| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yingqiu Xie, Aidana Mustafa, Adina Yerzhan, Dalmira Merzhakupova, Perizat Yerlan, Askarbek N Orakov, Xiao Wang, Yi Huang, Lixia Mia. Nuclear matrix metalloproteinases: functions resemble the evolution from the intracellular to the extracellular compartment. Cell death discovery. vol 3. 2020-09-30. PMID:28811933. |
matrix metalloproteinase (mmp) is defined as an endopeptidase in the extracellular matrix (ecm), which plays essential roles in physiological processes such as organogenesis, wound healing, angiogenesis, apoptosis and motility. |
2020-09-30 |
2023-08-13 |
Not clear |
| Claudia Pinheiro Sanches, Andre Gustavo Daher Vianna, Fellype de Carvalho Barret. The impact of type 2 diabetes on bone metabolism. Diabetology & metabolic syndrome. vol 9. 2020-09-30. PMID:29075333. |
type 2 diabetes mellitus (t2dm) compromises bone microarchitecture by inducing abnormal bone cell function and matrix structure, with increased osteoblast apoptosis, diminished osteoblast differentiation, and enhanced osteoclast-mediated bone resorption. |
2020-09-30 |
2023-08-13 |
Not clear |
| Prajakta Oak, Anne Hilgendorf. The BPD trio? Interaction of dysregulated PDGF, VEGF, and TGF signaling in neonatal chronic lung disease. Molecular and cellular pediatrics. vol 4. issue 1. 2020-09-30. PMID:29116547. |
disease development is characterized by inflammation, extracellular matrix remodeling, and apoptosis, closely intertwined with the dysregulation of growth factor signaling. |
2020-09-30 |
2023-08-13 |
Not clear |
| Mohamed B Fouda, Finosh G Thankam, Matthew F Dilisio, Devendra K Agrawa. Alterations in tendon microenvironment in response to mechanical load: potential molecular targets for treatment strategies. American journal of translational research. vol 9. issue 10. 2020-09-30. PMID:29118899. |
but, mechanical overload/burden exerts stress on tenocytes, and disrupts the tendon microenvironment by triggering a multitude of signaling pathways leading to extracellular matrix remodeling, disorganization, alteration in collagen composition and apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Pasquale Cocchiaro, Valeria De Pasquale, Rossella Della Morte, Simona Tafuri, Luigi Avallone, Anne Pizard, Anna Moles, Luigi Michele Pavon. The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease. Frontiers in cell and developmental biology. vol 5. 2020-09-30. PMID:29312937. |
specifically in the kidney, cathepsins b, d, l and s have been shown to regulate extracellular matrix homeostasis, autophagy, apoptosis, glomerular permeability, endothelial function, and inflammation. |
2020-09-30 |
2023-08-13 |
human |
| Nolan B Ayers, Chen-Ming Sun, Shi-You Che. Transforming growth factor-β signaling in systemic sclerosis. Journal of biomedical research. vol 32. issue 1. 2020-09-30. PMID:29353817. |
various processes, including cell growth, apoptosis, cell differentiation, and extracellular matrix synthesis are regulated by tgf-β, a type of cytokine secreted by macrophages and many other cell types. |
2020-09-30 |
2023-08-13 |
Not clear |
| Chen Guo, Ling-Feng Xu, Hui-Min Li, Wei Wang, Ji-Hua Guo, Meng-Qi Jia, Rong Jia, Jun Ji. Transcriptomic study of the mechanism of anoikis resistance in head and neck squamous carcinoma. PeerJ. vol 7. 2020-09-29. PMID:31198634. |
normal epithelial cells rapidly undergo apoptosis as soon as they lose contact with the extracellular matrix (ecm), which is termed as anoikis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Robert B Wilson, Wiebke Solass, Rami Archid, Frank-Jürgen Weinreich, Alfred Königsrainer, Marc A Reymon. Resistance to anoikis in transcoelomic shedding: the role of glycolytic enzymes. Pleura and peritoneum. vol 4. issue 1. 2020-09-29. PMID:31198853. |
detachment of cells from the extracellular matrix into the peritoneal cavity initiates a cascade of metabolic alterations, leading usually to cell death by apoptosis, so-called |
2020-09-29 |
2023-08-13 |
Not clear |
| Jialiang Lin, Jiaoxiang Chen, Zengjie Zhang, Tianzhen Xu, Zhenxuan Shao, Xiaobin Wang, Yuanzhe Ding, Naifeng Tian, Haiming Jin, Sunren Sheng, Weiyang Gao, Yan Lin, Xiaolei Zhang, Xiangyang Wan. Luteoloside Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration. Frontiers in pharmacology. vol 10. 2020-09-29. PMID:31427974. |
nuclear factor (erythroid-derived 2)-like 2 (nrf2) is involved in apoptosis, inflammation, and extracellular matrix (ecm) homeostasis. |
2020-09-29 |
2023-08-13 |
rat |
| Dharma Pally, Durjay Pramanik, Ramray Bha. An Interplay Between Reaction-Diffusion and Cell-Matrix Adhesion Regulates Multiscale Invasion in Early Breast Carcinomatosis. Frontiers in physiology. vol 10. 2020-09-29. PMID:31456688. |
the computational model, which comprises adhesion between cancer cells and the matrices, cell proliferation and apoptosis, and matrix remodeling through reaction-diffusion-based morphogen dynamics, is first trained to phenocopy controls run with the experimental model, wherein one or the other matrices have been removed. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yongming Xi, Jinfeng Ma, Yan Che. PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors. Cell biology international. vol 44. issue 2. 2020-09-29. PMID:31663655. |
intervertebral disc degeneration (idd) is induced by multiple factors including increased apoptosis, decreased survival, and reduced extracellular matrix (ecm) synthesis in the nucleus pulposus (np) cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| Hanting Xia, Duanguang Cao, Fo Yang, Wenlong Yang, Wei Li, Pu Liu, Shuhao Wang, Fengyun Yan. Jiawei Yanghe decoction ameliorates cartilage degradation in vitro and vivo via Wnt/β-catenin signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 122. 2020-09-29. PMID:31918279. |
in vitro, jwyhd increased the chondrocyte viability against interleukin (il)-1β-induced chondrocytes apoptosis and preserved glycosaminoglycans in the extracellular matrix. |
2020-09-29 |
2023-08-13 |
rat |
| Hanting Xia, Duanguang Cao, Fo Yang, Wenlong Yang, Wei Li, Pu Liu, Shuhao Wang, Fengyun Yan. Jiawei Yanghe decoction ameliorates cartilage degradation in vitro and vivo via Wnt/β-catenin signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 122. 2020-09-29. PMID:31918279. |
in conclusion, jwyhd possess multiple capabilities including preventing chondrocyte apoptosis, preserving integrity of extracellular matrix and anti-inflammatory effect in the treatment of oa both in vitro and in vivo. |
2020-09-29 |
2023-08-13 |
rat |
| Yinguang Zhang, Qiang Dong, Xiang Su. Positive Feedback Loop LINC00511/miR-150-5p/SP1 Modulates Chondrocyte Apoptosis and Proliferation in Osteoarthritis. DNA and cell biology. vol 39. issue 9. 2020-09-29. PMID:32635763. |
knockdown of linc00511 facilitated proliferation, and repressed the apoptosis and extracellular matrix (ecm) synthesis of chondrocyte. |
2020-09-29 |
2023-08-13 |
Not clear |
| M W Roomi, T Kalinovsky, J Cha, N W Roomi, A Niedzwiecki, M Rat. Effects of a nutrient mixture on immunohistochemical localization of cancer markers in human cervical cancer HeLa cell tumor xenografts in female nude mice. Experimental and therapeutic medicine. vol 9. issue 2. 2020-09-29. PMID:25574189. |
tumor growth was measured and immunohistochemical staining was evaluated for the following cancer markers: ki67 (proliferation); matrix metalloproteinase (mmp)-2 and -9 (invasion/metastasis); vascular endothelial growth factor (vegf) (angiogenesis); terminal deoxynucleotidyl transferase dutp nick end labeling (tunel) and b-cell lymphoma 2 (bcl-2) (apoptosis); cyclooxygenase 2 (cox-2) and inducible nitric oxide synthase (inos) (inflammation); and glutathione s-transferase π (gstπ) (a general cancer marker). |
2020-09-29 |
2023-08-13 |
mouse |
| Dorothy Ndishabandi, Cameron Duquette, Ghita El-Moatassim Billah, Millys Reyes, Mark Duquette, Jack Lawler, Shideh Kazerounia. Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro. Discoveries (Craiova, Romania). vol 2. issue 4. 2020-09-29. PMID:26273699. |
this inhibitory function of tsp-1 is actuated either by inhibiting mmp9 activation and the release of vegf from extracellular matrix or by an interaction with cd36 on the surface of endothelial cells resulting in an increase in apoptosis. |
2020-09-29 |
2023-08-13 |
mouse |
| Mou Peng, Zijun Wang, Zhonghua Yang, Liu Tao, Qingliang Liu, L U Yi, Xinghuan Wan. Overexpression of short TRPM8 variant α promotes cell migration and invasion, and decreases starvation-induced apoptosis in prostate cancer LNCaP cells. Oncology letters. vol 10. issue 3. 2020-09-29. PMID:26622677. |
overall, the results of the present study indicate that sm8α may be important in the regulation of prostate cancer cell migration and invasion through the activation of matrix metalloproteinase-2, as well as in the regulation of apoptosis through the activation of p-jnk in the mapk signaling pathway. |
2020-09-29 |
2023-08-13 |
Not clear |
| b' Kutay Deniz Atabay, Mehmet Taha Yildiz, Timucin Avsar, Arzu Karabay, T\\xc3\\xbcrker Kili\\xc3\\xa. Knockdown of Pin1 leads to reduced angiogenic potential and tumorigenicity in glioblastoma cells. Oncology letters. vol 10. issue 4. 2020-09-29. PMID:26622856.' |
furthermore, knockdown of pin1 decreased the levels of vascular endothelial growth factor and matrix metallopeptidase 9, and also triggered apoptosis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jiao Zhang, Ling Guo, Xia Zhou, Fengyun Dong, Liqun Li, Zuowang Cheng, Yinghua Xu, Jiyong Liang, Qi Xie, Ju Li. Dihydroartemisinin induces endothelial cell anoikis through the activation of the JNK signaling pathway. Oncology letters. vol 12. issue 3. 2020-09-29. PMID:27602117. |
during the process of angiogenesis, endothelial cells migrating from existing capillaries may undergo programmed cell death after detaching from the extracellular matrix, a process that is defined as anchorage-dependent apoptosis or anoikis. |
2020-09-29 |
2023-08-13 |
human |
| Eduardo T Santana, Regiane Dos Santos Feliciano, Andrey J Serra, Eduardo Brigidio, Ednei L Antonio, Paulo J F Tucci, Lubov Nathanson, Mariana Morris, José A Silv. Comparative mRNA and MicroRNA Profiling during Acute Myocardial Infarction Induced by Coronary Occlusion and Ablation Radio-Frequency Currents. Frontiers in physiology. vol 7. 2020-09-29. PMID:27932994. |
we analyzed 48 mrnas expressions of nine different signal transduction pathways (cell survival and metabolism signs, matrix extracellular, cell cycle, oxidative stress, apoptosis, calcium signaling, hypertrophy markers, angiogenesis, and inflammation) in rat left ventricle 1 week after mi generated by both coronary occlusion and ab-rf. |
2020-09-29 |
2023-08-13 |
rat |