| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianli Liu, Meijia Liu, Shuai Wang, Yin He, Yapeng Huo, Zhijun Yang, Xiangyu Ca. Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways. International journal of molecular medicine. vol 42. issue 4. 2018-11-08. PMID:30015828. |
alantolactone induced apoptosis of mcf‑7 cells by regulating the protein expression levels of b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein, p53, caspase‑3 and caspase‑12, which are associated with the apoptotic pathway, and suppressed colony formation and migration by regulating the protein expression of matrix metalloproteinase (mmp)‑2, mmp‑7 and mmp‑9. |
2018-11-08 |
2023-08-13 |
human |
| Meng-Ya Zhao, La-Mei Wang, Jing Liu, Xing Huang, Jing Liu, Ya-Fei Zhan. MiR-21 Suppresses Anoikis through Targeting PDCD4 and PTEN in Human Esophageal Adenocarcinoma. Current medical science. vol 38. issue 2. 2018-11-02. PMID:30074182. |
anoikis is a form of apoptosis induced upon cell detachment from extracellular matrix. |
2018-11-02 |
2023-08-13 |
mouse |
| Jiranuwat Sapudom, Tilo Pomp. Biomimetic tumor microenvironments based on collagen matrices. Biomaterials science. vol 6. issue 8. 2018-10-29. PMID:29999062. |
the extracellular matrix (ecm) establishes the basis for the cell's microenvironment providing structural and mechanical support to cells and tissues, and regulating multiple cell functions including gene expression, cell cycle, apoptosis, morphogenesis, and migration. |
2018-10-29 |
2023-08-13 |
Not clear |
| Ruize Qu, Xiaomin Chen, Wenhan Wang, Cheng Qiu, Miaomiao Ban, Linlin Guo, Krasimir Vasilev, Jianying Chen, Weiwei Li, Yunpeng Zha. Ghrelin protects against osteoarthritis through interplay with Akt and NF-κB signaling pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 32. issue 2. 2018-10-23. PMID:29070587. |
ghrelin down-regulated the production of various inflammatory cytokines, inhibited apoptosis of chondrocytes, decreased the levels of metalloproteinases (including matrix metalloproteinase-13 and a disintegrin and metalloproteinase with thrombospondin motif-5), and maintained the expression of critical matrix components, such as aggrecan and collagen 2. |
2018-10-23 |
2023-08-13 |
mouse |
| Feng Lian, Chengbin Zhao, Jing Qu, Yongyun Lian, Yong Cui, Liang Shan, Jinglong Ya. Icariin attenuates titanium particle-induced inhibition of osteogenic differentiation and matrix mineralization via miR-21-5p. Cell biology international. vol 42. issue 8. 2018-10-23. PMID:29500883. |
here, we investigated the effect of icariin on cell proliferation, apoptosis, osteogenic differentiation and matrix mineralization of osteoblasts in an in vitro model of titanium (ti) particle-induced osteolysis. |
2018-10-23 |
2023-08-13 |
Not clear |
| Chaowei Wang, Yi Zhou, Xiaoxu Guan, Mengfei Yu, Huiming Wan. β-Estradiol antagonizes the inhibitory effects of caffeine in BMMSCs via the ERβ-mediated cAMP-dependent PKA pathway. Toxicology. vol 394. 2018-10-19. PMID:29154944. |
we found that caffeine and β-estradiol inversely affected bmmcss proliferation, apoptosis, osteogenic lineage commitment, extracellular matrix synthesis and mineralization. |
2018-10-19 |
2023-08-13 |
rat |
| Shuwei Zhang, Yichi Zhou, Yuanyu Zha, Yang Yang, Linlong Wang, Jingfeng Li, Wei Ji. PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines. Molecular medicine reports. vol 18. issue 1. 2018-10-19. PMID:29845265. |
the expression levels of the cell apoptosis and tumor metastasis associated proteins b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein, e‑cadherin, twist, matrix metalloproteinase (mmp)‑9 and mmp2 were measured via western blotting. |
2018-10-19 |
2023-08-13 |
human |
| Huan Zhai, Xun Qi, Zixuan Li, Wei Zhang, Chenguang Li, Lu Ji, Ke Xu, Hongshan Zhon. TIMP‑3 suppresses the proliferation and migration of SMCs from the aortic neck of atherosclerotic AAA in rabbits, via decreased MMP‑2 and MMP‑9 activity, and reduced TNF‑α expression. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29956789. |
the present study investigated the role of tissue inhibitor of matrix metalloproteinase‑3 (timp‑3) in regulating the proliferation, migration, apoptosis and activity of matrix metalloproteinase (mmp)‑2 and ‑9, during the development of an atherosclerotic abdominal artery aneurysm (aaa). |
2018-10-19 |
2023-08-13 |
rabbit |
| Nan Guo, Nan Zhang, Liqiu Yan, Zheng Lian, Jiawang Wang, Fengfeng Lv, Yunfei Wang, Xufen Ca. Weighted gene co‑expression network analysis in identification of key genes and networks for ischemic‑reperfusion remodeling myocardium. Molecular medicine reports. vol 18. issue 2. 2018-10-18. PMID:29901145. |
the present study revealed that heart remodeling following ir is a complicated process, involving extracellular matrix organization, neural development, apoptosis and energy metabolism. |
2018-10-18 |
2023-08-13 |
Not clear |
| Xintian Shao, Qixin Chen, Xixi Dou, Lei Chen, Jixu Wu, Wei Zhang, Huarong Shao, Peixue Ling, Fei Liu, Fengshan Wan. Lower range of molecular weight of xanthan gum inhibits cartilage matrix destruction via intrinsic bax-mitochondria cytochrome c-caspase pathway. Carbohydrate polymers. vol 198. 2018-10-18. PMID:30093011. |
the results showed that lrwxg could inhibit the loss of collagen in cartilage matrix, protect trabecular bone in subchondral, decrease the apoptosis of chondrocytes, down-regulate the expressions of active caspase-9, active caspase-3 and bax, and up-regulate the expression of bcl-2. |
2018-10-18 |
2023-08-13 |
rabbit |
| Mark Zada, Ushasree Pattamatta, Andrew Whit. Modulation of Fibroblasts in Conjunctival Wound Healing. Ophthalmology. vol 125. issue 2. 2018-10-11. PMID:29079272. |
the search for novel and more targeted means to control conjunctival fibrosis without such limitations has brought much attention to the regulation of fibroblast proliferation, differentiation, extracellular matrix production, and apoptosis. |
2018-10-11 |
2023-08-13 |
Not clear |
| Indrakumar Janani, Rachita Lakra, Manikantan Syamala Kiran, Purna Sai Korrapat. Selectivity and sensitivity of molybdenum oxide-polycaprolactone nanofiber composites on skin cancer: Preliminary in-vitro and in-vivo implications. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 49. 2018-10-09. PMID:29895373. |
polycaprolactone nanofibers were chosen as a matrix to localize the nanoparticles topically facilitating selective apoptosis of the tumor cells over the normal cells with mitigated side effects. |
2018-10-09 |
2023-08-13 |
zebrafish |
| Oscar Orihuela-Rodríguez, Héctor A. Carmona-Ruíz, Fernando Laredo-Sánchez, José Ramón Paniagua-Sierr. Left ventricular hypertrophy, fibrosis heart, and diastolic dysfunction in chronic kidney disease Revista medica del Instituto Mexicano del Seguro Social. vol 55. issue Suppl. 2. 2018-10-02. PMID:29697909. |
myocardial hypertrophy induces the activation of cellular apoptosis signals and activates metabolic pathways able to increase extracellular matrix production up to fibrosis. |
2018-10-02 |
2023-08-13 |
Not clear |
| Zheng Li, Xingye Li, Chong Chen, Shugang Li, Jianxiong Shen, Gary Tse, Matthew T V Chan, William K K W. Long non-coding RNAs in nucleus pulposus cell function and intervertebral disc degeneration. Cell proliferation. vol 51. issue 5. 2018-10-01. PMID:30039593. |
deregulated phenotypes of nucleus pulposus cells, including aberrant differentiation, apoptosis, proliferation and extracellular matrix deposition, are involved in the initiation and progression of idd. |
2018-10-01 |
2023-08-13 |
Not clear |
| Alexandre P Sater, Leonard T Rael, Allen H Tanner, Mark J Lieser, David L Acuna, Charles W Mains, David Bar-O. Cell death after traumatic brain injury: Detrimental role of anoikis in healing. Clinica chimica acta; international journal of clinical chemistry. vol 482. 2018-09-28. PMID:29627488. |
anoikis, a form of apoptosis, results from cells detaching from the extracellular matrix leading to cell death. |
2018-09-28 |
2023-08-13 |
Not clear |
| Saliha Boumaza, Aicha Belkebir, Samia Neggazi, Hamid Sahraoui, Sihem Berdja, Leila Smail, Yasmina Benazzoug, Ghoti Kacimi, Souhila Aouichat Bouguerr. Therapeutic Role of Resveratrol and Quercetin on Aortic Fibroblasts of Psammomys obesus After Oxidative Stress by Hydrogen Peroxide. American journal of therapeutics. vol 25. issue 3. 2018-09-27. PMID:26766292. |
treatment of fibroblasts stressed by res and qrc inverted the oxidative stress situation decreasing apoptosis and inflammation, and improving the altered redox status and rearrangement of disorders observed in extracellular matrix. |
2018-09-27 |
2023-08-13 |
Not clear |
| Bruna De Felice, Francesco Manfellotto, Corrado Garbi, Margherita Santoriello, Massimo Nacc. miR-34 modulates apoptotic gene expression in Ingenol mebutate treated keloid fibroblasts. Molecular medicine reports. vol 17. issue 5. 2018-09-25. PMID:29568916. |
keloids are characterized by a deregulated wound‑healing process, atypical fibroblasts with extreme deposition of extracellular matrix components, particularly collagen, increased cell proliferation and associated failure of apoptosis. |
2018-09-25 |
2023-08-13 |
human |
| Ke-Feng Zhai, Hong Duan, Yuan Chen, Ghulam Jilany Khan, Wen-Gen Cao, Gui-Zhen Gao, Ling-Ling Shan, Zhao-Jun We. Apoptosis effects of imperatorin on synoviocytes in rheumatoid arthritis through mitochondrial/caspase-mediated pathways. Food & function. vol 9. issue 4. 2018-09-17. PMID:29577119. |
the results showed that ipt significantly reduced cell viability, accelerated cell apoptosis and decreased matrix metalloproteinases-1/-3 expression in il-1β-induced ra-flss. |
2018-09-17 |
2023-08-13 |
rat |
| Murali Ganesan, Raghubendra Singh Dagur, Edward Makarov, Larisa I Poluektova, Srivatsan Kidambi, Natalia A Osn. Matrix stiffness regulate apoptotic cell death in HIV-HCV co-infected hepatocytes: Importance for liver fibrosis progression. Biochemical and biophysical research communications. vol 500. issue 3. 2018-09-14. PMID:29679566. |
in this study, we hypothesize that increased matrix stiffness enhances apoptosis in hcv-hiv-co-infected hepatocytes and that capturing of apoptotic bodies (ab) derived from these infected hepatocytes by hepatic stellate cells (hsc) drives the fibrosis progression. |
2018-09-14 |
2023-08-13 |
Not clear |
| Kena Song, Zirui Wang, Ruchuan Liu, Guo Chen, Liyu Li. Microfabrication-Based Three-Dimensional (3-D) Extracellular Matrix Microenvironments for Cancer and Other Diseases. International journal of molecular sciences. vol 19. issue 4. 2018-09-03. PMID:29561794. |
one of the major challenges is the ability to mimic the complex 3-d tissue microenvironment that particularly influences cell proliferation, migration, invasion, and apoptosis in relation to the extracellular matrix (ecm). |
2018-09-03 |
2023-08-13 |
Not clear |