| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Hui Yuan, Ping Zhang, Ting-Ting Yu, Hua-Kun Huang, Lu-Lu Zhang, Chun-Mei Yang, Tao Tan, Sheng-Dong Yang, Xiao-Ji Luo, Jin-Yong Lu. Lycorine inhibits tumor growth of human osteosarcoma cells by blocking Wnt/β-catenin, ERK1/2/MAPK and PI3K/AKT signaling pathway. American journal of translational research. vol 12. issue 9. 2020-10-13. PMID:33042426. |
moreover, we validated that lycorine promoted apoptosis via death receptor pathway and mitochondrial pathway, suppressed migration and invasion by reversing epithelial mesenchymal transition (emt) and suppressing the degradation of extracellular matrix (ecm) |
2020-10-13 |
2023-08-13 |
human |
| Lei Wu, Kan Zhang, Liping Sun, Jie Bai, Mazhong Zhang, Jijian Zhen. Laminin degradation by matrix metalloproteinase 9 promotes ketamine-induced neuronal apoptosis in the early developing rat retina. CNS neuroscience & therapeutics. 2020-10-10. PMID:32562453. |
laminin degradation by matrix metalloproteinase 9 promotes ketamine-induced neuronal apoptosis in the early developing rat retina. |
2020-10-10 |
2023-08-13 |
rat |
| ShaoWen Cheng, Lei Peng, BaiChao Xu, WenSheng Chen, YangPing Chen, YunTao G. Protective Effects of Hydrogen-Rich Water Against Cartilage Damage in a Rat Model of Osteoarthritis by Inhibiting Oxidative Stress, Matrix Catabolism, and Apoptosis. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-10-07. PMID:31927559. |
protective effects of hydrogen-rich water against cartilage damage in a rat model of osteoarthritis by inhibiting oxidative stress, matrix catabolism, and apoptosis. |
2020-10-07 |
2023-08-13 |
rat |
| Wencai Sun, Yintai Li, Suizhuan We. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29434702. |
furthermore, cell viability, cell apoptosis, cell autophagy and matrix synthesis, as well as the expressions of proteins associated with the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) signaling pathway were detected. |
2020-10-01 |
2023-08-13 |
rat |
| Wencai Sun, Yintai Li, Suizhuan We. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29434702. |
in addition, the effects of mir-4262 on cell viability, cell apoptosis, cell autophagy and matrix synthesis were inhibited by sirt1 (p<0.05). |
2020-10-01 |
2023-08-13 |
rat |
| Wencai Sun, Yintai Li, Suizhuan We. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Experimental and therapeutic medicine. vol 15. issue 1. 2020-10-01. PMID:29434702. |
the present study revealed that the upregulation of mir-4262 may promote the occurrence and development of oa in rats by regulating cell viability, cell apoptosis, cell autophagy, and matrix synthesis. |
2020-10-01 |
2023-08-13 |
rat |
| Bo Diao, Ying Liu, Guo-Zheng Xu, Yi Zhang, Jun Xie, Jie Gon. The role of galectin-3 in the tumorigenesis and progression of pituitary tumors. Oncology letters. vol 15. issue 4. 2020-10-01. PMID:29545898. |
meanwhile, bcl2 associated x, apoptosis regulator (bax), caspase-3 and matrix metalloproteinase 7 (mmp7) protein expression levels were analyzed by western blotting. |
2020-10-01 |
2023-08-13 |
rat |
| Yujie Ning, Xi Wang, Pan Zhang, Amin Liu, Xin Qi, Meidan Liu, Xiong Gu. Dietary exosome-miR-23b may be a novel therapeutic measure for preventing Kashin-Beck disease. Experimental and therapeutic medicine. vol 15. issue 4. 2020-10-01. PMID:29556257. |
recent international research studies have revealed a therapeutic role of dietary exosome micro (mi)rnas in repairing chondrocyte lesions by regulating genes and proteins associated with cellular apoptosis and extracellular matrix. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xin-Hui Xie, Xin-Luan Wang, Hui-Lin Yang, De-Wei Zhao, Ling Qi. Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview). Journal of orthopaedic translation. vol 3. issue 2. 2020-10-01. PMID:30035041. |
we summarised different pathophysiologies of saon which have adverse effects on multiple systems such as bone marrow stem cells (bmscs) pool, bone matrix, cell apoptosis, lipid metabolism, and angiogenesis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Bin Yu, Anouar Hafiane, George Thanassoulis, Leah Ott, Nial Filwood, Marta Cerruti, Ophélie Gourgas, Dominique Shum-Tim, Hamood Al Kindi, Benoit de Varennes, Alawi Alsheikh-Ali, Jacques Genest, Adel Schwertan. Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification. JACC. Basic to translational science. vol 2. issue 4. 2020-10-01. PMID:30062157. |
lipoprotein(a), or lp(a), significantly increased alkaline phosphatase activity, release of phosphate, calcium deposition, hydroxyapatite, cell apoptosis, matrix vesicle formation, and phosphorylation of signal transduction proteins; increased expression of chondro-osteogenic mediators; and decreased sox9 and matrix gla protein (p < 0.001). |
2020-10-01 |
2023-08-13 |
human |
| Patrick Ming-Kuen Tang, Ying-Ying Zhang, Hui-Yao La. LncRNAs in TGF-β-Driven Tissue Fibrosis. Non-coding RNA. vol 4. issue 4. 2020-10-01. PMID:30287731. |
transforming growth factor-β (tgf-β) is a crucial mediator in tissue fibrosis that promotes accumulation of extracellular matrix (ecm), myofibroblasts to epithelial⁻mesenchymal transition (emt), endothelial-mesenchymal transition (endomt), and apoptosis via canonical and noncanonical signaling pathways. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xin Jiang, Yanwei Du, Xinxin Meng, Hongmei Zhang, Di Zhao, Lijing Zhao, Junyu Chen, Shengxiang Xiao, Hongyu Jian. Low-Dose Radiation Enhanced Inhibition of Breast Tumor Xenograft and Reduced Myocardial Injury Induced by Doxorubicin. Dose-response : a publication of International Hormesis Society. vol 16. issue 4. 2020-10-01. PMID:30622447. |
the histology of tumor tissue was observed by hematoxylin and eosin staining, the apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling, and the expression of ki67, bcl-2, bax, cleaved caspase3, matrix metalloproteinase 2 (mmp2), mmp9, and cd34 was detected by western blot. |
2020-10-01 |
2023-08-13 |
mouse |
| Can-Can Zheng, Hui-Fang Hu, Pan Hong, Qi-Hua Zhang, Wen Wen Xu, Qing-Yu He, Bin L. Significance of integrin-linked kinase (ILK) in tumorigenesis and its potential implication as a biomarker and therapeutic target for human cancer. American journal of cancer research. vol 9. issue 1. 2020-10-01. PMID:30755822. |
ilk has multiple functions in cells, such as cell-extracellular matrix interactions, cell cycle, apoptosis, cell proliferation and cell motility, which are associated with the interacting partners of ilk and downstream signaling pathways. |
2020-10-01 |
2023-08-13 |
human |
| Jeffrey M Gimble, Trivia Frazier, Xiying Wu, Andrea Alarcon Uquillas, Claire Llamas, Theodore Brown, Doan Nguyen, H Alan Tucker, Douglas M Arm, Dale R Peterson, Bruce A Bunnel. A Novel, Sterilized Microvascular Tissue Product Improves Healing in a Murine Pressure Ulcer Model. Plastic and reconstructive surgery. Global open. vol 6. issue 11. 2020-10-01. PMID:30881803. |
since pmvt serves as a source of extracellular matrix (ecm), growth factors, cytokines, and chemokines modulating angiogenesis, inflammation, apoptosis, and endogenous cell recruitment, we hypothesized its application would accelerate wound regeneration in a validated pressure ulcer (pu) model developed in c57bl/6 mice using two 24-hour cycles of skin ischemia/reperfusion created by placement and removal of external magnets. |
2020-10-01 |
2023-08-13 |
mouse |
| Charles Saby, Guillaume Collin, Maha Sinane, Emilie Buache, Laurence Van Gulick, Frédéric Saltel, Erik Maquoi, Hamid Morjan. DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31130862. |
ddr1 and mt1-mmp expression levels are determinant for triggering bik-mediated apoptosis by 3d type i collagen matrix in invasive basal-like breast carcinoma cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Charles Saby, Guillaume Collin, Maha Sinane, Emilie Buache, Laurence Van Gulick, Frédéric Saltel, Erik Maquoi, Hamid Morjan. DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31130862. |
we have previously shown that in 3d collagen matrix, ddr1 plays a key role as it promotes cell growth suppression and apoptosis through the upregulation of the pro-apoptotic mediator bik in noninvasive luminal-like breast carcinoma cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Po-Jung Pan, Yu-Chang Liu, Fei-Ting Hs. Protein Kinase B and Extracellular Signal-Regulated Kinase Inactivation is Associated with Regorafenib-Induced Inhibition of Osteosarcoma Progression In Vitro and In Vivo. Journal of clinical medicine. vol 8. issue 6. 2020-10-01. PMID:31238539. |
after regorafenib treatment, downregulation of related genes in invasion (vascular endothelial growth factor (vegf) and matrix metallopeptidase 9 (mmp-9)), proliferation (cyclind1) and anti-apoptosis (x-linked inhibitor of apoptosis protein (xiap), myeloid cell leukemia-1 (mcl-1), and cellular flice (fadd-like il-1β-converting enzyme)-inhibitory protein (c-flip)) were found. |
2020-10-01 |
2023-08-13 |
human |
| Dongmei Zhang, Yiling Cao, Yongdi Zuo, Zheng Wang, Xuhua Mi, Wanxin Tan. Integrated bioinformatics analysis reveals novel hub genes closely associated with pathological mechanisms of immunoglobulin A nephropathy. Experimental and therapeutic medicine. vol 18. issue 2. 2020-10-01. PMID:31316619. |
the major pathological changes associated with it affect cell proliferation, fibrosis, apoptosis, inflammation and extracellular matrix (ecm) organization. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yingying Zhang, Jinfeng Liu, Yan Lv, Chao Zhang, Shuai Gu. LncRNA meg3 suppresses hepatocellular carcinoma in vitro and vivo studies. American journal of translational research. vol 11. issue 7. 2020-10-01. PMID:31396320. |
furthermore, overexpression of meg3 (a) decreased proliferation, migration, and invasion of hepg2 cells; (b) enhanced apoptosis and the proportion of hepg2 cells in g1 of the cell cycle; (c) increased the expression of phosphatase and tensin homolog (pten), bcl2-associated x (bax), and p53 proteins; and (d) decreased the expression of mirna-10a-5p, akt, p-akt, bcl-2, and the matrix metalloproteinases (mmps)-2 and -9. |
2020-10-01 |
2023-08-13 |
Not clear |
| Na Li, Tao Liu, Hui Li, Lifang Zhang, Liping Chu, Qingge Meng, Qinzeng Qiao, Weikun Han, Junhui Zhang, Minying Guo, Jia Zha. ILF2 promotes anchorage independence through direct regulation of PTEN. Oncology letters. vol 18. issue 2. 2020-10-01. PMID:31423236. |
furthermore, the results from the detection of cell adhesion and apoptosis in cell suspension culture demonstrated that this mechanism enabled nsclc cells to reduce adherence to the matrix and to survive in this abnormal state. |
2020-10-01 |
2023-08-13 |
Not clear |