| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Patrick Ming-Kuen Tang, Ying-Ying Zhang, Hui-Yao La. LncRNAs in TGF-β-Driven Tissue Fibrosis. Non-coding RNA. vol 4. issue 4. 2020-10-01. PMID:30287731. |
transforming growth factor-β (tgf-β) is a crucial mediator in tissue fibrosis that promotes accumulation of extracellular matrix (ecm), myofibroblasts to epithelial⁻mesenchymal transition (emt), endothelial-mesenchymal transition (endomt), and apoptosis via canonical and noncanonical signaling pathways. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xin Jiang, Yanwei Du, Xinxin Meng, Hongmei Zhang, Di Zhao, Lijing Zhao, Junyu Chen, Shengxiang Xiao, Hongyu Jian. Low-Dose Radiation Enhanced Inhibition of Breast Tumor Xenograft and Reduced Myocardial Injury Induced by Doxorubicin. Dose-response : a publication of International Hormesis Society. vol 16. issue 4. 2020-10-01. PMID:30622447. |
the histology of tumor tissue was observed by hematoxylin and eosin staining, the apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling, and the expression of ki67, bcl-2, bax, cleaved caspase3, matrix metalloproteinase 2 (mmp2), mmp9, and cd34 was detected by western blot. |
2020-10-01 |
2023-08-13 |
mouse |
| Can-Can Zheng, Hui-Fang Hu, Pan Hong, Qi-Hua Zhang, Wen Wen Xu, Qing-Yu He, Bin L. Significance of integrin-linked kinase (ILK) in tumorigenesis and its potential implication as a biomarker and therapeutic target for human cancer. American journal of cancer research. vol 9. issue 1. 2020-10-01. PMID:30755822. |
ilk has multiple functions in cells, such as cell-extracellular matrix interactions, cell cycle, apoptosis, cell proliferation and cell motility, which are associated with the interacting partners of ilk and downstream signaling pathways. |
2020-10-01 |
2023-08-13 |
human |
| Jeffrey M Gimble, Trivia Frazier, Xiying Wu, Andrea Alarcon Uquillas, Claire Llamas, Theodore Brown, Doan Nguyen, H Alan Tucker, Douglas M Arm, Dale R Peterson, Bruce A Bunnel. A Novel, Sterilized Microvascular Tissue Product Improves Healing in a Murine Pressure Ulcer Model. Plastic and reconstructive surgery. Global open. vol 6. issue 11. 2020-10-01. PMID:30881803. |
since pmvt serves as a source of extracellular matrix (ecm), growth factors, cytokines, and chemokines modulating angiogenesis, inflammation, apoptosis, and endogenous cell recruitment, we hypothesized its application would accelerate wound regeneration in a validated pressure ulcer (pu) model developed in c57bl/6 mice using two 24-hour cycles of skin ischemia/reperfusion created by placement and removal of external magnets. |
2020-10-01 |
2023-08-13 |
mouse |
| Charles Saby, Guillaume Collin, Maha Sinane, Emilie Buache, Laurence Van Gulick, Frédéric Saltel, Erik Maquoi, Hamid Morjan. DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31130862. |
ddr1 and mt1-mmp expression levels are determinant for triggering bik-mediated apoptosis by 3d type i collagen matrix in invasive basal-like breast carcinoma cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Charles Saby, Guillaume Collin, Maha Sinane, Emilie Buache, Laurence Van Gulick, Frédéric Saltel, Erik Maquoi, Hamid Morjan. DDR1 and MT1-MMP Expression Levels Are Determinant for Triggering BIK-Mediated Apoptosis by 3D Type I Collagen Matrix in Invasive Basal-Like Breast Carcinoma Cells. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:31130862. |
we have previously shown that in 3d collagen matrix, ddr1 plays a key role as it promotes cell growth suppression and apoptosis through the upregulation of the pro-apoptotic mediator bik in noninvasive luminal-like breast carcinoma cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Po-Jung Pan, Yu-Chang Liu, Fei-Ting Hs. Protein Kinase B and Extracellular Signal-Regulated Kinase Inactivation is Associated with Regorafenib-Induced Inhibition of Osteosarcoma Progression In Vitro and In Vivo. Journal of clinical medicine. vol 8. issue 6. 2020-10-01. PMID:31238539. |
after regorafenib treatment, downregulation of related genes in invasion (vascular endothelial growth factor (vegf) and matrix metallopeptidase 9 (mmp-9)), proliferation (cyclind1) and anti-apoptosis (x-linked inhibitor of apoptosis protein (xiap), myeloid cell leukemia-1 (mcl-1), and cellular flice (fadd-like il-1β-converting enzyme)-inhibitory protein (c-flip)) were found. |
2020-10-01 |
2023-08-13 |
human |
| Dongmei Zhang, Yiling Cao, Yongdi Zuo, Zheng Wang, Xuhua Mi, Wanxin Tan. Integrated bioinformatics analysis reveals novel hub genes closely associated with pathological mechanisms of immunoglobulin A nephropathy. Experimental and therapeutic medicine. vol 18. issue 2. 2020-10-01. PMID:31316619. |
the major pathological changes associated with it affect cell proliferation, fibrosis, apoptosis, inflammation and extracellular matrix (ecm) organization. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yingying Zhang, Jinfeng Liu, Yan Lv, Chao Zhang, Shuai Gu. LncRNA meg3 suppresses hepatocellular carcinoma in vitro and vivo studies. American journal of translational research. vol 11. issue 7. 2020-10-01. PMID:31396320. |
furthermore, overexpression of meg3 (a) decreased proliferation, migration, and invasion of hepg2 cells; (b) enhanced apoptosis and the proportion of hepg2 cells in g1 of the cell cycle; (c) increased the expression of phosphatase and tensin homolog (pten), bcl2-associated x (bax), and p53 proteins; and (d) decreased the expression of mirna-10a-5p, akt, p-akt, bcl-2, and the matrix metalloproteinases (mmps)-2 and -9. |
2020-10-01 |
2023-08-13 |
Not clear |
| Na Li, Tao Liu, Hui Li, Lifang Zhang, Liping Chu, Qingge Meng, Qinzeng Qiao, Weikun Han, Junhui Zhang, Minying Guo, Jia Zha. ILF2 promotes anchorage independence through direct regulation of PTEN. Oncology letters. vol 18. issue 2. 2020-10-01. PMID:31423236. |
furthermore, the results from the detection of cell adhesion and apoptosis in cell suspension culture demonstrated that this mechanism enabled nsclc cells to reduce adherence to the matrix and to survive in this abnormal state. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yousef Douzandegan, Alireza Tahamtan, Zahra Gray, Hadi Razavi Nikoo, Alijan Tabarraei, Abdolvahab Morad. Cell Death Mechanisms in Esophageal Squamous Cell Carcinoma Induced by Vesicular Stomatitis Virus Matrix Protein. Osong public health and research perspectives. vol 10. issue 4. 2020-10-01. PMID:31497497. |
in this study the effects of vsv wild-type (wt) and m51r-mutant matrix proteins (m51r-mmp) on apoptosis, pyroptosis, necroptosis, and autophagy pathways, in an esophagus cancer cell line (kyse-30) were investigated. |
2020-10-01 |
2023-08-13 |
Not clear |
| Ping Yang, Ye-Mei Tian, Wen-Xiang Deng, Xiong Cai, Wang-Hua Liu, Liang Li, Hui-Yong Huan. Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia-reperfusion in rats. Experimental and therapeutic medicine. vol 18. issue 4. 2020-10-01. PMID:31572528. |
sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia-reperfusion in rats. |
2020-10-01 |
2023-08-13 |
rat |
| Alexandre Vallée, Yves Lecarpentie. TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts. Cell & bioscience. vol 9. 2020-10-01. PMID:31827764. |
during the fibrotic process, tissue retraction rather than contraction is correlated with collagen synthesis in the extracellular matrix, leading to irreversible fibrosis and, finally, apoptosis of myofibroblasts. |
2020-10-01 |
2023-08-13 |
human |
| Jieun Lee, Panseon Ko, Eunae You, Jangho Jeong, Seula Keum, Jaegu Kim, Mizanur Rahman, Dong Ho Lee, Sangmyung Rhe. Shwachman-Bodian-Diamond syndrome protein desensitizes breast cancer cells to apoptosis in stiff matrices by repressing the caspase 8-mediated pathway. Animal cells and systems. vol 23. issue 6. 2020-10-01. PMID:31853379. |
in this study, we demonstrate that expression of the shwachman-bodian-diamond syndrome protein (sdbs) in a stiff matrix protects cells from apoptosis induced by environmental stress, including anticancer drugs. |
2020-10-01 |
2023-08-13 |
Not clear |
| Frank Murphy, Julian Waung, Jane Collins, Michael JP Arthur, Hideaki Nagase, Derek Mann, R Christopher Benyon, John P Iredal. N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. Comparative hepatology. vol 3 Suppl 1. 2020-09-30. PMID:14960160. |
timp-1 has also been shown to have a key role because of its ability to inhibit apoptosis of hsc via matrix metalloproteinase (mmp) inhibition. |
2020-09-30 |
2023-08-12 |
rat |
| Hafiz Ahmed, Prasun Guha, Engin Kaptan, Gargi Bandyopadhyay. Galectin-3: a potential target for cancer prevention. Trends in carbohydrate research. vol 3. issue 2. 2020-09-30. PMID:25484547. |
protein-carbohydrate interactions play significant role in modulating cell-cell and cell-extracellular matrix interactions, which, in turn, mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Mirae Park, Hyeyoung Ki. Anti-cancer Mechanism of Docosahexaenoic Acid in Pancreatic Carcinogenesis: A Mini-review. Journal of cancer prevention. vol 22. issue 1. 2020-09-30. PMID:28382280. |
dha shows anti-cancer activity by inducing oxidative stress and apoptosis, inhibiting wnt/β-catenin signaling, and decreasing extracellular matrix degradation and expression of pro-angiogenic factors in pancreatic cancer cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Maren Schoepp, Anda Jana Ströse, Jörg Haie. Dysregulation of miRNA Expression in Cancer Associated Fibroblasts (CAFs) and Its Consequences on the Tumor Microenvironment. Cancers. vol 9. issue 6. 2020-09-30. PMID:28538690. |
in summary, deregulated mirs affect various intracellular functional complexes, such as transcriptional factors, extracellular matrix, cytoskeleton, emt/met regulation, soluble factors, tyrosine kinase and g-protein signaling, apoptosis and cell cycle & differentiation, but also formation and composition of the extracellular microenvironment. |
2020-09-30 |
2023-08-13 |
Not clear |
| Muhammad Omer Jamil, Mary S Jerome, Deborah Miley, Katri S Selander, Francisco Rober. A pilot study of zoledronic acid in the treatment of patients with advanced malignant pleural mesothelioma. Lung Cancer (Auckland, N.Z.). vol 8. 2020-09-30. PMID:28652837. |
in preclinical studies, nitrogen-containing bisphosphonates (zoledronic acid) inhibit growth of mesothelioma cells by different mechanisms: inhibition of mevalonate pathway, inhibition of angiogenesis, activation of apoptosis through caspase activation, and alteration in activity of matrix metalloproteinases, thereby affecting invasiveness of cancer cells. |
2020-09-30 |
2023-08-13 |
Not clear |
| Daniela Melchiorre, Mirko Manetti, Marco Matucci-Cerini. Pathophysiology of Hemophilic Arthropathy. Journal of clinical medicine. vol 6. issue 7. 2020-09-30. PMID:28672826. |
both cytokines and matrix metalloproteinases and hydroxyl radicals may induce chondrocyte apoptosis. |
2020-09-30 |
2023-08-13 |
Not clear |