| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rafia Asjid, Tayyaba Faisal, Khadija Qamar, Saleem Ahmed Khan, Aamna Khalil, Muhammad Sarwar Zi. Platelet-rich Plasma-induced Inhibition of Chondrocyte Apoptosis Directly Affects Cartilage Thickness in Osteoarthritis. Cureus. vol 11. issue 11. 2020-09-28. PMID:31827985. |
conclusion this study thus concluded that prp had induced an inhibitory effect on the apoptosis of chondrocytes, which, in turn, prevented the loss of cartilage height by inhibiting matrix loss. |
2020-09-28 |
2023-08-13 |
rat |
| Federico Carbone, Aldo Bonaventura, Fabrizio Montecucc. Neutrophil-Related Oxidants Drive Heart and Brain Remodeling After Ischemia/Reperfusion Injury. Frontiers in physiology. vol 10. 2020-09-28. PMID:32116732. |
the exaggerated activation of this signaling system can result in adverse consequences, such as cell apoptosis and extracellular matrix degradation. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xinhao Wang, Hongpeng Zhang, Long Cao, Yuan He, Airong Ma, Wei Gu. The Role of Macrophages in Aortic Dissection. Frontiers in physiology. vol 11. 2020-09-28. PMID:32116765. |
stimulated macrophages can secrete metalloproteinases, inflammatory factors and other substances to cause matrix destruction, smooth muscle cell apoptosis, neovascularization and more, all of which destroy the aortic wall structure. |
2020-09-28 |
2023-08-13 |
Not clear |
| Oana-Maria Zahan, Oana Serban, Claudia Gherman, Daniela Fodo. The evaluation of oxidative stress in osteoarthritis. Medicine and pharmacy reports. vol 93. issue 1. 2020-09-28. PMID:32133442. |
this review is focused on the mechanism of ros which regulate intracellular signaling processes, chondrocyte senescence and apoptosis, extracellular matrix synthesis and degradation, along with synovial inflammation and dysfunction of the subcondral bone, targeting the complex oxidative stress signaling pathways. |
2020-09-28 |
2023-08-13 |
Not clear |
| Tetsuro Ohba, Hirotaka Har. TWEAK and TSLP in disc degeneration and spontaneous hernia resorption. JOR spine. vol 3. issue 1. 2020-09-28. PMID:32211586. |
a member of the tumor necrosis factor-α (tnf-α) superfamily, tnf-like weak inducer of apoptosis (tweak) is constitutively expressed in the intervertebral disc, and induces a chronic, but relatively weak inflammatory response, thereby suppressing the formation of cartilage matrix and inducing production of matrix metalloproteinases (mmps). |
2020-09-28 |
2023-08-13 |
Not clear |
| Takashi Yurube, Masaaki Ito, Yuji Kakiuchi, Ryosuke Kuroda, Kenichiro Kakutan. Autophagy and mTOR signaling during intervertebral disc aging and degeneration. JOR spine. vol 3. issue 1. 2020-09-28. PMID:32211593. |
the selective rna interference-mediated and pharmacological inhibition of mtor complex 1 (mtorc1) was protective against inflammation-induced disc cellular apoptosis, senescence, and extracellular matrix catabolism, through the induction of autophagy and the activation of the akt-signaling network. |
2020-09-28 |
2023-08-13 |
human |
| Nathan Piazza, Mehdi Dehghani, Thomas R Gaborski, Karin Wuertz-Koza. Therapeutic Potential of Extracellular Vesicles in Degenerative Diseases of the Intervertebral Disc. Frontiers in bioengineering and biotechnology. vol 8. 2020-09-28. PMID:32363187. |
msc-derived evs not only promote extracellular matrix synthesis and proliferation in ivd cells, but also reduce apoptosis and inflammation, hence having multifunctional beneficial effects that seem to be mediated by specific mirnas (such as mir-233 and mir-21) within the evs. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ming Xue, Gang Li, Dan Li, Zhu Wang, Lei Mi, Jingjing Da, Xing Ji. Up-regulated MCPIP1 in abdominal aortic aneurysm is associated with vascular smooth muscle cell apoptosis and MMPs production. Bioscience reports. vol 39. issue 11. 2020-09-25. PMID:31651935. |
in vitro ang-ii administration of vsmcs induced mcpip1 expression, accompanied by up-regulation of matrix metalloproteinase (mmp) 2 (mmp-2) and mmp-9, as well as enhancement of vsmcs proliferation and apoptosis, which may cause damage of intima-media elasticity. |
2020-09-25 |
2023-08-13 |
mouse |
| Ning Zhu, Yijia Xiang, Xuyong Zhao, Changhong Cai, Hao Chen, Wenbing Jiang, Yi Wang, Chunlai Zen. Thymoquinone suppresses platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferation, migration and neointimal formation. Journal of cellular and molecular medicine. vol 23. issue 12. 2020-09-22. PMID:31638340. |
molecules including the mitochondria-dependent apoptosis factors, matrix metalloproteinase 2 (mmp2), matrix metalloproteinase 9 (mmp9), pten/akt and mitogen-activated protein kinases (mapks) were determined by western blot. |
2020-09-22 |
2023-08-13 |
rat |
| Qing-Yun Bai, Si-Min Tao, Jin-Hong Tian, Chun-Rong Ca. [Progress of research on effect and mechanism of Scutellariae Radix on preventing liver diseases]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 12. 2020-09-17. PMID:32627454. |
scutellariae radix and its active components can significantly inhibit the activation of hepatic stellate cells and reduce extracellular matrix, and its anti-fibrosis mechanism involves antioxidation, anti-inflammatory, inducing apoptosis of hepatic stellate cells and so on. |
2020-09-17 |
2023-08-13 |
Not clear |
| Xue-Qiang Wang, Wen-Zhan Tu, Jia-Bao Guo, Ge Song, Juan Zhang, Chang-Cheng Chen, Pei-Jie Che. A Bioinformatic Analysis of MicroRNAs' Role in Human Intervertebral Disc Degeneration. Pain medicine (Malden, Mass.). vol 20. issue 12. 2020-09-14. PMID:30953590. |
this report identified 40 different dysregulated mirnas in 53 studies, including studies examining cell apoptosis (26 studies, 49.06%), cell proliferation (15 studies, 28.3%), extracellular matrix (ecm) degradation (10 studies, 18.86%), and inflammation (five studies, 9.43%) in idd patients. |
2020-09-14 |
2023-08-13 |
human |
| Weijia Zhao, Zonghan Chen, Meng Gua. Polydatin enhances the chemosensitivity of osteosarcoma cells to paclitaxel. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31106479. |
furthermore, it altered the expression of various proteins associated with cell growth (ki67, p21, cyclin a, cyclin e, and cyclin-dependent kinase 2), migration (matrix metalloproteinase-2 [mmp-2], mmp-9, and tissue inhibitor of metalloproteinase-1), apoptosis (poly[adp-ribose] polymerase 1 and caspase 3), and drug resistance (p-glycoprotein 1, lung resistance-related protein 1, growth arrest and dna damage-45α, glutathione s-transferase π, and heat shock protein 27) in paclitaxel-resistant osteosarcoma cells. |
2020-09-14 |
2023-08-13 |
human |
| Gui-Cheng Gao, Xi-Gao Cheng, Qiang-Qiang Wei, Wei-Cai Chen, Wen-Zhou Huan. Long noncoding RNA MALAT-1 inhibits apoptosis and matrix metabolism disorder in interleukin-1β-induced inflammation in articular chondrocytes via the JNK signaling pathway. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31111559. |
long noncoding rna malat-1 inhibits apoptosis and matrix metabolism disorder in interleukin-1β-induced inflammation in articular chondrocytes via the jnk signaling pathway. |
2020-09-14 |
2023-08-13 |
rat |
| Gui-Cheng Gao, Xi-Gao Cheng, Qiang-Qiang Wei, Wei-Cai Chen, Wen-Zhou Huan. Long noncoding RNA MALAT-1 inhibits apoptosis and matrix metabolism disorder in interleukin-1β-induced inflammation in articular chondrocytes via the JNK signaling pathway. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31111559. |
in this current study, we explored the chondroprotective effects of long noncoding rna (lncrna) malat-1 on cell proliferation, apoptosis, and matrix metabolism in il-1β-induced inflammation in articular chondrocytes. |
2020-09-14 |
2023-08-13 |
rat |
| Gui-Cheng Gao, Xi-Gao Cheng, Qiang-Qiang Wei, Wei-Cai Chen, Wen-Zhou Huan. Long noncoding RNA MALAT-1 inhibits apoptosis and matrix metabolism disorder in interleukin-1β-induced inflammation in articular chondrocytes via the JNK signaling pathway. Journal of cellular biochemistry. vol 120. issue 10. 2020-09-14. PMID:31111559. |
taken together these results, lncrna malat-1 blocked the activation of the jnk signaling pathway; thereby, il-1β-induced inflammation in articular chondrocytes was reduced with enhanced chondrocyte proliferation and suppressed chondrocyte apoptosis and extracellular matrix degradation. |
2020-09-14 |
2023-08-13 |
rat |
| Jianhong Qiang, Tingting Lv, Zhenbiao Wu, Xichao Yan. Down-regulation of microRNA-142-3p inhibits the aggressive phenotypes of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting nuclear factor-κB signaling. Bioscience reports. vol 39. issue 7. 2020-09-11. PMID:31239367. |
the viability, colony formation, apoptosis, migration, invasion, and the levels of interleukin (il)-6, and matrix metalloproteinase 3 (mmp-3) were detected. |
2020-09-11 |
2023-08-13 |
human |
| Wenmei Zhang, Yanna Li, Xin Xi, Guangfa Zhu, Shenghao Wang, Yan Liu, Man Son. MicroRNA‑15a‑5p induces pulmonary artery smooth muscle cell apoptosis in a pulmonary arterial hypertension model via the VEGF/p38/MMP‑2 signaling pathway. International journal of molecular medicine. vol 45. issue 2. 2020-09-11. PMID:31894295. |
in addition, the overexpression of mir‑15a‑5p reduced pasmc proliferation, induced apoptosis, promoted the activity of caspase‑3/9, induced the protein expression of b‑cell lymphoma 2‑associated x protein (bax), decreased the expression of b‑cell lymphoma 2 (bcl‑2), increased inflammation, as indicated by the expression of tumor necrosis factor‑α (tnf)‑α and interleukin (il)‑1β, il‑6 and il‑18, suppressed the protein expression of vascular endothelial growth factor (vegf), and promoted the protein expression levels of phosphorylated (p)‑p38 mitogen‑activated protein kinase (p38) and matrix metalloproteinase (mmp)‑2 in the pasmcs of rats with mct‑induced pah. |
2020-09-11 |
2023-08-13 |
rat |
| Yihui Tu, Tong Ma, Tao Wen, Tao Yang, Long Xue, Minwei Cai, Fangxin Wang, Mengying Guan, Huaming Xu. MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6. Biochemical and biophysical research communications. vol 523. issue 1. 2020-09-10. PMID:31831175. |
overexpression of mir-377-3p enhanced chondrocyte proliferation and restrained apoptosis and signs of cartilage matrix degradation and of an inflammatory response. |
2020-09-10 |
2023-08-13 |
Not clear |
| Yihui Tu, Tong Ma, Tao Wen, Tao Yang, Long Xue, Minwei Cai, Fangxin Wang, Mengying Guan, Huaming Xu. MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6. Biochemical and biophysical research communications. vol 523. issue 1. 2020-09-10. PMID:31831175. |
overexpression of itga6 reversed the effects of mir-377-3p on il-1β-caused chondrocyte apoptosis, cartilage matrix degradation, and the inflammatory response. |
2020-09-10 |
2023-08-13 |
Not clear |
| Mitali Ray, Michael V Autier. Regulation of pro- and anti-atherogenic cytokines. Cytokine. vol 122. 2020-09-09. PMID:29221669. |
cytokines mediate atherogenesis by stimulating expression of numerous proteins necessary for induction of a host of cellular responses, including inflammation, extravasation, proliferation, apoptosis, and matrix production. |
2020-09-09 |
2023-08-13 |
Not clear |