| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qingpu Zhang, Xiaomiao Qiao, Wenwei Xi. CircSERPINE2 weakens IL-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33094798. |
circserpine2 weakens il-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating mir-495/tgfbr2 axis. |
2021-04-12 |
2023-08-13 |
Not clear |
| Qingpu Zhang, Xiaomiao Qiao, Wenwei Xi. CircSERPINE2 weakens IL-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33094798. |
circserpine2 overexpression mitigated il-1β-caused apoptosis and extracellular matrix degradation. |
2021-04-12 |
2023-08-13 |
Not clear |
| Qingpu Zhang, Xiaomiao Qiao, Wenwei Xi. CircSERPINE2 weakens IL-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33094798. |
mir-495 up-regulation reversed overexpression of circserpine2-mediated inhibition of apoptosis and extracellular matrix degradation. |
2021-04-12 |
2023-08-13 |
Not clear |
| Qingpu Zhang, Xiaomiao Qiao, Wenwei Xi. CircSERPINE2 weakens IL-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating miR-495/TGFBR2 axis. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33094798. |
as a conclusion, circserpine2 attenuated il-1β-caused apoptosis and extracellular matrix degradation of chondrocytes by regulating mir-495/tgfbr2 axis, indicating a new target for oa treatment. |
2021-04-12 |
2023-08-13 |
Not clear |
| Liping Xue, Cheng Xiong, Juanjuan Li, Yuling Ren, Liwei Zhang, Kangwei Jiao, Chen Chen, Peng Din. miR-200-3p suppresses cell proliferation and reduces apoptosis in diabetic retinopathy via blocking the TGF-β2/Smad pathway. Bioscience reports. vol 40. issue 11. 2021-04-12. PMID:33150936. |
subsequently, overexpression of mir-200a-3p significantly promoted cell proliferation, reduced apoptosis, as well as inhibited the levels of inflammatory cytokines secreted, matrix metalloprotease 2/9 (mmp2/9), and vascular endothelial growth factor (vegf) in hg-injured arpe-19 cells. |
2021-04-12 |
2023-08-13 |
rat |
| Ujval Anilkumar, Mireille Khacho, Alexanne Cuillerier, Richard Harris, David A Patten, Maria Bilen, Mohamed Ariff Iqbal, Ding Yuan Guo, Louis-Eric Trudeau, David S Park, Mary-Ellen Harper, Yan Burelle, Ruth S Slac. MCL-1 Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32371858. |
mcl-1 is an anti-apoptotic bcl-2 protein localized to mitochondria either in the outer membrane (om) or inner membrane (matrix), which have distinct roles in inhibiting apoptosis and promoting bioenergetics, respectively. |
2021-04-07 |
2023-08-13 |
Not clear |
| Peng Shen, Yanfeng Chen. Long noncoding RNA lncARSR confers resistance to Adriamycin and promotes osteosarcoma progression. Cell death & disease. vol 11. issue 5. 2021-04-07. PMID:32404870. |
further investigation revealed that the upregulation of lncarsr enhanced multidrug resistance-associated protein-1 (mrp1), apoptosis inhibitor survivin, and matrix metalloproteinase-2 (mmp2) through activating akt. |
2021-04-07 |
2023-08-13 |
mouse |
| Yong Zhou, Mingsi Deng, Jiqing Su, Wei Zhang, Dongbiao Liu, Zhengguang Wan. The Role of miR-31-5p in the Development of Intervertebral Disc Degeneration and Its Therapeutic Potential. Frontiers in cell and developmental biology. vol 9. 2021-04-06. PMID:33816484. |
overexpression of mir-31-5p facilitates nucleus pulposus cell proliferation, inhibits apoptosis, facilitates ecm formation, and inhibits the level of matrix degrading enzymes in np cells. |
2021-04-06 |
2023-08-13 |
mouse |
| Ryoko Sakamoto, Ikko Kajihara, Hitomi Miyauchi, Saki Maeda-Otsuka, Saori Yamada-Kanazawa, Soichiro Sawamura, Hisashi Kanemaru, Katsunari Makino, Jun Aoi, Takamitsu Makino, Satoshi Fukushima, Mamiko Masuzawa, Mikio Masuzawa, Yasuyuki Amoh, Daichi Hoshina, Riichiro Abe, Hironobu Ih. Inhibition of Endoglin Exerts Antitumor Effects through the Regulation of Non-Smad TGF-β Signaling in Angiosarcoma. The Journal of investigative dermatology. vol 140. issue 10. 2021-04-05. PMID:32142796. |
knockdown of endoglin activated caspase 3/7 that is essential for apoptosis, reduced survivin levels, and decreased paxillin and vascular endothelial cadherin phosphorylation and matrix metalloproteinase 2 and matrix metalloproteinase 9 activities in angiosarcoma cells. |
2021-04-05 |
2023-08-13 |
Not clear |
| Tatiana Kisseleva, David Brenne. Molecular and cellular mechanisms of liver fibrosis and its regression. Nature reviews. Gastroenterology & hepatology. vol 18. issue 3. 2021-04-05. PMID:33128017. |
we also discuss strategies to target hepatic myofibroblasts (for example, via apoptosis or inactivation) and the myeloid cells that degrade the matrix (for example, via their recruitment to fibrotic liver) to facilitate fibrosis resolution and liver regeneration. |
2021-04-05 |
2023-08-13 |
Not clear |
| Philippe Chouvarine, Joachim Photiadis, Robert Cesnjevar, Jens Scheewe, Ulrike M M Bauer, Thomas Pickardt, Hans-Heiner Kramer, Sven Dittrich, Felix Berger, Georg Hansman. RNA expression profiles and regulatory networks in human right ventricular hypertrophy due to high pressure load. iScience. vol 24. issue 3. 2021-04-02. PMID:33786422. |
these genes are significantly overrepresented in pathways related to regulation of glucose and lipid metabolism (sik1, fabp4), cell surface interactions (thbs2, fn1), apoptosis (pik3ip1, sik1), extracellular matrix composition (ctgf, igf1), and other biological events. |
2021-04-02 |
2023-08-13 |
human |
| Hui Zhang, Yajing Wang, Khalid Mehmood, Yung-Fu Chang, Zhaoxin Tang, Ying L. Treatment of tibial dyschondroplasia with traditional Chinese medicines: "Lesson and future directions". Poultry science. vol 99. issue 12. 2021-04-01. PMID:33248557. |
selecting a tcm approach and its pharmacologic effects on td chickens mainly focused on the differentiation, proliferation, and apoptosis of chondrocytes, angiogenesis, matrix metabolism, oxidative damage, cytokines, and calcification of cartilage in tibia. |
2021-04-01 |
2023-08-13 |
Not clear |
| Hongtao Liu, Qing Zhang, Qianqian Lou, Xin Zhang, Yunxia Cui, Panpan Wang, Fan Yang, Fan Wu, Jing Wang, Tianli Fan, Shenglei L. Differential Analysis of lncRNA, miRNA and mRNA Expression Profiles and the Prognostic Value of lncRNA in Esophageal Cancer. Pathology oncology research : POR. vol 26. issue 2. 2021-03-31. PMID:30972633. |
we found 145 lncrnas, 112 mirnas and 2000 protein coding mrnas were differentially expressed in esca samples, which were tightly involved in chromosome segregation, extracellular matrix assembly by go assay, and kegg assay revealed the correlation of differentially expressed genes with cell cycle, apoptosis and cgmp-pkg signaling pathway. |
2021-03-31 |
2023-08-13 |
Not clear |
| Jin Shu, Yiwen Gu, Li Jin, Haiya Wan. Matrix metalloproteinase 3 regulates angiotensin II‑induced myocardial fibrosis cell viability, migration and apoptosis. Molecular medicine reports. vol 23. issue 2. 2021-03-31. PMID:33655326. |
matrix metalloproteinase 3 regulates angiotensin ii‑induced myocardial fibrosis cell viability, migration and apoptosis. |
2021-03-31 |
2023-08-13 |
rat |
| Hyun-Joo Park, Yeon Kim, Mi-Kyoung Kim, Jae Joon Hwang, Hyung Joon Kim, Soo-Kyung Bae, Moon-Kyoung Ba. Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification. Cells. vol 9. issue 3. 2021-03-29. PMID:32192106. |
this attenuation was caused by inhibiting phenotype change, apoptosis and matrix vesicle release in vsmcs. |
2021-03-29 |
2023-08-13 |
mouse |
| Jian Sun, Weiwei Sheng, Yuteng Ma, Ming Don. Potential Role of Musashi-2 RNA-Binding Protein in Cancer EMT. OncoTargets and therapy. vol 14. 2021-03-26. PMID:33762829. |
local invasion and distant metastasis are the key hallmarks in the aggressive progression of malignant tumors, including the ability of cancer cells to detach from the extracellular matrix overcome apoptosis, and disseminate into distant sites. |
2021-03-26 |
2023-08-13 |
Not clear |
| Yanchang Liu, Juehua Jing, Haoran Yu, Jisen Zhang, Qiliang Cao, Xin Zhang, Jianjun Liu, Shuo Zhang, Wendan Chen. Expression profiles of long non-coding RNAs in the cartilage of patients with knee osteoarthritis and normal individuals. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-20. PMID:33732338. |
abnormal expression of long non-coding rnas (lncrnas) affects the metabolism, synovitis, autophagy and apoptosis of chondrocytes, as well as the production of cartilage matrix. |
2021-03-20 |
2023-08-13 |
Not clear |
| Xiaoli Ruan, Dongming Zhou, Rencan Nie, Yanbu Gu. Predictions of Apoptosis Proteins by Integrating Different Features Based on Improving Pseudo-Position-Specific Scoring Matrix. BioMed research international. vol 2020. 2021-03-18. PMID:32420339. |
predictions of apoptosis proteins by integrating different features based on improving pseudo-position-specific scoring matrix. |
2021-03-18 |
2023-08-13 |
Not clear |
| Dake Hao, Ruiwu Liu, Kewa Gao, Chuanchao He, Siqi He, Cunyi Zhao, Gang Sun, Diana L Farmer, Alyssa Panitch, Kit S Lam, Aijun Wan. Developing an Injectable Nanofibrous Extracellular Matrix Hydrogel With an Integrin αvβ3 Ligand to Improve Endothelial Cell Survival, Engraftment and Vascularization. Frontiers in bioengineering and biotechnology. vol 8. 2021-03-16. PMID:32850742. |
however, the therapeutic effect of transplanted ecs is limited by their poor viability, which partially occurs as a result of cellular apoptosis triggered by the insufficient cell-extracellular matrix (ecm) engagement. |
2021-03-16 |
2023-08-13 |
Not clear |
| Heming Ge, Mengxiang Tian, Qian Pei, Fengbo Tan, Haiping Pe. Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism. Frontiers in oncology. vol 11. 2021-03-16. PMID:33718214. |
in recent years, in-depth studies have shown that extracellular matrix stiffness plays an important role in cell growth, proliferation, migration, immunity, malignant transformation, and apoptosis. |
2021-03-16 |
2023-08-13 |
Not clear |