| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisabetta Chiaradia, Marco Pepe, Paola Sassi, Ronny Mohren, Pier Luigi Orvietani, Marco Paolantoni, Alessia Tognoloni, Monica Sforna, Maxime Eveque, Niki Tombolesi, Berta Cillero-Pasto. Comparative label-free proteomic analysis of equine osteochondrotic chondrocytes. Journal of proteomics. vol 228. 2021-06-18. PMID:32768606. |
in particular, we identified proteins involved in extracellular matrix degradation and organization, vitamin metabolism, osteoblast differentiation, apoptosis, protein folding and localization, signalling and gene expression modulation and lysosomal activities. |
2021-06-18 |
2023-08-13 |
Not clear |
| Lei Luo, Fanshu Xu, Huilan Peng, Yonghuang Luo, Xiaohe Tian, Giuseppe Battaglia, Hu Zhang, Qiyong Gong, Zhongwei Gu, Kui Lu. Stimuli-responsive polymeric prodrug-based nanomedicine delivering nifuroxazide and doxorubicin against primary breast cancer and pulmonary metastasis. Journal of controlled release : official journal of the Controlled Release Society. vol 318. 2021-06-17. PMID:31838206. |
meanwhile, histological immunofluorescence and immunohistochemical analyses revealed a high level of apoptosis, suppressed expression of matrix metalloproteinases and reduction in mdscs infiltration, and all these contributed to inhibit pulmonary metastasis. |
2021-06-17 |
2023-08-13 |
mouse |
| Bo Li, Yue Zhou, Jing Chen, Tingting Wang, Zhijuan Li, Yili Fu, Aixia Zhai, Changlong B. Long noncoding RNA H19 acts as a miR-29b sponge to promote wound healing in diabetic foot ulcer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 1. 2021-06-15. PMID:33174326. |
silencing of lncrna h19 led to inhibited proliferation, migration, and enhanced apoptosis of fibroblasts, accompanied by downregulated fbn1 but upregulated mir-29b, which diminished the expression of tgf-β1, smad3, fn, and col-1 and reduced extracellular matrix accumulation. |
2021-06-15 |
2023-08-13 |
mouse |
| Q Liu, H Yang, M Zhang, J Zhang, L Lu, S Yu, Y Wu, M Wan. Initiation and progression of dental-stimulated temporomandibular joints osteoarthritis. Osteoarthritis and cartilage. vol 29. issue 5. 2021-06-14. PMID:33422706. |
in the case of insufficient restoration of the matrix, the cells in the deep zone flow into the ones undergoing autophagy, apoptosis, and terminal differentiation while the cells in the superficial zone are promoted to differentiate to supply the loss of the deep zone cells. |
2021-06-14 |
2023-08-13 |
Not clear |
| G Chao-Yang, C Peng, Z Hai-Hon. Roles of NLRP3 inflammasome in intervertebral disc degeneration. Osteoarthritis and cartilage. vol 29. issue 6. 2021-06-14. PMID:33609693. |
with the exploration of the mechanism of ivdd, recent studies have shown that activation of the nlrp3 inflammasome is associated with intervertebral disc (ivd) inflammation, pyroptosis, extracellular matrix degradation and apoptosis of ivd cells. |
2021-06-14 |
2023-08-13 |
Not clear |
| Kenneth P Hough, Miranda L Curtiss, Trevor J Blain, Rui-Ming Liu, Jennifer Trevor, Jessy S Deshane, Victor J Thannicka. Airway Remodeling in Asthma. Frontiers in medicine. vol 7. 2021-06-11. PMID:32509793. |
airway remodeling in asthma constitutes cellular and extracellular matrix changes in the large and small airways, epithelial cell apoptosis, airway smooth muscle cell proliferation, and fibroblast activation. |
2021-06-11 |
2023-08-13 |
Not clear |
| Litao Yan, Xing W. Exosomes produced from 3D cultures of umbilical cord mesenchymal stem cells in a hollow-fiber bioreactor show improved osteochondral regeneration activity. Cell biology and toxicology. vol 36. issue 2. 2021-06-10. PMID:31820164. |
the in vitro experiments indicated that both 2d-exos and 3d-exos can stimulate chondrocyte proliferation, migration, and matrix synthesis, and inhibit apoptosis, with 3d-exos exerting a stronger effect than 2d-exos. |
2021-06-10 |
2023-08-13 |
Not clear |
| Ren Wu, Fan Zhang, Yuzhong Cai, Zeling Long, Zhixi Duan, Dengke Wu, Yu Zhou, Qiyuan Wan. Circ_0134111 knockdown relieves IL-1β-induced apoptosis, inflammation and extracellular matrix degradation in human chondrocytes through the circ_0134111-miR-515-5p-SOCS1 network. International immunopharmacology. vol 95. 2021-06-10. PMID:33684877. |
circ_0134111 knockdown relieves il-1β-induced apoptosis, inflammation and extracellular matrix degradation in human chondrocytes through the circ_0134111-mir-515-5p-socs1 network. |
2021-06-10 |
2023-08-13 |
human |
| Ren Wu, Fan Zhang, Yuzhong Cai, Zeling Long, Zhixi Duan, Dengke Wu, Yu Zhou, Qiyuan Wan. Circ_0134111 knockdown relieves IL-1β-induced apoptosis, inflammation and extracellular matrix degradation in human chondrocytes through the circ_0134111-miR-515-5p-SOCS1 network. International immunopharmacology. vol 95. 2021-06-10. PMID:33684877. |
osteoarthritis (oa) is characterized by chondrocyte injury and dysfunction, such as excessive apoptosis, inflammatory response and extracellular matrix (ecm) degradation. |
2021-06-10 |
2023-08-13 |
human |
| Laura Seclì, Federica Fusella, Lidia Avalle, Mara Brancacci. The dark-side of the outside: how extracellular heat shock proteins promote cancer. Cellular and molecular life sciences : CMLS. vol 78. issue 9. 2021-06-09. PMID:33544155. |
ehsps are implicated in extracellular matrix remodelling, resistance to apoptosis, promotion of cell migration and invasion, induction of epithelial to mesenchymal transition, angiogenesis and activation of stromal cells, supporting ultimately, metastasis dissemination. |
2021-06-09 |
2023-08-13 |
Not clear |
| Ying Chen, Yingjie Xu, Zhoufeng Deng, Yin Wang, Ying Zheng, Weihua Jiang, Li Jian. MicroRNA expression profiling involved in doxorubicin-induced cardiotoxicity using high-throughput deep-sequencing analysis. Oncology letters. vol 22. issue 1. 2021-06-08. PMID:34093775. |
these mirnas were involved in the regulation of different pathways, whose functions included apoptosis, cell proliferation, extracellular matrix remodeling, oxidative stress and lipid metabolism. |
2021-06-08 |
2023-08-13 |
Not clear |
| Lin Qiu, Shaolei Yi, Tingting Yu, Yan Ha. Sirt3 Protects Against Thoracic Aortic Dissection Formation by Reducing Reactive Oxygen Species, Vascular Inflammation, and Apoptosis of Smooth Muscle Cells. Frontiers in cardiovascular medicine. vol 8. 2021-06-08. PMID:34095262. |
reactive oxygen species (ros) promote degradation of the extracellular matrix and vascular smooth muscle cell (vsmc) apoptosis. |
2021-06-08 |
2023-08-13 |
Not clear |
| Fangyuan Wang, Jingjing Li, Haixia Wang, Fan Zhang, Jin Ga. Activating transcription factor 3 inhibits endometrial carcinoma aggressiveness via JunB suppression. International journal of oncology. vol 57. issue 3. 2021-06-07. PMID:32582999. |
the properties of ec cells, including the expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, the cell cycle and apoptosis were all altered by overexpression of atf3. |
2021-06-07 |
2023-08-13 |
Not clear |
| Alan M Elder, Alexander R Stoller, Sarah A Black, Traci R Lyon. Macphatics and PoEMs in Postpartum Mammary Development and Tumor Progression. Journal of mammary gland biology and neoplasia. vol 25. issue 2. 2021-06-04. PMID:32535810. |
this event is characterized by apoptosis and lysosomal-mediated cell death of the majority of the lactational mammary epithelium, followed by remodeling of the extracellular matrix, influx of immune cell populations (in particular, t helper cells, monocytes, and macrophages), and neo-lymphangiogenesis. |
2021-06-04 |
2023-08-13 |
Not clear |
| Mingzhu Xu, Mengqiu Yi, Na L. MicroRNA-17-5p restrains the dysfunction of Ang-II induced podocytes by suppressing secreted modular calcium-binding protein 2 via NF-κB and TGFβ signaling. Environmental toxicology. vol 36. issue 7. 2021-06-04. PMID:33835671. |
smoc2 regulated cell viability, apoptosis and extracellular matrix (ecm) deposition in ang ii-induced podocytes via tgfβ signaling, and smoc2 regulated inflammation in ang ii-induced podocytes through nf-κb signaling. |
2021-06-04 |
2023-08-13 |
Not clear |
| Christian David Hernández-Silva, Julio César Villegas-Pineda, Ana Laura Pereira-Suáre. Expression and Role of the G Protein-Coupled Estrogen Receptor (GPR30/GPER) in the Development and Immune Response in Female Reproductive Cancers. Frontiers in endocrinology. vol 11. 2021-06-03. PMID:32973677. |
besides, the g protein-coupled estrogen receptor (gper, formerly known as gpr30) was recently described as a seven-transmembrane receptor that mediates non-genomic estrogenic signaling, including calcium mobilization, camp synthesis, cleavage of matrix metalloproteinases, transactivation of epidermal growth factor receptor (egfr), and the subsequent activation of pi3k and mapk signaling pathways, which are the reasons why it is related to cellular processes, such as cell-cycle progression, cellular proliferation, differentiation, apoptosis, migration, and invasion. |
2021-06-03 |
2023-08-13 |
Not clear |
| Dorit Schleinitz, Kerstin Krause, Tobias Wohland, Claudia Gebhardt, Nicolas Linder, Michael Stumvoll, Matthias Blüher, Ingo Bechmann, Peter Kovacs, Martin Gericke, Anke Tönje. Identification of distinct transcriptome signatures of human adipose tissue from fifteen depots. European journal of human genetics : EJHG. vol 28. issue 12. 2021-06-02. PMID:32661330. |
moreover, the epicardial fat transcriptome was enriched for genes involved in extracellular matrix remodeling, inflammation, immune signaling, coagulation, thrombosis, beigeing, and apoptosis. |
2021-06-02 |
2023-08-13 |
human |
| Hiroyuki Jinnouchi, Yu Sato, Atsushi Sakamoto, Anne Cornelissen, Masayuki Mori, Rika Kawakami, Neel V Gadhoke, Frank D Kolodgie, Renu Virmani, Aloke V Fin. Calcium deposition within coronary atherosclerotic lesion: Implications for plaque stability. Atherosclerosis. vol 306. 2021-05-31. PMID:32654790. |
pro-inflammatory cytokines observed in unstable plaques may provoke an early phase of osteogenic differentiation of smooth muscle cells (smcs), a release of calcifying extracellular matrix vesicles, and/or induce apoptosis of macrophages and smcs, which also calcify. |
2021-05-31 |
2023-08-13 |
Not clear |
| Shishen Pei, Jinwei Ying, Yan Zhang, Linhao Su, Shi Cheng, Dike Rua. RhTSG-6 inhibits IL-1β-induced extracellular matrix degradation and apoptosis by suppressing the p38, and JNK pathways in nucleus pulposus cells. Folia histochemica et cytobiologica. vol 58. issue 3. 2021-05-31. PMID:32936927. |
rhtsg-6 inhibits il-1β-induced extracellular matrix degradation and apoptosis by suppressing the p38, and jnk pathways in nucleus pulposus cells. |
2021-05-31 |
2023-08-13 |
human |
| Zhao-Hui Yu, Yi-Chao Ji, Kun Li, Ting Liang, Bo Liu, Hai-Lei Chen, Li Ni, Zong-Ping Luo, Hui-Lin Yan. Stiffness of the extracellular matrix affects apoptosis of nucleus pulposus cells by regulating the cytoskeleton and activating the TRPV2 channel protein. Cellular signalling. vol 84. 2021-05-31. PMID:33862152. |
stiffness of the extracellular matrix affects apoptosis of nucleus pulposus cells by regulating the cytoskeleton and activating the trpv2 channel protein. |
2021-05-31 |
2023-08-13 |
Not clear |