| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daniele Vergara, William H Catherino, Giuseppe Trojano, Andrea Tinell. Vitamin D: Mechanism of Action and Biological Effects in Uterine Fibroids. Nutrients. vol 13. issue 2. 2021-05-06. PMID:33670322. |
in vitro studies proved vitamin d efficacy in inhibiting ufs growth by targeting pathways involved in the regulation of various biological processes, including proliferation, extracellular matrix (ecm) remodeling, dna repair, signaling and apoptosis. |
2021-05-06 |
2023-08-13 |
Not clear |
| Hao Zhang, Fang Liang, Junmin Yue, Peng Liu, Junyong Wang, Zhaoyang Wang, Hongxing Li, Duo Cheng, Jie Du, Kai Zhang, Peng D. MicroRNA‑137 regulates hypoxia‑mediated migration and epithelial‑mesenchymal transition in prostate cancer by targeting LGR4 via the EGFR/ERK signaling pathway. International journal of oncology. vol 57. issue 2. 2021-05-05. PMID:32626928. |
further results from the cell counting kit‑8, cell death detection elisa plus kit, transwell assay, rt‑qpcr and western blotting assays revealed that the mir‑137 mimic prevented cell proliferation, facilitated apoptosis and repressed cell migration, invasiveness, and expression of n‑cadherin, vimentin and matrix metalloproteinase 2; the mir‑137 inhibitor exerted the opposite effects. |
2021-05-05 |
2023-08-13 |
Not clear |
| Wei Liu, Xifeng Xiong, Weiguang Chen, Xiaojian Li, Xing Hua, Zhihe Liu, Zhi Zhan. High expression of FUSE binding protein 1 in breast cancer stimulates cell proliferation and diminishes drug sensitivity. International journal of oncology. vol 57. issue 2. 2021-05-05. PMID:32626933. |
furthermore, the knockdown of fbp1 decreased cell migration and metastasis by downregulating matrix metalloproteinase 2 expression, and enhanced the sensitivity of tnbc cells to cisplatin by inducing apoptosis. |
2021-05-05 |
2023-08-13 |
human |
| Rakhee K Ramakrishnan, Khuloud Bajbouj, Saba Al Heialy, Bassam Mahboub, Abdul Wahid Ansari, Ibrahim Y Hachim, Surendra Rawat, Laila Salameh, Mahmood Y Hachim, Ronald Olivenstein, Rabih Halwani, Rifat Hamoudi, Qutayba Hami. IL-17 Induced Autophagy Regulates Mitochondrial Dysfunction and Fibrosis in Severe Asthmatic Bronchial Fibroblasts. Frontiers in immunology. vol 11. 2021-05-05. PMID:32670268. |
the accumulation of fibroblasts, their synthesis of extracellular matrix (ecm) proteins and their innate resistance to apoptosis are characteristics of subepithelial fibrosis observed in severe asthma. |
2021-05-05 |
2023-08-13 |
human |
| Z-L Han, H-Q Wang, T-S Zhang, Y-X He, H Zho. Up-regulation of exosomal miR-106a may play a significant role in abdominal aortic aneurysm by inducing vascular smooth muscle cell apoptosis and targeting TIMP-2, an inhibitor of metallopeptidases that suppresses extracellular matrix degradation. European review for medical and pharmacological sciences. vol 24. issue 15. 2021-05-04. PMID:32767336. |
up-regulation of exosomal mir-106a may play a significant role in abdominal aortic aneurysm by inducing vascular smooth muscle cell apoptosis and targeting timp-2, an inhibitor of metallopeptidases that suppresses extracellular matrix degradation. |
2021-05-04 |
2023-08-13 |
Not clear |
| Hannah J Yu, Charles C Wykof. Investigational Agents in Development for the Treatment of Geographic Atrophy Secondary to Age-Related Macular Degeneration. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 35. issue 3. 2021-05-03. PMID:33893984. |
several other biochemical pathways have also been implicated in ga development and progression, such as mitochondrial components, mediators of apoptosis and molecules involved in extracellular matrix remodeling, many of which are also being investigated for their potential value as therapeutic targets for ga treatment. |
2021-05-03 |
2023-08-13 |
human |
| Mingqi Sun, Junli Yang, Dianming Jiang, Guoyu Ba. Overexpression of hsa_circ_0094742 inhibits IL-1β-induced decline in CHON-001 cell viability by targeting microRNA-127-5p. Histology and histopathology. vol 36. issue 2. 2021-04-29. PMID:33665792. |
furthermore, il-1β-induced alterations in aggrecan, matrix metallopeptidase 13, x-linked inhibitor of apoptosis protein (xiap), bax and active caspase 3 were reversed by hsa_circ_0094742 oe. |
2021-04-29 |
2023-08-13 |
human |
| Sabrina L Roberti, Romina Higa, Hugo Sato, Dalmiro Gomez Ribot, Evangelina Capobianco, Alicia Jawerbau. Olive oil supplementation prevents extracellular matrix deposition and reduces prooxidant markers and apoptosis in the offspring´s heart of diabetic rats. Reproductive toxicology (Elmsford, N.Y.). vol 95. 2021-04-28. PMID:32417168. |
olive oil supplementation prevents extracellular matrix deposition and reduces prooxidant markers and apoptosis in the offspring´s heart of diabetic rats. |
2021-04-28 |
2023-08-13 |
rat |
| Sabrina L Roberti, Romina Higa, Hugo Sato, Dalmiro Gomez Ribot, Evangelina Capobianco, Alicia Jawerbau. Olive oil supplementation prevents extracellular matrix deposition and reduces prooxidant markers and apoptosis in the offspring´s heart of diabetic rats. Reproductive toxicology (Elmsford, N.Y.). vol 95. 2021-04-28. PMID:32417168. |
the aim of this study was to investigate the effect of a maternal diet enriched in olive oil on the levels of components and regulators of the extracellular matrix, on prooxidant markers and on apoptosis rate in the heart of 21-day-old offspring of diabetic rats. |
2021-04-28 |
2023-08-13 |
rat |
| Albert J Pedroza, Tiffany Koyano, Jeffrey Trojan, Adam Rubin, Itai Palmon, Kevin Jaatinen, Grayson Burdon, Paul Chang, Yasushi Tashima, Jason Z Cui, Gerry Berry, Cristiana Iosef, Michael P Fischbei. Divergent effects of canonical and non-canonical TGF-β signalling on mixed contractile-synthetic smooth muscle cell phenotype in human Marfan syndrome aortic root aneurysms. Journal of cellular and molecular medicine. vol 24. issue 3. 2021-04-27. PMID:31886938. |
reversing notch3 overexpression with sirna demonstrated that notch3 promotes several protective remodelling pathways, including increased smc proliferation, decreased apoptosis and reduced matrix metalloproteinase activity, in vitro. |
2021-04-27 |
2023-08-13 |
human |
| Kexin Zheng, Qilong Li, Dongdong Lin, Xiaoyan Zong, Xue Luo, Mei Yang, Xiqing Yue, Shiliang M. Peptidomic analysis of pilose antler and its inhibitory effect on triple-negative breast cancer at multiple sites. Food & function. vol 11. issue 9. 2021-04-26. PMID:32789330. |
pawps activated the expression of cleaved-caspase3 and increased tumor apoptosis, resulting in the reduction of platelet-endothelial cell adhesion molecule (pecam-1/cd31) expression and the number of blood vessels, as well as the inhibition of matrix metalloproteinase (mmp) 2 and 9, increasing the ratio of cadherin-1 (cdh1)/cadherin-2 (cdh2) and inhibiting epithelial-mesenchymal transition (emt) in these tumors. |
2021-04-26 |
2023-08-13 |
mouse |
| Zhonghui Chen, Weibing Zhang, Ming Deng, Yaming Li, Yan Zho. CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1. Aging. vol 12. issue 21. 2021-04-23. PMID:33159017. |
circglce alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of mir-587/stap1. |
2021-04-23 |
2023-08-13 |
mouse |
| Sizhen Li, Qingsong Yang, Zixiu Zhou, Min Fu, Xiaodong Yang, Kuanxiao Hao, Yating Li. SNHG3 cooperates with ELAVL2 to modulate cell apoptosis and extracellular matrix accumulation by stabilizing SNAI2 in human trabecular meshwork cells under oxidative stress. Environmental toxicology. vol 36. issue 6. 2021-04-23. PMID:33522089. |
snhg3 cooperates with elavl2 to modulate cell apoptosis and extracellular matrix accumulation by stabilizing snai2 in human trabecular meshwork cells under oxidative stress. |
2021-04-23 |
2023-08-13 |
human |
| J S Lawson, H M Syme, C P D Wheeler-Jones, J Elliot. Investigation of the transforming growth factor-beta 1 signalling pathway as a possible link between hyperphosphataemia and renal fibrosis in feline chronic kidney disease. Veterinary journal (London, England : 1997). vol 267. 2021-04-22. PMID:33375963. |
the aims of this study were to explore the interaction between increased extracellular phosphate and the tgf-β1 signalling pathway by investigating: (a) the effect of a commercially available, phosphate-restricted, diet on urinary tgf-β1 excretion in cats with ckd; and (b) the role of increased extracellular phosphate in regulating proliferation, apoptosis, and expression of genes related to tgf-β1 signalling and extracellular matrix (ecm) production in feline proximal tubular epithelial cells (fptec) and cortical fibroblasts from cats with azotaemic ckd (ckd-fcf). |
2021-04-22 |
2023-08-13 |
Not clear |
| Federica Morani, Luisa Bisceglia, Giulia Rosini, Luciano Mutti, Ombretta Melaiu, Stefano Landi, Federica Gemignan. Identification of Overexpressed Genes in Malignant Pleural Mesothelioma. International journal of molecular sciences. vol 22. issue 5. 2021-04-22. PMID:33800494. |
seven genes were involved in cell adhesion and extracellular matrix organization, with the others in control of the mitotic cell division or apoptosis inhibition. |
2021-04-22 |
2023-08-13 |
Not clear |
| Motomichi Fujita, Manabu Sasada, Takuya Iyoda, Reo Nagai, Chikako Kudo, Tetsuya Yamamoto, Satoshi Osada, Hiroaki Kodama, Fumio Fuka. Anoikis resistance conferred by tenascin-C-derived peptide TNIIIA2 and its disruption by integrin inactivation. Biochemical and biophysical research communications. vol 536. 2021-04-21. PMID:33360093. |
in general, cancer cells often acquire an additional malignant property that confers resistance to apoptosis due to loss of adhesion to the extracellular matrix, termed anoikis resistance. |
2021-04-21 |
2023-08-13 |
human |
| Caifeng Deng, Quan Zhang, Penghui He, Bin Zhou, Ke He, Xun Sun, Guanghua Lei, Tao Gong, Zhirong Zhan. Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis. Nature communications. vol 12. issue 1. 2021-04-21. PMID:33846342. |
cel-loaded prnps (cel-prnps) dually target ocs and inflammatory macrophages derived from patients with ra via an rgd-αvβ3 integrin interaction after peg cleavage by matrix metalloprotease 9, leading to increased apoptosis of these cells. |
2021-04-21 |
2023-08-13 |
rat |
| Ting Su, Xian-Yang Qin, Yutaka Furutan. Transglutaminase 2 as a Marker for Inflammation and Therapeutic Target in Sepsis. International journal of molecular sciences. vol 22. issue 4. 2021-04-19. PMID:33672962. |
tg2 plays important roles in diverse cellular processes, including extracellular matrix stabilization, cytoskeletal function, cell motility, adhesion, signal transduction, apoptosis, and cell survival. |
2021-04-19 |
2023-08-13 |
Not clear |
| Jian Jiang, Yuefeng Sun, Gaoran Xu, Hong Wang, Ling Wan. The role of miRNA, lncRNA and circRNA in the development of intervertebral disk degeneration (Review). Experimental and therapeutic medicine. vol 21. issue 6. 2021-04-16. PMID:33850527. |
dysregulated phenotypes of nucleus pulposus (np) cells and endplate chondrocytes, such as proliferation, senescence and apoptosis, along with aberrant expression of extracellular matrix components, including type ii collagen and aggrecan, are involved in the pathological process of ivdd. |
2021-04-16 |
2023-08-13 |
Not clear |
| Bashdar Mahmud Hussen, Hamed Shoorei, Mahdi Mohaqiq, Marcel E Dinger, Hazha Jamal Hidayat, Mohammad Taheri, Soudeh Ghafouri-Far. The Impact of Non-coding RNAs in the Epithelial to Mesenchymal Transition. Frontiers in molecular biosciences. vol 8. 2021-04-13. PMID:33842553. |
epithelial to mesenchymal transition (emt) is a course of action that enables a polarized epithelial cell to undertake numerous biochemical alterations that allow it to adopt features of mesenchymal cells such as high migratory ability, invasive properties, resistance to apoptosis, and importantly higher-order formation of extracellular matrix elements. |
2021-04-13 |
2023-08-13 |
Not clear |