| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sebastian Wangler, Amir Kamali, Christina Wapp, Karin Wuertz-Kozak, Sonja Häckel, Claudia Fortes, Lorin M Benneker, Lisbet Haglund, R Geoff Richards, Mauro Alini, Marianna Peroglio, Sibylle Gra. Uncovering the secretome of mesenchymal stromal cells exposed to healthy, traumatic, and degenerative intervertebral discs: a proteomic analysis. Stem cell research & therapy. vol 12. issue 1. 2021-07-05. PMID:33413584. |
in intervertebral disc (ivd) cells, application of msc secretome has been shown to decrease the apoptosis rate, induce proliferation, and promote production of extracellular matrix (ecm). |
2021-07-05 |
2023-08-13 |
Not clear |
| Rou Wan, Joshua P Weissman, Kendra Grundman, Lin Lang, Damian J Grybowski, Robert D Galian. Diabetic wound healing: The impact of diabetes on myofibroblast activity and its potential therapeutic treatments. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 29. issue 4. 2021-07-02. PMID:34157786. |
based on these studies, hyperglycaemic conditions can interfere with cytokine signalling pathways (such as growth factor-β pathway) affecting fibroblast differentiation, alter fibroblast apoptosis, dysregulate dermal lipolysis, and enhance hypoxia damage, thus leading to damaged microenvironment for myofibroblast formation, inappropriate extracellular matrix modulation, and weakened wound contraction. |
2021-07-02 |
2023-08-13 |
Not clear |
| Haitao Jiang, Jian Dai, Cheng Zhang, Hailang Sun, Xiaoming Tan. Circ_0045714 alleviates TNF-α-induced chondrocyte injury and extracellular matrix degradation through miR-218-5p/HRAS axis. Journal of bioenergetics and biomembranes. vol 53. issue 1. 2021-07-01. PMID:33394311. |
circ_0045714 expression was decreased in oa and tnf-α-induced chondrocytes, ectopic overexpression of circ_0045714 abolished tnf-α-induced cell apoptosis, inflammation, extracellular matrix (ecm) degradation promotion and proliferation inhibition. |
2021-07-01 |
2023-08-13 |
Not clear |
| Fengguang Yang, Jizu Wang, Zhixin Chen, Yuping Yang, Wenhui Zhang, Shifang Guo, Qingshan Yan. Role of microRNAs in intervertebral disc degeneration (Review). Experimental and therapeutic medicine. vol 22. issue 2. 2021-06-29. PMID:34178133. |
abnormal expression of mirnas in the intervertebral disc is implicated in various pathological processes underlying the development of idd, including nucleus pulposus (np) cell (npc) proliferation, npc apoptosis, extracellular matrix remodeling, inflammation and cartilaginous endplate changes, among others. |
2021-06-29 |
2023-08-13 |
Not clear |
| Manjunath Supriya, Rita Christopher, Bhagavatula Indira Devi, Dhananjaya Ishwar Bhat, Dhaval Shukla, Saligrama Ramegowda Kalpan. Altered MicroRNA Expression in Intracranial Aneurysmal Tissues: Possible Role in TGF-β Signaling Pathway. Cellular and molecular neurobiology. 2021-06-29. PMID:34185228. |
we suggest that mir-26b, mir-199a, mir-497and mir-365, could target multiple genes in tgf-β and mapk signaling cascades to influence inflammatory processes, extracellular matrix and vascular smooth muscle cell degradation and apoptosis, and ultimately cause vessel wall degradation and rupture. |
2021-06-29 |
2023-08-13 |
Not clear |
| Li Yue, Brian Vuong, Hongwei Yao, Brett D Owen. Doxycycline preserves chondrocyte viability and function in human and calf articular cartilage ex vivo. Physiological reports. vol 8. issue 17. 2021-06-28. PMID:32918797. |
incubation of doxycycline protects against chondrocyte apoptosis, reduced extracellular matrix, and impaired mechanical properties in cartilage plugs. |
2021-06-28 |
2023-08-13 |
human |
| Xiangyun Li, Jianbo Yu, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Cui Li, Yuting Li, Yanfang Zhang, Haibo L. Heme oxygenase-1(HO-1) regulates Golgi stress and attenuates endotoxin-induced acute lung injury through hypoxia inducible factor-1α (HIF-1α)/HO-1 signaling pathway. Free radical biology & medicine. vol 165. 2021-06-28. PMID:33493554. |
the knockout of heme oxygenase-1(ho-1) aggravated oxidative stress, inflammation, apoptosis and reduced the expression of golgi matrix protein 130 (gm130), mannosidase Ⅱ, golgi-associated protein golgin a1 (golgin 97), and increased the expression of golgi phosphoprotein 3 (golph3), which caused the fragmentation of golgi. |
2021-06-28 |
2023-08-13 |
Not clear |
| Yu Chen, Yukun Huang, Songlei Zhou, Minli Sun, Liang Chen, Jiahao Wang, Minjun Xu, Shanshan Liu, Kaifan Liang, Qian Zhang, Tianze Jiang, Qingxiang Song, Gan Jiang, Xuyi Tang, Xiaoling Gao, Jun Che. Tailored Chemodynamic Nanomedicine Improves Pancreatic Cancer Treatment via Controllable Damaging Neoplastic Cells and Reprogramming Tumor Microenvironment. Nano letters. vol 20. issue 9. 2021-06-24. PMID:32809834. |
pancreatic ductal adenocarcinoma (pdac) strongly resists standard therapies since kras-mutated cancer cells harbor endogenous resistance toward chemotherapy-induced apoptosis and tumor-associated macrophages (tams) activate stroma cells to create the nearly impenetrable matrix. |
2021-06-24 |
2023-08-13 |
Not clear |
| Alexi Surette, Byong Hoon Yoo, Tallal Younis, Kara Matheson, Tarek Rameh, Jaime Snowdon, Gillian Bethune, Kirill V Rose. Tumor levels of the mediators of ErbB2-driven anoikis resistance correlate with breast cancer relapse in patients receiving trastuzumab-based therapies. Breast cancer research and treatment. vol 187. issue 3. 2021-06-23. PMID:33728523. |
we found previously that erbb2 blocks breast tumor cell anoikis, apoptosis induced by cell detachment from the extracellular matrix, by downregulating the pro-apoptotic protein irf6 and upregulating the anti-apoptotic protein epidermal growth factor receptor (egfr) in the cells and, thus, promotes their three-dimensional growth. |
2021-06-23 |
2023-08-13 |
Not clear |
| Guangxuan Zeng, Gang Deng, Shiliang Xiao, Fei L. Fibroblast-like Synoviocytes-derived Exosomal PCGEM1 Accelerates IL-1β-induced Apoptosis and Cartilage Matrix Degradation by miR-142-5p/RUNX2 in Chondrocytes. Immunological investigations. 2021-06-23. PMID:34160339. |
fibroblast-like synoviocytes-derived exosomal pcgem1 accelerates il-1β-induced apoptosis and cartilage matrix degradation by mir-142-5p/runx2 in chondrocytes. |
2021-06-23 |
2023-08-13 |
Not clear |
| Ximiao Chen, Chongan Huang, Haiqiu Sun, Haofeng Hong, Jie Jin, Chaoyong Bei, Zhongqiu Lu, Xiaolei Zhan. Puerarin suppresses inflammation and ECM degradation through Nrf2/HO-1 axis in chondrocytes and alleviates pain symptom in osteoarthritic mice. Food & function. vol 12. issue 5. 2021-06-22. PMID:33543180. |
the effects of puerarin on apoptosis, extracellular matrix (ecm) metabolism, and inflammation-related factors were assessed; also, the nuclear factor-κb (nf-κb) signaling pathway and nrf2/ho-1 (nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1) axis were evaluated to elucidate the working mechanism of puerarin. |
2021-06-22 |
2023-08-13 |
mouse |
| Soumya Ganguly, Saikat Dewanjee, Ramkrishna Sen, Dipankar Chattopadhyay, Shantanu Ganguly, Raghuvir Gaonkar, Mita Chatterjee Debnat. Apigenin-loaded galactose tailored PLGA nanoparticles: A possible strategy for liver targeting to treat hepatocellular carcinoma. Colloids and surfaces. B, Biointerfaces. vol 204. 2021-06-22. PMID:33915380. |
in in vivo studies, api-gal-nps exhibited a better protective effect against den-induced hcc in rats evidenced by the significant reduction of nodule formation, downregulation of matrix metalloproteinases (mmp-2 and mmp-9), and induction of apoptosis in the liver than api and api-nps. |
2021-06-22 |
2023-08-13 |
rat |
| Jinhua Luo, Haoyuan You, Jianhua Zhan, Guanghua Guo, Xing Cheng, Guoyu Zhen. Long non-coding RNA TPT1-AS1 alleviates cell injury and promotes the production of extracellular matrix by targeting the microRNA-324-5p/CDK16 axis in human dermal fibroblasts after thermal injury. Experimental and therapeutic medicine. vol 22. issue 2. 2021-06-22. PMID:34149889. |
cell viability, cell cycle distribution, cell apoptosis rate and extracellular matrix (ecm) synthesis were assessed with a series of |
2021-06-22 |
2023-08-13 |
human |
| Deyu Zuo, Botao Tan, Gongwei Jia, Dandong Wu, Lehua Yu, Lang Ji. A treatment combined prussian blue nanoparticles with low-intensity pulsed ultrasound alleviates cartilage damage in knee osteoarthritis by initiating PI3K/Akt/mTOR pathway. American journal of translational research. vol 13. issue 5. 2021-06-22. PMID:34149994. |
reactive oxidative stress (ros) related apoptosis in chondrocytes and extracellular matrix (ecm) degradation play crucial roles in the process of osteoarthritis. |
2021-06-22 |
2023-08-13 |
Not clear |
| Deyu Zuo, Botao Tan, Gongwei Jia, Dandong Wu, Lehua Yu, Lang Ji. A treatment combined prussian blue nanoparticles with low-intensity pulsed ultrasound alleviates cartilage damage in knee osteoarthritis by initiating PI3K/Akt/mTOR pathway. American journal of translational research. vol 13. issue 5. 2021-06-22. PMID:34149994. |
the pbnps/lipus combination treatment reduced cellular ros, apoptosis, and matrix metalloproteinases (mmps), as a consequence, alleviated articular cartilage damage in koa. |
2021-06-22 |
2023-08-13 |
Not clear |
| Fei Xue, Jianmin Yang, Jing Cheng, Wenhai Sui, Cheng Cheng, Hongxuan Li, Meng Zhang, Jie Zhang, Xingli Xu, Jing Ma, Lin Lu, Jinfeng Xu, Meng Zhang, Yun Zhang, Cheng Zhan. Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice. British journal of pharmacology. vol 177. issue 8. 2021-06-21. PMID:31658493. |
to test the hypothesis that angiotensin-(1-7) [ang-(1-7)] may attenuate abdominal aortic aneurysm (aaa) via inhibiting vascular inflammation, extracellular matrix degradation, and smooth muscle cell (smc) apoptosis, an animal model of aaa was established by angiotensin ii (ang ii) infusion to apolipoprotein e-knockout (apoe |
2021-06-21 |
2023-08-13 |
mouse |
| Lulu Wang, Zheng Liu, Dongni Huang, Yuxin Ran, Hanwen Zhang, Jie He, Nanlin Yin, Hongbo Q. IL-37 Exerts Anti-Inflammatory Effects in Fetal Membranes of Spontaneous Preterm Birth via the NF- Mediators of inflammation. vol 2020. 2021-06-21. PMID:32733162. |
however, the inflammatory imbalance at the maternal-fetal interface promotes excessive secretion of inflammatory factors and induces apoptosis and degradation of the extracellular matrix (ecm), which can subsequently lead to preterm birth. |
2021-06-21 |
2023-08-13 |
human |
| Marc Clément, Fabien Lareyre, Alexia Loste, Aurélie Sannier, Fanny Burel-Vandenbos, Nicolas Massiot, Joseph Carboni, Elixène Jean-Baptiste, Giuseppina Caligiuri, Antonino Nicoletti, Juliette Raffor. Vascular Remodeling and Immune Cell Infiltration in Splenic Artery Aneurysms. Angiology. vol 72. issue 6. 2021-06-21. PMID:32851875. |
splenic artery aneurysms were characterized by a profound vascular remodeling with a dramatic loss of vsmcs, elastin degradation, adventitial fibrosis associated with enhanced apoptosis, and increased matrix metalloproteinase 9 expression. |
2021-06-21 |
2023-08-13 |
Not clear |
| Wenchao Zhang, Lin Qi, Ruiqi Chen, Jieyu He, Zhongyue Liu, Wanchun Wang, Chao Tu, Zhihong L. Circular RNAs in osteoarthritis: indispensable regulators and novel strategies in clinical implications. Arthritis research & therapy. vol 23. issue 1. 2021-06-21. PMID:33436088. |
more importantly, circrnas have been demonstrated to interplay with components in oa microenvironments, such as chondrocytes, synoviocytes and macrophages, by regulation of their proliferation, apoptosis, autophagy, inflammation, or extracellular matrix reorganization. |
2021-06-21 |
2023-08-13 |
Not clear |
| Pinfang Kang, Jiahui Wang, Dian Fang, Tingting Fang, Ying Yu, Weiping Zhang, Lin Shen, Zhenghong Li, Hongju Wang, Hongwei Ye, Qin Ga. Activation of ALDH2 attenuates high glucose induced rat cardiomyocyte fibrosis and necroptosis. Free radical biology & medicine. vol 146. 2021-06-18. PMID:31689484. |
in contrast to normal glucose group, in hg group, with the decreases of aldh2 activity, mrna and protein levels, the cardiomyocytes viability was decreased, reactive oxygen species (ros), the inflammation factors - tumor necrosis factor-α (tnf-α), interleukin-6 (il-6), interleukin-1β (il-1β) levels, collagen i (col i) and col iii mrna expressions and tissue inhibitors of matrix metalloproteinase 4 (timp4) protein expression were increased, while matrix metalloproteinase 14 (mmp14) protein level, the ratio of mmp14/timp4 were decreased, and the necroptosis key factors - the receptor interacting protein 1 (rip1), rip3 and mixed lineage kinase domain-like protein (mlkl) at mrna and protein expressions were increased, the inflammasome core proteins - nlrp3 and asc protein expressions were also increased, the apoptosis rate and necrosis rate were also increased. |
2021-06-18 |
2023-08-13 |
rat |