| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya-Ju Sung, Ting-Yu Kao, Cheng-Liang Kuo, Chi-Chen Fan, An Ning Cheng, Wei-Cheng Fang, Han-Yu Chou, Yu-Kang Lo, Chung-Hsing Chen, Shih Sheng Jiang, I-Shou Chang, Chun-Hua Hsu, Jin-Ching Lee, Alan Yueh-Luen Le. Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity. Cell death & disease. vol 9. issue 6. 2019-11-05. PMID:29899330. |
here we found that increased lon interacts with p53 in mitochondrial matrix and restrains the apoptosis induced by p53 under oxidative stress by rescuing the loss of mitochondrial membrane potential (Δψm) and the release of cytochrome c and smac/diablo. |
2019-11-05 |
2023-08-13 |
Not clear |
| Yuji Kondo, Jianxin Fu, Hua Wang, Christopher Hoover, J Michael McDaniel, Richard Steet, Debabrata Patra, Jianhua Song, Laura Pollard, Sara Cathey, Tadayuki Yago, Graham Wiley, Susan Macwana, Joel Guthridge, Samuel McGee, Shibo Li, Courtney Griffin, Koichi Furukawa, Judith A James, Changgeng Ruan, Rodger P McEver, Klaas J Wierenga, Patrick M Gaffney, Lijun Xi. Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking. JCI insight. vol 3. issue 14. 2019-11-04. PMID:30046013. |
collectively, these abnormalities lead to apoptosis of chondrocytes and lysosomal enzyme-mediated degradation of the bone matrix. |
2019-11-04 |
2023-08-13 |
mouse |
| Honghui Cao, Cong Wang, Xiang Chen, Jiwei Hou, Zou Xiang, Yi Shen, Xiaodong Ha. Inhibition of Wnt/β-catenin signaling suppresses myofibroblast differentiation of lung resident mesenchymal stem cells and pulmonary fibrosis. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30206265. |
in vivo, icg-001 exerted its lung protective effects after bleomycin treatment through blocking mesenchymal-myofibroblast transition, repressing matrix gene expression, and reducing cell apoptosis. |
2019-10-28 |
2023-08-13 |
Not clear |
| Yang Song, Kang Xu, Can Yu, Lili Dong, Peixing Chen, Yonggang Lv, Martin Y M Chiang, Linhao Li, Wanqian Liu, Li Yan. The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis. Journal of tissue engineering and regenerative medicine. vol 12. issue 3. 2019-10-18. PMID:28599103. |
this study demonstrated that mgf treatment can inhibit the pathological apoptosis of oa chondrocytes and promote the proliferation, migration, and matrix synthesis of the chondrocytes. |
2019-10-18 |
2023-08-13 |
human |
| Amir Tajbakhsh, Mahdi Rivandi, Soheila Abedini, Alireza Pasdar, Amirhossein Sahebka. Regulators and mechanisms of anoikis in triple-negative breast cancer (TNBC): A review. Critical reviews in oncology/hematology. vol 140. 2019-10-17. PMID:31154235. |
anoikis is a type of apoptosis commenced by the detachment of cells from the native extracellular matrix and prohibits the attachment of detached cells to other body organs. |
2019-10-17 |
2023-08-13 |
Not clear |
| Molly M Morgan, Megan K Livingston, Jay W Warrick, Eli M Stanek, Elaine T Alarid, David J Beebe, Brian P Johnso. Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model. Scientific reports. vol 8. issue 1. 2019-10-11. PMID:29740030. |
when the surrounding matrix contained hmfs, the onset and severity of e2-induced ductal hyperplasia was increased due to decreased apoptosis. |
2019-10-11 |
2023-08-13 |
human |
| Qin-de An, Yun-Yun Li, Hong-Xing Zhang, Jun Lu, Xiao-Dong Yu, Qiang Lin, Yin-Gang Zhan. Inhibition of bromodomain-containing protein 4 ameliorates oxidative stress-mediated apoptosis and cartilage matrix degeneration through activation of NF-E2-related factor 2-heme oxygenase-1 signaling in rat chondrocytes. Journal of cellular biochemistry. vol 119. issue 9. 2019-10-08. PMID:29878401. |
inhibition of bromodomain-containing protein 4 ameliorates oxidative stress-mediated apoptosis and cartilage matrix degeneration through activation of nf-e2-related factor 2-heme oxygenase-1 signaling in rat chondrocytes. |
2019-10-08 |
2023-08-13 |
rat |
| Shivam H Patel, Arman Sabbaghi, Chad C Carrol. Streptozotocin-induced diabetes alters transcription of multiple genes necessary for extracellular matrix remodeling in rat patellar tendon. Connective tissue research. vol 59. issue 5. 2019-10-03. PMID:29745261. |
in the present study, we evaluated that impact of stz-induced diabetes on mrna transcripts involved with collagen fibril organization, extracellular matrix (ecm) remodeling, apoptosis, and proliferation. |
2019-10-03 |
2023-08-13 |
rat |
| Yvonne Peck, Li Ting Leom, Pei Fen Patricia Low, Dong-An Wan. Establishment of an in vitro three-dimensional model for cartilage damage in rheumatoid arthritis. Journal of tissue engineering and regenerative medicine. vol 12. issue 1. 2019-10-02. PMID:28079986. |
the activated chondrocytes subsequently displayed aberrant behaviours as seen in a disease state such as increased apoptosis, decreased gene expression for matrix components such as type ii collagen and aggrecan, increased gene expression for tissue-degrading enzymes (mmp-1, -3, -13 and adamts-4, -5), and upregulation of inflammatory mediator gene expression (tnf-α, il-1β, il-6 and ikbkb). |
2019-10-02 |
2023-08-13 |
human |
| Joel S Riley, Giovanni Quarato, Catherine Cloix, Jonathan Lopez, Jim O'Prey, Matthew Pearson, James Chapman, Hiromi Sesaki, Leo M Carlin, João F Passos, Ann P Wheeler, Andrew Oberst, Kevin M Ryan, Stephen Wg Tai. Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. The EMBO journal. vol 37. issue 17. 2019-09-30. PMID:30049712. |
because the mitochondrial inner membrane is thought to remain intact during apoptosis, we sought to address how matrix mtdna could activate the cytosolic cgas-sting signalling pathway. |
2019-09-30 |
2023-08-13 |
Not clear |
| Ming-Yang Chang, Albert C M On. Targeting new cellular disease pathways in autosomal dominant polycystic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 33. issue 8. 2019-09-25. PMID:28992279. |
the classic cellular cystic phenotype includes changes in proliferation, apoptosis, fluid secretion, extracellular matrix and cilia function. |
2019-09-25 |
2023-08-13 |
Not clear |
| Il-Yeong Hwang, Yoon-Seok Youm, Sung-Do Cho, Seung-Won Choi, Mun-Hee Bae, Seon-Jae Park, Han-Wook Ki. Synovial fluid levels of TWEAK and matrix metalloproteinase 1 in patients with osteoarthritis, and associations with disease severity. Journal of orthopaedic surgery (Hong Kong). vol 26. issue 1. 2019-09-23. PMID:29486670. |
this study assessed the levels of soluble tumor necrosis factor-like weak inducer of apoptosis (tweak) and matrix metalloproteinase 1 (mmp-1) in the synovial fluid from osteoarthritic knees to determine their role as well as the relationship between these levels and the severity of osteoarthritis (oa). |
2019-09-23 |
2023-08-13 |
Not clear |
| Ankita Solanki, Lokesh K Bhatt, Thomas P Johnston, Kedar S Prabhavalka. Targeting Matrix Metalloproteinases for Diabetic Retinopathy: The Way Ahead? Current protein & peptide science. vol 20. issue 4. 2019-09-23. PMID:30215334. |
under physiological conditions, mmps cause remodeling of the extracellular matrix in the retina, while under pathological conditions, they induce retinal cell apoptosis. |
2019-09-23 |
2023-08-13 |
Not clear |
| Bo Yuan, James A Broadbent, Jingning Huan, Huizhong Yan. The Effects of Adipose Stem Cell-Conditioned Media on Fibrogenesis of Dermal Fibroblasts Stimulated by Transforming Growth Factor-β1. Journal of burn care & research : official publication of the American Burn Association. vol 39. issue 1. 2019-09-18. PMID:29931303. |
fibroblast proliferation, apoptosis, differentiation and expression of extracellular matrix genes and proteins, type i collagen, and type iii collagen were measured. |
2019-09-18 |
2023-08-13 |
human |
| Luis Granadeiro, Ron P Dirks, Juan B Ortiz-Delgado, Paulo J Gavaia, Carmen Sarasquete, Vincent Laizé, M Leonor Cancela, Ignacio Fernánde. Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner - From molecular mechanisms to environmental concerns. Ecotoxicology and environmental safety. vol 181. 2019-09-18. PMID:31238190. |
gene ontology analysis revealed particular cellular components (cytoplasm, extracellular matrix, lysosome and vacuole), biological processes (mainly amino acid and lipid metabolism and response to stimulus) and pathways (oxidative stress response and apoptosis signaling pathways) being significantly overrepresented in zebrafish embryos upon warfarin exposure. |
2019-09-18 |
2023-08-13 |
human |
| Biao Chen, Kai-Hang Lu, Qu-Bo Ni, Qing-Xian Li, Hui Gao, Hui Wang, Liao-Bin Che. Prenatal nicotine exposure increases osteoarthritis susceptibility in male elderly offspring rats via low-function programming of the TGFβ signaling pathway. Toxicology letters. vol 314. 2019-09-16. PMID:31299270. |
furthermore, the expression of apoptosis factors (caspase-3 and caspase-8), inflammatory factors [interleukin (il)-1, il-6] and matrix degradation enzymes [matrix metalloproteinase (mmp)-3, mmp-13] were also significantly increased. |
2019-09-16 |
2023-08-13 |
rat |
| Biao Chen, Kai-Hang Lu, Qu-Bo Ni, Qing-Xian Li, Hui Gao, Hui Wang, Liao-Bin Che. Prenatal nicotine exposure increases osteoarthritis susceptibility in male elderly offspring rats via low-function programming of the TGFβ signaling pathway. Toxicology letters. vol 314. 2019-09-16. PMID:31299270. |
these results suggested that pne enhanced the susceptibility of oa in male elderly offspring rats by down-regulating tgfβ signaling, which increased articular cartilage local inflammation, matrix degradation, and cell apoptosis. |
2019-09-16 |
2023-08-13 |
rat |
| Daniel M Tremmel, Jon S Odoric. Rebuilding a better home for transplanted islets. Organogenesis. vol 14. issue 4. 2019-09-13. PMID:30252586. |
despite this being an effective treatment, the process of isolating islets from the pancreas requires collagenase digestion which disrupts the islet extracellular matrix (ecm) and activates anoikis-mediated apoptosis. |
2019-09-13 |
2023-08-13 |
human |
| Junjun Liang, Nina Liu, Haibin Xi. Knockdown long non-coding RNA PEG10 inhibits proliferation, migration and invasion of glioma cell line U251 by regulating miR-506. General physiology and biophysics. vol 38. issue 4. 2019-09-11. PMID:31241046. |
the cell proliferation and apoptosis related p16, p53, bcl-2, bax, and pro-/cleaved-caspase-3/9, migration and invasion related-protein: matrix metalloproteinases mmp-2, mmp-9 and vimentin, and raf/mek/erk and jak1/stat3 pathways-related proteins were accessed by western blot. |
2019-09-11 |
2023-08-13 |
human |
| Anca-Narcisa Neag. Proteome Imaging: From Classic to Modern Mass Spectrometry-Based Molecular Histology. Advances in experimental medicine and biology. vol 1140. 2019-09-11. PMID:31347042. |
additionally, in situ proteome imaging may help to elucidate the physiological and pathological mechanisms involved in developmental biology, reproductive research, amyloidogenesis, tumorigenesis, wound healing, neural network regeneration, matrix mineralization, apoptosis and oxidative stress, pain tolerance, cell cycle and transformation under oncogenic stress, tumor heterogeneity, behavior and aggressiveness, drugs bioaccumulation and biotransformation, organism's reaction against environmental penetrating xenobiotics, immune signaling, assessment of integrity and functionality of tissue barriers, behavioral biology, and molecular origins of diseases. |
2019-09-11 |
2023-08-13 |
human |