| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chenggang Zhao, Zhiyang Zhao, Zhen Wang, Lizhu Hu, Hongzhi Wang, Zhiyou Fan. Supervillin promotes tumor angiogenesis in liver cancer. Oncology reports. vol 44. issue 2. 2021-03-08. PMID:32468064. |
svil knockdown inhibited vm formation and induced tumor cell apoptosis via the vegf‑p38 signaling axis and through various vm‑associated transcriptional factors, including vascular endothelial‑cadherin, matrix metalloproteinase 9/12 and migration‑inducing protein 7. |
2021-03-08 |
2023-08-13 |
mouse |
| Frederic Shapiro, Kathleen Maguire, Srilatha Swami, Hui Zhu, Evelyn Flynn, Jamie Wang, Joy Y W. Histopathology of osteogenesis imperfecta bone. Supramolecular assessment of cells and matrices in the context of woven and lamellar bone formation using light, polarization and ultrastructural microscopy. Bone reports. vol 14. 2021-03-06. PMID:33665234. |
at differing levels of microscopic resolution: lamellar bone is characterized by short, obliquely oriented lamellae with a mosaic appearance in progressively deforming forms; polarization defines tissue conformations and localizes initiation of lamellar formation; ultrastructure of bone forming cells shows markedly dilated rough endoplasmic reticulum (rer) and prominent golgi bodies with disorganized cisternae and swollen dispersed tubules and vesicles, structural indications of storage disorder/stress responses and mitochondrial swelling in cells with massively dilated rer indicating apoptosis; ultrastructural matrix assessments in woven bone show randomly oriented individual fibrils but also short pericellular bundles of parallel oriented fibrils positioned obliquely and oriented randomly to one another and in lamellar bone show unidirectional fibrils that deviate at slight angles to adjacent bundles and obliquely oriented fibril groups consistent with twisted plywood fibril organization. |
2021-03-06 |
2023-08-13 |
Not clear |
| Dongmei Gao, Long Hao, Zilong Zha. Long non-coding RNA PART1 promotes intervertebral disc degeneration through regulating the miR‑93/MMP2 pathway in nucleus pulposus cells. International journal of molecular medicine. vol 46. issue 1. 2021-03-05. PMID:32319551. |
the levels of the cell proliferation marker ki‑67 and the apoptosis marker cleaved caspase‑3, and the levels of genes related to extracellular matrix (ecm) synthesis and degradation, were also evaluated by western blotting and rt‑qpcr, as appropriate. |
2021-03-05 |
2023-08-13 |
Not clear |
| Nandini Nai. Epidemiology and pathogenesis of heart failure with preserved ejection fraction. Reviews in cardiovascular medicine. vol 21. issue 4. 2021-03-02. PMID:33387998. |
newer insights into myocardial remodeling have led to an interesting finding of abnormal fibroblasts in hfpef which are apoptosis resistant and initiate the development of an abnormal myocardial matrix resulting in initiation and progression of the disease. |
2021-03-02 |
2023-08-13 |
Not clear |
| Fu-Xing-Zi Li, Feng Xu, Xiao Lin, Feng Wu, Jia-Yu Zhong, Yi Wang, Bei Guo, Ming-Hui Zheng, Su-Kang Shan, Ling-Qing Yua. The Role of Substance P in the Regulation of Bone and Cartilage Metabolic Activity. Frontiers in endocrinology. vol 11. 2021-03-02. PMID:32180759. |
previous studies have shown that bone and chondrocytes can synthesize and secrete sensory neuropeptides and express their receptors, and can promote proliferation, differentiation, apoptosis, matrix synthesis, and the degradation of target cells through autocrine/paracrine modes. |
2021-03-02 |
2023-08-13 |
Not clear |
| Hao Yang, Cheng Chen, Hao Chen, Xiaojun Duan, Juan Li, Yi Zhou, Weinan Zeng, Liu Yan. Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis. Aging. vol 12. issue 13. 2021-03-01. PMID:32611834. |
we found that abt263 reduced the expression of inflammatory cytokines and promoted cartilage matrix aggregation in oa chondrocyte pellet culture by inducing snc apoptosis. |
2021-03-01 |
2023-08-13 |
rat |
| Shih-Hung Tsai, Lung-An Hsu, Hsiao-Ya Tsai, Yung-Hsin Yeh, Cheng-Yo Lu, Po-Chuan Chen, Jen-Chun Wang, Yi-Lin Chiu, Chih-Yuan Lin, Yu-Juei Hs. Aldehyde dehydrogenase 2 protects against abdominal aortic aneurysm formation by reducing reactive oxygen species, vascular inflammation, and apoptosis of vascular smooth muscle cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 7. 2021-03-01. PMID:32463165. |
reactive oxygen species (ros) promote degradation of the extracellular matrix (ecm) and vascular smooth muscle cell (vsmc) apoptosis. |
2021-03-01 |
2023-08-13 |
mouse |
| Yunke Liu, Ke Liu, Chao Tang, Zuxuan Shi, Kai Jing, Jia Zhen. Long non-coding RNA XIST contributes to osteoarthritis progression via miR-149-5p/DNMT3A axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 128. 2021-02-26. PMID:32521454. |
xist knockdown promoted cell viability but restrained cell apoptosis and extracellular matrix (ecm) protein degradation in il-1β-treated chondrocytes. |
2021-02-26 |
2023-08-13 |
rat |
| Xing Zhang, Chao-Ran Huang, Sheng Pan, Yong Pang, Ye-Shuai Chen, Guo-Chun Zha, Kai-Jin Guo, Xin Zhen. Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression. International immunopharmacology. vol 83. 2021-02-26. PMID:32247266. |
the lower expression of snhg15 was negatively associated with the observed modified mankin scale scores, extracellular matrix (ecm) degradation and chondrocyte apoptosis. |
2021-02-26 |
2023-08-13 |
Not clear |
| Nao Komatsu, Mikihito Kajiya, Shin Morimoto, Souta Motoike, Hiroki Yoshii, Tomoyuki Iwata, Kazuhisa Ouhara, Shinji Matsuda, Noriyoshi Mizuno, Hidemi Kurihar. Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes. Biochemical and biophysical research communications. vol 530. issue 2. 2021-02-25. PMID:32553627. |
cox2-mediated pge2 production via p38/jnk-c-fos signaling inhibits cell apoptosis in 3d floating culture clumps of mesenchymal stem cell/extracellular matrix complexes. |
2021-02-25 |
2023-08-13 |
Not clear |
| Roos J Leguit, Reinier A P Raymakers, Konnie M Hebeda, Roel Goldschmedin. CCN2 (Cellular Communication Network factor 2) in the bone marrow microenvironment, normal and malignant hematopoiesis. Journal of cell communication and signaling. vol 15. issue 1. 2021-02-25. PMID:33428075. |
furthermore, ccn2 and its fragments have been implicated in the regulation of a multitude of biological processes, including cell proliferation, differentiation, adhesion, migration, cell survival, apoptosis and the production of extracellular matrix products, as well as in more complex processes such as embryonic development, angiogenesis, chondrogenesis, osteogenesis, fibrosis, mechanotransduction and inflammation. |
2021-02-25 |
2023-08-13 |
Not clear |
| Penggui Zhang, Guangming Gao, Ziyu Zhou, Xuejun H. microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 54. issue 4. 2021-02-25. PMID:33624729. |
the effect of mir-130b on the viability, inflammation, apoptosis, and extracellular matrix of oa chondrocytes was studied. |
2021-02-25 |
2023-08-13 |
Not clear |
| Janet Palacios-Martinez, Juan Caballero-Perez, Annie Espinal-Centeno, Gilberto Marquez-Chavoya, Hilda Lomeli, Enrique Salas-Vidal, Denhi Schnabel, Jesus Chimal-Monroy, Alfredo Cruz-Ramire. Multi-organ transcriptomic landscape of Ambystoma velasci metamorphosis. Developmental biology. vol 466. issue 1-2. 2021-02-23. PMID:32828730. |
in the case of the gills, the most prominent biological processes identified are degradation of extracellular matrix, apoptosis and keratin production. |
2021-02-23 |
2023-08-13 |
Not clear |
| Sabine Schäfer-Somi, Cordula Gabriel, Selim Asla. Embryo-maternal communication in dogs: Immune system related factors. Theriogenology. vol 150. 2021-02-22. PMID:32061404. |
secretory products are transported to the embryo-maternal interface and contribute to extra-cellular matrix (ecm) degradation, a change in the intrauterine immune milieu towards a reduction of immune cells and a change in lymphocyte subsets, cell differentiation, angiogenesis, and the balance between proliferation and apoptosis. |
2021-02-22 |
2023-08-13 |
Not clear |
| Guohua Lü, Lei Li, Bing Wang, Lei Kuan. LINC00623/miR-101/HRAS axis modulates IL-1β-mediated ECM degradation, apoptosis and senescence of osteoarthritis chondrocytes. Aging. vol 12. issue 4. 2021-02-18. PMID:32062610. |
chondrocyte apoptosis and extracellular matrix (ecm) degeneration have been implicated in the pathogenesis of osteoarthritis (oa). |
2021-02-18 |
2023-08-13 |
rat |
| Ming Li, Ruoyu Li, Sidong Yang, Dalong Yang, Xianda Gao, Jiayuan Sun, Wenyuan Ding, Lei M. Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Prevent Acidic pH-Induced Damage in Human Nucleus Pulposus Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-18. PMID:32436493. |
conclusions in the pathological acid environment, msc-derived exo promotes the expression of chondrocyte extracellular matrix, collagen ii, and aggrecan, and reduces matrix degradation by downregulating matrix-degrading enzymes, protecting npcs from acidic ph-induced apoptosis. |
2021-02-18 |
2023-08-13 |
human |
| Yongjie Wang, Mingxue Che, Jingguo Xin, Zhi Zheng, Jiangbi Li, Shaokun Zhan. The role of IL-1β and TNF-α in intervertebral disc degeneration. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 131. 2021-02-17. PMID:32853910. |
they are also upregulated in the degenerative ivds, and they are closely related to various pathological idd processes, including inflammatory response, matrix destruction, cellular senescence, autophagy, apoptosis, pyroptosis, and proliferation. |
2021-02-17 |
2023-08-13 |
Not clear |
| Jiajie Tu, Wei Huang, Weiwei Zhang, Jiawei Mei, Chen Zh. The emerging role of lncRNAs in chondrocytes from osteoarthritis patients. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 131. 2021-02-17. PMID:32927251. |
recent studies have demonstrated that lncrnas are involved in the pathogenesis of oa by affecting various essential cellular features of chondrocytes, such as proliferation, apoptosis, inflammation, and degradation of the extracellular matrix (ecm). |
2021-02-17 |
2023-08-13 |
Not clear |
| Petra Cazzanelli, Karin Wuertz-Koza. MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology. International journal of molecular sciences. vol 21. issue 10. 2021-02-16. PMID:32443722. |
key characteristics of the pathological changes connected with degenerative disc disease (ddd) are the degradation of the extracellular matrix (ecm), apoptosis and senescence, as well as inflammation. |
2021-02-16 |
2023-08-13 |
Not clear |
| Hanrong Xu, Liefeng Ji, Chunhua Yu, Qiming Chen, Qiangqiang Ge, Yinjiang L. MiR-423-5p Regulates Cells Apoptosis and Extracellular Matrix Degradation via Nucleotide-Binding, Leucine-Rich Repeat Containing X1 (NLRX1) in Interleukin 1 beta (IL-1β)-Induced Human Nucleus Pulposus Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-02-16. PMID:32467560. |
mir-423-5p regulates cells apoptosis and extracellular matrix degradation via nucleotide-binding, leucine-rich repeat containing x1 (nlrx1) in interleukin 1 beta (il-1β)-induced human nucleus pulposus cells. |
2021-02-16 |
2023-08-13 |
human |