| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ashay D Bhatwadekar, Viral Kansara, Qianyi Luo, Thomas Ciull. Anti-integrin therapy for retinovascular diseases. Expert opinion on investigational drugs. vol 29. issue 9. 2021-02-02. PMID:32657172. |
integrins are a family of multi-functional cell-adhesion molecules, heterodimeric receptors that connect extracellular matrix (ecm) to actin cytoskeleton in the cell cortex, thus regulating cellular adhesion, migration, proliferation, invasion, survival, and apoptosis. |
2021-02-02 |
2023-08-13 |
Not clear |
| Savalan Babapoor-Farrokhran, Roozbeh Tarighati Rasekhi, Deanna Gill, Jafar Alzubi, Sumeet K Mainig. How transforming growth factor contributes to atrial fibrillation? Life sciences. vol 266. 2021-02-01. PMID:33309721. |
the transforming growth factor-β (tgf-β) superfamily are cytokines that have the ability to regulate numerous cell functions including proliferation, differentiation, apoptosis, epithelial-mesenchymal transition, and production of extracellular matrix. |
2021-02-01 |
2023-08-13 |
Not clear |
| Hussam Alkaissi, Srinivas Kolla, Cameron Page, Latif Salam, Moro O Salifu, Isabel M McFarlan. Fluoroquinolone-Induced Rotator Cuff Tendinopathy: A Case Report. American journal of medical case reports. vol 9. issue 2. 2021-01-31. PMID:33511269. |
the postulated mechanisms for quinolone-associated tendinopathy are alteration of the tendon extracellular matrix, impairment of tenocyte proliferation, and enhanced apoptosis due to the quinolone cation chelation properties. |
2021-01-31 |
2023-08-13 |
Not clear |
| Steven E Wilso. Biology of keratorefractive surgery- PRK, PTK, LASIK, SMILE, inlays and other refractive procedures. Experimental eye research. vol 198. 2021-01-28. PMID:32653492. |
this article details what is known about these specific wound healing responses that include apoptosis of keratocytes and myofibroblasts, mitosis of corneal fibroblasts and myofibroblast precursors, the development of myofibroblasts from keratocyte-derived corneal fibroblasts and bone marrow-derived fibrocytes, deposition of disordered extracellular matrix by corneal fibroblasts and myofibroblasts, healing of the epithelial injury, and regeneration of the epithelial basement membrane. |
2021-01-28 |
2023-08-13 |
Not clear |
| Kalpana K Bhanumathy, Amrutha Balagopal, Frederick S Vizeacoumar, Franco J Vizeacoumar, Andrew Freywald, Vincenzo Giambr. Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia. Cancers. vol 13. issue 2. 2021-01-26. PMID:33430292. |
tyrosine kinases execute their biological functions by controlling a variety of cellular responses, such as cell division, metabolism, migration, cell-cell and cell matrix adhesion, cell survival and apoptosis. |
2021-01-26 |
2023-08-13 |
human |
| Eun-Ju Jang, Jee Young Sung, Ha-Eun Yoo, Hyonchol Jang, Jaegal Shim, Eok-Soo Oh, Sung-Ho Goh, Yong-Nyun Ki. FAM188B Downregulation Sensitizes Lung Cancer Cells to Anoikis via EGFR Downregulation and Inhibits Tumor Metastasis In Vivo. Cancers. vol 13. issue 2. 2021-01-26. PMID:33440835. |
anoikis is a type of apoptosis induced by cell detachment from the extracellular matrix (ecm), which removes mislocalized cells. |
2021-01-26 |
2023-08-13 |
mouse |
| Tian Tian, Rujia Xie, Kaize Ding, Bing Han, Qin Yang, Xue Yan. IOX1 protects from TGF-β induced fibrosis in LX-2 cells via the regulation of extracellular matrix protein expression. Experimental and therapeutic medicine. vol 21. issue 3. 2021-01-26. PMID:33488789. |
cellular proliferation, apoptosis, histone h3k9 dimethylation (h3k9me2), protein expression of extracellular matrix (ecm)-related proteins α-smooth muscle actin (sma), type i collagen (col i), mmp-1 and timp-1 were measured. |
2021-01-26 |
2023-08-13 |
human |
| Ying Liu, Jia-Wei Song, Jian-Yu Lin, Ran Miao, Jiu-Chang Zhon. Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases. Cardiovascular toxicology. vol 20. issue 5. 2021-01-25. PMID:32856216. |
mir-122 overexpression appears to exacerbate the angiotensin ii-mediated loss of autophagy and increased inflammation, apoptosis, extracellular matrix deposition, cardiovascular fibrosis and dysfunction by modulating the sirt6-elabela-ace2, lgr4-β-catenin, tgfβ-ctgf and pten-pi3k-akt signaling pathways. |
2021-01-25 |
2023-08-13 |
Not clear |
| Jun He, Xiaotao Su, Wenwei Xi. MiR-582-3p alleviates osteoarthritis progression by targeting YAP1. Molecular immunology. vol 128. 2021-01-25. PMID:33190006. |
functional investigations indicated that mir-582-3p inhibited chondrocyte apoptosis, reduced the proinflammatory cytokine production and suppressed extracellular matrix (ecm) degradation. |
2021-01-25 |
2023-08-13 |
rat |
| Meixiong Cheng, Yi Zeng, Tian Zhang, Min Xu, Zhili Li, Yaqiu W. Transcription Factor ELF1 Activates MEIS1 Transcription and Then Regulates the GFI1/FBW7 Axis to Promote the Development of Glioma. Molecular therapy. Nucleic acids. vol 23. 2021-01-22. PMID:33473327. |
importantly, silencing of elf1 decreased the capacities of proliferation, migration, and invasion of glioma cells whereas it increased apoptosis, supported by increased capase-3 and decreased matrix metalloproteinase-9 (mmp-9) and proliferating cell nuclear antigen (pcna) expression. |
2021-01-22 |
2023-08-13 |
Not clear |
| Qing Wang, Di Zhuang, Wenchang Feng, Bitao Ma, Liping Qin, Lilun Ji. Fraxetin inhibits interleukin-1β-induced apoptosis, inflammation, and matrix degradation in chondrocytes and protects rat cartilage Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 28. issue 12. 2021-01-12. PMID:33424243. |
fraxetin inhibits interleukin-1β-induced apoptosis, inflammation, and matrix degradation in chondrocytes and protects rat cartilage osteoarthritis (oa) is a disease characterized by degeneration of the joint complex due to cartilage destruction. |
2021-01-12 |
2023-08-13 |
rat |
| Zeynep Karagöz, Laura Rijns, Patricia Y W Dankers, Martijn van Griensven, Aurélie Carlie. Towards understanding the messengers of extracellular space: Computational models of outside-in integrin reaction networks. Computational and structural biotechnology journal. vol 19. 2021-01-12. PMID:33425258. |
the interactions between cells and their extracellular matrix (ecm) are critically important for homeostatic control of cell growth, proliferation, differentiation and apoptosis. |
2021-01-12 |
2023-08-13 |
Not clear |
| Yingjuan Lv, Zhanheng Zhang, Xiaoli Xing, Aihua Li. lncRNA TGFβ2-AS1 promotes ECM production via TGF-β2 in human trabecular meshwork cells. Biochemical and biophysical research communications. vol 527. issue 4. 2021-01-11. PMID:32423825. |
the important pathological manifestations of open-angle glaucoma (oag) are human trabecular meshwork cells (htmcs) apoptosis and excessive deposition of extracellular matrix (ecm) components in tm, which can cause pathological changes in the outflow pathway. |
2021-01-11 |
2023-08-13 |
human |
| Caio P Gomes, Danilo E Fernandes, Fernanda Casimiro, Gustavo F da Mata, Michelle T Passos, Patricia Varela, Gianna Mastroianni-Kirsztajn, João Bosco Pesquer. Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics. Frontiers in cellular and infection microbiology. vol 10. 2021-01-11. PMID:33364201. |
catl is a lysosomal enzyme that participates in numerous physiological processes, including apoptosis, antigen processing, and extracellular matrix remodeling. |
2021-01-11 |
2023-08-13 |
Not clear |
| Yuanyuan Che, Xu Shi, Yunpeng Shi, Xiaoming Jiang, Qing Ai, Ying Shi, Fengyan Gong, Wenyan Jian. Exosomes Derived from miR-143-Overexpressing MSCs Inhibit Cell Migration and Invasion in Human Prostate Cancer by Downregulating TFF3. Molecular therapy. Nucleic acids. vol 18. 2021-01-10. PMID:31563120. |
furthermore, elevated mir-143 or exosome-mir-143 or silencing tff3 inhibited the expression of tff3, proliferating cell nuclear antigen (pcna), matrix metalloproteinase (mmp)-2, and mmp-9 and pc3 cell proliferation, migration, invasion, and tumor growth, whereas it promoted apoptosis. |
2021-01-10 |
2023-08-13 |
human |
| Eve Helena Rogers, Vanja Pekovic-Vaughan, John Alan Hun. Mechanical stretch and chronotherapeutic techniques for progenitor cell transplantation and biomaterials. BioMedicine. vol 8. issue 3. 2021-01-09. PMID:30141401. |
tensile stress, or compression loading are just two of these forces, and here we examine the role of cyclical or dynamic mechanical loading on progenitor cell proliferation and differentiation, as well as on other cellular processes including cell morphology, apoptosis and matrix mineralisation. |
2021-01-09 |
2023-08-13 |
human |
| Lifeng Jiang, Kai Xu, Jin Li, Xindie Zhou, Langhai Xu, Zhipeng Wu, Chiyuan Ma, Jisheng Ran, Pengfei Hu, Jiapeng Bao, Lidong Wu, Yan Xion. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. Aging. vol 12. issue 2. 2021-01-08. PMID:32003758. |
nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. |
2021-01-08 |
2023-08-13 |
rat |
| Lifeng Jiang, Kai Xu, Jin Li, Xindie Zhou, Langhai Xu, Zhipeng Wu, Chiyuan Ma, Jisheng Ran, Pengfei Hu, Jiapeng Bao, Lidong Wu, Yan Xion. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. Aging. vol 12. issue 2. 2021-01-08. PMID:32003758. |
osteoarthritis (oa) is a chronic degenerative joint disease, related to the overexpression of matrix metalloproteinases (mmps), a disintegrin and metalloproteinase with thrombospondin motifs (adamts), inflammation, and chondrocyte apoptosis. |
2021-01-08 |
2023-08-13 |
rat |
| Gary H F Yam, Andri K Riau, Martha L Funderburgh, Jodhbir S Mehta, Vishal Jhanj. Keratocyte biology. Experimental eye research. vol 196. 2021-01-08. PMID:32442558. |
trauma-induced apoptosis of keratocytes and replacement by fibroblasts and myofibroblasts disrupt the stromal matrix organization, resulting in corneal haze formation and vision loss. |
2021-01-08 |
2023-08-13 |
Not clear |
| Mingyan Yao, Jing Zhang, Zhihong Li, Shuqin Guo, Xue Zhou, Wenjing Zhan. Marein protects human nucleus pulposus cells against high glucose-induced injury and extracellular matrix degradation at least partly by inhibition of ROS/NF-κB pathway. International immunopharmacology. vol 80. 2021-01-04. PMID:31931363. |
intervertebral disc degeneration (idd), a major cause of discogenic low back pain, is a musculoskeletal disorder involving the apoptosis of nucleus pulposus cells (npcs) and extracellular matrix (ecm) degradation. |
2021-01-04 |
2023-08-13 |
human |