| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jason M Knight, Eunji Kim, Ivan Ivanov, Laurie A Davidson, Jennifer S Goldsby, Meredith A J Hullar, Timothy W Randolph, Andrew M Kaz, Lisa Levy, Johanna W Lampe, Robert S Chapki. Comprehensive site-specific whole genome profiling of stromal and epithelial colonic gene signatures in human sigmoid colon and rectal tissue. Physiological genomics. vol 48. issue 9. 2018-01-25. PMID:27401218. |
for example, consistent with a key role of stroma in the crypt niche, mrnas associated with immunoregulatory and inflammatory processes (i.e., cxcl14, antxr1), smooth muscle contraction (cald1), proliferation and apoptosis (glp2r, igfbp3), and modulation of extracellular matrix (mmp2, col3a1, mfap4) were all highly expressed in the stroma. |
2018-01-25 |
2023-08-13 |
human |
| Chen Liu, Chaoyu Mu, Zeng Li, Liang X. Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1. Molecular medicine reports. vol 15. issue 5. 2018-01-22. PMID:28350086. |
mtt assays, western blotting, wound healing assay and matrigel invasion assays revealed that imazamethabenz induced apoptosis and inhibited migration and invasion of the breast cancer cell line mcf‑7, which overexpresses pin1, by inhibiting the pin1‑mediated signaling pathway involving vascular endothelial growth factor and matrix metalloproteinase 9. |
2018-01-22 |
2023-08-13 |
human |
| Y Qin, Y Wang, O Liu, L Jia, W Fang, J Du, Y We. Tauroursodeoxycholic Acid Attenuates Angiotensin II Induced Abdominal Aortic Aneurysm Formation in Apolipoprotein E-deficient Mice by Inhibiting Endoplasmic Reticulum Stress. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. vol 53. issue 3. 2018-01-16. PMID:27889204. |
abdominal aortic aneurysm (aaa) is characterised by the infiltration of smooth muscle cell (smc) apoptosis, inflammatory cells, neovascularisation, and degradation of the extracellular matrix. |
2018-01-16 |
2023-08-13 |
mouse |
| Tomoko Hirakawa, Kaei Nasu, Wakana Abe, Yoko Aoyagi, Mamiko Okamoto, Kentaro Kai, Kanetoshi Takebayashi, Hisashi Narahar. miR-503, a microRNA epigenetically repressed in endometriosis, induces apoptosis and cell-cycle arrest and inhibits cell proliferation, angiogenesis, and contractility of human ovarian endometriotic stromal cells. Human reproduction (Oxford, England). vol 31. issue 11. 2018-01-12. PMID:27619772. |
summary answer: mir-503 expression is downregulated in ecscs by dna hypermethylation and this contributes to their proliferation, resistance to apoptosis, extracellular matrix (ecm) contractility and angiogenesis through effects on cyclin d1, b-cell lymphoma/leukemia (bcl)-2, ras homology a and vascular endothelial growth factor a (vegf-a). |
2018-01-12 |
2023-08-13 |
human |
| Shaohua Li, Yanmei Qi, Karen McKee, Jie Liu, June Hsu, Peter D Yurchenc. Integrin and dystroglycan compensate each other to mediate laminin-dependent basement membrane assembly and epiblast polarization. Matrix biology : journal of the International Society for Matrix Biology. vol 57-58. 2018-01-05. PMID:27449702. |
finally, ebs that cannot assemble a matrix undergo apoptosis. |
2018-01-05 |
2023-08-13 |
Not clear |
| Xiaobin Wang, Guohua Lv, Jing Li, Bing Wang, Qianshi Zhang, Chang L. LncRNA-RP11-296A18.3/miR-138/HIF1A Pathway Regulates the Proliferation ECM Synthesis of Human Nucleus Pulposus Cells (HNPCs). Journal of cellular biochemistry. vol 118. issue 12. 2018-01-02. PMID:28543639. |
during the process of intervertebral disc degeneration (idd), nucleus pulposus apoptosis increases, extracellular matrix (ecm) alters and/or degrades, abnormal proliferation of cells forms cell clusters, and the expression of various inflammatory factors increases. |
2018-01-02 |
2023-08-13 |
human |
| Arul J Duraisamy, Manish Mishra, Renu A Kowlur. Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes. Investigative ophthalmology & visual science. vol 58. issue 14. 2017-12-29. PMID:29261844. |
diabetes activates matrix metalloproteinase-9 (mmp-9), and mmp-9 via damaging retinal mitochondria, activates capillary cell apoptosis. |
2017-12-29 |
2023-08-13 |
Not clear |
| Shuai Li, Yuling Mao, Ti Zhou, Chuanghua Luo, Jinye Xie, Weiwei Qi, Zhonghan Yang, JianXing Ma, Guoquan Gao, Xia Yan. Manganese superoxide dismutase mediates anoikis resistance and tumor metastasis in nasopharyngeal carcinoma. Oncotarget. vol 7. issue 22. 2017-12-26. PMID:27083052. |
metastatic cancer cells are able to survive the loss of attachment to the extracellular matrix (ecm) by developing resistance to anoikis, a specialized form of apoptosis. |
2017-12-26 |
2023-08-13 |
Not clear |
| Lucio Díaz-Flores, Ricardo Gutiérrez, Lucio Díaz-Flores, Miriam González Goméz, Francisco J Sáez, Juan F Madri. Behaviour of telocytes during physiopathological activation. Seminars in cell & developmental biology. vol 55. 2017-12-22. PMID:26826526. |
these cells are involved in organisation and control of the extracellular matrix, structural support, creation of microenvironments, intercellular communication, neurotransmission, immunomodulation and immunosurveillance, inhibition of apoptosis, and control, regulation and source of other cell types. |
2017-12-22 |
2023-08-13 |
Not clear |
| J S Possomato-Vieira, R A Khali. Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia. Advances in pharmacology (San Diego, Calif.). vol 77. 2017-12-20. PMID:27451103. |
in search for the upstream mechanisms that could cause endothelial dysfunction, certain genetic, demographic, and environmental risk factors have been suggested to cause abnormal expression of uteroplacental integrins, cytokines, and matrix metalloproteinases, leading to decreased maternal tolerance, apoptosis of invasive trophoblast cells, inadequate spiral arteries remodeling, reduced uterine perfusion pressure (rupp), and placental ischemia/hypoxia. |
2017-12-20 |
2023-08-13 |
Not clear |
| Wei-Hung Wang, Ting-Han Chien, Sabrina Mai-Yi Fan, Wen-Yen Huang, Shih-Fan Lai, June-Tai Wu, Sung-Jan Li. Activation of mTORC1 Signaling is Required for Timely Hair Follicle Regeneration from Radiation Injury. Radiation research. vol 188. issue 6. 2017-12-18. PMID:29019741. |
inhibition of mtorc1 by rapamycin treatment increased radiation-induced cell apoptosis, reduced cell proliferation and delayed restoration of wnt signaling in the hair matrix after radiation injury, leading to prolonged dystrophy and hair loss. |
2017-12-18 |
2023-08-13 |
mouse |
| Janne Capra, Sinikka Eskeline. Correlation between E-cadherin interactions, survivin expression, and apoptosis in MDCK and ts-Src MDCK cell culture models. Laboratory investigation; a journal of technical methods and pathology. vol 97. issue 12. 2017-12-14. PMID:28892098. |
we could confirm that inhibition of apoptosis and simultaneous downregulation of survivin in mdck cells required both intact cell-cell junctions, trans-interactions of e-cadherin and soft 3d matrix environment. |
2017-12-14 |
2023-08-13 |
Not clear |
| J Y Peng, K X Gao, H Y Xin, P Han, G Q Zhu, B Y Ca. Molecular cloning, expression analysis, and function of decorin in goat ovarian granulosa cells. Domestic animal endocrinology. vol 57. 2017-12-13. PMID:27565237. |
decorin (dcn), a component of the extracellular matrix (ecm), participates in ecm assembly and influences cell proliferation and apoptosis in many mammalian tissues and cells. |
2017-12-13 |
2023-08-13 |
Not clear |
| S Keisin Wang, Jie Xie, Linden A Green, Robert A McCready, Raghu L Motaganahalli, Andres Fajardo, Clifford C Babbey, Michael P Murph. TSG-6 is highly expressed in human abdominal aortic aneurysms. The Journal of surgical research. vol 220. 2017-12-11. PMID:29180197. |
the formation of abdominal aortic aneurysms (aaa) is characterized by a dominance of proinflammatory forces that result in smooth muscle cell apoptosis, extracellular matrix degradation, and progressive diameter expansion. |
2017-12-11 |
2023-08-13 |
human |
| Guanqing Ou, Dhruv Thakar, Jason C Tung, Yekaterina A Miroshnikova, Christopher C Dufort, Edgar Gutierrez, Alex Groisman, Valerie M Weave. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integrative biology : quantitative biosciences from nano to macro. vol 8. issue 7. 2017-12-04. PMID:27334548. |
the mechanical properties of the extracellular matrix influence cell signaling to regulate key cellular processes, including differentiation, apoptosis, and transformation. |
2017-12-04 |
2023-08-13 |
Not clear |
| Wei Deying, Geng Feng, Liang Shumei, Zhao Hui, Liu Ming, Wang Hongqin. CAF-derived HGF promotes cell proliferation and drug resistance by up-regulating the c-Met/PI3K/Akt and GRP78 signalling in ovarian cancer cells. Bioscience reports. vol 37. issue 2. 2017-12-04. PMID:28258248. |
moreover, hgf in caf matrix attenuated paclitaxel (pac)-caused inhibition of cell proliferation and increase in cell apoptosis through activating c-met/pi3k/akt and grp78 pathways in skov3 and ho-8910 cells. |
2017-12-04 |
2023-08-13 |
human |
| Avinaba Mukherjee, Nilanjan Adhikari, Tarun Jh. A pentanoic acid derivative targeting matrix metalloproteinase-2 (MMP-2) induces apoptosis in a chronic myeloid leukemia cell line. European journal of medicinal chemistry. vol 141. 2017-11-28. PMID:29028530. |
a pentanoic acid derivative targeting matrix metalloproteinase-2 (mmp-2) induces apoptosis in a chronic myeloid leukemia cell line. |
2017-11-28 |
2023-08-13 |
Not clear |
| Victoria E Pedanou, Stéphane Gobeil, Sébastien Tabariès, Tessa M Simone, Lihua Julie Zhu, Peter M Siegel, Michael R Gree. The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L. eLife. vol 5. 2017-11-17. PMID:27472901. |
epithelial cells that lose attachment to the extracellular matrix undergo a specialized form of apoptosis called anoikis. |
2017-11-17 |
2023-08-13 |
mouse |
| Pavel Osmancik, Anna Louckov. Biomarkers of apoptosis, inflammation, and cardiac extracellular matrix remodelling in the prognosis of heart failure. Kardiologia polska. vol 75. issue 4. 2017-11-09. PMID:27747854. |
biomarkers of apoptosis, inflammation, and cardiac extracellular matrix remodelling in the prognosis of heart failure. |
2017-11-09 |
2023-08-13 |
Not clear |
| Erica T Goddard, Ryan C Hill, Travis Nemkov, Angelo D'Alessandro, Kirk C Hansen, Ori Maller, Solange Mongoue-Tchokote, Motomi Mori, Ann H Partridge, Virginia F Borges, Pepper Schedi. The Rodent Liver Undergoes Weaning-Induced Involution and Supports Breast Cancer Metastasis. Cancer discovery. vol 7. issue 2. 2017-11-03. PMID:27974414. |
upon weaning, we observed liver weight loss, hepatocyte apoptosis, extracellular matrix remodeling including deposition of collagen and tenascin-c, and myeloid cell influx, data consistent with weaning-induced liver involution and establishment of a prometastatic microenvironment. |
2017-11-03 |
2023-08-13 |
mouse |