| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Bell, M A Robles-Harris, M Anderson, D Laudier, M B Schaffler, E L Flatow, N Andarawis-Pur. Inhibition of apoptosis exacerbates fatigue-damage tendon injuries in an in vivo rat model. European cells & materials. vol 36. 2018-12-24. PMID:30058060. |
consequently, this study aimed to determine: (1) whether apoptosis could be inhibited after fatigue damage and (2) whether its inhibition could lead to remodeling of the extracellular matrix (ecm) and pericellular matrix (pcm), to ultimately improve the mechanical properties of fatigue-damaged tendons. |
2018-12-24 |
2023-08-13 |
rat |
| R Bell, M A Robles-Harris, M Anderson, D Laudier, M B Schaffler, E L Flatow, N Andarawis-Pur. Inhibition of apoptosis exacerbates fatigue-damage tendon injuries in an in vivo rat model. European cells & materials. vol 36. 2018-12-24. PMID:30058060. |
the working hypothesis was that, despite the low vascular nature of the tendon, apoptosis would be inhibited, prompting increased production of matrix proteins and restoring tendon mechanical properties. |
2018-12-24 |
2023-08-13 |
rat |
| Peng Ao, Wenzhou Huang, Jian Li, Tianlong Wu, Libiao Xu, Zhongbo Deng, Wenjie Chen, Changchang Yin, Xigao Chen. 17β-estradiol protects nucleus pulposus cells from serum deprivation-induced apoptosis and regulates expression of MMP-3 and MMP-13 through promotion of autophagy. Biochemical and biophysical research communications. vol 503. issue 2. 2018-12-17. PMID:29928874. |
the aim of this study is to understand whether autophagy is involved in the protective effect of e2 against serum deprivation-induced cell apoptosis and expression of matrix metalloproteinase (mmp)-3 and mmp-13. |
2018-12-17 |
2023-08-13 |
Not clear |
| Jianlin Long, Yuping Yang, Tianyi Kang, Wei Zhao, Hao Cheng, Yujiao Wu, Ting Du, Beibei Liu, Yang Li, Feng Luo, Maling Go. Ovarian Cancer Therapy by VSVMP Gene Mediated by a Paclitaxel-Enhanced Nanoparticle. ACS applied materials & interfaces. vol 9. issue 45. 2018-12-12. PMID:28944654. |
by the p-dpp nanoparticle, vesicular stomatitis virus matrix protein (vsvmp) that could induce cell apoptosis was delivered to treat ovarian cancer. |
2018-12-12 |
2023-08-13 |
Not clear |
| Muhammad Farooq Rai, Xin Duan, James D Quirk, Nilsson Holguin, Eric J Schmidt, Nobuaki Chinzei, Matthew J Silva, Linda J Sandel. Post-Traumatic Osteoarthritis in Mice Following Mechanical Injury to the Synovial Joint. Scientific reports. vol 7. 2018-12-11. PMID:28345597. |
these features included cartilage extracellular matrix loss without proteoglycan replacement, chondrocyte apoptosis at day 5, synovitis present at day 14, osteophytes, ectopic calcification, and meniscus pathology. |
2018-12-11 |
2023-08-13 |
mouse |
| Je-Keun Rhee, Sejoon Lee, Woong-Yang Park, Young-Ho Kim, Tae-Min Ki. Allelic imbalance of somatic mutations in cancer genomes and transcriptomes. Scientific reports. vol 7. issue 1. 2018-12-11. PMID:28490743. |
for missense mutations, we observed that mutations frequently subject to ai are enriched to genes related to cancer, especially those of apoptosis and the extracellular matrix, and c:g > a:t transversions. |
2018-12-11 |
2023-08-13 |
human |
| Yan Wei, Yuxi Wang, Dengning Xia, Shiyan Guo, Feng Wang, Xinxin Zhang, Yong Ga. Thermosensitive Liposomal Codelivery of HSA-Paclitaxel and HSA-Ellagic Acid Complexes for Enhanced Drug Perfusion and Efficacy Against Pancreatic Cancer. ACS applied materials & interfaces. vol 9. issue 30. 2018-12-11. PMID:28696100. |
with superior tumor accumulation, impressive matrix penetration, and simultaneous action upon tumor cells and pscs to disrupt pscs-pda interaction, tsl/hsa-pe treatment combined with heat exhibited strong tumor growth inhibition and apoptosis in vivo. |
2018-12-11 |
2023-08-13 |
human |
| Seung Hyeon Kim, Xiancai Zhong, Wonki Kim, Kyeojin Kim, Young-Ger Suh, Chaekyun Kim, Yeonsoo Joe, Hun Taeg Chung, Young-Nam Cha, Young-Joon Sur. Taurine chloramine potentiates phagocytic activity of peritoneal macrophages through up-regulation of dectin-1 mediated by heme oxygenase-1-derived carbon monoxide. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 4. 2018-12-11. PMID:29247123. |
as neutrophils undergo apoptosis, taucl is released to the extracellular matrix at the inflamed sites, thereby affecting coexisting macrophages in the inflammatory microenvironment. |
2018-12-11 |
2023-08-13 |
Not clear |
| Feng Tong, Youhua Ying, Haihua Pan, Wei Zhao, Hongchen Li, Xiaoli Zha. MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC). Bosnian journal of basic medical sciences. vol 18. issue 3. 2018-12-11. PMID:29338680. |
mrna and protein levels of cyclin d1, apoptosis regulator bax (bax), and matrix metalloproteinase-2 (mmp-2) were analyzed by qrt-pcr and western blot, respectively, in sw-620 crc cells transfected with mir-466 mimics or negative control mirna. |
2018-12-11 |
2023-08-13 |
Not clear |
| Linus Angenendt, Jan-Henrik Mikesch, Dennis Görlich, Alina Busch, Irina Arnhold, Claudia Rudack, Wolfgang Hartmann, Eva Wardelmann, Wolfgang E Berdel, Markus Stenner, Christoph Schliemann, Inga Grünewal. Stromal collagen type VI associates with features of malignancy and predicts poor prognosis in salivary gland cancer. Cellular oncology (Dordrecht). vol 41. issue 5. 2018-12-11. PMID:29949051. |
collagen type vi (colvi) is an extracellular matrix protein that is upregulated in various solid tumours during tumour progression and has been shown to stimulate proliferation, suppress apoptosis and promote invasion and metastasis. |
2018-12-11 |
2023-08-13 |
Not clear |
| Qing Chen, Kai-Ting Li, Si Tian, Ting-He Yu, Le-Hu Yu, Hai-Dan Lin, Ding-Qun Ba. Photodynamic Therapy Mediated by Aloe-Emodin Inhibited Angiogenesis and Cell Metastasis Through Activating MAPK Signaling Pathway on HUVECs. Technology in cancer research & treatment. vol 17. 2018-12-11. PMID:30068242. |
an essential step in angiogenesis involves the formation of tube-like structures during matrix degradation, rearrangement, and apoptosis of endothelial cells. |
2018-12-11 |
2023-08-13 |
human |
| Ailing Sui, Yisheng Zhong, Anna M Demetriades, Jikui Shen, Ting Su, Yiyun Yao, Yushuo Gao, Yanji Zhu, Xi Shen, Bing Xi. ATN-161 as an Integrin α5β1 Antagonist Depresses Ocular Neovascularization by Promoting New Vascular Endothelial Cell Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-11. PMID:30133427. |
the activation of nuclear factor-κb (nf-κb), matrix metalloproteinase-2/9 (mmp-2/9), and cell apoptosis were detected by immunofluorescence staining, western blot, real-time rt-pcr, and terminal deoxynucleotidyl transferase dutp nick-end labeling (tunel). |
2018-12-11 |
2023-08-13 |
mouse |
| Ailing Sui, Yisheng Zhong, Anna M Demetriades, Jikui Shen, Ting Su, Yiyun Yao, Yushuo Gao, Yanji Zhu, Xi Shen, Bing Xi. ATN-161 as an Integrin α5β1 Antagonist Depresses Ocular Neovascularization by Promoting New Vascular Endothelial Cell Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2018-12-11. PMID:30133427. |
blocking integrin a5b1 by atn-161 strongly inhibited nuclear factor-κb (nf-κb) activation and matrix metalloproteinase-2/9 (mmp-2/9) expression and promoted cell apoptosis, but the effect of atn-161 on proliferation in cnv mice was indirect and required the inhibition of neovascularization. |
2018-12-11 |
2023-08-13 |
mouse |
| Quan Wang, Yilin Shen, Bin Ye, Haixia Hu, Cui Fan, Tan Wang, Yuqin Zheng, Jingrong Lv, Yan Ma, Mingliang Xian. Gene expression differences between thyroid carcinoma, thyroid adenoma and normal thyroid tissue. Oncology reports. vol 40. issue 6. 2018-12-11. PMID:30272326. |
in a vs. c, the most significant cluster had 14 genes: bcl2-like 1, galectin 3, mcl1 bcl2 family apoptosis regulator, dna damage inducible transcript 3, bcl2 apoptosis regulator, ctgf, matrix metallopeptidase 7, early growth response 1, kinase insert domain receptor, timp metallopeptidase inhibitor 1, apolipoprotein e, vwf, cyclin d1 and placental growth factor. |
2018-12-11 |
2023-08-13 |
Not clear |
| Han-Sung Kwon, Ji Hyun Park, Han-Sung Hwang, In-Sook Sohn, Young-Han Kim, SiHyun Ch. Effect of DJ-1 Downregulation on the Functions of the First Trimester Extravillous Trophoblasts. Reproductive sciences (Thousand Oaks, Calif.). vol 25. issue 9. 2018-11-27. PMID:29258409. |
data of this study showed that dj-1 downregulation increased apoptosis and reduced migration by regulating matrix metalloproteinase 2 and matrix metalloproteinase 9 in htr-8/svneo cells under both ambient and oxidative stress. |
2018-11-27 |
2023-08-13 |
Not clear |
| Manish Mishra, Renu A Kowlur. Role of PARP-1 as a novel transcriptional regulator of MMP-9 in diabetic retinopathy. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 7. 2018-11-26. PMID:28478229. |
in diabetes, matrix metalloproteinase-9 (mmp-9) is activated, which damages mitochondria, resulting in accelerated capillary cell apoptosis. |
2018-11-26 |
2023-08-13 |
mouse |
| Weili Lu, Yingji Mao, Xue Chen, Jun Ni, Rui Zhang, Yuting Wang, Jun Wang, Lifang W. Fordin: A novel type I ribosome inactivating protein from Vernicia fordii modulates multiple signaling cascades leading to anti-invasive and pro-apoptotic effects in cancer cells in vitro. International journal of oncology. vol 53. issue 3. 2018-11-26. PMID:30015835. |
fordin also reduced the mrna and protein levels of nf-κb downstream targets associated with cell apoptosis and metastasis, particularly b-cell lymphoma‑2-related protein a1 (blf-1) and matrix metalloproteinase (mmp)-9. |
2018-11-26 |
2023-08-13 |
Not clear |
| Guillaume E Courtoy, Jacques Donnez, Jérôme Ambroise, Pablo Arriagada, Mathieu Luyckx, Etienne Marbaix, Marie-Madeleine Dolman. Gene expression changes in uterine myomas in response to ulipristal acetate treatment. Reproductive biomedicine online. vol 37. issue 2. 2018-11-14. PMID:29807764. |
does ulipristal acetate (upa) modify the expression of genes related to apoptosis or the extracellular matrix in uterine myomas and are any modifications associated with a clinical response? |
2018-11-14 |
2023-08-13 |
Not clear |
| Dawei Wang, Xiaoqian Lou, Xiao-Ming Jiang, Chenxi Yang, Xiao-Liang Liu, Nan Zhan. Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression. Molecular medicine reports. vol 18. issue 1. 2018-11-13. PMID:29749525. |
the current study evaluated whether quercetin protects against inflammation, matrix metalloproteinase‑2 (mmp‑2) activation and apoptosis induction in a rat model of cardiopulmonary resuscitation (cpr), and whether bmi‑1 expression was involved in the effects. |
2018-11-13 |
2023-08-13 |
rat |
| Anton Tkachenko, Dmytro Marakushyn, Iuliia Kalashnyk, Yevgen Korniyenko, Anatolii Onishchenko, Tatyana Gorbach, Oksana Nakonechna, Yevgen Posokhov, Alexander Tsyganko. A study of enterocyte membranes during activation of apoptotic processes in chronic carrageenan-induced gastroenterocolitis. Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina. vol 15. issue 2. 2018-11-09. PMID:29790482. |
activity of apoptosis signal-regulating kinase 1 and poly (adp-ribose) polymerase in small intestinal homogenates, blood serum levels of matrix metalloproteinase-2 and caspase-3 and the level of dna fragmentation in small intestinal homogenates were determined. |
2018-11-09 |
2023-08-13 |
rat |