| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Chen, Zengming Zheng, Jianle Wang, Chengxuan Tang, Sinan Khor, Jian Chen, Xibang Chen, Zengjie Zhang, Qian Tang, Chenggui Wang, Yiting Lou, Zhouguang Wang, Jian Xiao, Xiangyang Wan. Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model. International journal of biological sciences. vol 14. issue 6. 2019-06-11. PMID:29904282. |
berberine suppresses apoptosis and extracellular matrix (ecm) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model. |
2019-06-11 |
2023-08-13 |
Not clear |
| Yu Chen, Zengming Zheng, Jianle Wang, Chengxuan Tang, Sinan Khor, Jian Chen, Xibang Chen, Zengjie Zhang, Qian Tang, Chenggui Wang, Yiting Lou, Zhouguang Wang, Jian Xiao, Xiangyang Wan. Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model. International journal of biological sciences. vol 14. issue 6. 2019-06-11. PMID:29904282. |
intervertebral disc degeneration (ivdd) is a chronic disease with complicated pathology involving nucleus pulposus (np) cell apoptosis and extracellular matrix (ecm) degradation. |
2019-06-11 |
2023-08-13 |
Not clear |
| Muhammad Imran, Abdur Rauf, Zafar Ali Shah, Farhan Saeed, Ali Imran, Muhammad Umair Arshad, Bashir Ahmad, Sami Bawazeer, Muhammad Atif, Dennis G Peters, Mohammad S Mubara. Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review. Phytotherapy research : PTR. vol 33. issue 2. 2019-06-10. PMID:30402931. |
kaempferol acts through different mechanisms: it induces apoptosis (hela cervical cancer cells), decreases cell viability (g2/m phase), downregulates phosphoinositide 3-kinase (pi3k)/akt (protein kinase b) and human t-cell leukemia/lymphoma virus-i (htlv-i) signaling pathways, suppresses protein expression of epithelial-mesenchymal transition (emt)-related markers including n-cadherin, e-cadherin, slug, and snail, and metastasis-related markers such as matrix metallopeptidase 2 (mmp-2). |
2019-06-10 |
2023-08-13 |
human |
| Shu-Qi Yao, Wei Yi, Rong Liu, Neng-Gui X. [Development of research on mechanisms of electroacupuncture intervention underlying improvement of cerebral ischemia rats in recent five years]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 5. 2019-06-07. PMID:31155874. |
moreover, ea preconditioning also could suppress the expression of pro-apoptosis genes and proteins to relieve apoptosis, regulate activation of microglia, and down-regulate the expression of blood brain barrier integrity-related matrix metalloprotein 9. |
2019-06-07 |
2023-08-13 |
rat |
| Iman Aftab Khan, Byong Hoon Yoo, Michael McPhee, Olivier Masson, Alexi Surette, Kelly Dakin-Hache, Tallal Younis, Gillian Bethune, Kirill V Rose. ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth. Breast cancer research : BCR. vol 20. issue 1. 2019-06-06. PMID:30545388. |
the ability of solid tumor cells to resist anoikis, apoptosis triggered by cell detachment from the extracellular matrix (ecm), is thought to be critical for 3d tumor growth. |
2019-06-06 |
2023-08-13 |
human |
| Kelly Bowlt Blacklock, Zeynep Birand, Deborah Biasoli, Elena Fineberg, Sue Murphy, Debs Flack, Joyce Bass, Stefano Di Palma, Laura Blackwood, Jenny McKay, Trevor Whitbread, Richard Fox, Tom Eve, Stuart Beaver, Mike Starke. Identification of molecular genetic contributants to canine cutaneous mast cell tumour metastasis by global gene expression analysis. PloS one. vol 13. issue 12. 2019-06-06. PMID:30566430. |
dysregulated gene expression may also promote extracellular matrix and base membrane degradation, suppression of cell cycle arrest and apoptosis, and angiogenesis. |
2019-06-06 |
2023-08-13 |
Not clear |
| Christopher R Lattimer, Jawed Fareed, Debra Hoppensteadt, Paula Maia, Daniela Ligi, Ferdinando Mannello, Evi Kalodik. Validation of a Gravitational Model to Study Local Endogenous Biomarkers in Chronic Venous Insufficiency. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. vol 56. issue 6. 2019-05-29. PMID:30181065. |
annexin v (apoptosis) and microparticles (cell membrane debris) were used as markers of cell destruction, with matrix metalloproteinases (mmps) as markers of tissue remodelling. |
2019-05-29 |
2023-08-13 |
Not clear |
| Wei-Ting Chen, Fei-Ting Hsu, Yu-Chang Liu, Cheng-Hsien Chen, Li-Cho Hsu, Song-Shei Li. Fluoxetine Induces Apoptosis through Extrinsic/Intrinsic Pathways and Inhibits ERK/NF-κB-Modulated Anti-Apoptotic and Invasive Potential in Hepatocellular Carcinoma Cells In Vitro. International journal of molecular sciences. vol 20. issue 3. 2019-05-29. PMID:30754643. |
the results demonstrated that fluoxetine significantly reduced cell viability, cell migration/invasion, nf-κb, extracellular signal-regulated kinases (erk) activation, and expression of anti-apoptotic (cellular flice (fadd-like il-1β-converting enzyme)-inhibitory protein (c-flip), myeloid cell leukemia-1 (mcl-1), x-linked inhibitor of apoptosis protein (xaip), and survivin), proliferation (cyclin-d1), angiogenesis (vascular endothelial growth factor (vegf)), and metastasis-associated proteins (matrix metalloproteinase-9 (mmp-9)). |
2019-05-29 |
2023-08-13 |
human |
| Chi Zhang, Weizhong Yu, Chongbo Huang, Qinghe Ding, Chizhang Liang, Le Wang, Zhiqi Hou, Zhiyong Zhan. Chrysin protects human osteoarthritis chondrocytes by inhibiting inflammatory mediator expression via HMGB1 suppression. Molecular medicine reports. vol 19. issue 2. 2019-05-28. PMID:30535473. |
the results demonstrated that ch inhibited cell apoptosis, dose‑dependently reduced matrix metalloproteinase (mmp) 13, collagenase and il‑6 expression, and increased collagen α‑1 (ii) chain (col2a1) expression in human osteoarthritis chondrocytes. |
2019-05-28 |
2023-08-13 |
human |
| Ayse Sahin, Yaprak Engin-Ustun, Aytekin Tokmak, Hasan Sahin, Salim Erkaya, A Seval Ozgu-Erdin. Serum levels of transforming growth factor β1 and C-reactive protein as possible markers of intra uterine insemination outcome. European cytokine network. vol 29. issue 4. 2019-05-28. PMID:30698143. |
transforming growth factor β1 (tgf-β1) plays a role in the modulation of cellular growth, maturation and differentiation, extracellular matrix formation, immunoregulation, and apoptosis. |
2019-05-28 |
2023-08-13 |
human |
| Elena Strekalova, Dmitry Malin, Harisha Rajanala, Vincent L Cryn. Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction. Methods in molecular biology (Clifton, N.J.). vol 1866. 2019-05-27. PMID:30725408. |
multiple cell-based methods are detailed to measure cell viability, cell survival, caspase activity, apoptosis, and matrix detachment-induced cell death (anoikis). |
2019-05-27 |
2023-08-13 |
human |
| Dan Xiong, Wei Hu, Shu-Ting Ye, Yuan-Sheng Ta. Isoliquiritigenin alleviated the Ang II-induced hypertensive renal injury through suppressing inflammation cytokines and oxidative stress-induced apoptosis via Nrf2 and NF-κB pathways. Biochemical and biophysical research communications. vol 506. issue 1. 2019-05-21. PMID:30340829. |
in this study, the protective effects of isl on angiotensin ii (ang ii)- induced apoptosis, inflammation and extracellular matrix production in hk-2 cells were observed and its mechanisms were elucidated. |
2019-05-21 |
2023-08-13 |
Not clear |
| Shireen R Lamandé, John F Batema. Collagen VI disorders: Insights on form and function in the extracellular matrix and beyond. Matrix biology : journal of the International Society for Matrix Biology. vol 71-72. 2019-05-20. PMID:29277723. |
collagen vi deficiency alters extracellular matrix structure and biomechanical properties and leads to increased apoptosis and oxidative stress, decreased autophagy, and impaired muscle regeneration. |
2019-05-20 |
2023-08-13 |
mouse |
| Yi Zhang, Li Zhang, Qiyu Zhang, Weilong Hong, Xiaohua Li. [microRNA-222 regulates proliferation and apoptosis of fibroblasts in hypertrophic scar via matrix metalloproteinase 1]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 46. issue 6. 2019-05-20. PMID:29658663. |
[microrna-222 regulates proliferation and apoptosis of fibroblasts in hypertrophic scar via matrix metalloproteinase 1]. |
2019-05-20 |
2023-08-13 |
Not clear |
| Sneha Dhapare, Hua Li, Masahiro Sakagam. Salvianolic acid B as an anti-emphysema agent II: In vivo reversal activities in two rat models of emphysema. Pulmonary pharmacology & therapeutics. vol 53. 2019-05-20. PMID:30193865. |
functional treadmill exercise endurance; morphological airspace enlargement and alveolar destruction; apoptosis, cell proliferation and tissue matrix proteins; phosphorylated stat3 (pstat3) and vegf expressions; neutrophil accumulation; and lipid peroxidation were determined. |
2019-05-20 |
2023-08-13 |
rat |
| Ling Liu, Li Yang, Hui Chang, Yan-Nan Chen, Feng Zhang, Shuo Feng, Juan Peng, Chen-Chen Ren, Xiao-An Zhan. CP‑31398 attenuates endometrial cancer cell invasion, metastasis and resistance to apoptosis by downregulating MDM2 expression. International journal of oncology. vol 54. issue 3. 2019-05-20. PMID:30628640. |
the expression of p53, p21, bad, bax, b‑cell lymphoma‑2 (bcl‑2), cytochrome c (cyt‑c), caspase‑3, cox‑2, matrix metalloproteinase (mmp)‑2 and mmp‑9 was measured to further confirm the effects of cp‑31398 on cell migration, invasion and apoptosis. |
2019-05-20 |
2023-08-13 |
Not clear |
| Swamy K Tripurani, Yan Wang, Ying-Xin Fan, Massod Rahimi, Lily Wong, Min-Hyung Lee, Matthew F Starost, Jeffrey S Rubin, Gibbes R Johnso. Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development. Molecular biology of the cell. vol 29. issue 22. 2019-05-17. PMID:30188763. |
genetic ablation of egfr in mice resulted in increased mitotic activity in matrix cells, apoptosis in hair follicles, and impaired differentiation of epithelial lineages that form hair. |
2019-05-17 |
2023-08-13 |
mouse |
| Wen-Qi Ma, Xue-Jiao Sun, Ying Wang, Yi Zhu, Xi-Qiong Han, Nai-Feng Li. Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis. Molecular and cellular endocrinology. vol 479. 2019-05-15. PMID:30170182. |
we also observed that overexpression of pyruvate dehydrogenase kinase 4 (pdk4), an important mitochondrial matrix enzyme in cellular energy metabolism, exacerbated β-gp-induced oxidative stress and subsequent apoptosis in vsmcs but that these effects were suppressed by dichloroacetate, a widely reported pdk4 inhibitor. |
2019-05-15 |
2023-08-13 |
Not clear |
| Mahdi Rivandi, Mohammad-Sadegh Khorrami, Hamid Fiuji, Soodabeh Shahidsales, Malihe Hasanzadeh, Mir Hadi Jazayeri, Seyed Mahdi Hassanian, Gordon A Ferns, Nafiseh Saghafi, Amir Ava. The 9p21 locus: A potential therapeutic target and prognostic marker in breast cancer. Journal of cellular physiology. vol 233. issue 7. 2019-05-14. PMID:29240242. |
anril has a post transcriptional modulatory activity, which has been shown to perturb the expression of nearby genes and may play an important role in coordinating tissue remodeling through regulation of cell proliferation, apoptosis, aging, extra-cellular matrix remodeling, and inflammatory response. |
2019-05-14 |
2023-08-13 |
Not clear |
| Cyril Thouverey, Serge Ferrari, Joseph Caverzasi. Selective inhibition of Src family kinases by SU6656 increases bone mass by uncoupling bone formation from resorption in mice. Bone. vol 113. 2019-05-14. PMID:29751129. |
however, it blocked c-fms signaling, osteoclastogenesis and matrix resorption, and induced osteoclast apoptosis in vitro. |
2019-05-14 |
2023-08-13 |
mouse |