| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Behrendt, A Preusse-Prange, T Klüter, M Haake, B Rolauffs, A J Grodzinsky, S Lippross, B Kur. IL-10 reduces apoptosis and extracellular matrix degradation after injurious compression of mature articular cartilage. Osteoarthritis and cartilage. vol 24. issue 11. 2018-05-01. PMID:27349464. |
il-10 reduces apoptosis and extracellular matrix degradation after injurious compression of mature articular cartilage. |
2018-05-01 |
2023-08-13 |
Not clear |
| Niloofar Farhang, Jonathan M Brunger, Joshua D Stover, Pratiksha I Thakore, Brandon Lawrence, Farshid Guilak, Charles A Gersbach, Lori A Setton, Robby D Bowle. Tissue engineering. Part A. vol 23. issue 15-16. 2018-04-30. PMID:28095751. |
these inflammatory cytokines promote apoptosis and senescence of cells in diseased tissue and extracellular matrix breakdown. |
2018-04-30 |
2023-08-13 |
human |
| Hanliang He, Chunqing Wang, Qifeng Tang, Fan Yang, Youjia X. Elucidation of possible molecular mechanisms underlying the estrogen-induced disruption of cartilage development in zebrafish larvae. Toxicology letters. vol 289. 2018-04-27. PMID:29499231. |
gene ontology functional and kegg pathway enrichment analysis of differentially expressed genes (degs) showed that the extracellular matrix (ecm), extracellular region, ecm-interaction receptor, focal adhesion, cell cycle, apoptosis, and bone-related signaling pathways were disrupted. |
2018-04-27 |
2023-08-13 |
zebrafish |
| Dimitry A Chistiakov, Alexandra A Melnichenko, Veronika A Myasoedova, Andrey V Grechko, Alexander N Orekho. Thrombospondins: A Role in Cardiovascular Disease. International journal of molecular sciences. vol 18. issue 7. 2018-04-26. PMID:28714932. |
tsp1, tsp2, and tsp4 also influence cardiac remodeling by affecting collagen production, activity of matrix metalloproteinases and tgf-β signaling, myofibroblast differentiation, cardiomyocyte apoptosis, and stretch-mediated enhancement of myocardial contraction. |
2018-04-26 |
2023-08-13 |
Not clear |
| Neal L Millar, Moeed Akbar, Abigail L Campbell, James H Reilly, Shauna C Kerr, Michael McLean, Marina Frleta-Gilchrist, Umberto G Fazzi, William J Leach, Brian P Rooney, Lindsay A N Crowe, George A C Murrell, Iain B McInne. IL-17A mediates inflammatory and tissue remodelling events in early human tendinopathy. Scientific reports. vol 6. 2018-04-24. PMID:27263531. |
il-17a treated tenocytes exhibited increased production of proinflammatory cytokines (p < 0.001), altered matrix regulation (p < 0.01) with increased collagen type iii and increased expression of several apoptosis related factors. |
2018-04-24 |
2023-08-13 |
human |
| Yue Yang, Yudong Qiu, Mubai Tang, Zhaoshu Wu, Weidong Hu, Chaobo Che. Expression and function of transforming growth factor‑β‑activated protein kinase 1 in gastric cancer. Molecular medicine reports. vol 16. issue 3. 2018-04-24. PMID:28714004. |
in addition, treatment with the tak1 selective inhibitor oz reduced the proliferation and invasion abilities of mgc803 cells and significantly reduced the expression levels of phosphorylated‑tak1 (thr187), nuclear p65, cyclin d1, bcl‑2 apoptosis regulator and matrix metallopeptidase (mmp)9 (p<0.05). |
2018-04-24 |
2023-08-13 |
human |
| Yeyang Li, Gang Li, Xiao Hu, Weihua Lin, Jingen Sun, Lan Mi, Renkun Wang, Jinlun Wang, Xiaohong Wang, Rixing Zho. Integrin-Linked Kinase Senses Hypoxia During Scar Angiogenesis. The international journal of lower extremity wounds. vol 15. issue 4. 2018-04-18. PMID:27230895. |
integrin-linked kinase (ilk) mediates signal transduction between cells and the extracellular matrix, regulating cell proliferation, migration, angiogenesis, and apoptosis. |
2018-04-18 |
2023-08-13 |
human |
| Kodandaram Sumalatha, Mohan Gowda, Sreepriya Meenakshisundara. ROS-mediated induction of apoptosis by benzoquinone embelin in human colon adenocarcinoma cells HT-29. Journal of complementary & integrative medicine. vol 14. issue 2. 2018-04-18. PMID:28306533. |
influence of embelin on the expression of genes regulating apoptosis (caspase 3 and 9, bcl-2, bax, cytochrome c and x-linked inhibitor of apoptosis protein) and migration/invasion (matrix metalloproteinase [mmp]-2 and mmp-9) was investigated by reverse transcription polymerase chain reaction (pcr). |
2018-04-18 |
2023-08-13 |
human |
| Mays Merjaneh, Amélie Langlois, Sébastien Larochelle, Chanel Beaudoin Cloutier, Sylvie Ricard-Blum, Véronique J Mouli. Pro-angiogenic capacities of microvesicles produced by skin wound myofibroblasts. Angiogenesis. vol 20. issue 3. 2018-04-18. PMID:28391377. |
using the david database, clusters of proteins involved in cell motion, apoptosis and adhesion, but also in extracellular matrix production (21 proteins, enrichment score: 3.32) and in blood vessel development/angiogenesis (19 proteins, enrichment score: 2.66) were identified. |
2018-04-18 |
2023-08-13 |
human |
| Kai-Yen Peng, Yuan-Hung Liu, Yu-Wei Li, Betty Linju Yen, Men-Luh Ye. Extracellular matrix protein laminin enhances mesenchymal stem cell (MSC) paracrine function through αvβ3/CD61 integrin to reduce cardiomyocyte apoptosis. Journal of cellular and molecular medicine. vol 21. issue 8. 2018-04-17. PMID:28600799. |
extracellular matrix protein laminin enhances mesenchymal stem cell (msc) paracrine function through αvβ3/cd61 integrin to reduce cardiomyocyte apoptosis. |
2018-04-17 |
2023-08-13 |
human |
| Kai-Yen Peng, Yuan-Hung Liu, Yu-Wei Li, Betty Linju Yen, Men-Luh Ye. Extracellular matrix protein laminin enhances mesenchymal stem cell (MSC) paracrine function through αvβ3/CD61 integrin to reduce cardiomyocyte apoptosis. Journal of cellular and molecular medicine. vol 21. issue 8. 2018-04-17. PMID:28600799. |
moreover, culturing pdmcs on plates coated with laminin, an extracellular matrix (ecm) protein, resulted in significantly enhanced secretion of all three paracrine factors, which further reduced cardiomyocyte apoptosis. |
2018-04-17 |
2023-08-13 |
human |
| Kar Lai Pang, Matthew Parnall, Siobhan Loughn. Effect of altered haemodynamics on the developing mitral valve in chick embryonic heart. Journal of molecular and cellular cardiology. vol 108. 2018-04-11. PMID:28576718. |
a decrease in apoptosis, and aberrant expression of a shear stress responsive gene and extracellular matrix markers in the endocardial cushions were seen in the chick hh29 outflow tract banded hearts. |
2018-04-11 |
2023-08-13 |
chicken |
| Sulsal Haque, John C Morri. Transforming growth factor-β: A therapeutic target for cancer. Human vaccines & immunotherapeutics. vol 13. issue 8. 2018-04-09. PMID:28575585. |
transforming growth factor-β (tgf-β) regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and cellular immunity. |
2018-04-09 |
2023-08-13 |
Not clear |
| Anne Nègre-Salvayre, Sandra Garoby-Salom, Audrey Swiader, Myriam Rouahi, Mélanie Pucelle, Robert Salvayr. Proatherogenic effects of 4-hydroxynonenal. Free radical biology & medicine. vol 111. 2018-04-03. PMID:28040472. |
among a variety of cellular targets, hne can modify signaling proteins involved in atherosclerotic plaque remodeling, particularly growth factor receptors (pdgfr, egfr), cell cycle proteins, mitochondrial and endoplasmic reticulum components or extracellular matrix proteins, which progressively alters smooth muscle cell proliferation, angiogenesis and induces apoptosis. |
2018-04-03 |
2023-08-13 |
Not clear |
| Liang Kang, Cao Yang, Yu Song, Kangcheng Zhao, Wei Liu, Wenbin Hua, Kun Wang, Ji Tu, Shuai Li, Huipeng Yin, Yukun Zhan. MicroRNA-494 promotes apoptosis and extracellular matrix degradation in degenerative human nucleus pulposus cells. Oncotarget. vol 8. issue 17. 2018-04-03. PMID:28427186. |
microrna-494 promotes apoptosis and extracellular matrix degradation in degenerative human nucleus pulposus cells. |
2018-04-03 |
2023-08-13 |
human |
| Xiaorong Mao, Senrong Du, Zhongxia Yang, Liting Zhang, Xuebin Peng, Ni Jiang, Haiyu Zho. Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28498459. |
flow cytometry was used to detect the apoptosis of hepg2 cells, western blot analysis was used to detect the protein expression of casepase‑3, casepase‑8, b‑cell lymphoma 2 (bcl‑2)‑associated x protein (bax), bcl‑2, phosphatase and tensin homolog (pten), tissue inhibitor of metalloproteinase (timp) 3 and matrix metalloprotease (mmp) 3. |
2018-03-26 |
2023-08-13 |
Not clear |
| Dong-Sheng He, Xiao-Jian Hu, Yi-Qi Yan, Hui Li. Underlying mechanism of Sirt1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28586000. |
underlying mechanism of sirt1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes. |
2018-03-26 |
2023-08-13 |
Not clear |
| Dong-Sheng He, Xiao-Jian Hu, Yi-Qi Yan, Hui Li. Underlying mechanism of Sirt1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28586000. |
the study investigated the effects and underlying mechanisms of silent information regulation of transcription 1 (sirt1) action on apoptosis in chondrocytes and degradation of the extracellular matrix. |
2018-03-26 |
2023-08-13 |
Not clear |
| Dong-Sheng He, Xiao-Jian Hu, Yi-Qi Yan, Hui Li. Underlying mechanism of Sirt1 on apoptosis and extracellular matrix degradation of osteoarthritis chondrocytes. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28586000. |
in conclusion, upregulation of sirt1 expression may inhibit oa chondrocyte apoptosis and extracellular matrix degradation by increasing bcl‑2 expression and decreasing bax, mmp1 and mmp13 expression, via downregulation of p38, jnk and erk phosphorylation. |
2018-03-26 |
2023-08-13 |
Not clear |
| Di Wu, Chao Zheng, Ji Wu, Rongrong Huang, Xuanyu Chen, Tong Zhang, Lili Zhan. Molecular Biological Effects of Weightlessness and Hypergravity on Intervertebral Disc Degeneration. Aerospace medicine and human performance. vol 88. issue 12. 2018-03-19. PMID:29157342. |
extracellular matrix (ecm) destruction and apoptosis of intervertebral disc cells are major characteristics of ivdd. |
2018-03-19 |
2023-08-13 |
Not clear |