| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bisher Abuyassin, Mohammad Badran, Najib T Ayas, Ismail Lahe. Intermittent hypoxia causes histological kidney damage and increases growth factor expression in a mouse model of obstructive sleep apnea. PloS one. vol 13. issue 2. 2018-03-13. PMID:29389945. |
we conclude that ih causes kidney injury that is accompanied by glomerular hypertrophy, mesangial matrix expansion, increased expression of glomerular growth factors and an increased cellular apoptosis. |
2018-03-13 |
2023-08-13 |
mouse |
| Alka Jaudan, Sapna Sharma, Sri Nurestri Abd Malek, Aparna Dixi. Induction of apoptosis by pinostrobin in human cervical cancer cells: Possible mechanism of action. PloS one. vol 13. issue 2. 2018-03-13. PMID:29420562. |
condensed nuclei with fragmented chromatin and changes in mitochondrial matrix morphology clearly indicated the role of mitochondria in pn induced apoptosis. |
2018-03-13 |
2023-08-13 |
human |
| Ji Tu, Wentian Li, Yukun Zhang, Xinghuo Wu, Yu Song, Liang Kang, Wei Liu, Kun Wang, Shuai Li, Wenbin Hua, Cao Yan. Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells. Inflammation. vol 40. issue 3. 2018-03-12. PMID:28188410. |
simvastatin inhibits il-1β-induced apoptosis and extracellular matrix degradation by suppressing the nf-kb and mapk pathways in nucleus pulposus cells. |
2018-03-12 |
2023-08-13 |
Not clear |
| Patricia G Tremblay, Marc-André Sirar. Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†. Biology of reproduction. vol 96. issue 4. 2018-03-12. PMID:28383663. |
gene associations with seven major ovarian functions were identified: prostaglandin- endoperoxide synthase 2 (ptgs2), interleukin 8 (il8), and interleukin 6 (il6) with inflammation; steroidogenic acute regulatory protein (star), cytochrome p450scc (cyp11a1), and cytochrome p450 family 19 subfamily a member 1 (cyp19a1) with steroidogenesis; vascular endothelial growth factor c (vegfc), vascular endothelial growth factor a (vegfa), and c-x-c chemokine receptor type 4 (cxcr4) with angiogenesis; amphiregulin (areg), epidermal growth factor receptor (egfr), and sprouty rtk signaling antagonist 2 (spry2) with differentiation, bcl2 associated x (bax), bcl2 like 12 (bcl2l12), and caspase 1(casp1) with apoptosis, cyclin d1 (ccnd1), cyclin b1 (ccnb1), and cyclin b2 (ccnb2) with division; and matrix metalloproteinase-1 (mmp1), matrix metallopeptidase 9 (mmp9), and timp metallopeptidase inhibitor 1 (timp1) with ovulation. |
2018-03-12 |
2023-08-13 |
human |
| L M Sosedova, M A Novikov, E A Titov, V S Rukavishniko. [Induction of apoptosis in neurons of white rats under exposure of nanobiocomposite based on ag (0) nanoparticles and arabinogalactan]. Gigiena i sanitariia. vol 95. issue 12. 2018-03-09. PMID:29446584. |
the evaluation of results of the immunohistochemical study of the nervous tissue of albino rats according to data concerning the proteins caspase-3 and bcl-2 expression permits to make a conclusion about the capability of nanoargentum encapsulated into polymer matrix by passing the blood-brain barrier to induce the triggering apoptosis cascade in neurons of the cerebral cortex. |
2018-03-09 |
2023-08-13 |
rat |
| Xin Zheng, Feng-Chao Zhao, Yong Pang, Dong-Ya Li, Sheng-Cheng Yao, Shao-Song Sun, Kai-Jin Gu. Downregulation of miR-221-3p contributes to IL-1β-induced cartilage degradation by directly targeting the SDF1/CXCR4 signaling pathway. Journal of molecular medicine (Berlin, Germany). vol 95. issue 6. 2018-03-08. PMID:28236026. |
through gain-of-function and loss-of-function studies, mir-221-3p was shown to significantly affect matrix synthesis gene expression and chondrocyte proliferation and apoptosis. |
2018-03-08 |
2023-08-13 |
human |
| Esther L Ashworth Briggs, Tze'Yo Toh, Rajaraman Eri, Alex W Hewitt, Anthony L Coo. Uteroglobin and FLRG concentrations in aqueous humor are associated with age in primary open angle glaucoma patients. BMC ophthalmology. vol 18. issue 1. 2018-03-06. PMID:29482497. |
the pathophysiological changes occurring in the trabecular meshwork in primary open angle glaucoma are poorly understood, but are thought to include increased extracellular matrix deposition, trabecular meshwork cell apoptosis, inflammation, trabecular meshwork calcification and altered protein composition of the aqueous humor. |
2018-03-06 |
2023-08-13 |
Not clear |
| Ignacio Norambuena-Soto, Constanza Núñez-Soto, Fernanda Sanhueza-Olivares, Nicole Cancino-Arenas, David Mondaca-Ruff, Raul Vivar, Guillermo Díaz-Araya, Rosemarie Mellado, Mario Chion. Transforming growth factor-beta and Forkhead box O transcription factors as cardiac fibroblast regulators. Bioscience trends. vol 11. issue 2. 2018-03-05. PMID:28239053. |
in pathological conditions myofibroblasts became resistant to apoptosis, remaining in the tissue, causing excessive extracellular matrix secretion and deposition, which contributes to the progressive tissue remodeling. |
2018-03-05 |
2023-08-13 |
Not clear |
| Jee Y Lee, Won H Na, Hae Y Choi, Kwang H Lee, Bong G Ju, Tae Y Yun. Jmjd3 mediates blood-spinal cord barrier disruption after spinal cord injury by regulating MMP-3 and MMP-9 expressions. Neurobiology of disease. vol 95. 2018-02-27. PMID:27425890. |
the disruption of the blood-spinal cord barrier (bscb) by matrix metalloprotease (mmp) activation is a detrimental event that leads to blood cell infiltration, inflammation, and apoptosis, thereby contributing to permanent neurological disability after spinal cord injury (sci). |
2018-02-27 |
2023-08-13 |
Not clear |
| Bao-Feng Li, Ying Zhang, Jin Xiao, Fei Wang, Mei Li, Xiao-Ze Guo, Hui-Bin Xie, Hong Xia, Bei Che. Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R. Human cell. vol 30. issue 4. 2018-02-27. PMID:28795385. |
hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of mir-193b target gene igf1r. |
2018-02-27 |
2023-08-13 |
Not clear |
| Bao-Feng Li, Ying Zhang, Jin Xiao, Fei Wang, Mei Li, Xiao-Ze Guo, Hui-Bin Xie, Hong Xia, Bei Che. Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R. Human cell. vol 30. issue 4. 2018-02-27. PMID:28795385. |
therefore, hsa_circ_0045714 can regulate extracellular matrix synthesis as well as proliferation and apoptosis of chondrocytes by promoting the expression of mir-193b target gene igf1r. |
2018-02-27 |
2023-08-13 |
Not clear |
| Qi-Zhi Zhang, Yu-Dong Guo, Hao-Mei Li, Rui-Zheng Wang, Shou-Gang Guo, Yi-Feng D. Protection against cerebral infarction by Withaferin A involves inhibition of neuronal apoptosis, activation of PI3K/Akt signaling pathway, and reduced intimal hyperplasia via inhibition of VSMC migration and matrix metalloproteinases. Advances in medical sciences. vol 62. issue 1. 2018-02-23. PMID:28282606. |
protection against cerebral infarction by withaferin a involves inhibition of neuronal apoptosis, activation of pi3k/akt signaling pathway, and reduced intimal hyperplasia via inhibition of vsmc migration and matrix metalloproteinases. |
2018-02-23 |
2023-08-13 |
Not clear |
| Xiao-Qian Guo, Yu-Ling Cao, Fang Hao, Zhong-Rui Yan, Mei-Ling Wang, Xue-Wu Li. Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway. Advances in medical sciences. vol 62. issue 2. 2018-02-23. PMID:28501723. |
tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the pi3k/akt cell survival pathway. |
2018-02-23 |
2023-08-13 |
rat |
| Irene Amigo-Jiménez, Elvira Bailón, Noemí Aguilera-Montilla, José A García-Marco, Angeles García-Pard. Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. vol 7. issue 50. 2018-02-22. PMID:27829220. |
gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. |
2018-02-22 |
2023-08-13 |
Not clear |
| Ling Zhang, Dian He, Kun Li, Hongli Liu, Baitao Wang, Lifang Zheng, Jiazhong L. Emodin targets mitochondrial cyclophilin D to induce apoptosis in HepG2 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-20. PMID:28363167. |
specifically, a mitochondrial matrix protein (cyclophilin d, cypd) is involved in emodin-induced apoptosis, and the inhibitor of cypd (cyclosporin a) could almost completely suppressing the apoptosis; moreover, as the expression of cypd could be effectively inhibited by antioxidant n-acetyl-l-cysteine and epidermal growth factor (the activator of erk), reactive oxygen species and erk might be involved in the relevant role of cypd. |
2018-02-20 |
2023-08-13 |
human |
| Hai-Bin Zhang, Ying Zhang, Cheng Chen, Yu-Qing Li, Chi Ma, Zhao-Jun Wan. Pioglitazone inhibits advanced glycation end product-induced matrix metalloproteinases and apoptosis by suppressing the activation of MAPK and NF-κB. Apoptosis : an international journal on programmed cell death. vol 21. issue 10. 2018-02-13. PMID:27515513. |
pioglitazone inhibits advanced glycation end product-induced matrix metalloproteinases and apoptosis by suppressing the activation of mapk and nf-κb. |
2018-02-13 |
2023-08-13 |
mouse |
| b' Abdoulaye B\\xc3\\xa. Alcohol and thiamine deficiency trigger differential mitochondrial transition pore opening mediating cellular death. Apoptosis : an international journal on programmed cell death. vol 22. issue 6. 2018-02-12. PMID:28417285.' |
this study indicates two different mitochondria pathways regulating cellular death: the first mechanism may engage alcohol which activates the c-subunit ring of the f0-atp synthase to form mpt pore-dependent apoptosis; following the second mechanism, td activates cyp-d translocation from mitochondrial matrix towards the mitochondrial inner membrane to form mpt pore-dependent necrosis. |
2018-02-12 |
2023-08-13 |
Not clear |
| Ahmed M Abu El-Asrar, Ajmal Ahmad, Emilie Bittoun, Mohammad Mairaj Siddiquei, Ghulam Mohammad, Ahmed Mousa, Gert De Hertogh, Ghislain Opdenakke. Differential expression and localization of human tissue inhibitors of metalloproteinases in proliferative diabetic retinopathy. Acta ophthalmologica. vol 96. issue 1. 2018-02-09. PMID:28391660. |
tissue inhibitors of metalloproteinases (timps) block the catalysis by matrix metalloproteinases (mmps) and have additional biologic activities, including regulation of cell growth and differentiation, apoptosis, angiogenesis and oncogenesis. |
2018-02-09 |
2023-08-13 |
human |
| Lara Baticic Pucar, Ester Pernjak Pugel, Dijana Detel, Jadranka Varlje. Involvement of DPP IV/CD26 in cutaneous wound healing process in mice. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 25. issue 1. 2018-02-07. PMID:27868279. |
it has potential influence on different processes crucial for wound healing, including cell adhesion, migration, apoptosis, and extracellular matrix degradation. |
2018-02-07 |
2023-08-13 |
mouse |
| Takashi Kawahara, Satoshi Inoue, Hiroki Ide, Eiji Kashiwagi, Shinji Ohtake, Taichi Mizushima, Peng Li, Yi Li, Yichun Zheng, Hiroji Uemura, George J Netto, Hitoshi Ishiguro, Hiroshi Miyamot. ZKSCAN3 promotes bladder cancer cell proliferation, migration, and invasion. Oncotarget. vol 7. issue 33. 2018-01-30. PMID:27447553. |
zkscan3 silencing via its short hairpin rna (shrna) in umuc3 and 647v resulted in significant decreases in cell viability/colony formation, cell migration/invasion, and the expression of matrix metalloproteinase (mmp)-2/mmp-9 and oncogenes c-myc/fgfr3, as well as significant increases in apoptosis and the expression of tumor suppressor genes p53/pten. |
2018-01-30 |
2023-08-13 |
mouse |