in response to tgf-β through fak activation potentially complicating attempts to nonspecifically target this pathway for antifibrotic therapy. |
2017-07-31 |
2023-08-13 |
mouse |
| M E Ridano, A C Racca, J B Flores-Martin, R Fretes, C L Bandeira, L Reyna, E Bevilacqua, S Genti-Raimondi, G M Panzetta-Dutar. Impact of chlorpyrifos on human villous trophoblasts and chorionic villi. Toxicology and applied pharmacology. vol 329. 2017-07-31. PMID:28549829. |
indeed, cpf exposure increased stroma cell apoptosis, altered villi matrix composition, basement membrane thickness, and trophoblastic layer integrity. |
2017-07-31 |
2023-08-13 |
human |
| Mona G Amer, Nehad F Mazen, Ahmed M Mohame. Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: Biochemical and histological study. International journal of immunopathology and pharmacology. vol 30. issue 1. 2017-07-24. PMID:28281876. |
taa induced liver toxicity with elevated liver enzymes and histological alterations, fatty changes, apoptosis, and fibrosis evidenced by increased immunohistochemical reaction to matrix metalloproteinase-9 (mmp-9) and collagen type iv in hepatocytes. |
2017-07-24 |
2023-08-13 |
rat |
| Tsai-Ching Hsu, Chih-Yang Huang, Chung-Hsien Liu, Kuo-Ching Hsu, Yi-Hsing Chen, Bor-Show Tzan. Lactobacillus paracasei GMNL-32, Lactobacillus reuteri GMNL-89 and L. reuteri GMNL-263 ameliorate hepatic injuries in lupus-prone mice. The British journal of nutrition. vol 117. issue 8. 2017-07-24. PMID:28502277. |
the results thus obtained reveal that supplementary gmnl-32, gmnl-89 or gmnl-263 in nzb/w f1 mice ameliorates hepatic apoptosis and inflammatory indicators, such as matrix metalloproteinase-9 activity and c-reactive protein and inducible nitric oxide synthase expressions. |
2017-07-24 |
2023-08-13 |
mouse |
| Ioannis P Tomos, Argyrios Tzouvelekis, Vassilis Aidinis, Effrosyni D Manali, Evangelos Bouros, Demosthenes Bouros, Spyros A Papiri. Extracellular matrix remodeling in idiopathic pulmonary fibrosis. It is the 'bed' that counts and not 'the sleepers'. Expert review of respiratory medicine. vol 11. issue 4. 2017-07-17. PMID:28274188. |
current disease pathogenesis assumes an aberrant wound healing process in response to repetitive injurious stimuli leading to apoptosis of epithelial cells, activation of fibroblasts and accumulation of extracellular matrix (ecm). |
2017-07-17 |
2023-08-13 |
Not clear |
| Shwetha K Shetty, Nivedita Tiwari, Amarnath S Marudamuthu, Bijesh Puthusseri, Yashodhar P Bhandary, Jian Fu, Jeffrey Levin, Steven Idell, Sreerama Shett. p53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis. The American journal of pathology. vol 187. issue 5. 2017-07-11. PMID:28273432. |
alveolar epithelial cell (aec) apoptosis, proliferation, and accumulation of myofibroblasts and extracellular matrix deposition results in progressive loss of lung function in ipf. |
2017-07-11 |
2023-08-13 |
mouse |
| Tae-Wook Chung, Hyunju Choi, Ji-Min Lee, Sun-Hyung Ha, Choong-Hwan Kwak, Fukushi Abekura, Jun-Young Park, Young-Chae Chang, Ki-Tae Ha, Seung-Hak Cho, Hyeun Wook Chang, Young-Choon Lee, Cheorl-Ho Ki. Oldenlandia diffusa suppresses metastatic potential through inhibiting matrix metalloproteinase-9 and intercellular adhesion molecule-1 expression via p38 and ERK1/2 MAPK pathways and induces apoptosis in human breast cancer MCF-7 cells. Journal of ethnopharmacology. vol 195. 2017-07-03. PMID:27876502. |
oldenlandia diffusa suppresses metastatic potential through inhibiting matrix metalloproteinase-9 and intercellular adhesion molecule-1 expression via p38 and erk1/2 mapk pathways and induces apoptosis in human breast cancer mcf-7 cells. |
2017-07-03 |
2023-08-13 |
human |