| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeng-Long Hsieh, I-Ming Jou, Chao-Liang Wu, Po-Ting Wu, Ai-Li Shiau, Hao-Earn Chong, Yu-Ting Lo, Po-Chuan Shen, Shih-Yao Che. Estrogen and mechanical loading-related regulation of estrogen receptor-β and apoptosis in tendinopathy. PloS one. vol 13. issue 10. 2019-03-27. PMID:30296306. |
mechanical stress altered the morphology of primary tenocytes and collagen fiber alignment in tendons, and up-regulated the expression of matrix metalloproteinase-9, er-β, and interleukin-1β, as well as induced apoptosis in tenocytes and tendon tissue from ovx rats. |
2019-03-27 |
2023-08-13 |
rat |
| Cheng-Long Xie, Jun-Li Li, En-Xing Xue, Hai-Cheng Dou, Jin-Ti Lin, Kai Chen, Hong-Qiang Wu, Long Wu, Jun Xuan, Qi-Shan Huan. Vitexin alleviates ER-stress-activated apoptosis and the related inflammation in chondrocytes and inhibits the degeneration of cartilage in rats. Food & function. vol 9. issue 11. 2019-03-20. PMID:30321247. |
excessive extracellular matrix degradation and chondrocyte apoptosis are the pathological features of osteoarthritis (oa). |
2019-03-20 |
2023-08-13 |
rat |
| Mariana M Oliveira, Bianca A Ratti, Regina G Daré, Sueli O Silva, Maria da Conceição T Truiti, Tânia Ueda-Nakamura, Rachel Auzély-Velty, Celso V Nakamur. Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway. Oxidative medicine and cellular longevity. vol 2019. 2019-03-18. PMID:30800206. |
the aim of this study was to evaluate the antioxidant and protective effect of dhca against oxidative stress, apoptosis, and matrix metalloproteinase (mmp) expression via the mitogen-activated protein kinase (mapk) signaling pathway on l929 fibroblasts irradiated with uvb. |
2019-03-18 |
2023-08-13 |
Not clear |
| Byeong-Wook Song, Hyunki Hong, Yu Jin Jung, Ju Hyung Lee, Bong Soo Kim, Hoon-Bum Le. Combination Therapy Comprising a Static Magnetic Field with Contractility Improves Skin Wounds. Tissue engineering. Part A. vol 24. issue 17-18. 2019-03-14. PMID:29652610. |
during mb-induced wound healing, apoptosis was significantly reduced and matrix remodeling-related factors were initially regulated. |
2019-03-14 |
2023-08-13 |
rat |
| Ying Gao, Botao Wang, Huanan Luo, Qing Zhang, Min X. miR-217 represses TGF-β1-induced airway smooth muscle cell proliferation and migration through targeting ZEB1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-14. PMID:30212709. |
overexpression of mir-217 significantly inhibited tgf-β1-induced proliferation, migration, extracellular matrix (ecm) deposition, but promoted apoptosis in asmcs, whereas, mir-217 inhibitor showed an opposed effect. |
2019-03-14 |
2023-08-13 |
Not clear |
| Javed Ahsan Quadri, Saba Sarwar, Pinky, Parmita Kar, Seema Singh, Saumya Ranjan Mallick, Sudheer Arava, Tapash Chand Nag, Tara Sankar Roy, A Sharif. Fluoride induced tissue hypercalcemia, IL-17 mediated inflammation and apoptosis lead to cardiomyopathy: Ultrastructural and biochemical findings. Toxicology. vol 406-407. 2019-03-11. PMID:29800585. |
it was hypothesized that chronic fluoride exposure induces apoptosis in cardiomyocytes due to inflammation, lysis of extra cellular matrix and altered calcium metabolism. |
2019-03-11 |
2023-08-13 |
human |
| Bruno Martinucci, Brenda de Carvalho Minatel, Maira Smaniotto Cucielo, Mariana Medeiros, Ivan José Vechetti-Junior, Sérgio Luis Felisbino, Flávia Karina Delell. Basement membrane extract attenuates the more malignant gene expression profile accentuated by fibronectin in prostate cancer cells. Molecular and cellular biochemistry. vol 451. issue 1-2. 2019-03-08. PMID:29961211. |
when fn was the predominant matrix element, such as in blood plasma, pca tumor cells increased their expression of genes related to an invasive behavior and resistance to apoptosis, including cdh2, itga5, akt1, and bcl2. |
2019-03-08 |
2023-08-13 |
Not clear |
| Xingyu Chai, Haipeng Si, Jiang Song, Yanxue Chong, Jing Wang, Gang Zha. miR-486-5p Inhibits Inflammatory Response, Matrix Degradation and Apoptosis of Nucleus Pulposus Cells through Directly Targeting FOXO1 in Intervertebral Disc Degeneration. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 52. issue 1. 2019-03-08. PMID:30790508. |
mir-486-5p inhibits inflammatory response, matrix degradation and apoptosis of nucleus pulposus cells through directly targeting foxo1 in intervertebral disc degeneration. |
2019-03-08 |
2023-08-13 |
Not clear |
| Yanlin Tan, Xingwang Yao, Zhehao Dai, Yunhua Wang, Guohua L. Bone morphogenetic protein 2 alleviated intervertebral disc degeneration through mediating the degradation of ECM and apoptosis of nucleus pulposus cells via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30387830. |
bmp2 alleviated idd via the pi3k/akt signaling pathway by inhibiting np cell apoptosis and decreasing the levels of matrix proteins. |
2019-03-05 |
2023-08-13 |
human |
| Zhi-Feng Xiao, Guo-Yi Su, Yu Hou, Shu-Dong Chen, Ding-Kun Li. Cartilage degradation in osteoarthritis: A process of osteochondral remodeling resembles the endochondral ossification in growth plate? Medical hypotheses. vol 121. 2019-03-05. PMID:30396477. |
many factors such as mechanics, inflammation and immunological abnormality could drive the joint tissues metabolic and disturb the steady state of cartilage and bone, which further devoted to a serial pathological manifestations, consisting of hypertrophy and apoptosis of articular chondrocytes, degradation of cartilage matrix, angiogenesis and calcification of hyaline cartilage, replication of tidemark, formation of osteophytes, degeneration of ligaments and, in the knee, the menisci, hypertrophy of the joint capsule and remodeling of subchondral bone along with increased permeability of the osteochondral interface. |
2019-03-05 |
2023-08-13 |
Not clear |
| Fan Wu, Peng Tian, Yun Ma, Jingyi Wang, Huashuang Ou, Hua Zo. Reactive Oxygen Species Are Necessary for Bleomycin A5-Induced Apoptosis and Extracellular Matrix Elimination of Nasal Polyp-Derived Fibroblasts. The Annals of otology, rhinology, and laryngology. vol 128. issue 2. 2019-02-27. PMID:30450917. |
reactive oxygen species are necessary for bleomycin a5-induced apoptosis and extracellular matrix elimination of nasal polyp-derived fibroblasts. |
2019-02-27 |
2023-08-13 |
Not clear |
| Muthu K Shanmugam, Hongyuan Shen, Feng Ru Tang, Frank Arfuso, Mohanraj Rajesh, Lingzhi Wang, Alan Prem Kumar, Jinsong Bian, Boon Cher Goh, Anupam Bishayee, Gautam Seth. Potential role of genipin in cancer therapy. Pharmacological research. vol 133. 2019-02-26. PMID:29758279. |
several lines of evidence suggest that genipin is a potent inhibitor of ucp2, which functions as a tumor promoter in a variety of cancers, attenuates generation of reactive oxygen species and the expression of matrix metalloproteinase 2, as well as induces caspase-dependent apoptosis in vitro and in in vivo models. |
2019-02-26 |
2023-08-13 |
Not clear |
| Rajesh Kushwaha, Juhi Mishra, Sachin Tripathi, Waseem Raza, Kapil Mandrah, Somendu Kumar Roy, Sanghamitra Bandyopadhya. Arsenic Attenuates Heparin-Binding EGF-Like Growth Factor/EGFR Signaling That Promotes Matrix Metalloprotease 9-Dependent Astrocyte Damage in the Developing Rat Brain. Toxicological sciences : an official journal of the Society of Toxicology. vol 162. issue 2. 2019-02-25. PMID:29228391. |
exploring the pathways downstream of reduced hb-egfr/egfr revealed that an upregulated matrix metalloproteinase 9 (mmp9) within the astrocytes ultimately led to apoptosis and gfap loss. |
2019-02-25 |
2023-08-13 |
rat |
| Ahmad Salimi, Jalal Pourahma. Measurement of Mitochondrial Toxicity Parameters in Embryonic Hippocampus. Methods in molecular biology (Clifton, N.J.). vol 1797. 2019-02-25. PMID:29896715. |
they have role in oxidative phosphorylation and metabolism, they play central role in cell differentiation, apoptosis, oxygen sensing and detoxification of reactive oxygen species, innate immunity, mitochondrial matrix calcium, and maintenance of cell quality and regulation of cytoplasmic. |
2019-02-25 |
2023-08-13 |
mouse |
| Hadi S Hosseini, Larry A Tabe. How mechanical forces shape the developing eye. Progress in biophysics and molecular biology. vol 137. 2019-02-18. PMID:29432780. |
taken together, experimental and numerical results suggest that the driving forces for early eye morphogenesis are generated mainly by differential growth, actomyosin contraction, and regional apoptosis, with morphology mediated by physical constraints provided by adjacent tissues and extracellular matrix. |
2019-02-18 |
2023-08-13 |
Not clear |
| Li Cai, Wei-Na Chen, Rong Li, Ming-Ming Liu, Chao Lei, Chun-Mei Li, Yuan-Ye Qi. Acetazolamide protects rat articular chondrocytes from IL-1β-induced apoptosis by inhibiting the activation of NF-κB signal pathway. Canadian journal of physiology and pharmacology. vol 96. issue 11. 2019-02-18. PMID:30067070. |
because the excessive apoptosis of articular chondrocytes contributes to extracellular matrix (ecm) loss and cartilage damage in rheumatoid arthritis (ra), inhibiting chondrocyte apoptosis might be a promising strategy for ra. |
2019-02-18 |
2023-08-13 |
rat |
| Junwen Wang, Dan Luo, Ming Liang, Ting Zhang, Xiquan Yin, Ying Zhang, Xiangliang Yang, Wei Li. Spectrum-Effect Relationships between High-Performance Liquid Chromatography (HPLC) Fingerprints and the Antioxidant and Anti-Inflammatory Activities of Collagen Peptides. Molecules (Basel, Switzerland). vol 23. issue 12. 2019-02-12. PMID:30544714. |
the anti-inflammatory activity of collagen peptides may include increased synthesis of the key components of extracellular matrix (ecm) and inhibited apoptosis of chondrocytes. |
2019-02-12 |
2023-08-13 |
rat |
| Kotaro Soji, Shigehiro Doi, Ayumu Nakashima, Kensuke Sasaki, Toshiki Doi, Takao Masak. Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction. PloS one. vol 13. issue 8. 2019-02-11. PMID:30114247. |
administration of pr-619 attenuated renal fibrosis with downregulation of mesenchymal markers, extracellular matrix proteins, matrix metalloproteinases, apoptosis, macrophage infiltration, and the tgf-β1 mrna level in uuo mice. |
2019-02-11 |
2023-08-13 |
mouse |
| Eric Goethe, Bing Z Carter, Ganesh Rao, Naveen Pemmaraj. Glioblastoma and acute myeloid leukemia: malignancies with striking similarities. Journal of neuro-oncology. vol 136. issue 2. 2019-02-06. PMID:29196926. |
the primary versions of aml and gb are characterized by aberrant ras pathway, matrix metalloproteinase 9, and bcl-2 expression, and their secondary counterparts share abnormalities in tp53, isocitrate dehydrogenase, atrx, inhibitor of apoptosis proteins, and survivin that both influence the course of the diseases themselves and their progression from precursor disease. |
2019-02-06 |
2023-08-13 |
Not clear |
| Martin Roderfel. Matrix metalloproteinase functions in hepatic injury and fibrosis. Matrix biology : journal of the International Society for Matrix Biology. vol 68-69. 2019-01-30. PMID:29221811. |
in this regard matrix metalloproteinases (mmps) have been focused as therapeutic targets due to their ability to modulate tissue turnover during fibrogenesis as well as regeneration and, of special interest, due to their influence on cellular behavior like proliferation, gene expression, and apoptosis that, in turn, impact fibrosis and regeneration. |
2019-01-30 |
2023-08-13 |
Not clear |