| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adeeb Shehzad, Sajida Parveen, Munibah Qureshi, Fazli Subhan, Young Sup Le. Decursin and decursinol angelate: molecular mechanism and therapeutic potential in inflammatory diseases. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 67. issue 3. 2018-08-29. PMID:29134229. |
decursin and da have shown potential anti-inflammatory activity by modulating growth factors such as vascular endothelial growth factor, transcription factors such as signal transducer and activator of transcription 3 and nuclear factor kappa-light-chain-enhancer of activated b cells, cellular enzymes including matrix metalloproteinases cyclooxygenase, and protein kinases such as extracellular receptor kinase, phosphatidylinositol-3-kinase, and protein kinase c. these compounds have the ability to induce apoptosis by activating pro-apoptotic proteins and the caspase cascade, and reduced the expression of anti-apoptotic proteins such as b-cell lymphoma 2 and b-cell lymphoma-extra-large. |
2018-08-29 |
2023-08-13 |
Not clear |
| Stefan Riwaldt, Monica Monici, Asbjørn Graver Petersen, Uffe Birk Jensen, Katja Evert, Desiré Pantalone, Kirsten Utpatel, Matthias Evert, Markus Wehland, Marcus Krüger, Sascha Kopp, Sofie Frandsen, Thomas Corydon, Jayashree Sahana, Johann Bauer, Ronald Lützenberg, Manfred Infanger, Daniela Grim. Preparation of A Spaceflight: Apoptosis Search in Sutured Wound Healing Models. International journal of molecular sciences. vol 18. issue 12. 2018-08-27. PMID:29207508. |
the overall goal is to test: (i) the viability of tissue specimens; (ii) the gene expression of activators and inhibitors of apoptosis and extracellular matrix components in wound and suture models; and (iii) to design analytical protocols for future tissue specimens after post-spaceflight download. |
2018-08-27 |
2023-08-13 |
cattle |
| Weiheng Wang, Guoying Deng, Yuanyuan Qiu, Xiaodong Huang, Yanhai Xi, Jiangming Yu, Xiangqun Yang, Xiaojian Y. Transplantation of allogenic nucleus pulposus cells attenuates intervertebral disc degeneration by inhibiting apoptosis and increasing migration. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436582. |
the results demonstrated that injection of npcs suppressed ddd by inhibiting apoptosis and increasing extracellular matrix in vivo and in vitro. |
2018-08-27 |
2023-08-13 |
rat |
| Xinghuo Wu, Yu Song, Suyun Li, Xianzhe Liu, Wenbin Hua, Kun Wang, Wei Liu, Shuai Li, Yunkun Zhang, Zengwu Shao, Cao Yan. Pramlintide regulation of extracellular matrix (ECM) and apoptosis through mitochondrial-dependent pathways in human nucleus pulposus cells. International journal of immunopathology and pharmacology. vol 31. 2018-08-20. PMID:29256292. |
pramlintide regulation of extracellular matrix (ecm) and apoptosis through mitochondrial-dependent pathways in human nucleus pulposus cells. |
2018-08-20 |
2023-08-13 |
human |
| Fatemeh Suri, Shahin Yazdani, Elahe Elah. LTBP2 knockdown and oxidative stress affect glaucoma features including TGFβ pathways, ECM genes expression and apoptosis in trabecular meshwork cells. Gene. vol 673. 2018-08-20. PMID:29908281. |
although the etiology of glaucoma is incompletely understood, it is known that the extracellular matrix (ecm) of the trabecular meshwork, oxidative stress, tgfβ signaling pathways, and apoptosis are important components of glaucoma pathogenesis. |
2018-08-20 |
2023-08-13 |
human |
| Lufang Wang, Yanyan Zhao, Qiong Wu, Yifu Guan, Xin W. Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells. Molecular medicine reports. vol 17. issue 3. 2018-08-16. PMID:29363722. |
the expression levels of cyclin‑dependent kinase inhibitor 2b (p15), cyclin d1, cellular tumor antigen p53, apoptosis regulator bcl‑2 (bcl‑2), apoptosis regulator bax (bax), 72 kda type iv collagenase (mmp‑2), matrix metalloproteinase‑9 (mmp‑9), β‑catenin, transcription factor 7 (tcf7), and myc proto‑oncogene protein (c‑myc) were analyzed via western blotting. |
2018-08-16 |
2023-08-13 |
human |
| Yang Yang, Yawei Wang, Meng Zhao, Haobo Jia, Bing Li, Dan Xin. Tormentic acid inhibits IL-1β-induced chondrocyte apoptosis by activating the PI3K/Akt signaling pathway. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328385. |
interleukin-1β (il-1β) accelerates degradation of the cartilage matrix and induces apoptosis of chondrocytes. |
2018-08-14 |
2023-08-13 |
human |
| Yongming Xu, Shujuan Xu, Zhi Gao, Liang Xiao, Fei Xiao, Hongguang Xu, Xiaoling Zhan. Degree of endplate chondrocyte degeneration in different tension regions during mechanical stimulation. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29344659. |
apoptosis was detected by flow cytometry and the mrna and protein expression levels of collagen type ii α1, aggrecan, sry‑box 9 and matrix metalloproteinase 13 were detected by reverse transcription‑quantitative polymerase chain reaction (rt‑qpcr) and western blotting, respectively. |
2018-08-14 |
2023-08-13 |
rat |
| Jelena Milenkovic, Maja Milojkovic, Tatjana Jevtovic Stoimenov, Boris Djindjic, Edita Miljkovi. Mechanisms of plasminogen activator inhibitor 1 action in stromal remodeling and related diseases. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. vol 161. issue 4. 2018-08-13. PMID:29097819. |
however, it is also involved in many physiological processes such as extracellular matrix (ecm) proteolysis and remodeling, cell adhesion, motility, and apoptosis, angiogenesis, etc. |
2018-08-13 |
2023-08-13 |
Not clear |
| Min Chen, Lina Ren, Yanyan Meng, Liye Shi, Ling Chen, Bo Yu, Qianqian Wu, Guoxian Q. The protease inhibitor E64d improves ox-LDL-induced endothelial dysfunction in human aortic endothelial cells. Canadian journal of physiology and pharmacology. vol 96. issue 2. 2018-08-10. PMID:28854341. |
e64d, a cysteine protease inhibitor, blocks the elastolytic activity of cathepsin essential for vascular matrix remodeling and reduces neurovascular endothelial apoptosis. |
2018-08-10 |
2023-08-13 |
human |
| Jian Chen, Yun-Tao Gu, Jun-Jun Xie, Cong-Cong Wu, Jun Xuan, Wei-Jun Guo, Ying-Zhao Yan, Long Chen, Yao-Sen Wu, Xiao-Lei Zhang, Jian Xiao, Xiang-Yang Wan. Gastrodin reduces IL-1β-induced apoptosis, inflammation, and matrix catabolism in osteoarthritis chondrocytes and attenuates rat cartilage degeneration in vivo. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-08. PMID:29101808. |
gastrodin reduces il-1β-induced apoptosis, inflammation, and matrix catabolism in osteoarthritis chondrocytes and attenuates rat cartilage degeneration in vivo. |
2018-08-08 |
2023-08-13 |
rat |
| b' Vesna Stankovi\\xc4\\x87, Vladimir Mihailovi\\xc4\\x87, Slobodanka Mitrovi\\xc4\\x87, Vladimir Juri\\xc5\\xa1i\\xc4\\x8. Protective and therapeutic possibility of medical herbs for liver cirrhosis. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 58. issue 3. 2018-08-07. PMID:29250647.' |
results suggest that mechanisms include reduction of oxidative stress, suppression of the inflammatory and immune response, as well as the inhibition of the activation of hepatic stellate cells (hscs), decreasing extracellular matrix (ecm) deposition and induction of apoptosis, protection of hepatocytes from apoptosis and creating apoptotic bodies, which are phagocytic and activate hscs. |
2018-08-07 |
2023-08-13 |
Not clear |
| Lixia Sun, Yaru Dong, Jing Zhao, Yuan Yin, Bainan Tong, Yajuan Zheng, Hua Xi. NPPB modulates apoptosis, proliferation, migration and extracellular matrix synthesis of conjunctival fibroblasts by inhibiting PI3K/AKT signaling. International journal of molecular medicine. vol 41. issue 3. 2018-08-03. PMID:29286070. |
nppb modulates apoptosis, proliferation, migration and extracellular matrix synthesis of conjunctival fibroblasts by inhibiting pi3k/akt signaling. |
2018-08-03 |
2023-08-13 |
human |
| Agata Karowicz-Bilińska, Urszula Kowalska-Koprek, Dorota Estemberg, Anita Sikora-Szuber. Evaluation of tissue metalloproteinase inhibitor TIMP-1 and Survivin levels during third trimester pregnancy - a preliminary report. Ginekologia polska. vol 88. issue 4. 2018-07-31. PMID:28509321. |
the activity of tissue matrix metaloproteinases can be inhibited by their matrix inhibitors - timp-s. survivin is a member of inhibitor of apoptosis proteins family (iap), that suppresses caspase activation, influences vegf expression and promotes proliferative action of endothelial cells. |
2018-07-31 |
2023-08-13 |
Not clear |
| Bradley K Wacker, Lianxiang Bi, David A Diche. In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium. Journal of visualized experiments : JoVE. issue 135. 2018-07-30. PMID:29782016. |
results obtained with this method include: transgene-related alterations in arterial structure, cellularity, extracellular matrix, or vasomotor function; increases or reductions in arterial inflammation; alterations in vascular cell apoptosis; and progression, retardation, or regression of diseases such as intimal hyperplasia or atherosclerosis. |
2018-07-30 |
2023-08-13 |
human |
| Brad Bolo. Mini-Review: Toxic Tendinopathy. Toxicologic pathology. vol 45. issue 7. 2018-07-24. PMID:28553748. |
the pathogenesis is incompletely understood, but proposed mechanisms include apoptosis of tenoblasts and tenocytes, deficient tenocyte function (leading to abnormal extracellular matrix maintenance and repair as well as disrupted intercellular signaling), and structural disintegration (via a combination of increased expression of lytic enzymes, lessened cholesterol content in cell membranes, and neoangiogenesis within highly ordered tendon tissue). |
2018-07-24 |
2023-08-13 |
Not clear |
| Dimitry A Chistiakov, Veronika A Myasoedova, Alexandra A Melnichenko, Andrey V Grechko, Alexander N Orekho. Calcifying Matrix Vesicles and Atherosclerosis. BioMed research international. vol 2017. 2018-07-20. PMID:29238720. |
in the intima media, calcification starts with apoptosis of vascular smooth muscle cells (vsmcs) and the release of calcifying matrix vesicles with diameter of 0.5-15 |
2018-07-20 |
2023-08-13 |
Not clear |
| M Ito, T Yurube, K Kakutani, K Maeno, T Takada, Y Terashima, Y Kakiuchi, Y Takeoka, S Miyazaki, R Kuroda, K Nishid. Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction. Osteoarthritis and cartilage. vol 25. issue 12. 2018-07-18. PMID:28888905. |
selective interference of mtorc1/raptor protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with akt and autophagy induction. |
2018-07-18 |
2023-08-13 |
human |
| Jun Lu, Ming-Liang Ji, Xue-Jun Zhang, Pei-Liang Shi, Hao Wu, Chen Wang, Hee-Jeong I. MicroRNA-218-5p as a Potential Target for the Treatment of Human Osteoarthritis. Molecular therapy : the journal of the American Society of Gene Therapy. vol 25. issue 12. 2018-07-17. PMID:28919376. |
through gain-of-function and loss-of-function studies, mir-218-5p was shown to significantly affect matrix synthesis gene expression and chondrocyte proliferation and apoptosis. |
2018-07-17 |
2023-08-13 |
mouse |
| Steven E Wilson, Gustavo K Marino, Andre A M Torricelli, Carla S Medeiro. Injury and defective regeneration of the epithelial basement membrane in corneal fibrosis: A paradigm for fibrosis in other organs? Matrix biology : journal of the International Society for Matrix Biology. vol 64. 2018-07-09. PMID:28625845. |
corneal fibrosis may resolve over a period of months to years if the inciting injury is eliminated through keratocyte-facilitated regeneration of normal ebm, ensuing apoptosis of myofibroblasts, and reorganization of disordered extracellular matrix by repopulating keratocytes. |
2018-07-09 |
2023-08-13 |
Not clear |