| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Juan Chen, Jian-Guo Zhang, Lan W. Plumbagin inhibits neuronal apoptosis, intimal hyperplasia and also suppresses TNF-α/NF-κB pathway induced inflammation and matrix metalloproteinase-2/9 expression in rat cerebral ischemia. Saudi journal of biological sciences. vol 25. issue 6. 2020-09-28. PMID:30174499. |
plumbagin inhibits neuronal apoptosis, intimal hyperplasia and also suppresses tnf-α/nf-κb pathway induced inflammation and matrix metalloproteinase-2/9 expression in rat cerebral ischemia. |
2020-09-28 |
2023-08-13 |
rat |
| Rafia Asjid, Tayyaba Faisal, Khadija Qamar, Saleem Ahmed Khan, Aamna Khalil, Muhammad Sarwar Zi. Platelet-rich Plasma-induced Inhibition of Chondrocyte Apoptosis Directly Affects Cartilage Thickness in Osteoarthritis. Cureus. vol 11. issue 11. 2020-09-28. PMID:31827985. |
conclusion this study thus concluded that prp had induced an inhibitory effect on the apoptosis of chondrocytes, which, in turn, prevented the loss of cartilage height by inhibiting matrix loss. |
2020-09-28 |
2023-08-13 |
rat |
| Federico Carbone, Aldo Bonaventura, Fabrizio Montecucc. Neutrophil-Related Oxidants Drive Heart and Brain Remodeling After Ischemia/Reperfusion Injury. Frontiers in physiology. vol 10. 2020-09-28. PMID:32116732. |
the exaggerated activation of this signaling system can result in adverse consequences, such as cell apoptosis and extracellular matrix degradation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xinhao Wang, Hongpeng Zhang, Long Cao, Yuan He, Airong Ma, Wei Gu. The Role of Macrophages in Aortic Dissection. Frontiers in physiology. vol 11. 2020-09-28. PMID:32116765. |
stimulated macrophages can secrete metalloproteinases, inflammatory factors and other substances to cause matrix destruction, smooth muscle cell apoptosis, neovascularization and more, all of which destroy the aortic wall structure. |
2020-09-28 |
2023-08-13 |
Not clear |
| Oana-Maria Zahan, Oana Serban, Claudia Gherman, Daniela Fodo. The evaluation of oxidative stress in osteoarthritis. Medicine and pharmacy reports. vol 93. issue 1. 2020-09-28. PMID:32133442. |
this review is focused on the mechanism of ros which regulate intracellular signaling processes, chondrocyte senescence and apoptosis, extracellular matrix synthesis and degradation, along with synovial inflammation and dysfunction of the subcondral bone, targeting the complex oxidative stress signaling pathways. |
2020-09-28 |
2023-08-13 |
Not clear |
| Tetsuro Ohba, Hirotaka Har. TWEAK and TSLP in disc degeneration and spontaneous hernia resorption. JOR spine. vol 3. issue 1. 2020-09-28. PMID:32211586. |
a member of the tumor necrosis factor-α (tnf-α) superfamily, tnf-like weak inducer of apoptosis (tweak) is constitutively expressed in the intervertebral disc, and induces a chronic, but relatively weak inflammatory response, thereby suppressing the formation of cartilage matrix and inducing production of matrix metalloproteinases (mmps). |
2020-09-28 |
2023-08-13 |
Not clear |
| Takashi Yurube, Masaaki Ito, Yuji Kakiuchi, Ryosuke Kuroda, Kenichiro Kakutan. Autophagy and mTOR signaling during intervertebral disc aging and degeneration. JOR spine. vol 3. issue 1. 2020-09-28. PMID:32211593. |
the selective rna interference-mediated and pharmacological inhibition of mtor complex 1 (mtorc1) was protective against inflammation-induced disc cellular apoptosis, senescence, and extracellular matrix catabolism, through the induction of autophagy and the activation of the akt-signaling network. |
2020-09-28 |
2023-08-13 |
human |
| Nathan Piazza, Mehdi Dehghani, Thomas R Gaborski, Karin Wuertz-Koza. Therapeutic Potential of Extracellular Vesicles in Degenerative Diseases of the Intervertebral Disc. Frontiers in bioengineering and biotechnology. vol 8. 2020-09-28. PMID:32363187. |
msc-derived evs not only promote extracellular matrix synthesis and proliferation in ivd cells, but also reduce apoptosis and inflammation, hence having multifunctional beneficial effects that seem to be mediated by specific mirnas (such as mir-233 and mir-21) within the evs. |
2020-09-28 |
2023-08-13 |
Not clear |
| Nana Meng, Zhi Zhao, Chunhe Shi, Leizhou Xi. Inhibiting the Progression of Human Retinoblastoma Cell by Downregulation of MMP-2/MMP-9 Using Short Hairpin RNAs (shRNAs) In Vitro. Journal of ophthalmology. vol 2020. 2020-09-28. PMID:32509341. |
to investigate the effect of downregulated matrix metalloproteinases (mmps) gene on the proliferation, apoptosis, cell cycle, migration, and invasion of human retinoblastoma (rb) cell line in vitro. |
2020-09-28 |
2023-08-13 |
human |
| Bo Fu, Yuhui Zhang, Qingliang Chen, Zhigang Guo, Nan Jian. Antibody microarray analysis of serum inflammatory cytokines in patients with calcific aortic valve disease. Annals of translational medicine. vol 8. issue 12. 2020-09-28. PMID:32647686. |
multiple steps characterize the process: inflammation, cell apoptosis, lipid deposition, renin-angiotensin system activation, extracellular matrix remodeling, and bone formation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Katarzyna Białkowska, Wojciech Marciniak, Magdalena Muszyńska, Piotr Baszuk, Satish Gupta, Katarzyna Jaworska-Bieniek, Grzegorz Sukiennicki, Katarzyna Durda, Tomasz Gromowski, Marcin Lener, Karolina Prajzendanc, Alicja Łukomska, Cezary Cybulski, Tomasz Huzarski, Jacek Gronwald, Tadeusz Dębniak, Jan Lubiński, Anna Jakubowsk. Polymorphisms in Hereditary cancer in clinical practice. vol 18. 2020-09-28. PMID:32765800. |
polymorphisms in matrix metalloproteinases (mmps) and metallothioneins (mts) are zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Krisztina Mikulás, Timea Komlódi, Anna Földes, Gergely Sváb, Gergő Horváth, Ádám Miklós Nagy, Attila Ambrus, Szabolcs Gyulai-Gaál, István Gera, Péter Hermann, Gábor Varga, László Trette. Bioenergetic Impairment of Triethylene Glycol Dimethacrylate- (TEGDMA-) Treated Dental Pulp Stem Cells (DPSCs) and Isolated Brain Mitochondria are Amended by Redox Compound Methylene Blue Materials (Basel, Switzerland). vol 13. issue 16. 2020-09-28. PMID:32781723. |
bioenergetic impairment of triethylene glycol dimethacrylate- (tegdma-) treated dental pulp stem cells (dpscs) and isolated brain mitochondria are amended by redox compound methylene blue triethylene glycol dimethacrylate (tegdma) monomers released from resin matrix are toxic to dental pulp cells, induce apoptosis, oxidative stress and decrease viability. |
2020-09-28 |
2023-08-13 |
human |
| Cong Wang, Yuelong Li, Hao Li, Yali Zhang, Zhangguo Ying, Xuye Wang, Tingting Zhang, Wenshu Zhang, Zhichao Fan, Xiaokun Li, Jisheng Ma, Xuebo Pa. Disruption of FGF Signaling Ameliorates Inflammatory Response in Hepatic Stellate Cells. Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32793588. |
however, disruption of fgf signaling with fgfr inhibitors prominently reduced the apoptosis, inflammatory response, nf-κb nuclear translocation, and expression of matrix metalloproteinase-9 (mmp-9) induced by tnfα in hscs. |
2020-09-28 |
2023-08-13 |
human |
| Yi Li. Hydrogen peroxide induces nucleus pulposus cell apoptosis by ATF4/CHOP signaling pathway. Experimental and therapeutic medicine. vol 20. issue 4. 2020-09-28. PMID:32855694. |
oxidative stress induces excessive apoptosis resulting in the reduction of intervertebral disc cells, the consequent reduction of extracellular matrix (ecm) synthesis, and compositional changes, which is the pathological basis for intervertebral disc degeneration (ivdd). |
2020-09-28 |
2023-08-13 |
Not clear |
| Aixin Zhao, Yunfang Qi, Kun Li. CLDN3 expression and function in pregnancy-induced hypertension. Experimental and therapeutic medicine. vol 20. issue 4. 2020-09-28. PMID:32855729. |
cell counting kit-8 (cck-8) assay, flow cytometry, transwell chamber assays, confocal laser scanning microscopy and western blot analysis were performed to detect cell proliferation, invasion, migration and apoptosis, in addition to matrix metalloproteinase (mmp) expression and erk1/2 phosphorylation. |
2020-09-28 |
2023-08-13 |
human |
| Eric Guberman, Hikmet Sherief, Erzsébet Ravasz Rega. Boolean model of anchorage dependence and contact inhibition points to coordinated inhibition but semi-independent induction of proliferation and migration. Computational and structural biotechnology journal. vol 18. 2020-09-28. PMID:32913583. |
here we propose a boolean regulatory network model that synthesizes mechanosensitive signaling that links anchorage to a matrix of varying stiffness and cell density sensing to contact inhibition, proliferation, migration, and apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ming Xue, Gang Li, Dan Li, Zhu Wang, Lei Mi, Jingjing Da, Xing Ji. Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular smooth muscle cell apoptosis and MMPs production. Bioscience reports. vol 39. issue 11. 2020-09-25. PMID:31651935. |
in vitro ang-ii administration of vsmcs induced mcpip1 expression, accompanied by up-regulation of matrix metalloproteinase (mmp) 2 (mmp-2) and mmp-9, as well as enhancement of vsmcs proliferation and apoptosis, which may cause damage of intima-media elasticity. |
2020-09-25 |
2023-08-13 |
mouse |
| Ning Zhu, Yijia Xiang, Xuyong Zhao, Changhong Cai, Hao Chen, Wenbing Jiang, Yi Wang, Chunlai Zen. Thymoquinone suppresses platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferation, migration and neointimal formation. Journal of cellular and molecular medicine. vol 23. issue 12. 2020-09-22. PMID:31638340. |
molecules including the mitochondria-dependent apoptosis factors, matrix metalloproteinase 2 (mmp2), matrix metalloproteinase 9 (mmp9), pten/akt and mitogen-activated protein kinases (mapks) were determined by western blot. |
2020-09-22 |
2023-08-13 |
rat |
| Qing-Yun Bai, Si-Min Tao, Jin-Hong Tian, Chun-Rong Ca. [Progress of research on effect and mechanism of Scutellariae Radix on preventing liver diseases]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 12. 2020-09-17. PMID:32627454. |
scutellariae radix and its active components can significantly inhibit the activation of hepatic stellate cells and reduce extracellular matrix, and its anti-fibrosis mechanism involves antioxidation, anti-inflammatory, inducing apoptosis of hepatic stellate cells and so on. |
2020-09-17 |
2023-08-13 |
Not clear |
| Xue-Qiang Wang, Wen-Zhan Tu, Jia-Bao Guo, Ge Song, Juan Zhang, Chang-Cheng Chen, Pei-Jie Che. A Bioinformatic Analysis of MicroRNAs' Role in Human Intervertebral Disc Degeneration. Pain medicine (Malden, Mass.). vol 20. issue 12. 2020-09-14. PMID:30953590. |
this report identified 40 different dysregulated mirnas in 53 studies, including studies examining cell apoptosis (26 studies, 49.06%), cell proliferation (15 studies, 28.3%), extracellular matrix (ecm) degradation (10 studies, 18.86%), and inflammation (five studies, 9.43%) in idd patients. |
2020-09-14 |
2023-08-13 |
human |