| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao Tu, Jieyu He, Bei Wu, Wanchun Wang, Zhihong L. An extensive review regarding the adipokines in the pathogenesis and progression of osteoarthritis. Cytokine. vol 113. 2020-02-19. PMID:30539776. |
beyond mechanical loading, adipokines, including leptin, visfatin, adiponectin, resistin and others, are demonstrated to have metabolic implications in the pathogenesis and progression in obesity-induced osteoarthritis by modulating the pro/anti-inflammatory and anabolic/catabolic balance, apoptosis, matrix remodeling and subchondral bone ossification. |
2020-02-19 |
2023-08-13 |
Not clear |
| Peng Chen, Hongguang Zhang, Qingtao Zhang, Wei Zhou, Yongbing Deng, Xi Hu, Lianyang Zhan. Basic Fibroblast Growth Factor Reduces Permeability and Apoptosis of Human Brain Microvascular Endothelial Cells in Response to Oxygen and Glucose Deprivation Followed by Reoxygenation via the Fibroblast Growth Factor Receptor 1 (FGFR1)/ERK Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-14. PMID:31551405. |
results following ogd/r of hbmecs, bfgf significantly reduced cell permeability and apoptosis and significantly inhibited the down-regulation of the expressions of proteins associated with tight junctions, adherens junctions, apoptosis and matrix metalloproteinases (mmps). |
2020-02-14 |
2023-08-13 |
human |
| Li Song, Huajie Liu, Qiang Li. Matrix metalloproteinase 1 promotes tumorigenesis and inhibits the sensitivity to 5-fluorouracil of nasopharyngeal carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 118. 2020-02-13. PMID:31302419. |
this research was aimed to study the effects of matrix metalloproteinase 1 (mmp1) gene on nasopharyngeal carcinoma (npc) cell proliferation, viability, invasiveness, apoptosis, and sensitivity to 5-fu. |
2020-02-13 |
2023-08-13 |
human |
| Yun-Fu Zeng, Rong Wang, Yang Bian, Wen-Sheng Chen, Lei Pen. Catalpol Attenuates IL-1β Induced Matrix Catabolism, Apoptosis and Inflammation in Rat Chondrocytes and Inhibits Cartilage Degeneration. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-02-12. PMID:31484919. |
catalpol attenuates il-1β induced matrix catabolism, apoptosis and inflammation in rat chondrocytes and inhibits cartilage degeneration. |
2020-02-12 |
2023-08-13 |
rat |
| Scott A Barman, Xueyi Li, Stephen Haigh, Dmitry Kondrikov, Keyvan Mahboubi, Zsuzsanna Bordan, David W Stepp, Jiliang Zhou, Yusi Wang, Daniel S Weintraub, Peter Traber, William Snider, Danny Jonigk, Jennifer Sullivan, G Ryan Crislip, Joshua T Butcher, Jennifer Thompson, Yunchao Su, Feng Chen, David J R Fulto. Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis. American journal of physiology. Lung cellular and molecular physiology. vol 316. issue 5. 2020-02-11. PMID:30724100. |
there is no cure for ph and identification of novel molecular mechanisms that underlie increased proliferation, reduced apoptosis, and excessive extracellular matrix production in pulmonary artery smooth muscle cells (pasmcs) is a vital objective. |
2020-02-11 |
2023-08-13 |
rat |
| Michael J Daseke, Fritz M Valerio, William J Kalusche, Yonggang Ma, Kristine Y DeLeon-Pennell, Merry L Lindse. Neutrophil proteome shifts over the myocardial infarction time continuum. Basic research in cardiology. vol 114. issue 5. 2020-02-10. PMID:31418072. |
d3 mi neutrophil profiles showed upregulation of apoptosis and induction of extracellular matrix (ecm) organization. |
2020-02-10 |
2023-08-13 |
mouse |
| Béla Kovács, Enikő Vajda, Előd Ernő Nag. Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis. International journal of molecular sciences. vol 20. issue 18. 2020-02-04. PMID:31546898. |
experimental conditions mimicking abnormal mechanical load, the pro-inflammatory milieu, but also a decreased opg/rankl ratio in the cartilage, trigger chondrocyte apoptosis and loss of the matrix via degradative matrix metalloproteinases, like mmp-13 or mmp-9. |
2020-02-04 |
2023-08-13 |
Not clear |
| Fei Liu, Christina Mallarino Haeger, Paul B Dieffenbach, Delphine Sicard, Izabela Chrobak, Anna Maria F Coronata, Margarita M Suárez Velandia, Sally Vitali, Romain A Colas, Paul C Norris, Aleksandar Marinković, Xiaoli Liu, Jun Ma, Chase D Rose, Seon-Jin Lee, Suzy A A Comhair, Serpil C Erzurum, Jacob D McDonald, Charles N Serhan, Stephen R Walsh, Daniel J Tschumperlin, Laura E Fredenburg. Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension. JCI insight. vol 1. issue 8. 2020-01-31. PMID:27347562. |
pulmonary artery smooth muscle cells (pasmc) grown on substrates with the stiffness of remodeled pas showed increased proliferation, decreased apoptosis, exaggerated contraction, enhanced matrix deposition, and reduced cox-2-derived prostanoid production compared with cells grown on substrates approximating normal pa stiffness. |
2020-01-31 |
2023-08-13 |
human |
| Anna Brodziak, Paweł Sobczuk, Ewa Bartnik, Michał Fiedorowicz, Camillo Porta, Cezary Szczylik, Anna M Czarneck. Drug resistance in papillary RCC: from putative mechanisms to clinical practicalities. Nature reviews. Urology. vol 16. issue 11. 2020-01-30. PMID:31602010. |
drug resistance to multiple therapies in prcc occurs via genetic alteration (such as mutations resulting in abnormal receptor tyrosine kinase activation or ralbp1 inhibition), dysregulation of signalling pathways (such as gsk3β-eif4ebp1, pi3k-akt and the mapk or interleukin signalling pathways), deregulation of cellular processes (such as resistance to apoptosis or epithelial-to-mesenchymal transition) and interactions between the cell and its environment (for example, through activation of matrix metalloproteinases). |
2020-01-30 |
2023-08-13 |
Not clear |
| Yanhai Jiang, Lianqiang Fu, Yeliang Son. Responses of apoptosis and matrix metabolism of annulus fibrosus cells to different magnitudes of mechanical tension Bioscience reports. vol 39. issue 2. 2020-01-28. PMID:30700570. |
responses of apoptosis and matrix metabolism of annulus fibrosus cells to different magnitudes of mechanical tension annulus fibrosus (af) is important to confine disc nucleus pulposus (np) tissue during mechanical load experience. |
2020-01-28 |
2023-08-13 |
Not clear |
| Lechen Li, Amir H Ameri, Simeng Wang, Keith H Jansson, Orla M Casey, Qi Yang, Michael L Beshiri, Lei Fang, Ross G Lake, Supreet Agarwal, Aian N Alilin, Wanhai Xu, JuanJuan Yin, Kathleen Kell. EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis. Oncogene. vol 38. issue 35. 2020-01-28. PMID:31312026. |
egr1 has been shown to regulate genes influencing proliferation, apoptosis, immune cell activation, and matrix degradation, among others. |
2020-01-28 |
2023-08-13 |
Not clear |
| Zhi-Yong Gao, Liang-Liang Yu, Ben-Xia Shi, Zhen-Ling Dong, Yu-Jie Sun, Hou-Sheng M. T140 Inhibits Apoptosis and Promotes Proliferation and Matrix Formation Through the SDF-1/CXC Receptor-4 Signaling Pathway in Endplate Chondrocytes of the Rat Intervertebral Discs. World neurosurgery. vol 133. 2020-01-28. PMID:31476465. |
t140 inhibits apoptosis and promotes proliferation and matrix formation through the sdf-1/cxc receptor-4 signaling pathway in endplate chondrocytes of the rat intervertebral discs. |
2020-01-28 |
2023-08-13 |
rat |
| Zhi-Yong Gao, Liang-Liang Yu, Ben-Xia Shi, Zhen-Ling Dong, Yu-Jie Sun, Hou-Sheng M. T140 Inhibits Apoptosis and Promotes Proliferation and Matrix Formation Through the SDF-1/CXC Receptor-4 Signaling Pathway in Endplate Chondrocytes of the Rat Intervertebral Discs. World neurosurgery. vol 133. 2020-01-28. PMID:31476465. |
the objective of this study was to evaluate the influence of t140 (polyphemusin ii-derived peptide) on the cep cell growth, apoptosis, and the matrix formation via the stromal cell-derived factor-1 (sdf-1)/cysteine x cysteine (cxc) receptor-4 (cxcr4) signaling pathway. |
2020-01-28 |
2023-08-13 |
rat |
| Yeo Reum Jeon, Hyun Roh, Ji Hyuk Jung, Hyo Min Ahn, Ju Hee Lee, Chae-Ok Yun, Won Jai Le. Antifibrotic Effects of High-Mobility Group Box 1 Protein Inhibitor (Glycyrrhizin) on Keloid Fibroblasts and Keloid Spheroids through Reduction of Autophagy and Induction of Apoptosis. International journal of molecular sciences. vol 20. issue 17. 2020-01-24. PMID:31450620. |
overabundance of extracellular matrix resulting from hyperproliferation of keloid fibroblasts (kfs) and dysregulation of apoptosis represents the main pathophysiology underlying keloids. |
2020-01-24 |
2023-08-13 |
Not clear |
| Panagiotis Lepetsos, Kostas A Papavassiliou, Athanasios G Papavassilio. Redox and NF-κB signaling in osteoarthritis. Free radical biology & medicine. vol 132. 2020-01-20. PMID:30236789. |
overall, nf-κb signaling affects cartilage matrix remodeling, chondrocyte apoptosis, synovial inflammation, and has indirect stimulatory effects on downstream regulators of terminal chondrocyte differentiation. |
2020-01-20 |
2023-08-13 |
human |
| Huiying Zhao, Guiying Chen, Haifeng Wan. Gadd153 deficiency attenuates abdominal aortic aneurysm formation in mice. International journal of clinical and experimental pathology. vol 11. issue 1. 2020-01-19. PMID:31938098. |
moreover, gadd153 deficiency significantly reduced lesion macrophage and cd4+ t-cell content, t-cell proliferation, smc apoptosis, and matrix metalloproteinase expression. |
2020-01-19 |
2023-08-13 |
mouse |
| Jie Sun, Xin Song, Ling Su, Shifeng Ca. Long non-coding RNA LncHIFCAR promotes osteoarthritis development via positively regulating HIF-1α and activating the PI3K/AKT/mTOR pathway. International journal of clinical and experimental pathology. vol 11. issue 6. 2020-01-19. PMID:31938425. |
additionally, lnchifcar was suppressed in atdc5 cells and the effects of lnchifcar suppression on hypoxia-induced cell injury were investigated by assessing cell proliferation, apoptosis, inflammatory response, and matrix synthesis. |
2020-01-19 |
2023-08-13 |
Not clear |
| Jie Sun, Xin Song, Ling Su, Shifeng Ca. Long non-coding RNA LncHIFCAR promotes osteoarthritis development via positively regulating HIF-1α and activating the PI3K/AKT/mTOR pathway. International journal of clinical and experimental pathology. vol 11. issue 6. 2020-01-19. PMID:31938425. |
lnchifcar promoted hypoxia-induced inflammatory response and matrix synthesis by upregulation of vegf, and induced hypoxia-induced apoptosis via upregulation of bnip3. |
2020-01-19 |
2023-08-13 |
Not clear |
| Wenfeng Cai, Shuping Zhong, Fuchun Zheng, Yanmei Zhang, Fenfei Gao, Hongquan Xu, Xiangna Cai, Junhong Lan, Danmei Huang, Ganggang Sh. Angiotensin II confers resistance to apoptosis in cardiac myofibroblasts through the AT1/ERK1/2/RSK1 pathway. IUBMB life. vol 71. issue 2. 2020-01-13. PMID:30452117. |
impaired cardiac myofibroblast (cmf) apoptosis is associated with excessive extracellular matrix (ecm) deposition, which could be responsible for pathological cardiac fibrosis. |
2020-01-13 |
2023-08-13 |
human |
| Maximillian A Rogers, Elena Aikaw. Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery. Nature reviews. Cardiology. vol 16. issue 5. 2020-01-13. PMID:30531869. |
numerous biological processes are involved in calcific disease, including matrix remodelling, transcriptional regulation, mitochondrial dysfunction, oxidative stress, calcium and phosphate signalling, endoplasmic reticulum stress, lipid and mineral metabolism, autophagy, inflammation, apoptosis, loss of mineralization inhibition, impaired mineral resorption, cellular senescence and extracellular vesicles that act as precursors of microcalcification. |
2020-01-13 |
2023-08-13 |
human |