| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tatiana Kisseleva, David Brenne. Molecular and cellular mechanisms of liver fibrosis and its regression. Nature reviews. Gastroenterology & hepatology. vol 18. issue 3. 2021-04-05. PMID:33128017. |
we also discuss strategies to target hepatic myofibroblasts (for example, via apoptosis or inactivation) and the myeloid cells that degrade the matrix (for example, via their recruitment to fibrotic liver) to facilitate fibrosis resolution and liver regeneration. |
2021-04-05 |
2023-08-13 |
Not clear |
| Ryoko Sakamoto, Ikko Kajihara, Hitomi Miyauchi, Saki Maeda-Otsuka, Saori Yamada-Kanazawa, Soichiro Sawamura, Hisashi Kanemaru, Katsunari Makino, Jun Aoi, Takamitsu Makino, Satoshi Fukushima, Mamiko Masuzawa, Mikio Masuzawa, Yasuyuki Amoh, Daichi Hoshina, Riichiro Abe, Hironobu Ih. Inhibition of Endoglin Exerts Antitumor Effects through the Regulation of Non-Smad TGF-β Signaling in Angiosarcoma. The Journal of investigative dermatology. vol 140. issue 10. 2021-04-05. PMID:32142796. |
knockdown of endoglin activated caspase 3/7 that is essential for apoptosis, reduced survivin levels, and decreased paxillin and vascular endothelial cadherin phosphorylation and matrix metalloproteinase 2 and matrix metalloproteinase 9 activities in angiosarcoma cells. |
2021-04-05 |
2023-08-13 |
Not clear |
| Philippe Chouvarine, Joachim Photiadis, Robert Cesnjevar, Jens Scheewe, Ulrike M M Bauer, Thomas Pickardt, Hans-Heiner Kramer, Sven Dittrich, Felix Berger, Georg Hansman. RNA expression profiles and regulatory networks in human right ventricular hypertrophy due to high pressure load. iScience. vol 24. issue 3. 2021-04-02. PMID:33786422. |
these genes are significantly overrepresented in pathways related to regulation of glucose and lipid metabolism (sik1, fabp4), cell surface interactions (thbs2, fn1), apoptosis (pik3ip1, sik1), extracellular matrix composition (ctgf, igf1), and other biological events. |
2021-04-02 |
2023-08-13 |
human |
| Hui Zhang, Yajing Wang, Khalid Mehmood, Yung-Fu Chang, Zhaoxin Tang, Ying L. Treatment of tibial dyschondroplasia with traditional Chinese medicines: "Lesson and future directions". Poultry science. vol 99. issue 12. 2021-04-01. PMID:33248557. |
selecting a tcm approach and its pharmacologic effects on td chickens mainly focused on the differentiation, proliferation, and apoptosis of chondrocytes, angiogenesis, matrix metabolism, oxidative damage, cytokines, and calcification of cartilage in tibia. |
2021-04-01 |
2023-08-13 |
Not clear |
| Jin Shu, Yiwen Gu, Li Jin, Haiya Wan. Matrix metalloproteinase 3 regulates angiotensin II‑induced myocardial fibrosis cell viability, migration and apoptosis. Molecular medicine reports. vol 23. issue 2. 2021-03-31. PMID:33655326. |
matrix metalloproteinase 3 regulates angiotensin ii‑induced myocardial fibrosis cell viability, migration and apoptosis. |
2021-03-31 |
2023-08-13 |
rat |
| Hongtao Liu, Qing Zhang, Qianqian Lou, Xin Zhang, Yunxia Cui, Panpan Wang, Fan Yang, Fan Wu, Jing Wang, Tianli Fan, Shenglei L. Differential Analysis of lncRNA, miRNA and mRNA Expression Profiles and the Prognostic Value of lncRNA in Esophageal Cancer. Pathology oncology research : POR. vol 26. issue 2. 2021-03-31. PMID:30972633. |
we found 145 lncrnas, 112 mirnas and 2000 protein coding mrnas were differentially expressed in esca samples, which were tightly involved in chromosome segregation, extracellular matrix assembly by go assay, and kegg assay revealed the correlation of differentially expressed genes with cell cycle, apoptosis and cgmp-pkg signaling pathway. |
2021-03-31 |
2023-08-13 |
Not clear |
| Hyun-Joo Park, Yeon Kim, Mi-Kyoung Kim, Jae Joon Hwang, Hyung Joon Kim, Soo-Kyung Bae, Moon-Kyoung Ba. Inhibition of Gastrin-Releasing Peptide Attenuates Phosphate-Induced Vascular Calcification. Cells. vol 9. issue 3. 2021-03-29. PMID:32192106. |
this attenuation was caused by inhibiting phenotype change, apoptosis and matrix vesicle release in vsmcs. |
2021-03-29 |
2023-08-13 |
mouse |
| Jian Sun, Weiwei Sheng, Yuteng Ma, Ming Don. Potential Role of Musashi-2 RNA-Binding Protein in Cancer EMT. OncoTargets and therapy. vol 14. 2021-03-26. PMID:33762829. |
local invasion and distant metastasis are the key hallmarks in the aggressive progression of malignant tumors, including the ability of cancer cells to detach from the extracellular matrix overcome apoptosis, and disseminate into distant sites. |
2021-03-26 |
2023-08-13 |
Not clear |
| Yanchang Liu, Juehua Jing, Haoran Yu, Jisen Zhang, Qiliang Cao, Xin Zhang, Jianjun Liu, Shuo Zhang, Wendan Chen. Expression profiles of long non-coding RNAs in the cartilage of patients with knee osteoarthritis and normal individuals. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-20. PMID:33732338. |
abnormal expression of long non-coding rnas (lncrnas) affects the metabolism, synovitis, autophagy and apoptosis of chondrocytes, as well as the production of cartilage matrix. |
2021-03-20 |
2023-08-13 |
Not clear |
| Xiaoli Ruan, Dongming Zhou, Rencan Nie, Yanbu Gu. Predictions of Apoptosis Proteins by Integrating Different Features Based on Improving Pseudo-Position-Specific Scoring Matrix. BioMed research international. vol 2020. 2021-03-18. PMID:32420339. |
predictions of apoptosis proteins by integrating different features based on improving pseudo-position-specific scoring matrix. |
2021-03-18 |
2023-08-13 |
Not clear |
| Dake Hao, Ruiwu Liu, Kewa Gao, Chuanchao He, Siqi He, Cunyi Zhao, Gang Sun, Diana L Farmer, Alyssa Panitch, Kit S Lam, Aijun Wan. Developing an Injectable Nanofibrous Extracellular Matrix Hydrogel With an Integrin αvβ3 Ligand to Improve Endothelial Cell Survival, Engraftment and Vascularization. Frontiers in bioengineering and biotechnology. vol 8. 2021-03-16. PMID:32850742. |
however, the therapeutic effect of transplanted ecs is limited by their poor viability, which partially occurs as a result of cellular apoptosis triggered by the insufficient cell-extracellular matrix (ecm) engagement. |
2021-03-16 |
2023-08-13 |
Not clear |
| Heming Ge, Mengxiang Tian, Qian Pei, Fengbo Tan, Haiping Pe. Extracellular Matrix Stiffness: New Areas Affecting Cell Metabolism. Frontiers in oncology. vol 11. 2021-03-16. PMID:33718214. |
in recent years, in-depth studies have shown that extracellular matrix stiffness plays an important role in cell growth, proliferation, migration, immunity, malignant transformation, and apoptosis. |
2021-03-16 |
2023-08-13 |
Not clear |
| Xiufang Dong, Baoyu He, Di Jiang, Chenxu Yu, Beiwei Zhu, Hang Q. Proteome analysis reveals the important roles of protease during tenderization of sea cucumber Apostichopus japonicus using iTRAQ. Food research international (Ottawa, Ont.). vol 131. 2021-03-12. PMID:32247476. |
furthermore, proteins involved in oxidative stress response, innate immune response, apoptosis and reorganization of cytoskeleton and extracellular matrix were upregulated, which could be the potential biomarkers. |
2021-03-12 |
2023-08-13 |
Not clear |
| Jing Li, Sufang Wang, Yuhui Li, Nu Zhang, Michael Gribskov, Xi Zhang, Min Lin, Dongyan Shao, Chen Zhang, Liangliang Dai, Chuanguang Qin, Xianglong Duan, Juntang Li, Feng Xu, Hui Yan. miRNA-mediated macrophage behaviors responding to matrix stiffness and ox-LDL. Journal of cellular physiology. vol 235. issue 9. 2021-03-11. PMID:32020590. |
in this study, we developed a model system to investigate the synergistic role of ox-ldl and matrix stiffness on macrophage behaviors, such as migration, inflammatory and apoptosis. |
2021-03-11 |
2023-08-13 |
Not clear |
| Chao Peng He, Xin Chen Jiang, Cheng Chen, Hai Bin Zhang, Wen Dong Cao, Qi Wu, Chi M. The function of lncRNAs in the pathogenesis of osteoarthritis. Bone & joint research. vol 10. issue 2. 2021-03-10. PMID:33560158. |
in recent years, a large number of lncrnas have been found to be differentially expressed in a variety of pathological processes of oa, including extracellular matrix (ecm) degradation, synovial inflammation, chondrocyte apoptosis, and angiogenesis. |
2021-03-10 |
2023-08-13 |
Not clear |
| Zhiqiang Li, Pengtao Wang, Jie Zhang, Dongkui Zha. MicroRNA-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating Smad7. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-10. PMID:33680106. |
microrna-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating smad7. |
2021-03-10 |
2023-08-13 |
human |
| Zhiqiang Li, Pengtao Wang, Jie Zhang, Dongkui Zha. MicroRNA-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating Smad7. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-10. PMID:33680106. |
moreover, smad7 upregulation significantly inhibited cell viability, decreased extracellular matrix deposition and induced apoptosis in hhsfs compared with the control-plasmid group. |
2021-03-10 |
2023-08-13 |
human |
| Zhiqiang Li, Pengtao Wang, Jie Zhang, Dongkui Zha. MicroRNA-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating Smad7. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-10. PMID:33680106. |
moreover, the results indicated that, compared with the inhibitor control group, mir-497-5p inhibitor inhibited cell viability, decreased extracellular matrix deposition and induced apoptosis in hhsfs, which were significantly reversed by smad7 knockdown. |
2021-03-10 |
2023-08-13 |
human |
| Amany Tawfik, Yara A Samra, Nehal M Elsherbiny, Mohamed Al-Shabrawe. Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction. Biomolecules. vol 10. issue 8. 2021-03-09. PMID:32751132. |
different mechanisms have been proposed to explain hhcy-induced visual dysfunction, including oxidative stress, upregulation of inflammatory mediators, retinal ganglion cell apoptosis, and extracellular matrix remodeling. |
2021-03-09 |
2023-08-13 |
Not clear |
| Xin Chen, Tailang Yin, Baozhen Zhang, Beini Sun, Jie Chen, Tianxia Xiao, Baobei Wang, Mengxia Li, Jing Yang, Xiujun Fa. Inhibitory effects of brusatol delivered using glycosaminoglycan‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of cancer cells. International journal of molecular medicine. vol 46. issue 2. 2021-03-08. PMID:32626948. |
further studies demonstrated that the plcsa‑bnps promoted the apoptosis of cancer cells more effectively and inhibited their proliferation, invasion and migration, accompanied by downregulation of matrix metalloproteinase (mmp)‑2, mmp‑9 and b‑cell cll/lymphoma 2 (bcl2) levels, but upregulation of bcl2‑associated x protein bax and cleaved caspase‑3 levels. |
2021-03-08 |
2023-08-13 |
Not clear |