| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meixiong Cheng, Yi Zeng, Tian Zhang, Min Xu, Zhili Li, Yaqiu W. Transcription Factor ELF1 Activates MEIS1 Transcription and Then Regulates the GFI1/FBW7 Axis to Promote the Development of Glioma. Molecular therapy. Nucleic acids. vol 23. 2021-01-22. PMID:33473327. |
importantly, silencing of elf1 decreased the capacities of proliferation, migration, and invasion of glioma cells whereas it increased apoptosis, supported by increased capase-3 and decreased matrix metalloproteinase-9 (mmp-9) and proliferating cell nuclear antigen (pcna) expression. |
2021-01-22 |
2023-08-13 |
Not clear |
| Qing Wang, Di Zhuang, Wenchang Feng, Bitao Ma, Liping Qin, Lilun Ji. Fraxetin inhibits interleukin-1β-induced apoptosis, inflammation, and matrix degradation in chondrocytes and protects rat cartilage Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 28. issue 12. 2021-01-12. PMID:33424243. |
fraxetin inhibits interleukin-1β-induced apoptosis, inflammation, and matrix degradation in chondrocytes and protects rat cartilage osteoarthritis (oa) is a disease characterized by degeneration of the joint complex due to cartilage destruction. |
2021-01-12 |
2023-08-13 |
rat |
| Zeynep Karagöz, Laura Rijns, Patricia Y W Dankers, Martijn van Griensven, Aurélie Carlie. Towards understanding the messengers of extracellular space: Computational models of outside-in integrin reaction networks. Computational and structural biotechnology journal. vol 19. 2021-01-12. PMID:33425258. |
the interactions between cells and their extracellular matrix (ecm) are critically important for homeostatic control of cell growth, proliferation, differentiation and apoptosis. |
2021-01-12 |
2023-08-13 |
Not clear |
| Caio P Gomes, Danilo E Fernandes, Fernanda Casimiro, Gustavo F da Mata, Michelle T Passos, Patricia Varela, Gianna Mastroianni-Kirsztajn, João Bosco Pesquer. Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics. Frontiers in cellular and infection microbiology. vol 10. 2021-01-11. PMID:33364201. |
catl is a lysosomal enzyme that participates in numerous physiological processes, including apoptosis, antigen processing, and extracellular matrix remodeling. |
2021-01-11 |
2023-08-13 |
Not clear |
| Yingjuan Lv, Zhanheng Zhang, Xiaoli Xing, Aihua Li. lncRNA TGFβ2-AS1 promotes ECM production via TGF-β2 in human trabecular meshwork cells. Biochemical and biophysical research communications. vol 527. issue 4. 2021-01-11. PMID:32423825. |
the important pathological manifestations of open-angle glaucoma (oag) are human trabecular meshwork cells (htmcs) apoptosis and excessive deposition of extracellular matrix (ecm) components in tm, which can cause pathological changes in the outflow pathway. |
2021-01-11 |
2023-08-13 |
human |
| Yuanyuan Che, Xu Shi, Yunpeng Shi, Xiaoming Jiang, Qing Ai, Ying Shi, Fengyan Gong, Wenyan Jian. Exosomes Derived from miR-143-Overexpressing MSCs Inhibit Cell Migration and Invasion in Human Prostate Cancer by Downregulating TFF3. Molecular therapy. Nucleic acids. vol 18. 2021-01-10. PMID:31563120. |
furthermore, elevated mir-143 or exosome-mir-143 or silencing tff3 inhibited the expression of tff3, proliferating cell nuclear antigen (pcna), matrix metalloproteinase (mmp)-2, and mmp-9 and pc3 cell proliferation, migration, invasion, and tumor growth, whereas it promoted apoptosis. |
2021-01-10 |
2023-08-13 |
human |
| Eve Helena Rogers, Vanja Pekovic-Vaughan, John Alan Hun. Mechanical stretch and chronotherapeutic techniques for progenitor cell transplantation and biomaterials. BioMedicine. vol 8. issue 3. 2021-01-09. PMID:30141401. |
tensile stress, or compression loading are just two of these forces, and here we examine the role of cyclical or dynamic mechanical loading on progenitor cell proliferation and differentiation, as well as on other cellular processes including cell morphology, apoptosis and matrix mineralisation. |
2021-01-09 |
2023-08-13 |
human |
| Lifeng Jiang, Kai Xu, Jin Li, Xindie Zhou, Langhai Xu, Zhipeng Wu, Chiyuan Ma, Jisheng Ran, Pengfei Hu, Jiapeng Bao, Lidong Wu, Yan Xion. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. Aging. vol 12. issue 2. 2021-01-08. PMID:32003758. |
nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. |
2021-01-08 |
2023-08-13 |
rat |
| Lifeng Jiang, Kai Xu, Jin Li, Xindie Zhou, Langhai Xu, Zhipeng Wu, Chiyuan Ma, Jisheng Ran, Pengfei Hu, Jiapeng Bao, Lidong Wu, Yan Xion. Nesfatin-1 suppresses interleukin-1β-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats. Aging. vol 12. issue 2. 2021-01-08. PMID:32003758. |
osteoarthritis (oa) is a chronic degenerative joint disease, related to the overexpression of matrix metalloproteinases (mmps), a disintegrin and metalloproteinase with thrombospondin motifs (adamts), inflammation, and chondrocyte apoptosis. |
2021-01-08 |
2023-08-13 |
rat |
| Gary H F Yam, Andri K Riau, Martha L Funderburgh, Jodhbir S Mehta, Vishal Jhanj. Keratocyte biology. Experimental eye research. vol 196. 2021-01-08. PMID:32442558. |
trauma-induced apoptosis of keratocytes and replacement by fibroblasts and myofibroblasts disrupt the stromal matrix organization, resulting in corneal haze formation and vision loss. |
2021-01-08 |
2023-08-13 |
Not clear |
| Muraly Puttabyatappa, Xingzi Guo, John Dou, Daniel Dumesic, Kelly M Bakulski, Vasantha Padmanabha. Developmental Programming: Sheep Granulosa and Theca Cell-Specific Transcriptional Regulation by Prenatal Testosterone. Endocrinology. vol 161. issue 8. 2021-01-04. PMID:32516392. |
these data indicate that follicular function is affected by genes involved in transforming growth factor signaling, extracellular matrix, mitochondria, epigenetics, and apoptosis both in a common as well as a cell-specific manner and suggest possible mechanistic pathways for prenatal t treatment-induced pco morphology in sheep. |
2021-01-04 |
2023-08-13 |
Not clear |
| Mingyan Yao, Jing Zhang, Zhihong Li, Shuqin Guo, Xue Zhou, Wenjing Zhan. Marein protects human nucleus pulposus cells against high glucose-induced injury and extracellular matrix degradation at least partly by inhibition of ROS/NF-κB pathway. International immunopharmacology. vol 80. 2021-01-04. PMID:31931363. |
intervertebral disc degeneration (idd), a major cause of discogenic low back pain, is a musculoskeletal disorder involving the apoptosis of nucleus pulposus cells (npcs) and extracellular matrix (ecm) degradation. |
2021-01-04 |
2023-08-13 |
human |
| Xiao-Fei Shen, Yi Cheng, Qi-Rong Dong, Min-Qian Zhen. MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5. Biochemical and biophysical research communications. vol 527. issue 2. 2021-01-04. PMID:32336544. |
the overexpression of mir-675-3p inhibited apoptosis and cartilage matrix degradation and promoted cell proliferation in human chondrocytes. |
2021-01-04 |
2023-08-13 |
human |
| Yuchao Li, Guoning Guo, Jie Song, Zhiping Cai, Jin Yang, Zhiwen Chen, Yun Wang, Yaqin Huang, Qiangguo Ga. B7-H3 Promotes the Migration and Invasion of Human Bladder Cancer Cells via the PI3K/Akt/STAT3 Signaling Pathway. Journal of Cancer. vol 8. issue 5. 2021-01-03. PMID:28382144. |
b7-h3 did not affect cell proliferation and apoptosis, but cell migration and invasion were changed through the regulation of matrix metalloproteinase (mmp) 2/9. |
2021-01-03 |
2023-08-13 |
human |
| Yuuri Yasuok. Morphogenetic mechanisms forming the notochord rod: The turgor pressure-sheath strength model. Development, growth & differentiation. vol 62. issue 6. 2020-12-31. PMID:32275068. |
attributes of notochord cells, such as vacuolation, membrane trafficking, extracellular matrix formation, and apoptosis, can be understood in terms of two properties: turgor pressure of vacuoles and strength of the notochord sheath. |
2020-12-31 |
2023-08-13 |
zebrafish |
| Dong Wang, Xin He, Di Wang, Pandi Peng, Xiaolong Xu, Bo Gao, Chao Zheng, Han Wang, Haoruo Jia, Qiliang Shang, Zhen Sun, Zhuojing Luo, Liu Yan. Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway. Frontiers in cell and developmental biology. vol 8. 2020-12-29. PMID:33363176. |
previous studies demonstrated that the apoptosis of nucleus pulposus (np) cells and the dyshomeostasis of extracellular matrix (ecm) contributed to the pathogenesis of idd, and effective therapies were still lacking. |
2020-12-29 |
2023-08-13 |
Not clear |
| Qian Xiang, Liang Kang, Juntan Wang, Zhiwei Liao, Yu Song, Kangcheng Zhao, Kun Wang, Cao Yang, Yukun Zhan. CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis. EBioMedicine. vol 53. 2020-12-17. PMID:32114390. |
as a high-risk factor for idd, compression stress was reported to induce apoptosis of nucleus pulposus (np) cells and extracellular matrix (ecm) degradation during idd progression. |
2020-12-17 |
2023-08-13 |
human |
| Hai Ke, Xiaping Mou, Qing Xi. Remifentanil repairs cartilage damage and reduces the degradation of cartilage matrix in post-traumatic osteoarthritis, and inhibits IL-1β-induced apoptosis of articular chondrocytes via inhibition of PI3K/AKT/NF-κB phosphorylation. Annals of translational medicine. vol 8. issue 22. 2020-12-16. PMID:33313232. |
remifentanil repairs cartilage damage and reduces the degradation of cartilage matrix in post-traumatic osteoarthritis, and inhibits il-1β-induced apoptosis of articular chondrocytes via inhibition of pi3k/akt/nf-κb phosphorylation. |
2020-12-16 |
2023-08-13 |
Not clear |
| Sun Tae Hwang, Jae-Young Um, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Acharan S Narula, Ojas A Namjoshi, Bruce E Blough, Kwang Seok Ah. Evodiamine Mitigates Cellular Growth and Promotes Apoptosis by Targeting the c-Met Pathway in Prostate Cancer Cells. Molecules (Basel, Switzerland). vol 25. issue 6. 2020-12-16. PMID:32183146. |
then, we noted that evo arrested the cell cycle, caused apoptosis, and downregulated the expression of various carcinogenic markers such as b-cell lymphoma 2 (bcl-2), b-cell lymphoma-extra large (bcl-xl), cyclin d1, cyclooxygenase 2 (cox-2), survivin, vascular endothelial growth factor (vegf), and matrix metallopeptidases 9 (mmp-9). |
2020-12-16 |
2023-08-13 |
Not clear |
| Fang Xie, Yong-Li Liu, Xiu-Yuan Chen, Qian Li, Jia Zhong, Bin-Yu Dai, Xian-Fang Shao, Guan-Bao W. Role of MicroRNA, LncRNA, and Exosomes in the Progression of Osteoarthritis: A Review of Recent Literature. Orthopaedic surgery. vol 12. issue 3. 2020-12-16. PMID:32436304. |
in this review, we emphasized that different microrna, lncrna, and exosomes have different regulatory effects on chondrocyte proliferation and apoptosis, extracellular matrix degradation and inflammation. |
2020-12-16 |
2023-08-13 |
Not clear |