| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sang-Nee Tan, Sai-Peng Sim, Alan Soo-Beng Kho. Oxidative stress-induced chromosome breaks within the ABL gene: a model for chromosome rearrangement in nasopharyngeal carcinoma. Human genomics. vol 12. issue 1. 2019-01-30. PMID:29914565. |
apoptotic nuclease was found to be associated with nuclear matrix during apoptosis. |
2019-01-30 |
2023-08-13 |
human |
| Sang-Nee Tan, Sai-Peng Sim, Alan Soo-Beng Kho. Oxidative stress-induced chromosome breaks within the ABL gene: a model for chromosome rearrangement in nasopharyngeal carcinoma. Human genomics. vol 12. issue 1. 2019-01-30. PMID:29914565. |
when apoptotic nuclease is associated with nuclear matrix during apoptosis, it potentially cleaves at mar/sar. |
2019-01-30 |
2023-08-13 |
human |
| Shi-Lan Zhang, Xiao Du, Yan-Qiao Chen, Yuan-Sheng Tan, Ling Li. Potential Medication Treatment According to Pathological Mechanisms in Abdominal Aortic Aneurysm. Journal of cardiovascular pharmacology. vol 71. issue 1. 2019-01-28. PMID:28953105. |
there are many potential mechanisms, including inflammation, smooth muscle cell apoptosis, extracellular matrix degradation, oxidative stress, and so on, involving in aaa pathogenesis. |
2019-01-28 |
2023-08-13 |
Not clear |
| Lilian Zhang, Qi Chen, Haoli Wang, Jian Yang, Sunren Shen. Andrographolide mitigates IL‑1β‑induced human nucleus pulposus cells degeneration through the TLR4/MyD88/NF‑κB signaling pathway. Molecular medicine reports. vol 18. issue 6. 2019-01-28. PMID:30365119. |
intervertebral disc degeneration (idd) is a multifactorial disease with few efficacious clinical drugs, which has been demonstrated to be associated with nucleus pulposus (np) cells apoptosis and degeneration of the extracellular matrix (ecm). |
2019-01-28 |
2023-08-13 |
human |
| Lilian Zhang, Qi Chen, Haoli Wang, Jian Yang, Sunren Shen. Andrographolide mitigates IL‑1β‑induced human nucleus pulposus cells degeneration through the TLR4/MyD88/NF‑κB signaling pathway. Molecular medicine reports. vol 18. issue 6. 2019-01-28. PMID:30365119. |
np cells were treated with il‑1β in the absence or presence of ag to investigate the effects on cell viability, cellular apoptosis, production of ecm and matrix metalloproteinase (mmp)‑3, mmp‑9 and mmp‑13, and a disintegrin and metalloproteinase with thrombospondin motifs (adamts)‑4 and adamts‑5. |
2019-01-28 |
2023-08-13 |
human |
| Wan-Zhen Shao, Feng-E Zhang, Sen Wang, Xiong Guo, Cui-Yan W. [The Effect of Disordered Glycometabolism of Kashin-Beck Disease on the Function of Chondrocytes]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 49. issue 2. 2019-01-18. PMID:29737064. |
to reveal the effect of disordered glycometabolism in kashin-beck disease (kbd) chondrocytes,we compared changes in expressions of extracellular matrix components (collagen and aggrecan),apoptosis and oxidative stress under the condition of different concentrations of glucose. |
2019-01-18 |
2023-08-13 |
Not clear |
| Ruzanna Shkhyan, Ben Van Handel, Jacob Bogdanov, Siyoung Lee, Yifan Yu, Mila Scheinberg, Nicholas W Banks, Sean Limfat, Arthur Chernostrik, Carlos Eduardo Franciozi, Mohammad Parvez Alam, Varghese John, Ling Wu, Gabriel B Ferguson, Ali Nsair, Frank A Petrigliano, C Thomas Vangsness, Kanagasabai Vadivel, Paul Bajaj, Liming Wang, Nancy Q Liu, Denis Evseenk. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Annals of the rheumatic diseases. vol 77. issue 5. 2019-01-14. PMID:29436471. |
human adult articular cartilage (ac) has little capacity for repair, and joint surface injuries often result in osteoarthritis (oa), characterised by loss of matrix, hypertrophy and chondrocyte apoptosis. |
2019-01-14 |
2023-08-13 |
mouse |
| Jeong-Min Hong, Jun-Kyu Shin, Jeom-Yong Kim, Min-Jung Jang, Sun-Kyu Park, Jong-Hoon Lee, Jung-Hyo Choi, Sun-Mee Le. BST106 Protects against Cartilage Damage by Inhibition of Apoptosis and Enhancement of Autophagy in Osteoarthritic Rats. Biological & pharmaceutical bulletin. vol 41. issue 8. 2019-01-09. PMID:29794403. |
biochemical parameters for matrix metalloproteinase (mmp), apoptosis, and autophagy were also assessed. |
2019-01-09 |
2023-08-13 |
rat |
| Haixiang Yu, Adam Fellows, Kirsty Foote, Zhaoqing Yang, Nichola Figg, Trevor Littlewood, Martin Bennet. FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13). Arteriosclerosis, thrombosis, and vascular biology. vol 38. issue 3. 2019-01-07. PMID:29326312. |
foxo3a (forkhead transcription factor o subfamily member 3a) links vascular smooth muscle cell apoptosis, matrix breakdown, atherosclerosis, and vascular remodeling through a novel pathway involving mmp13 (matrix metalloproteinase 13). |
2019-01-07 |
2023-08-13 |
human |
| Haixiang Yu, Adam Fellows, Kirsty Foote, Zhaoqing Yang, Nichola Figg, Trevor Littlewood, Martin Bennet. FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13). Arteriosclerosis, thrombosis, and vascular biology. vol 38. issue 3. 2019-01-07. PMID:29326312. |
vascular smooth muscle cell (vsmc) apoptosis accelerates atherosclerosis and promotes breakdown of the extracellular matrix, but the mechanistic links between these 2 processes are unknown. |
2019-01-07 |
2023-08-13 |
human |
| Jiang Chen, Gen-Zhe Liu, Qi Sun, Fan Zhang, Chu-Yin Liu, Lin Yuan, Xue-Qian Zhao, Yong-Jun Wang, Yu-Song Ji. Protective effects of ginsenoside Rg3 on TNF-α-induced human nucleus pulposus cells through inhibiting NF-κB signaling pathway. Life sciences. vol 216. 2019-01-07. PMID:30428306. |
this work aims to evaluate the effect of ginsenoside rg3 on the apoptosis, proliferation, extracellular matrix (ecm) metabolism and oxidative stress-induced damage of human nucleus pulposus cells (npcs) induced by tnf-α. |
2019-01-07 |
2023-08-13 |
human |
| Di Yang, Danjie Zhu, Shaoyu Zhu, Fabo Feng, Chen Gong, Chunmao Chen, Liang Che. 17β-Estradiol/extrogen receptor β alleviates apoptosis and enhances matrix biosynthesis of nucleus pulposus cells through regulating oxidative damage under a high glucose condition. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 107. 2019-01-03. PMID:30257311. |
17β-estradiol/extrogen receptor β alleviates apoptosis and enhances matrix biosynthesis of nucleus pulposus cells through regulating oxidative damage under a high glucose condition. |
2019-01-03 |
2023-08-13 |
Not clear |
| Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikaw. Intracellular and extracellular TGF-β signaling in cancer: some recent topics. Frontiers of medicine. vol 12. issue 4. 2018-12-31. PMID:30043220. |
transforming growth factor (tgf)-β regulates a wide variety of cellular responses, including cell growth arrest, apoptosis, cell differentiation, motility, invasion, extracellular matrix production, tissue fibrosis, angiogenesis, and immune function. |
2018-12-31 |
2023-08-13 |
Not clear |
| Junlin Lv, Siyuan Li, Tingting Wan, Yimeng Yang, Yali Cheng, Rongliang Xu. Inhibition of microRNA-30d attenuates the apoptosis and extracellular matrix degradation of degenerative human nucleus pulposus cells by up-regulating SOX9. Chemico-biological interactions. vol 296. 2018-12-26. PMID:30243741. |
inhibition of microrna-30d attenuates the apoptosis and extracellular matrix degradation of degenerative human nucleus pulposus cells by up-regulating sox9. |
2018-12-26 |
2023-08-13 |
human |
| Junlin Lv, Siyuan Li, Tingting Wan, Yimeng Yang, Yali Cheng, Rongliang Xu. Inhibition of microRNA-30d attenuates the apoptosis and extracellular matrix degradation of degenerative human nucleus pulposus cells by up-regulating SOX9. Chemico-biological interactions. vol 296. 2018-12-26. PMID:30243741. |
the excessive apoptosis and extracellular matrix degradation of nucleus pulposus (np) cells contribute to the initiation of idd. |
2018-12-26 |
2023-08-13 |
human |
| Junlin Lv, Siyuan Li, Tingting Wan, Yimeng Yang, Yali Cheng, Rongliang Xu. Inhibition of microRNA-30d attenuates the apoptosis and extracellular matrix degradation of degenerative human nucleus pulposus cells by up-regulating SOX9. Chemico-biological interactions. vol 296. 2018-12-26. PMID:30243741. |
however, the precise regulatory role of mirnas in np cell apoptosis and extracellular matrix degradation remains largely unknown. |
2018-12-26 |
2023-08-13 |
human |
| Junlin Lv, Siyuan Li, Tingting Wan, Yimeng Yang, Yali Cheng, Rongliang Xu. Inhibition of microRNA-30d attenuates the apoptosis and extracellular matrix degradation of degenerative human nucleus pulposus cells by up-regulating SOX9. Chemico-biological interactions. vol 296. 2018-12-26. PMID:30243741. |
in this study, we aimed to investigate the role of mir-30d in regulating apoptosis and the extracellular matrix degradation of np cells, along with the potential underlying molecular mechanism. |
2018-12-26 |
2023-08-13 |
human |
| Junlin Lv, Siyuan Li, Tingting Wan, Yimeng Yang, Yali Cheng, Rongliang Xu. Inhibition of microRNA-30d attenuates the apoptosis and extracellular matrix degradation of degenerative human nucleus pulposus cells by up-regulating SOX9. Chemico-biological interactions. vol 296. 2018-12-26. PMID:30243741. |
moreover, sirna-mediated silencing of sox9 expression significantly blocked the protective effects of mir-30d inhibition against np cell apoptosis and extracellular matrix degradation. |
2018-12-26 |
2023-08-13 |
human |
| Junlin Lv, Siyuan Li, Tingting Wan, Yimeng Yang, Yali Cheng, Rongliang Xu. Inhibition of microRNA-30d attenuates the apoptosis and extracellular matrix degradation of degenerative human nucleus pulposus cells by up-regulating SOX9. Chemico-biological interactions. vol 296. 2018-12-26. PMID:30243741. |
overall, these results demonstrate that the inhibition of mir-30d attenuates the apoptosis and extracellular matrix degradation of degenerative human np cells by up-regulating sox9, suggesting a potential therapeutic target for idd. |
2018-12-26 |
2023-08-13 |
human |
| Yang Li, Nan Yan. Microarray expression profile analysis of long non-coding RNAs in thoracic aortic aneurysm. The Kaohsiung journal of medical sciences. vol 34. issue 1. 2018-12-24. PMID:29310814. |
through nearby protein-coding gene associated with extracellular matrix (ecm) metabolism and vascular smooth muscle cell (vsmc) apoptosis, 12 up-regulated and 9 down-regulated lncrnas were selected for further analysis. |
2018-12-24 |
2023-08-13 |
Not clear |