| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing-Chuan Sun, Bing Zheng, Rong-Xin Sun, Ya-Ke Meng, Shun-Min Wang, Hai-Song Yang, Yu Chen, Jian-Gang Shi, Yong-Fei Gu. MiR-499a-5p suppresses apoptosis of human nucleus pulposus cells and degradation of their extracellular matrix by targeting SOX4. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 113. 2019-07-22. PMID:30856535. |
furthermore, tnf-α-treated npcs showed increased apoptosis and induced an imbalance between anabolism and catabolism of the extracellular matrix (ecm); these changes were attenuated by mir-499a-5p overexpression. |
2019-07-22 |
2023-08-13 |
human |
| Ping Wang, Zunpeng Liu, Xiaoqian Zhang, Jingyi Li, Liang Sun, Zhenyu Ju, Jian Li, Piu Chan, Guang-Hui Liu, Weiqi Zhang, Moshi Song, Jing Q. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells. Protein & cell. vol 9. issue 11. 2019-07-17. PMID:29968158. |
multi-dimensional phenotypic assessments and transcriptomic analyses revealed that rela deficiency affected vascular cells via modulating inflammation, survival, vasculogenesis, cell differentiation and extracellular matrix organization in a cell type-specific manner under basal condition, and that rela protected vascular cells against apoptosis and modulated vascular inflammatory response upon tumor necrosis factor α (tnfα) stimulation. |
2019-07-17 |
2023-08-13 |
human |
| Mei Jing Piao, Kyoung Ah Kang, Ao Xuan Zhen, Hee Kyoung Kang, Young Sang Koh, Bong Seok Kim, Jin Won Hyu. Horse Oil Mitigates Oxidative Damage to Human HaCaT Keratinocytes Caused by Ultraviolet B Irradiation. International journal of molecular sciences. vol 20. issue 6. 2019-07-17. PMID:30934595. |
western blotting showed that horse oil increased the uvb-induced bcl-2/bax ratio, inhibited mitochondria-mediated apoptosis and matrix metalloproteinase expression, and altered mitogen-activated protein kinase signaling-related proteins. |
2019-07-17 |
2023-08-13 |
human |
| Junya Ning, Yi Zhao, Yingnan Ye, Jinpu Y. Opposing roles and potential antagonistic mechanism between TGF-β and BMP pathways: Implications for cancer progression. EBioMedicine. vol 41. 2019-07-12. PMID:30808576. |
the transforming growth factor β (tgf-β) superfamily participates in tumour proliferation, apoptosis, differentiation, migration, invasion, immune evasion and extracellular matrix remodelling. |
2019-07-12 |
2023-08-13 |
Not clear |
| M Trajkovic-Arsic, I Heid, K Steiger, A Gupta, A Fingerle, C Wörner, N Teichmann, S Sengkwawoh-Lueong, P Wenzel, A J Beer, I Esposito, R Braren, J T Sivek. Apparent Diffusion Coefficient (ADC) predicts therapy response in pancreatic ductal adenocarcinoma. Scientific reports. vol 7. issue 1. 2019-07-08. PMID:29213099. |
histopathological analyses showed increased apoptosis and matrix remodeling at this time point. |
2019-07-08 |
2023-08-13 |
mouse |
| S Drevet, G Gavazzi, L Grange, C Dupuy, B Lard. Reactive oxygen species and NADPH oxidase 4 involvement in osteoarthritis. Experimental gerontology. vol 111. 2019-07-08. PMID:30012342. |
age-related advanced glycation end products impact on extra cellular matrix (ecm) properties leading to the apoptosis of chondrocytes. |
2019-07-08 |
2023-08-13 |
Not clear |
| Keith Bre. Reflections on the evolution of the vertebrate tissue inhibitors of metalloproteinases. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 1. 2019-07-08. PMID:30125136. |
jawed vertebrates (gnathostomes) have 4 tissue inhibitors of metalloproteinases (timps), multifunctional proteins that all inhibit members of the large matrix metalloproteinase (mmp) family but differ in their other roles, including the regulation of pro-mmp activation, cell growth, apoptosis and angiogenesis, and the structure of extracellular matrices (ecms). |
2019-07-08 |
2023-08-13 |
Not clear |
| Rezvan Asgari, Kamran Mansouri, Mitra Bakhtiari, Asad Vaisi-Raygan. CD147 as an apoptosis regulator in spermatogenesis: deciphering its association with matrix metalloproteinases' pathway. Molecular biology reports. vol 46. issue 1. 2019-07-05. PMID:30600459. |
cd147 as an apoptosis regulator in spermatogenesis: deciphering its association with matrix metalloproteinases' pathway. |
2019-07-05 |
2023-08-13 |
Not clear |
| Rezvan Asgari, Kamran Mansouri, Mitra Bakhtiari, Asad Vaisi-Raygan. CD147 as an apoptosis regulator in spermatogenesis: deciphering its association with matrix metalloproteinases' pathway. Molecular biology reports. vol 46. issue 1. 2019-07-05. PMID:30600459. |
however, to best of our knowledge, there is no report on the exact role of cd147 gene in the regulation of germ cells apoptosis through matrix metalloproteinases (mmps). |
2019-07-05 |
2023-08-13 |
Not clear |
| Ke Wang, Tingting Chen, Xiaozhou Ying, Zengjie Zhang, Zhenxuan Shao, Jialiang Lin, Tianzhen Xu, Yu Chen, Xiangyang Wang, Jiaoxiang Chen, Sunren Shen. Ligustilide alleviated IL-1β induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo. International immunopharmacology. vol 69. 2019-07-05. PMID:30785069. |
ligustilide alleviated il-1β induced apoptosis and extracellular matrix degradation of nucleus pulposus cells and attenuates intervertebral disc degeneration in vivo. |
2019-07-05 |
2023-08-13 |
rat |
| Kerong Shi, Xue Liu, Honghui Li, Xueyan Lin, Zhengui Yan, Qiaoqiao Cao, Meng Zhao, Zhongjin Xu, Zhonghua Wan. Menin Modulates Mammary Epithelial Cell Numbers in Bovine Mammary Glands Through Cyclin D1. Journal of mammary gland biology and neoplasia. vol 22. issue 4. 2019-07-03. PMID:29188494. |
moreover, lower expression of men1/menin induced increased epithelial cell apoptosis and caused extracellular matrix remodeling by down-regulating its associated genes, such as dsg2 and krt5, suggesting that menin's role may also be involved in the control of cell-cell adhesion in normal mammary glands. |
2019-07-03 |
2023-08-13 |
cattle |
| Haiqing Wang, Fang Wang, Xu Wang, Xuejun Wu, Fei Xu, Kunpeng Wang, Mingjie Xiao, Xing Ji. Friend or Foe: A Cancer Suppressor MicroRNA-34 Potentially Plays an Adverse Role in Vascular Diseases by Regulating Cell Apoptosis and Extracellular Matrix Degradation. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-07-01. PMID:30873956. |
friend or foe: a cancer suppressor microrna-34 potentially plays an adverse role in vascular diseases by regulating cell apoptosis and extracellular matrix degradation. |
2019-07-01 |
2023-08-13 |
human |
| Kang Chen, Hao Zhu, Min-Qian Zheng, Qi-Rong Don. LncRNA MEG3 Inhibits the Degradation of the Extracellular Matrix of Chondrocytes in Osteoarthritis via Targeting miR-93/TGFBR2 Axis. Cartilage. 2019-06-29. PMID:31253047. |
long noncoding rnas (lncrnas) act critical roles in the regulation of oa development, including affecting the proliferation, apoptosis, extracellular matrix (ecm) degradation, and inflammatory response of chondrocytes. |
2019-06-29 |
2023-08-13 |
Not clear |
| Kerstin Nowotny, José Pedro Castro, Martín Hugo, Sabine Braune, Daniela Weber, Marc Pignitter, Veronika Somoza, Julia Bornhorst, Tanja Schwerdtle, Tilman Grun. Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts. Free radical biology & medicine. vol 120. 2019-06-25. PMID:29550330. |
after confirming collagen as a main target for mg modifications in vivo within the extracellular matrix, we show here that mg-collagen disrupts fibroblast redox homeostasis and induces endoplasmic reticulum (er) stress and apoptosis. |
2019-06-25 |
2023-08-13 |
mouse |
| Marzia Dolcino, Andrea Pelosi, Piera Filomena Fiore, Giuseppe Patuzzo, Elisa Tinazzi, Claudio Lunardi, Antonio Puccett. Gene Profiling in Patients with Systemic Sclerosis Reveals the Presence of Oncogenic Gene Signatures. Frontiers in immunology. vol 9. 2019-06-24. PMID:29559981. |
we therefore performed a gene expression profiling of peripheral blood mononuclear cells (pbmcs) derived from patients with limited and diffuse ssc, showing that the various classes of genes potentially linked to the pathogenesis of ssc (such as apoptosis, endothelial cell activation, extracellular matrix remodeling, immune response, and inflammation) include genes that directly participate in the development of malignancies or that are involved in pathways known to be associated with carcinogenesis. |
2019-06-24 |
2023-08-13 |
Not clear |
| Eui-Baek Byun, Hye-Min Kim, Ha-Yeon Song, Woo Sik Ki. Hesperidin structurally modified by gamma irradiation induces apoptosis in murine melanoma B16BL6 cells and inhibits both subcutaneous tumor growth and metastasis in C57BL/6 mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 127. 2019-06-24. PMID:30844437. |
this cytotoxicity was exerted via induction of apoptosis, as reflected by the high population of double-positive cells, increased sub-g1 phase cells, depolarization of matrix metalloproteinase, production of reactive oxygen species, weakness of cell adhesion, changes in cell morphology, and inhibition of b16bl6 cell migration. |
2019-06-24 |
2023-08-13 |
mouse |
| Jie Zhang, Charles N J McGhee, Dipika V Pate. The Molecular Basis of Fuchs' Endothelial Corneal Dystrophy. Molecular diagnosis & therapy. vol 23. issue 1. 2019-06-20. PMID:30607871. |
the proteins encoded by these genes cover a wide range of endothelial function, including transcription regulation, dna repair, mitochondrial dna mutations, targeting of proteins to the cell membrane, deglutamylation of proteins, extracellular matrix secretion, formation of cell-cell and cell-extracellular matrix junctions, water pump, and apoptosis. |
2019-06-20 |
2023-08-13 |
Not clear |
| R C Cornelison, S M Wellman, J H Park, S L Porvasnik, Y H Song, R A Wachs, C E Schmid. Development of an apoptosis-assisted decellularization method for maximal preservation of nerve tissue structure. Acta biomaterialia. vol 77. 2019-06-17. PMID:29981947. |
during apoptosis, a cell detaches from the extracellular matrix, degrades its internal components, and fragments its contents for easier clearance. |
2019-06-17 |
2023-08-13 |
Not clear |
| Menno E Groeneveld, Joyce A Struik, René J P Musters, Geert J Tangelder, Pieter Koolwijk, Hans W Niessen, Arjen W J Hoksbergen, Willem Wisselink, Kak K Yeun. The Potential Role of Neutrophil Gelatinase-Associated Lipocalin in the Development of Abdominal Aortic Aneurysms. Annals of vascular surgery. vol 57. 2019-06-17. PMID:30684630. |
key players in vessel wall degeneration are reactive oxygen species (ros), smooth muscle cell apoptosis, and extracellular matrix degeneration by matrix metalloproteinase-9 (mmp-9). |
2019-06-17 |
2023-08-13 |
Not clear |
| G Vicenti, D Bizzoca, V S Nappi, F Moretti, M Carrozzo, V Belviso, B Morett. Biophysical stimulation of the knee with PEMFs: from bench to bedside. Journal of biological regulators and homeostatic agents. vol 32. issue 6 Suppl. 1. 2019-06-14. PMID:30644277. |
preclinical studies have assessed the effects of pemfs on chondrocytes, synoviocytes, articular cartilage explants and animal models, showing positive effects of pemf-therapy on cells proliferation, extracellular matrix (ecm) production, chondrocytes apoptosis and inflammatory cytokines down-regulation. |
2019-06-14 |
2023-08-13 |
human |